全文获取类型
收费全文 | 4523篇 |
免费 | 293篇 |
国内免费 | 22篇 |
专业分类
耳鼻咽喉 | 52篇 |
儿科学 | 101篇 |
妇产科学 | 99篇 |
基础医学 | 935篇 |
口腔科学 | 89篇 |
临床医学 | 328篇 |
内科学 | 800篇 |
皮肤病学 | 148篇 |
神经病学 | 391篇 |
特种医学 | 154篇 |
外科学 | 515篇 |
综合类 | 14篇 |
预防医学 | 359篇 |
眼科学 | 100篇 |
药学 | 567篇 |
中国医学 | 27篇 |
肿瘤学 | 159篇 |
出版年
2023年 | 45篇 |
2022年 | 42篇 |
2021年 | 83篇 |
2020年 | 83篇 |
2019年 | 127篇 |
2018年 | 248篇 |
2017年 | 152篇 |
2016年 | 193篇 |
2015年 | 162篇 |
2014年 | 268篇 |
2013年 | 378篇 |
2012年 | 490篇 |
2011年 | 558篇 |
2010年 | 300篇 |
2009年 | 119篇 |
2008年 | 113篇 |
2007年 | 85篇 |
2006年 | 78篇 |
2005年 | 40篇 |
2004年 | 29篇 |
2003年 | 40篇 |
2002年 | 25篇 |
2001年 | 49篇 |
2000年 | 37篇 |
1999年 | 42篇 |
1998年 | 44篇 |
1997年 | 40篇 |
1996年 | 35篇 |
1995年 | 40篇 |
1994年 | 35篇 |
1993年 | 23篇 |
1992年 | 31篇 |
1991年 | 30篇 |
1990年 | 36篇 |
1989年 | 28篇 |
1988年 | 24篇 |
1986年 | 25篇 |
1985年 | 33篇 |
1984年 | 32篇 |
1982年 | 33篇 |
1981年 | 22篇 |
1980年 | 24篇 |
1979年 | 24篇 |
1978年 | 21篇 |
1977年 | 26篇 |
1976年 | 22篇 |
1975年 | 27篇 |
1974年 | 24篇 |
1973年 | 29篇 |
1971年 | 21篇 |
排序方式: 共有4838条查询结果,搜索用时 15 毫秒
91.
92.
Barbara Fumić Jasna Jablan Dominik Cinčić Marijana Zovko Končić 《Journal of microencapsulation》2018,35(1):1-12
This work aimed to investigate the potential effect of cyclodextrin encapsulation on intrinsic ability of daidzein (DAD) and genistein (GEN) to inhibit the glycosaminoglycan (GAG) synthesis in fibroblasts originating from patients with mucopolysaccharidosis (MPS), type II and III. DAD or GEN encapsulation with either 2-hydroxypropyl-β-cyclodextrin or sulphobuthylether-β-cyclodextrin were achieved by neat grinding and were characterised by thermal analysis, X-ray powder diffraction, scanning electron microscopy and solubility testing which confirmed the complexes formation with increased solubility with respect to starting compounds. Both isoflavones, as well as their co-ground cyclodextrin complexes reduced GAG levels in the fibroblasts of MPS II and MPS III patients from 54.8–77.5%, in a dose dependent manner, without any significant cytotoxic effect. Cyclodextrin encapsulation did not change the intrinsically high effect of both DAD and GEN on the GAG level reduction in the treated cells, thus could be considered as a part of combination therapies of MPS. 相似文献
93.
Assessment of the involvement of the macrophage migration inhibitory factor–glucocorticoid regulatory dyad in the expression of matrix metalloproteinase‐2 during periodontitis 下载免费PDF全文
Josefine Hirschfeld Mohammed Howait Alexandru Movila Marijo Parčina Isabelle Bekeredjian‐Ding James Deschner Søren Jepsen Toshihisa Kawai 《European journal of oral sciences》2017,125(5):345-354
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine and counter‐regulator of endogenous glucocorticoids (GCs). It is implicated in acute and chronic inflammatory diseases. This study investigated the role of the MIF–GC regulatory dyad in the expression and release of matrix metalloproteinase‐2 (MMP‐2) during periodontitis, in vivo and in vitro. In a Mif‐knockout (KO) mouse model of ligature‐induced periodontitis, gingival tissues and blood were collected and analysed for levels of interleukin‐6 (IL‐6), MIF, MMP‐2, and corticosterone. In addition, human gingival fibroblasts (HGFs) were tested for production of IL‐6 and MMP‐2 after stimulation with hydrocortisone (HC), MIF, tumour necrosis factor‐alpha (TNF‐α), or Fusobacterium nucleatum, a pathogen known to elicit immune responses during periodontitis. Wild‐type (WT) mice showed a local and systemic increase of MIF levels during inflammation, which was confirmed by increased local IL‐6 concentrations. Systemic GC levels were reduced in WT and Mif‐KO mice during inflammation, with overall lower concentrations in Mif‐KO mice. In vivo and in vitro, MMP‐2 production was not dependent on MIF or inflammatory stimuli, but was inhibited by HC. Therefore, MIF does not appear to stimulate expression of MMP‐2 in the gingival tissues, whereas GC upregulates MIF and downregulates MMP‐2. Our findings further suggest that MIF may regulate systemic GC levels. 相似文献
94.
95.
Katarina Gojko Kanurić Spasenija Danilo Milanović Bojana Branko Ikonić Eva Stjepan Lončar Mirela Dragoljub Iličić Vladimir Radovan Vukić Dajana Vukota Vukić 《Yao wu shi pin fen xi = Journal of food and drug analysis.》2018,26(4):1229-1234
The aim of this research was to investigate the effect of new, non-conventional starter culture on the kinetics of the lactose transformation during milk fermentation by kombucha, at pH 5.8; 5.4; 5.1; 4.8; and 4.6, at two different temperatures 37 °C and 42 °C. Milk fermentation at 42 °C lasted significantly shorter (about 5 h, 30 min) compared to the fermentation at 37 °C. Changes of lactose concentration at the both temperatures are consisting of two retaining stages and very steep decline in–between. The analysis of the rate curves showed that the reaction rate passes through the maximum after 9 h, 30 min at 37 °C and after 4 h at 42 °C. The sigmoidal saturation curve indicates a complex kinetics of lactose fermentation by kombucha starter. 相似文献
96.
Ivona Markelić Iva Hlapčić Dunja Rogić Ivana Rako Miroslav Samaržija Sanja Popović-Grle Lada Rumora Andrea Vukić Dugac 《Nutrition, metabolism, and cardiovascular diseases : NMCD》2021,31(1):153-161
Background and aimsLimited number of studies investigated lipid profile in chronic obstructive pulmonary disease (COPD) with inconsistent results. This study aimed to investigate lipid parameters in sera of patients with stable COPD and their associations with disease severity, smoking, comorbidities and therapy.Methods and resultsThe study included 137 COPD patients and 95 controls. Triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were assessed. Non-HDL-C (NHC), atherogenic coefficient (AC), TG/HDL-C, atherogenic index of plasma (AIP), Castelli's risk index I and II (CRI-I, CRI-II), and monocyte to HDL ratio (MHR) were calculated.HDL-C and MHR were increased, while other lipid parameters and indices were decreased in COPD patients compared to healthy individuals. Smoking did not influence lipid parameters. However, lipid profile was altered only in more severe disease stages. AC, CRI-I and CRI-II showed positive association with lung function parameters in COPD patients, and negative with COPD multicomponent indices (ADO, BODCAT, BODEx, CODEx and DOSE). Combined model that included CRI-II, C-reactive protein, fibrinogen and white blood cells showed great diagnostic performances, and correctly classified 72% of study participants with an AUC of 0.800 (0.742–0.849), P < 0.001. Bronchodilator monotherapy and statins have opposite impact on TC, LDL-C and NHC, while TG, TG/HDL-C and AIP were increased in COPD patients with cardiovascular diseases.ConclusionLipid disbalance is present in COPD, and it seems to occur later as the disease progresses. Further studies are needed to illuminate the underlying mechanism of dyslipidaemia. 相似文献
97.
Uroš Rajkovič Marija Milavec Kapun Dejan Dinevski Vesna Prijatelj Marija Zaletel Olga Šušteršič 《Journal of medical systems》2016,40(9):198
Health documentation is a prerequisite for good and sustainable health and social care. It is especially important for patient involvement and their empowerment. A transition from paper to e-documentation together with the electronic patient record should be based on thorough knowledge of the current state of documentation and its usages. The main objective of this paper was to analyse which documents and work methods of documenting processes within nursing are being used within different environments. Furthermore, what are the main reasons for their discrepancies from theoretical approaches and best practices. The analysis is based on a survey carried out on all three levels of healthcare. The survey questionnaire consisted of 12 questions to which responded 286 nursing teams from community health centres, hospitals and retirement homes in Slovenia. The results point to diversity in documenting as well as lack of interoperability. This is reflected in a great number of different documents. All phases of the nursing process were being documented in only 31.8 % of cases. The main reasons for this can be attributed to work organisation, different definitions of data-set requirements and inadequate knowledge by nurses. Survey results pointed out a need for the renewal of nursing documentation towards a more uniform system based on contemporary health technologies. 相似文献
98.
99.
100.
Zinkevičienė Auksė Dumalakienė Irena Mieliauskaitė Diana Vilienė Rita Narkevičiūtė Ieva Girkontaitė Irutė 《Clinical rheumatology》2019,38(10):2803-2809
Clinical Rheumatology - Both Sjögren’s syndrome (SS) and non-autoimmune sicca syndrome (nSS) can show symptoms of dry eyes and a dry mouth, and objective reductions in tear and saliva... 相似文献