前列康宝的药理学研究

实验结果表明，前列康宝具有明显的抗前列腺增生，抗炎及改善微循环作用。     

THE HUMORAL ANTITUMOR RESPONSES INDUCED BY IL-4 GENE-MODIFIED TUMOR VACCINE

ＴＨＥＨＵＭＯＲＡＬＡＮＴＩＴＵＭＯＲＲＥＳＰＯＮＳＥＳＩＮＤＵＣＥＤＢＹＩＬ４ＧＥＮＥＭＯＤＩＦＩＥＤＴＵＭＯＲＶＡＣＣＩＮＥ１ＹｕＹｉｚｈｉ于益芝ＣａｏＸｕｅｔａｏ２曹雪涛ＺｈａｎｇＭｉｎｇｈｕｉ张明徽ＬｅｉＨｏｎｇ雷虹ＴａｏＱｕｎ陶群Ｄｅｐ...     

分化诱导剂联合雄激素或小剂量化疗药物治疗骨髓增生异常综合征

报道３６例骨髓增生异常综合征（ＭＤＳ）的治疗效果。原始细胞不增多的ＭＤＳ（ＲＡ和ＲＡＳ）１７例，以雄激素丙酸睾丸素或康力龙联合分化诱导剂全反式维甲酸和１，２５（ＯＨ）２Ｄ３治疗，部分病例尚加用小剂量强的松；原始细胞增多的ＭＤＳ（ＲＡＥＢ、ＣＭＭＬ及ＲＡＥＢＴ）１９例，以小剂量阿糖胞苷或／和小剂量阿克拉霉素化疗并联用分化诱导剂。前组的有效率为７０．６％，基本缓解率为２９．４％，后组的有效率为５７．９％，完全缓解（ＣＲ）率为３６．８％，两组的总有效率为６３．９％。５例取得基本缓解的ＲＡ和ＲＡＳ目前都处于缓解期，已６个月～１６个月；７例ＣＲ的ＲＡＥＢ和ＲＡＥＢＴ３例于ＣＲ后６个月～１２个月转为急性白血病，另４例仍处于ＣＲ中，已３个月～５２个月。认为根据ＭＤＳ患者的类型予不同的药物联合治疗可取得较好的疗效。     

骨膦在肿瘤性骨转移综合治疗中的作用

我院１９９３．２－１９９５．１０用骨膦治疗骨转移癌３２例，以评价骨膦在肿瘤骨转移综合治疗中的作用。其中肺癌１７例，乳腺癌１１例，鼻咽癌３例，肝癌１例。３２例经骨膦治疗后止痛总的有效率为８１．２５％，其中ＣＲ８例（２５％），ＰＲ１０例（３１．２５％），ＭＲ８例（２５％）。与治疗前相比，有明显疗效。有效患者的Ｋａｒｎｏｆｓｋｙ状况分级法分别提高２０－４０分，由于治疗后患者疼痛减轻，症状缓解，生存质量得到明显提高。我们认为骨膦联合放疗对控制广泛骨转移性骨痛，提高晚期肿瘤患者生存质量有实际意义。     

HP感染与c—myc,c—erbB—2蛋白在胃粘膜病变中的表达

为了探讨幽门螺旋杆菌（HeliclbacterPylori，HP）感染与胃癌发生间的关系，我们采用免疫组化法对158例胃粘膜标本进行癌基因c－myc、c－erbB－2蛋白检测、其中胃癌、不典型增生及肠上皮化生各40例，正常对照38例。结果发现，c－myc蛋白在正常胃组织中无表过，c－erbB－2蛋白阳性表达7／38例。两种基因蛋白在不典型增生、肠上皮化生及胃癌中的阳性表达显著高于对照组（P＜0．01～0．05）。应用Giemsa法对上述各组胃粘膜同步进行HP测定，发现正常对照组中的HP阳性检出显著低于不典型增生及肠上皮化生（P＜0．025），而与胃癌组无明显统计学差异（P＞0．05）。联合检测HP与癌基因蛋白发现HP感染与其表达呈正相关。提示HP感染与胃癌发生有一定关系。     

浙贝母低温解除休眠过程中淀粉酶和还原糖的研究

研究了浙贝母低温解除休眠过程中淀粉酶的活性和还原糖的含量变化。结果表明,芽和鳞片的内在代谢均发生了变化,鳞片近轴面表皮的淀粉酶活性和还原糖含量比鳞片的内部贮备组织高,但和芽的该两项指标接近。     

纵断体层摄影在膝关节前后十字韧带胫骨止点撕脱骨折诊断中的应用

对膝关节前后十字韧带胫骨止点骨折，常因关节周围骨骼影像重叠使其显影不清而影响诊断。通过11例该类损伤患者的X线平片及纵断作层片的分析比较，认为纵断体层摄影可清晰显示关节内骨折的形状、大小、范围，获得完整的骨折分层像，从而有利于临床分型，对骨折的诊断及指导治疗有较大的应用价值。     

脉炎消注射液的免疫学实验研究

脉炎消注射液可在体外抑制ＰＨＡ诱导的健康人外周血淋巴细胞的增殖反应，对健康人外周血单个核细胞有直接的毒性杀伤作用，其中受作用的细胞主要为ＣＤ１９Ｂ细胞和ＣＤ４Ｔ细胞；脉炎消注射液还可抑制ｓＲＢＣ免疫小鼠ＩｇＭ型抗体生成细胞的产生及降低ｓＲＢＣ免疫小鼠的脾脏重量     

二子阳宝的药理实验研究

二子阳宝能明显提高去势雄性小鼠副性器官和提肛肌指数；明显增加性交配功能；并能增强肾阳虚小鼠的耐缺氧，抗疲劳能力。     

Effects of exercise training on left ventricular function and peripheral resistance in patients with chronic heart failure: A randomized trial

CONTEXT: Exercise training in patients with chronic heart failure improves work capacity by enhancing endothelial function and skeletal muscle aerobic metabolism, but effects on central hemodynamic function are not well established. OBJECTIVE: To evaluate the effects of exercise training on left ventricular (LV) function and hemodynamic response to exercise in patients with stable chronic heart failure. DESIGN: Prospective randomized trial conducted in 1994-1999. SETTING: University department of cardiology/outpatient clinic in Germany. PATIENTS: Consecutive sample of 73 men aged 70 years or younger with chronic heart failure (with LV ejection fraction of approximately 0.27). INTERVENTION: Patients were randomly assigned to 2 weeks of in-hospital ergometer exercise for 10 minutes 4 to 6 times per day, followed by 6 months of home-based ergometer exercise training for 20 minutes per day at 70% of peak oxygen uptake (n=36) or to no intervention (control group; n=37). MAIN OUTCOME MEASURES: Ergospirometry with measurement of central hemodynamics by thermodilution at rest and during exercise; echocardiographic determination of LV diameters and volumes, at baseline and 6-month follow-up, for the exercise training vs control groups. RESULTS: After 6 months, patients in the exercise training group had statistically significant improvements compared with controls in New York Heart Association functional class, maximal ventilation, exercise time, and exercise capacity as well as decreased resting heart rate and increased stroke volume at rest. In the exercise training group, an increase from baseline to 6-month follow-up was observed in mean (SD) resting LV ejection fraction (0.30 [0.08] vs 0.35 [0.09]; P=.003). Mean (SD) total peripheral resistance (TPR) during peak exercise was reduced by 157 (306) dyne/s/cm(-5) in the exercise training group vs an increase of 43 (148) dyne/s/cm(-5) in the control group (P=.003), with a concomitant increase in mean (SD) stroke volume of 14 (22) mL vs 1 (19) mL in the control group (P=.03). There was a small but significant reduction in mean (SD) LV end diastolic diameter of 4 (6) mm vs an increase of 1 (4) mm in the control group (P<.001). Changes from baseline in resting TPR for both groups were correlated with changes in stroke volume (r=-0.76; P<.001) and in LV end diastolic diameter (r=0.45; P<.001). CONCLUSIONS: In patients with stable chronic heart failure, exercise training is associated with reduction of peripheral resistance and results in small but significant improvements in stroke volume and reduction in cardiomegaly. JAMA. 2000.