全文获取类型
收费全文 | 1611篇 |
免费 | 191篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 52篇 |
妇产科学 | 7篇 |
基础医学 | 295篇 |
口腔科学 | 32篇 |
临床医学 | 153篇 |
内科学 | 416篇 |
皮肤病学 | 44篇 |
神经病学 | 56篇 |
特种医学 | 87篇 |
外科学 | 228篇 |
综合类 | 62篇 |
预防医学 | 107篇 |
眼科学 | 73篇 |
药学 | 114篇 |
中国医学 | 3篇 |
肿瘤学 | 72篇 |
出版年
2023年 | 16篇 |
2022年 | 24篇 |
2021年 | 46篇 |
2020年 | 45篇 |
2019年 | 56篇 |
2018年 | 56篇 |
2017年 | 46篇 |
2016年 | 33篇 |
2015年 | 42篇 |
2014年 | 63篇 |
2013年 | 87篇 |
2012年 | 87篇 |
2011年 | 84篇 |
2010年 | 66篇 |
2009年 | 48篇 |
2008年 | 76篇 |
2007年 | 68篇 |
2006年 | 76篇 |
2005年 | 49篇 |
2004年 | 57篇 |
2003年 | 54篇 |
2002年 | 42篇 |
2001年 | 35篇 |
2000年 | 31篇 |
1999年 | 48篇 |
1998年 | 38篇 |
1997年 | 24篇 |
1996年 | 20篇 |
1995年 | 32篇 |
1994年 | 25篇 |
1993年 | 28篇 |
1992年 | 22篇 |
1991年 | 31篇 |
1990年 | 24篇 |
1989年 | 29篇 |
1988年 | 16篇 |
1987年 | 21篇 |
1986年 | 19篇 |
1985年 | 20篇 |
1984年 | 9篇 |
1983年 | 7篇 |
1982年 | 10篇 |
1981年 | 13篇 |
1980年 | 14篇 |
1979年 | 13篇 |
1977年 | 7篇 |
1976年 | 6篇 |
1975年 | 10篇 |
1974年 | 6篇 |
1973年 | 7篇 |
排序方式: 共有1814条查询结果,搜索用时 421 毫秒
101.
Zhiwen Joseph Lo Sadhana Chandrasekar Enming Yong Qiantai Hong Li Zhang Lester Rhan Chaen Chong Glenn Tan Yam Meng Chan Hui Yan Koo Tiffany Chew Nur Faezah Sani Keet Yeng Cheong Leighton Ren Qin Cheng Audrey Hui Min Tan Sivakami Muthuveerappa Tina Peiting Lai Cheng Cheng Goh Gary Y. Ang Zhecheng Zhu Wai Han Hoi Jaime H. X. Lin Daniel E. K. Chew Brenda Lim Pei Shan Yeo Huiling Liew 《International wound journal》2022,19(4):765
Present guidelines recommend a multidisciplinary team (MDT) approach to diabetic foot ulcer (DFU) care, but relevant data from Asia are lacking. We aim to evaluate the clinical and economic outcomes of an MDT approach in a lower extremity amputation prevention programme (LEAPP) for DFU care in an Asian population. We performed a case‐control study of 84 patients with DFU between January 2017 and October 2017 (retrospective control) vs 117 patients with DFU between December 2017 and July 2018 (prospective LEAPP cohort). Comparing the clinical outcomes between the retrospective cohort and the LEAPP cohort, there was a significant decrease in mean time from referral to index clinic visit (38.6 vs 9.5 days, P < .001), increase in outpatient podiatry follow‐up (33% vs 76%, P < .001), decrease in 1‐year minor amputation rate (14% vs 3%, P = .007), and decrease in 1‐year major amputation rate (9% vs 3%, P = .05). Simulation of cost avoidance demonstrated an annualised cost avoidance of USD $1.86m (SGD $2.5m) for patients within the LEAPP cohort. In conclusion, similar to the data from Western societies, an MDT approach in an Asian population, via a LEAPP for patients with DFU, demonstrated a significant reduction in minor and major amputation rates, with annualised cost avoidance of USD $1.86m. 相似文献
102.
Alexander E White Andrew FW Ho Nur Shahidah Nurul Asyikin Le Xuan Liew Pin Pin Pek Jade PH Kua Michael YC Chia Yih Yng Ng Shalini Arulanandam Sieu-Hon Benjamin Leong Marcus EH Ong 《Singapore medical journal》2021,62(8):438
Care for patients who experience out-of-hospital cardiac arrest (OHCA) has rapidly evolved in the past decade. Increased sophistication of care in the community, emergency medical services (EMS) and hospital setting is associated with improved patient-centred outcomes. Notably, Utstein survival doubled from 11.6% to 23.1% between 2011 and 2016. These achievements involved collaboration between policymakers, clinicians and researchers, and were made possible by a strategic interplay of policy, research and implementation. We review the development and current state of OHCA in Singapore using primary population-based data from the Pan-Asian Resuscitation Outcomes Study and an unstructured search of research databases. We discuss the roles of important milestones in policy, community, dispatch, EMS and hospital interventions. Finally, we relate these interventions to relevant processes and outcomes, such as the relationship between the strategic implementation of bystander cardiopulmonary resuscitation and placement of automated external defibrillator with return of spontaneous circulation, survival to discharge and survival with favourable neurological outcomes. 相似文献
103.
Hau Wei Khoo Terrence Chi Hong Hui Salahudeen Mohamed Haja Mohideen Yeong Shyan Lee Charlene Jin Yee Liew Shawn Shi Xian Kok Barnaby Edward Young Sean Wei Xiang Ong Shirin Kalimuddin Seow Yen Tan Jiashen Loh Lai Peng Chan Angeline Choo Choo Poh Steven Bak Siew Wong Yee-Sin Leo David Chien Lye Gregory Jon Leng Kaw Cher Heng Tan 《Singapore medical journal》2021,62(9):458
INTRODUCTIONChest radiographs (CXRs) are widely used for the screening and management of COVID-19. This article describes the radiographic features of COVID-19 based on an initial national cohort of patients.METHODSThis is a retrospective review of swab-positive patients with COVID-19 who were admitted to four different hospitals in Singapore between 22 January and 9 March 2020. Initial and follow-up CXRs were reviewed by three experienced radiologists to identify the predominant pattern and distribution of lung parenchymal abnormalities.RESULTSIn total, 347 CXRs of 96 patients were reviewed. Initial CXRs were abnormal in 41 (42.7%) out of 96 patients. The mean time from onset of symptoms to CXR abnormality was 5.3 ± 4.7 days. The predominant pattern of lung abnormality was ground-glass opacity on initial CXRs (51.2%) and consolidation on follow-up CXRs (51.0%). Multifocal bilateral abnormalities in mixed central and peripheral distribution were observed in 63.4% and 59.2% of abnormal initial and follow-up CXRs, respectively. The lower zones were involved in 90.2% of initial CXRs and 93.9% of follow-up CXRs.CONCLUSIONIn a cohort of swab-positive patients, including those identified from contact tracing, we found a lower incidence of CXR abnormalities than was previously reported. The most common pattern was ground-glass opacity or consolidation, but mixed central and peripheral involvement was more common than peripheral involvement alone. 相似文献
104.
Syazmi Zul Arif Hakimi Saadon Noridah Binti Osman Moviin Damodaran Shan En Liew 《Materials》2022,15(8)
The torrefaction process in the preparation of energy materials has garnered a lot of attention and has been investigated as a means of improving biomass solid fuels. The aim of this study is to study the effect of the temperature and holding time of two biomass samples: wild Napier grass and oil palm petiole. The torrefied samples are operated in a pyrolysis reactor to replicate the torrefaction procedure. The temperature parameter ranges between 220 and 300 °C while the holding time of the reaction parameter ranges from 10 to 50 min. It is found that with increasing temperature and time, the moisture content and number of O and H atoms decrease and also cause both mass and energy yield to decrease. It is found that the calorific value and the energy density increase with both parameters, which shows that optimization is needed for better solid fuel production. Between the two parameters, temperature changes have more significant effects on the torrefied samples. The optimized temperature and time are found to be 260 °C and 30 min, respectively. The usage of the pyrolysis reactor for the torrefaction reaction has been proven to serve as a good option due to similar product characteristics and equivalent results. 相似文献
105.
Interventional radiologic procedures in liver transplantation 总被引:2,自引:0,他引:2
Yu Fan Cheng Yaw Sen Chen Tung Liang Huang Vanessa de Villa Tai Yi Chen Tze Yu Lee Chih Chi Wang Yuan Cheng Chiang Hock Liew Eng Hak Kim Cheung Bruno Jawan Shih Hor Wang Shigeru Goto Chao Long Chen 《Transplant international》2001,14(4):223-229
Postoperative biliary and vascular complications contribute significantly to morbidity and mortality in liver transplantation.
Interventional radiologists are an integral part of the multidisciplinary team necessary for optimizing the management of
these complications. During a 15-year period, 39 cadaveric and 25 living related liver transplantations were performed at
the Chang Gung Memorial hospital, Taiwan. Of 64 liver transplant recipients, 9 (3 adult and 6 pediatric) underwent 13 interventional
radiological procedures for the treatment of biliary sludge-casts (n = 2), bile duct occlusion or stenosis (n = 2), hepatic veins thrombosis (n = 1), hepatic veins stenosis (n = 1), portal vein stenosis with splenorenal shunting (n = 1), biloma (n = 1), and infected fluid collection or ascites (n = 4). Antegrade or retrograde interventional approach was used to successfully treat all biliary complications, and all percutaneous
drainage procedures were effective in the control of intra-abdominal fluid collections. Portal vein stenosis was treated by
balloon dilatation, and the associated splenorenal shunt was closed by metallic coil embolization via transhepatic catheterization
of the portal vein. Hepatic vein stenosis was effectively treated by balloon dilatation and expandable metallic stent deployment
via transfemoral and jugular venous approaches, respectively. Hepatic vein thrombosis was only partially lysed by transvenous
streptokinase administration, and surgical thrombectomy was needed to achieve complete recanalization. The total success rate
of the interventional procedures was 92 % with no procedure-related complications. The overall survival rate in this series
is 89 %, and all patients who underwent living related liver transplantation maintain to date a 100 % survival rate. We can
conclude that interventional radiological procedures are very useful for managing biliary and vascular complications after
liver transplantation. These techniques provide a cure in most situations, thus obviating the need for further surgical intervention
or re-transplantation.
Received: 6 March 2000 Accepted: 5 May 2001 相似文献
106.
二十碳五烯酸对三种肝癌细胞系作用的实验研究 总被引:2,自引:0,他引:2
目的 探讨二十碳五烯酸(eicosapentaenoic acid,EPA)对3种肝癌细胞系作用。方法 EPA作用于HepG2(携带有野生型p53基因)、Huh7(携带有突变型p53基因)和Hep3B(p53基因缺失)这3种肝癌细胞系,通过细胞计数、DNA电泳、流式细胞技术和末端转移酶标记技术等来检测EPA对这3种细胞系的作用和可能的机制。结果 EPA主要是通过诱导HepG2肝癌细胞系的细胞凋亡来抑制其生长,而且这种抑制作用呈现出时间和剂量依赖的关系。而且同时发现EPA对于Huh7和Hep3B这两种肝癌细胞系无明显抑制作用。结论 细胞凋亡的诱导可能是EPA抑制HepG2肝癌细胞系生长的主要机制。而且p53基因可能参与EPA诱导HepG2细胞系细胞凋亡的过程。 相似文献
107.
Ning Cheung Gerald Liew Richard I. Lindley Erica Y. Liu Jie Jin Wang Peter Hand Michelle Baker Paul Mitchell Tien Y. Wong 《Annals of neurology》2010,68(1):107-111
This study aimed to determine whether retinal fractal dimension, a quantitative measure of microvascular branching complexity and density, is associated with lacunar stroke. A total of 392 patients presenting with acute ischemic stroke had retinal fractal dimension measured from digital photographs, and lacunar infarct ascertained from brain imaging. After adjusting for age, gender, and vascular risk factors, higher retinal fractal dimension (highest vs lowest quartile and per standard deviation increase) was independently and positively associated with lacunar stroke (odds ratio [OR], 4.27; 95% confidence interval [CI], 1.49–12.17 and OR, 1.85; 95% CI, 1.20–2.84, respectively). Increased retinal microvascular complexity and density is associated with lacunar stroke. ANN NEUROL 2010;68:107–111 相似文献
108.
Objective: The effect of nightshift on ED staff performance is of clinical and risk‐management significance. Previous studies have demonstrated deterioration in psychomotor skills but the present study specifically assessed the impact of nightshift on clinical performance. Methods: The ED registrars in a tertiary hospital were enrolled in a prospective observational study and served as their own controls. During nightshift, subjects were presented simulated scenarios and tested with eight clinical questions developed to Fellowship examination standard. Matched scenarios and questions for the same subjects during dayshift served as controls. Two investigators, blinded to subject identity and the setting in which questions were attempted, independently collated answers. Results: Of 22 eligible subjects, all were recruited; four were excluded owing to incomplete data. A correlation of 0.99 was observed between the independent scoring investigators. Of a possible score of 17, the median result for nightshift was 9.5 (interquartile range: 8–11); corresponding value for dayshift was 12 (interquartile range: 10–13); P= 0.047. Conclusion: Nightshift effect on clinical performance is anecdotally well known. The present study quantifies such effects, specifically for the ED setting, and paves the way for focused research. The implications for clinical governance strategies are significant, as the fraternity embraces the mandate to maintain quality emergency care 24 h per day. 相似文献
109.
110.