全文获取类型
收费全文 | 9426篇 |
免费 | 570篇 |
国内免费 | 46篇 |
专业分类
耳鼻咽喉 | 124篇 |
儿科学 | 224篇 |
妇产科学 | 158篇 |
基础医学 | 1184篇 |
口腔科学 | 890篇 |
临床医学 | 736篇 |
内科学 | 2106篇 |
皮肤病学 | 218篇 |
神经病学 | 667篇 |
特种医学 | 375篇 |
外科学 | 930篇 |
综合类 | 65篇 |
一般理论 | 4篇 |
预防医学 | 1021篇 |
眼科学 | 189篇 |
药学 | 691篇 |
中国医学 | 97篇 |
肿瘤学 | 363篇 |
出版年
2023年 | 82篇 |
2022年 | 228篇 |
2021年 | 348篇 |
2020年 | 251篇 |
2019年 | 293篇 |
2018年 | 366篇 |
2017年 | 230篇 |
2016年 | 268篇 |
2015年 | 339篇 |
2014年 | 474篇 |
2013年 | 510篇 |
2012年 | 684篇 |
2011年 | 823篇 |
2010年 | 417篇 |
2009年 | 352篇 |
2008年 | 555篇 |
2007年 | 570篇 |
2006年 | 403篇 |
2005年 | 413篇 |
2004年 | 315篇 |
2003年 | 301篇 |
2002年 | 248篇 |
2001年 | 170篇 |
2000年 | 149篇 |
1999年 | 126篇 |
1998年 | 79篇 |
1997年 | 81篇 |
1996年 | 75篇 |
1995年 | 53篇 |
1994年 | 37篇 |
1993年 | 43篇 |
1992年 | 48篇 |
1991年 | 71篇 |
1990年 | 56篇 |
1989年 | 59篇 |
1988年 | 48篇 |
1987年 | 48篇 |
1986年 | 47篇 |
1985年 | 53篇 |
1984年 | 36篇 |
1983年 | 41篇 |
1982年 | 22篇 |
1981年 | 26篇 |
1980年 | 21篇 |
1979年 | 21篇 |
1978年 | 15篇 |
1977年 | 16篇 |
1973年 | 14篇 |
1970年 | 13篇 |
1966年 | 13篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
61.
Romeika Lorena Mendes da Silva Tmara Taynah Medeiros da Silva Renata Lima Pessoa Ayane Cristine Alves Sarmento Kleyton Santos Medeiros Daniele Vieira Dantas Rodrigo Assis Neves Dantas 《Medicine》2022,101(24)
Introduction:Uterine cervix tumors have an invasive nature, with the capacity to proliferate to surrounding organs such as the vagina, bladder, and rectum, as well as the capacity for dissemination and involvement of structures distant from its place of origin. According to the International Federation of Gynecology and Obstetrics, patients with stages IB I, IB I microscopic (small dimension <4 cm) are indicated for radiotherapy or adjuvant chemoradiotherapy with cisplatin (40 mg/m2). However, cisplatin has side effects such as hematological implications (anemia, neutropenia, and thrombocytopenia), gastrointestinal disorders (nausea, vomiting, diarrhea, constipation), and fatigue. Zingiber officinale contains bioactive compounds that act on pregnancy and postoperative nausea, chemotherapy-induced nausea and vomiting, and also in the management of fatigue, myalgia, and insomnia. This study aimed to evaluate the effects of ginger on chemotherapy-induced nausea and vomiting in patients with cervical cancer undergoing treatment with cisplatin and radiotherapy.Methods and analyses:A randomized intervention clinical and controlled trial with a triple-blind design is described, comparing the effects of institutional antiemetic therapy alone, as well as in combination with 2 different ginger concentrations.Ethics and dissemination:Due to the nature of the study, we obtained approval from the Division Ethics Committee of Liga Contra o Câncer. All participants signed an informed consent form prior to randomization. The results of this study will be published in peer-reviewed journals. The data collected will also be available in a public repository of data.Trial registration number:This study is registered in the Brazilian Registry of Clinical Trials under number RBR-47yx6p9. This study was approved by the Division Ethics Committee of Liga Contra o Câncer under CAAE 40602320.0.0000.5293. 相似文献
62.
Carla M. M. Prado Isac S. F. Lima Vickie E. Baracos Robert R. Bies Linda J. McCargar Tony Reiman John R. Mackey Michelle Kuzma Vijaya L. Damaraju Michael B. Sawyer 《Cancer chemotherapy and pharmacology》2011,67(1):93-101
Purpose
Although body composition has emerged as an important predictor of drug efficacy and toxicity, explanations for this association are unclear. Our goal was to investigate relationships between lean body mass (LBM), liver size/function and epirubicin pharmacokinetics (PK) and toxicity.Methods
Data from a clinical study (n?=?24) of patients with breast cancer receiving adjuvant intravenous FE100C chemotherapy were used to examine relationships between LBM, liver size, and epirubicin clearance. Muscle tissue and liver mass were measured by analysis of computerized tomography cross-sectional images, and an extrapolation of muscle mass to total LBM compartment was employed. Population PK analysis of epirubicin was undertaken to test effects of body composition on epirubicin clearance and area under the curve (AUC).Results
Estimated LBM was extremely variable in this cohort ranging from 32.9 to 67.3?kg. LBM was associated with neutrophil nadir (r?=?0.5, P?=?0.023), and mean LBM was lower for patients presenting with toxicity compared to those where toxicity was absent (41.6 vs. 56.2?kg, P?=?0.002); 33% of variance in clearance was explained by LBM and aspartate aminotransferase (AST). Liver mass was not related to epirubicin clearance likely due to larger livers presenting with larger fat content, but liver attenuation (degree of fat infiltration) and AST were associated with AUC.Conclusion
To our knowledge, this is the first study to examine relationships between LBM, liver mass/function and epirubicin PK and toxicity. This exploratory work investigates the notion of organs and tissues having distinctive contributions to the distribution and metabolism of antineoplastic drugs. 相似文献63.
64.
65.
Noguti AS Jarmy-Di Bella ZI de Oliveira E Castro RA Lima GR Baracat EC Sartori MG Girão MJ 《European journal of obstetrics, gynecology, and reproductive biology》2008,141(2):183-185
Objective
We aimed to study the cross-sectional area of levator ani muscle and the doppler velocimetric parameters of vessels its in premenopausal and postmenopausal women.Study design
Sixty-four patients, divided into 3 groups, were assessed: group I (20 women—average age 28 years) premenopausal and nulliparous (control); group II (24 women—average age 38 years, vaginal delivery 1–4) premenopausal with vaginal deliveries; group III (20 women—average age 55 years, parity 0–4) postmenopausal without hormonal therapy. Doppler velocimetry of levator ani muscle vessels through resistance and pulsatility indices was used and the means of the groups compared by adjusting the weighed variance model with multiple comparisons, according to Tukey's method. Similarly, we measured the cross-sectional area of the muscle using ultrasonography.Results
There was a significant increase in resistance and pulsatility indices in postmenopausal patients as compared to the other two groups. We also observed a significant decrease in the cross-sectional area of the muscle of postmenopausal patients when compared to those in premenopausal.Conclusion
The obtained results allow us to conclude that levator ani muscle vascularization significantly decreases after menopause (age and/or hipoestrogenism) and that it can be assumed that vaginal delivery does not promote long-term alterations in levator ani muscle vascularization. We also observed a significant decrease in the cross-sectional area of the muscle in postmenopausal women when compared to those in premenopausal. 相似文献66.
Enio R Vasques Estela RR Figueira Joel A Rocha-Filho Cinthia Lanchotte Jorge LS Ximenes Helena B Nader Ivarne LS Tersariol Marcelo A Lima Tiago Rodrigues José EM Cunha Eleazar Chaib Luiz AC D'Albuquerque Flávio HF Galv?o 《Hepatobiliary & pancreatic diseases international : HBPD INT》2022,21(2):190-192
<正>To the Editor:Ischemia-reperfusion injury following surgery and transplantation can lead to irreversible multiorgan failure.Intracellular calcium overload is associated to cellular death during ischemiareperfusion.A recently discovered heparin fragment (HF),trisulfated disaccharide (TD),that acts on sodium-calcium exchanger(NCX) decreasing intracellular Ca2+,showed effectiveness on protecting hepatocytes from ischemia-reperfusion injury [1], 相似文献
67.
Food labels are the first information tool used by consumers in the purchase and consumption of food products. Food labeling is a tool that can influence the consumers’ perception of quality and, in turn, their food choice. This study characterizes and demonstrates the importance of labeling and the degree of consumers’ perception and literacy about food labels through the application of an online questionnaire. The results obtained, in a sample of n = 467, showed that Portuguese consumers have the habit of reading the label and recognizing its importance but do not understand all the information contained in the label. They have an easier time understanding the front-of-pack labeling systems, especially those presented through symbols/colors. Thus, it demonstrates the need for greater education and literacy in the areas of food and nutrition so that through the reading and interpretation of labels, consumers can make informed food choices. 相似文献
68.
Vinicius Rossa Luanne Ester Monteiro Ferreira Sancler da Costa Vasconcelos Eric Thomas Tai Shimabukuro Vinicius Gomes da Costa Madriaga Anna Paula Carvalho Sibele Berenice Castell Pergher Fernando de Carvalho da Silva Vitor Francisco Ferreira Carlos Adam Conte Junior Thiago de Melo Lima 《RSC advances》2022,12(22):14084
Nanotechnology experienced a great technological advance after the discovery of the graphene family (graphene – Gr, graphene oxide – GO, and reduced graphene oxide-rGO). Based on the excellent properties of these materials, it is possible to develop novel polymeric nanocomposites for several applications in our daily routine. One of the most prominent applications is for food packaging, offering nanocomposites with improved thermal, mechanical, anti-microbial, and barrier properties against gas and water vapor. This paper reviewed food packaging from its inception to the present day, with the development of more resistant and intelligent packaging. Herein, the most common combinations of polymeric matrices (derived from non-renewable and renewable sources) with Gr, GO, and rGO and their typical preparation methods are presented. Besides, the interactions present in these nanocomposites will be discussed in detail, and their final properties will be thoroughly analyzed as a function of the preparation technique and graphene family-matrix combinations.Food packaging based on nanotechnology of polymeric nanocomposites of graphene and graphene oxide results in packaging with better thermal, mechanical, antimicrobial, electrical packaging, moisture barrier and gas properties. 相似文献
69.
刘隆健 孔翔瑜 JenniferA.Nettleton Alain G.Bertoni David Bluemke Jogio A.Lima Moyses Szklo 邹强 杨书 李茂全 陈建 《成都医学院学报》2013,(2):135-142
目的人们对膳食模式、代谢紊乱与左心室功能的关系研究报道不多,本研究旨在探讨膳食模式和左心室功能之间的关系以及代谢紊乱与动脉粥样硬化的关系。方法膳食模式采用降秩回归(reduced rankregression,RRR)方法构建;左室重量、心搏量和左室射血分数采用磁共振成像测量;膳食模式和左室指数之间的关系采用横断面分析法。结果选用4601例45~84岁、无临床心血管疾病受试者,RRR膳食模式得分数与高血糖指数、高脂肉类、奶酪、加工食品的摄人量呈正相关,而与蔬菜、大豆、水果、绿茶、黑茶、低脂甜点、种子、坚果和鱼肉的低摄入量呈负相关。多变量分析显示,RRR膳食模式得分增加1个单位,左室重量/体表面积就增加0.32g/ ㎡,心博量减少0.43mL/㎡,左室射血分数则减少0.21%。调整代谢综合征组分后,RRR膳食模式得分与左室重量和心搏指数之间的相关性减低,变为差异有统计学意义(P%0.05)。结论RRR膳食模式、代谢紊乱与左室功能紊乱有关。本研究属于横断面研究,结果的可靠性有待前瞻性研究进一步证实。 相似文献
70.