全文获取类型
收费全文 | 1048694篇 |
免费 | 73391篇 |
国内免费 | 3488篇 |
专业分类
耳鼻咽喉 | 14654篇 |
儿科学 | 31417篇 |
妇产科学 | 29641篇 |
基础医学 | 149143篇 |
口腔科学 | 27863篇 |
临床医学 | 88963篇 |
内科学 | 211400篇 |
皮肤病学 | 23201篇 |
神经病学 | 82632篇 |
特种医学 | 43958篇 |
外国民族医学 | 336篇 |
外科学 | 162508篇 |
综合类 | 20939篇 |
现状与发展 | 5篇 |
一般理论 | 326篇 |
预防医学 | 73579篇 |
眼科学 | 24145篇 |
药学 | 76738篇 |
中国医学 | 3355篇 |
肿瘤学 | 60770篇 |
出版年
2021年 | 10512篇 |
2019年 | 9829篇 |
2018年 | 13281篇 |
2017年 | 10283篇 |
2016年 | 11727篇 |
2015年 | 14175篇 |
2014年 | 19025篇 |
2013年 | 27279篇 |
2012年 | 37763篇 |
2011年 | 39039篇 |
2010年 | 23565篇 |
2009年 | 21618篇 |
2008年 | 34976篇 |
2007年 | 36444篇 |
2006年 | 35889篇 |
2005年 | 35016篇 |
2004年 | 33037篇 |
2003年 | 31290篇 |
2002年 | 30063篇 |
2001年 | 45167篇 |
2000年 | 46082篇 |
1999年 | 39075篇 |
1998年 | 11175篇 |
1997年 | 10048篇 |
1996年 | 9935篇 |
1995年 | 9227篇 |
1994年 | 8735篇 |
1993年 | 8172篇 |
1992年 | 29546篇 |
1991年 | 28306篇 |
1990年 | 27554篇 |
1989年 | 26393篇 |
1988年 | 24526篇 |
1987年 | 24060篇 |
1986年 | 23109篇 |
1985年 | 21904篇 |
1984年 | 16363篇 |
1983年 | 13960篇 |
1982年 | 8447篇 |
1979年 | 15014篇 |
1978年 | 10550篇 |
1977年 | 8962篇 |
1976年 | 8444篇 |
1975年 | 9218篇 |
1974年 | 11003篇 |
1973年 | 10469篇 |
1972年 | 9910篇 |
1971年 | 9106篇 |
1970年 | 8781篇 |
1969年 | 8186篇 |
排序方式: 共有10000条查询结果,搜索用时 250 毫秒
51.
52.
53.
Ho-Chul Jung Sung-Bin Chon Won Sup Oh Dong-Hyun Lee Ho-Jin Lee 《The American journal of tropical medicine and hygiene》2015,92(2):256-261
Scrub typhus usually presents as acute undifferentiated fever. This cross-sectional study included adult patients presenting with acute undifferentiated fever defined as any febrile illness for ≤ 14 days without evidence of localized infection. Scrub typhus cases were defined by an antibody titer of a ≥ fourfold increase in paired sera, a ≥ 1:160 in a single serum using indirect immunofluorescence assay, or a positive result of the immunochromatographic test. Multiple regression analysis identified predictors associated with scrub typhus to develop a prediction rule. Of 250 cases with known etiology of acute undifferentiated fever, influenza (28.0%), hepatitis A (25.2%), and scrub typhus (16.4%) were major causes. A prediction rule for identifying suspected cases of scrub typhus consisted of age ≥ 65 years (two points), recent fieldwork/outdoor activities (one point), onset of illness during an outbreak period (two points), myalgia (one point), and eschar (two points). The c statistic was 0.977 (95% confidence interval = 0.960–0.994). At a cutoff value ≥ 4, the sensitivity and specificity were 92.7% (79.0–98.1%) and 90.9% (86.0–94.3%), respectively. Scrub typhus, the third leading cause of acute undifferentiated fever in our region, can be identified early using the prediction rule. 相似文献
54.
55.
56.
57.
E. Niclas Jonsson Rujia Xie Scott F. Marshall Rosalin H. Arends 《British journal of clinical pharmacology》2016,81(4):688-699
AimsThe aims were to 1) develop the pharmacokinetics model to describe and predict observed tanezumab concentrations over time, 2) test possible covariate parameter relationships that could influence clearance and distribution and 3) assess the impact of fixed dosing vs. a dosing regimen adjusted by body weight.MethodsIndividual concentration–time data were determined from 1608 patients in four phase 3 studies conducted to assess efficacy and safety of intravenous tanezumab. Patients received two or three intravenous doses (2.5, 5 or 10 mg) every 8 weeks. Blood samples for assessment of tanezumab PK were collected at baseline, 1 h post‐dose and at weeks 4, 8, 16 and 24 (or early termination) in all studies. Blood samples were collected at week 32 in two studies. Plasma samples were analyzed using a sensitive, specific, validated enzyme‐linked immunosorbent assay.ResultsA two compartment model with parallel linear and non‐linear elimination processes adequately described the data. Population estimates for clearance (CL), central volume (V
1), peripheral volume (V
2), inter‐compartmental clearance, maximum elimination capacity (VM) and concentration at half‐maximum elimination capacity were 0.135 l day–1, 2.71 l, 1.98 l, 0.371 l day–1, 8.03 μg day–1 and 27.7 ng ml–1, respectively. Inter‐individual variability (IIV) was included on CL, V
1, V
2 and VM. A mixture model accounted for the distribution of residual error. While gender, dose and creatinine clearance were significant covariates, only body weight as a covariate of CL, V
1 and V
2 significantly reduced IIV.ConclusionsThe small increase in variability associated with fixed dosing is consistent with other monoclonal antibodies and does not change risk : benefit. 相似文献
58.
Kun‐Yong Sung Seungkoo Lee Yeonjin Jeong Sang‐Yeul Lee 《The Australasian journal of dermatology》2021,62(1):60-63
A classic pilomatricoma, which usually presents with an asymptomatic, solitary, firm, subcutaneous nodule in the head, neck, or extremities of the paediatric population, is easily diagnosed based on its characteristic clinical and histopathological features. However, its variants often pose particular diagnostic challenges to clinicians due to their rarity and diverse clinicopathological features. We present a new pseudocystic variant, manifesting as solid lesions floating in a fluid‐filled sac. 相似文献
59.
60.