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151.
Dr. C. A. Rubio G. Nylander B. Wallin M. Sveander M. -L. Alun A. Duvander 《Diseases of the colon and rectum》1984,27(7):468-470
For three months 65 male Sprague-Dawley rats received subcutaneous 1,2-dimethylhydrazine (DMH) weekly. Of the 65 animals,
45 were subjected to resection of the transverse colon, which subsequently was stitched to the abdominal wall. The remaining
20 animals were shamoperated controls. Fifty-four per cent of the tumors occurred either at the anastomotic site in the functioning
colon (31 per cent) or at the anastomotic site of the isolated and defunctionalized colonic loop (23 per cent). On the other
hand, only 10 per cent of the tumors occurred in the transverse colon of sham-operated controls. The difference was significant
(P<0.001).
This study was supported by grants from the Cancer Society, Stockholm, and the Karolinska Institute. 相似文献
152.
Target‐ and input‐dependent organization of AMPA and NMDA receptors in synaptic connections of the cochlear nucleus 下载免费PDF全文
María E Rubio Yugo Fukazawa Naomi Kamasawa Cheryl Clarkson Elek Molnár Ryuichi Shigemoto 《The Journal of comparative neurology》2014,522(18):4023-4042
We examined the synaptic structure, quantity, and distribution of α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionic acid (AMPA)‐ and N‐methyl‐D‐aspartate (NMDA)‐type glutamate receptors (AMPARs and NMDARs, respectively) in rat cochlear nuclei by a highly sensitive freeze‐fracture replica labeling technique. Four excitatory synapses formed by two distinct inputs, auditory nerve (AN) and parallel fibers (PF), on different cell types were analyzed. These excitatory synapse types included AN synapses on bushy cells (AN‐BC synapses) and fusiform cells (AN‐FC synapses) and PF synapses on FC (PF‐FC synapses) and cartwheel cell spines (PF‐CwC synapses). Immunogold labeling revealed differences in synaptic structure as well as AMPAR and NMDAR number and/or density in both AN and PF synapses, indicating a target‐dependent organization. The immunogold receptor labeling also identified differences in the synaptic organization of FCs based on AN or PF connections, indicating an input‐dependent organization in FCs. Among the four excitatory synapse types, the AN‐BC synapses were the smallest and had the most densely packed intramembrane particles (IMPs), whereas the PF‐CwC synapses were the largest and had sparsely packed IMPs. All four synapse types showed positive correlations between the IMP‐cluster area and the AMPAR number, indicating a common intrasynapse‐type relationship for glutamatergic synapses. Immunogold particles for AMPARs were distributed over the entire area of individual AN synapses; PF synapses often showed synaptic areas devoid of labeling. The gold‐labeling for NMDARs occurred in a mosaic fashion, with less positive correlations between the IMP‐cluster area and the NMDAR number. Our observations reveal target‐ and input‐dependent features in the structure, number, and organization of AMPARs and NMDARs in AN and PF synapses. J. Comp. Neurol. 522:4023–4042, 2014. © 2014 Wiley Periodicals, Inc. 相似文献
153.
Beatriz Domínguez‐Gil Elisabeth Coll Mario Fernndez‐Ruiz Esther Corral Francisco del Río Rafael Zaragoza Juan J. Rubio Domingo Hernndez 《American journal of transplantation》2020,20(9):2593-2598
Spain has been one of the most affected countries by the COVID‐19 outbreak. As of April 28, 2020, the number of confirmed cases is 210 773, including 102 548 patients recovered, more than 10 300 admitted to the ICU, and 23 822 deaths, with a global case fatality rate of 11.3%. From the perspective of donation and transplantation, the Spanish system first focused on safety issues, providing recommendations for donor evaluation and testing, and to rule out SARS‐CoV‐2 infection in potential recipients prior to transplantation. Since the country entered into an epidemiological scenario of sustained community transmission and saturation of intensive care, developing donation and transplantation procedures has become highly complex. Since the national state of alarm was declared in Spain on March 13, 2020, the mean number of donors has declined from 7.2 to 1.2 per day, and the mean number of transplants from 16.1 to 2.1 per day. Increased mortality on the waiting list may become a collateral damage of this terrible pandemic. 相似文献
154.
Are Chandrakanth Tyler D. Howe J. Olivares A. Nissan A. Zippel D. Gupta A. Savant D. D’Ugo D. Rubio I. Bargallo-Rocha J. E. Martinez-Said H. Takeuchi H. Taketomi A. Oliveira A. F. Ribeiro H. S. Castro Cheema M. A. Majid H. J. Chen G. Roviello F. Gronchi A. Leon A. Lee W. Y. Park D. J. Park J. Auer R. Gawad W. A. Zaghloul A. 《Annals of surgical oncology》2022,29(5):2773-2783
Annals of Surgical Oncology - The purpose of this article is to summarize the opinions of the surgical oncology leaders from the Global Forum of Cancer Surgeons (GFCS) about the global impact of... 相似文献
155.
M. Dolores del Toro López Javier Arias Díaz José M. Balibrea Natividad Benito Andrés Canut Blasco Erika Esteve Juan Pablo Horcajada Juan Diego Ruiz Mesa Alba Manuel Vázquez Cristóbal Muñoz Casares Jose Luis del Pozo Miquel Pujol Melchor Riera Jaime Jimeno Inés Rubio Pérez Jaime Ruiz-Tovar Polo Alejandro Serrablo Alex Soriano Josep M. Badia 《Cirugía espa?ola》2021,99(1):11-26
Antibiotic prophylaxis in surgery is one of the most effective measures for preventing surgical site infection, although its use is frequently inadequate and may even increase the risk of infection, toxicities and antimicrobial resistance. As a result of advances in surgical techniques and the emergence of multidrug-resistant organisms, the current guidelines for prophylaxis need to be revised.The Sociedad Española de Enfermedades Infecciosas (Spanish Society of Infectious Diseases and Clinical Microbiology) (SEIMC) together with the Asociación Española de Cirujanos (Spanish Association of Surgeons) (AEC) have revised and updated the recommendations for antibiotic prophylaxis in surgery to adapt them to any type of surgical intervention and to current epidemiology. This document gathers together the recommendations on antimicrobial prophylaxis in the various procedures, with doses, duration, prophylaxis in special patient groups, and in epidemiological settings of multidrug resistance to facilitate standardized management and the safe, effective and rational use of antibiotics in elective surgery. 相似文献
156.
Rectal adenocarcinoma: assessment of tumour involvement of the lateral resection margin by MRI of resected specimen. 总被引:8,自引:0,他引:8
L Blomqvist C Rubio T Holm M Machado T Hindmarsh 《The British journal of radiology》1999,72(853):18-23
The aim of the present study was to investigate whether MRI could predict tumour involvement of the lateral resection margin on resected rectal cancer specimens. 26 specimens obtained after total mesorectal excision were examined in the sagittal and axial plane on a clinical 1.5 T MR system using phased-array surface coils. The shortest distance between the deepest point of tumour penetration and the lateral resection margin was measured. This distance is referred to as LRM. The results were correlated to measurements on digital images of giant histopathological sections. The total number of lymph nodes and lymph node metastases was also counted. LRM was less than or equal to 1 mm (a distance considered for non-radically excised tumours) in eight of the histopathological specimens. On MR images of the resected specimen, LRM was less than or equal to 1 mm in seven of these specimens. LRM was shorter in MR examinations than in histopathological giant sections in 11 specimens. The sensitivity, specificity, positive and negative predictive values for prediction of tumour involvement of the lateral resection margin (LRM < or = 1 mm) by MR of the resected specimen were 88%, 78%, 64% and 93%, respectively. Presence of lymph node metastases could not accurately be predicted by MR. However, it is concluded that the presence of a tumour free lateral resection margin can be predicted by MRI of resected rectal specimens when this exceeds 1 mm. 相似文献
157.
Marina Pérez Redondo Sara Alcántara Carmona Inmaculada Fernández Simón Héctor Villanueva Fernández Alfonso Ortega López Cándido Pardo Rey Jorge Duerto Álvarez Inés Lipperheide Vallhonrat Manuel González Romero Daniel Ballesteros Ortega Francisco del Río Gallegos Juan José Rubio Muñoz 《Clinical transplantation》2020,34(8):e13899
Normothermic regional perfusion (NRP) in controlled donation after circulatory death is becoming a popular method due to the favorable results of the grafts procured under this technique. This procedure requires experience, and, sometimes, the availability of extracorporeal membrane oxygenation (ECMO) machines to implement NRP is limited to tertiary hospitals. In order to provide support with NRP in controlled donation after circulatory death across the different hospitals of the Autonomous Community of Madrid, a mobile NRP team was created. In the first 18 months since its creation, the mobile NRP team participated in 33 procurements across nine different hospitals, representing 72% of all controlled donations after circulatory death in the Autonomous Community of Madrid. NRP was successfully performed in 29 (88%) cases, with a mean duration of 69 ± 27 minutes. A total of 39 kidneys, 12 livers, and 5 bilateral lungs were recovered and transplanted. None of the livers were discarded due to an elevation in transaminases during NRP. A mobile NRP team is a feasible option and, in our series, aided in the optimization and recovery of organs from donors after controlled circulatory death in centers where ECMO technology was not available. 相似文献
158.
Patawut Bovonratwet Taylor D. Ottesen Raj J. Gala Daniel R. Rubio Nathaniel T. Ondeck Ryan P. McLynn Jonathan N. Grauer 《The spine journal》2018,18(7):1188-1196
Background Context
There has been growing interest in performing posterior lumbar fusions (PLFs) in the outpatient setting to optimize patient satisfaction and reduce cost. Although still done in only a small percentage of cases, this has been more possible because of advances in surgical techniques and anesthesia. However, data on the perioperative course of outpatient compared with inpatient PLF in a large sample size are scarce.Purpose
This study aimed to compare perioperative complications between outpatient and inpatient PLF in the American College of Surgeons National Surgical Quality Improvement Program (NSQIP) database.Study Design/Setting
A retrospective cohort comparison study was carried out.Patient Sample
Patients undergoing PLF with or without interbody fusion from the 2005 to 2015 NSQIP database comprised the sample.Outcome Measures
Outcome measures were postoperative complications within 30 days and readmission within 30 days.Methods
Patients who underwent PLF with or without interbody fusion were identified in the 2005–2015 NSQIP database. Outpatient procedures were defined as cases that had hospital length of stay (LOS)=0 days, whereas inpatient procedures were defined as LOS=1–30 days. Patient characteristics, comorbidities, and procedural variables (inclusion of interbody fusion, instrumentation, and number of levels fused) were compared between the two cohorts. Propensity score-matched comparisons were then performed for postoperative complications and 30-day readmissions between the two groups.Results
The current study included 360 outpatient and 36,610 inpatient PLF cases. After propensity matching to control potential confounding factors, statistical analysis revealed no significant difference in postoperative adverse events other than significantly lower blood transfusions in the outpatient group (2.78% vs. 10.83%, p<.001). Notably, the rate of readmissions was not different between the groups.Conclusions
Based on the lack of differences in rates of most perioperative complications and 30-day readmissions between the outpatient and inpatient cohorts, it seems that outpatient PLF may be appropriately considered for select patients. However, extremely careful patient selection should be exercised. 相似文献159.
160.
Fernando Rivera María E Vega-Villegas Marta F. López-Brea Almudena García-Castaño Ana de Juan Francisco Javier Ramos Antonio Collado Piedad Galdós Antonio Rubio Adolfo del Valle Julio Rama Marta Mayorga Jaime Sanz-Ortiz 《Clinical & translational oncology》2007,9(3):202-202
Purpose. To evaluate the response of advanced squamous cell head and neck carcinoma to a combination of induction chemotherapy and
radiotherapy.
Methods. We present long-term results of a phase II trial of Induction Chemotherapy with UFT 200 mg/m2 p.o. days 1 to 21, Vinorelbine 25 mg/m2 i.v. days 1 and 8 and Cisplatin 100 mg/m2 i.v. day 1 (UFTVP) each 21 days for 4 courses, followed by Radiotherapy concomitant with UFT 100 mg/m2 p.o. daily and Carboplatin AUC = 0.5 i.v. weekly (RT/UFTJ) in patients (pts) with Non-Resectable Locally Advanced (Stage IV-B)
Squamous Cell Head and Neck Carcinoma (IV-B-SCHNC). Primary endpoint was Complete Response to induction UFTVP and secondary
endpoints were Disease Free Status Rate after locoregional treatment and long-term Overall Survival. Between 1994 and 1997,
32 pts were included.
Results. Complete Response to Induction UFTVP was 59% (95% CI: 48%-70%). Main toxicity of UFTVP was G 3,4 neutropenia (94% of pts;
25% developed febrile neutropenia and 1 of this pts dead). After Induction Chemotherapy with UFTVP, 30 pts received radiotherapy
and 25 of them received cocomitant Carboplatin and UFT (RT/UFTJ): main toxicity was mucositis (G3-4: 72%) and one patient
died during RT/UFTJ because pneumonia. Twenty-five pts (78%) were alive and disease free at the end of the whole treatment.
Actuarial 5 year Overall survival is 32%.
Conclusion. Although toxicity is important, this approach has interesting activity and deserves further investigation.
In the January issue of Clin Transl Oncol the following article was published with a wrong reference:
Fernando Rivera, María E Vega-Villegas, Marta F. López-Brea, Almudena García-Casta?o, Ana de
Juan, Francisco Javier Ramos, Antonio Collado, Piedad Galdós, Antonio Rubio, Adolfo del Valle,
Julio Rama, Marta Mayorga and Jaime Sanz-Ortiz
Long term results of a phase II trial of Induction Chemotherapy with Uracil-Ftegafur (UFT),
Vinorelbine and Cisplatin (UFTVP) followed by Radiotherapy concomitant with UFT and Carboplatin
(RT/UFTJ) in Non-Resectable Locally Advanced (Stage IV-B) Squamous Cell Head and Neck
Carcinoma and Peripheral Blood Stem Cell Support (PBSCS) with Febrile Neutropenia
Clin Transl Oncol. 2007 Jan;9:40-47
DOI 10.1007/s12094-007-0008-5
The correct reference should be as follows:
Fernando Rivera, María E Vega-Villegas, Marta F. López-Brea, Almudena García-Casta?o, Ana de
Juan, Francisco Javier Ramos, Antonio Collado, Piedad Galdós, Antonio Rubio, Adolfo del Valle,
Julio Rama, Marta Mayorga and Jaime Sanz-Ortiz
Long term results of a phase II trial of Induction Chemotherapy with Uracil-Ftegafur (UFT),
Vinorelbine and Cisplatin (UFTVP) followed by Radiotherapy concomitant with UFT and Carboplatin
(RT/UFTJ) in Non-Resectable Locally Advanced (Stage IV-B) Squamous Cell Head and Neck
Carcinoma
Clin Transl Oncol. 2007 Jan;9:40-47The original article can be found online at 相似文献