Effects of Electroacupuncture on Arrhythmia of Model Rabbits in Different Functional States

目的 探讨电针对不同机能状态家兔心律失常的影响.方法 通过20、25、30 μg/k3种不同剂量的乌头碱,将59只家兔诱发出不同程度的心律失常,以心律失常开始时间和持续时间为指标,对比观察电针对不同机能状态家兔心律失常影响的差异.结果 3种剂量的乌头碱能诱发出家兔3种不同程度的心律失常,三者间差异具有统计学意义；电针对20 μg/kg乌头碱诱发的家兔心律失常的减缓作用明显优于30 μg/kg组.结论 针刺效应与机体异常状态的程度有关,在本实验中,针刺对抗中等程度的家兔心律失常效果最好.     

Botulinum injection for the treatment of acute esotropia resulting from complete acute abducens nerve palsy

PurposeThe objective of this study was to investigate the effectiveness of botulinum toxin A (BTX-A) injections in the treatment of acute esotropia resulting from complete acute abducens nerve palsy.MethodsFifteen patients treated for complete acute abducens nerve palsy in our clinic were retrospectively reviewed. All patients who experienced an onset within 3 months and who were treated with early subtenon BTX-A injections at the ipsilateral medial rectus muscle without electromyography (EMG) guidance were included in this study. Responses and complications were recorded during a follow-up of at least 6 months.ResultsThirteen patients who had trauma and two patients who had brain tumor that caused their abducens nerve palsy were enrolled. Overall, six patients (40%) had full recovery and two patients (13%) had partial recovery, but the residual esotropia could be tolerated with prism correction in an average of 14.6 weeks. Seven patients (47%) received strabismus surgery afterward. Patients who did not respond well to early BTX-A injections at the 1-week interval were prone to subsequent surgical intervention (p = 0.026). Three eyes (20%) had transient subconjunctival hemorrhage following the subtenon space injection; no other complications were found after the treatment.ConclusionBTX-A offers patients with complete abducens palsy a possible better chance to regain binocular vision and indicates whether additional surgical interventions are needed for these patients. We also discovered that the subtenon space injection of BTX-A without EMG guidance was a safe, time-saving, and simple technique.     

Progranulin correlated with rapid progressive interstitial lung disease in dermatomyositis with anti-melanoma differentiation-associated gene 5 antibody

Clinical Rheumatology - This study aimed to detect the expression of progranulin (PGRN) and elucidate associations with clinical features in dermatomyositis (DM) patients with anti-melanoma...     

An Update on the Clinical Development of Proprotein Convertase Subtilisin Kexin 9 Inhibitors,Novel Therapeutic Agents for Lowering Low‐Density Lipoprotein Cholesterol

Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays an essential role in the degradation of low‐density lipoprotein C (LDL‐C) receptors, and PCSK9 inhibitors have recently emerged as a potential treatment option to reduce LDL‐C. Our paper reviewed the current available Phase II clinical trials of PCSK9 inhibitors for the treatment of dyslipidemia. A second objective of this review was to evaluate the potential clinical role of PCSK9 inhibitors in the management of dyslipidemia. Studies evaluating the efficacy and safety of any PCSK9 inhibitors in patients with dyslipidemia were included. The monoclonal antibodies REGN727/SAR236553 and AMG145 have the most published clinical data. Seven phase II trials were retrieved that evaluated the efficacy and safety of REGN727/SAR236553 or AMG145 in patients with either hypercholesterolemia or heterozygous familial hypercholesterolemia (HeFH). These two agents significantly decreased LDL‐C levels either as monotherapy or in combination with other lipid‐lowering agents. REGN727/SAR236553 and AMG145 have been well tolerated. The ongoing phase III trials of these two agents are summarized. REGN727/SAR236553 and AMG145 have demonstrated the potential to further decrease LDL‐C levels when added to conventional lipid‐lowering therapy. Morbidity and mortality data are required to define their roles in clinical practice.     

A novel performance monitoring framework for health research systems: experiences of the National Institute for Health Research in England

Background  

The National Institute for Health Research (NIHR) was established in 2006 with the aim of creating an applied health research system embedded within the English National Health Service (NHS). NIHR sought to implement an approach for monitoring its performance that effectively linked early indicators of performance with longer-term research impacts. We attempted to develop and apply a conceptual framework for defining appropriate key performance indicators for NIHR.     

地震救援中流动医院手术室医院感染控制的难点及对策

目的 应对地震灾害救援中流动医院手术室消毒灭菌的难点,探讨其适合灾难救援的对策.方法 医院选址前应将感染控制做到实处,把握环境、物资、消毒灭菌等管理要点,确保医疗救援任务的圆满完成.结果 通过对医院选址、消毒灭菌管理、医疗废物处理等方面的有效管理,确保在历次地震救援中所完成的43例手术,其中包括Ⅰ类切口手术27例,无一例发生医院感染.结论 加强流动医院手术室医院感染控制管理,对于在灾害救援中做好医疗救援工作,增加手术成功率、有效降低感染率具有积极意义.