全文获取类型
收费全文 | 3103篇 |
免费 | 192篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 35篇 |
儿科学 | 75篇 |
妇产科学 | 43篇 |
基础医学 | 463篇 |
口腔科学 | 426篇 |
临床医学 | 226篇 |
内科学 | 583篇 |
皮肤病学 | 128篇 |
神经病学 | 173篇 |
特种医学 | 58篇 |
外科学 | 429篇 |
综合类 | 4篇 |
一般理论 | 1篇 |
预防医学 | 296篇 |
眼科学 | 59篇 |
药学 | 151篇 |
中国医学 | 15篇 |
肿瘤学 | 139篇 |
出版年
2024年 | 3篇 |
2023年 | 31篇 |
2022年 | 59篇 |
2021年 | 102篇 |
2020年 | 88篇 |
2019年 | 98篇 |
2018年 | 133篇 |
2017年 | 89篇 |
2016年 | 86篇 |
2015年 | 103篇 |
2014年 | 153篇 |
2013年 | 180篇 |
2012年 | 303篇 |
2011年 | 260篇 |
2010年 | 161篇 |
2009年 | 146篇 |
2008年 | 203篇 |
2007年 | 204篇 |
2006年 | 175篇 |
2005年 | 140篇 |
2004年 | 114篇 |
2003年 | 93篇 |
2002年 | 73篇 |
2001年 | 50篇 |
2000年 | 42篇 |
1999年 | 36篇 |
1998年 | 11篇 |
1996年 | 9篇 |
1995年 | 8篇 |
1994年 | 5篇 |
1993年 | 8篇 |
1992年 | 21篇 |
1991年 | 15篇 |
1990年 | 9篇 |
1989年 | 6篇 |
1988年 | 9篇 |
1987年 | 6篇 |
1986年 | 12篇 |
1985年 | 7篇 |
1983年 | 4篇 |
1979年 | 3篇 |
1977年 | 3篇 |
1976年 | 4篇 |
1974年 | 2篇 |
1971年 | 4篇 |
1970年 | 2篇 |
1969年 | 9篇 |
1968年 | 4篇 |
1966年 | 3篇 |
1965年 | 3篇 |
排序方式: 共有3304条查询结果,搜索用时 0 毫秒
21.
Tatiane Teixeira Oliveira Keina Maciele Campos Ana Tereza Cerqueira-Lima Tamires Cana Brasil Carneiro Eudes da Silva Velozo Ingrid Christie Alexandrino Ribeiro Melo Eugênia Abrantes Figueiredo Eduardo de Jesus Oliveira Darizy Flávia Silva Amorim de Vasconcelos Lain Carlos Pontes-de-Carvalho Neuza Maria Alcantara-Neves Camila Alexandrina Figueiredo 《Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences》2015,23(1)
Background
Asthma is an inflammatory condition characterized by airway hyperresponsiveness and chronic inflammation. The resolution of inflammation is an essential process to treat this condition. In this study we investigated the effect of Allium cepa L. extract (AcE) and quercetin (Qt) on cytokine and on smooth muscle contraction in vitro and its therapeutic potential in a murine model of asthma.Methods
AcE was obtained by maceration of Allium cepa L. and it was standardized in terms of quercetin concentration using high performance liquid chromatography (HPLC). In vitro, using AcE 10, 100 or 1000 μg/ml or Qt 3.5, 7.5, 15 μg/ml, we measured the concentration of cytokines in spleen cell culture supernatants, and the ability to relax tracheal smooth muscle from A/J mice. In vivo, Blomia tropicalis (BT)-sensitized A/J mice were treated with AcE 100, 1000 mg/kg or 30 mg/kg Qt. We measured cell influx in bronchoalveolar lavage (BAL), eosinophil peroxidase (EPO) in lungs, serum levels of Bt-specific IgE, cytokines levels in BAL, and lung histology.Results
We observed a reduction in the production of inflammatory cytokines, a relaxation of tracheal rings, and a reduction in total number of cells in BAL and EPO in lungs by treatment with AcE or Qt.Conclusion
AcE and Qt have potential as antiasthmatic drugs, as they possess both immunomodulatory and bronchodilatory properties. 相似文献22.
Sullivan MC Hawes K Winchester SB Miller RJ 《Journal of obstetric, gynecologic, and neonatal nursing : JOGNN / NAACOG》2008,37(2):158-164
Developmental Origins Theory has received little coverage in the nursing literature, even though it has received much attention in other sciences. The theory proposes that prenatal stress provokes adaptive changes in endocrine and metabolic processes that become permanently programmed and impact later adult health. This paper reviews the theory and describes the primary neuroendocrine mechanism of hypothalamic-pituitary-adrenal axis function. Supporting research evidence in preterm infant and adult samples is presented. Through knowledge of the theory and the long-term sequelae for preterm infants, nurses will have a different theoretical perspective and growing evidence to consider in their care for pregnant women and infants. 相似文献
23.
Antonio Haddad Tapias Filho Gustavo Bernardes de Figueiredo Oliveira Joo Italo Dias Frana Rui Fernando Ramos 《Arquivos brasileiros de cardiologia》2022,118(6):1006
Background Contemporary diagnosis of ACS and risk stratification are essential for appropriate management and reduction of mortality and recurrent ischemic events, in the acute phase of disease and after hospitalization. The Universal Definition of Myocardial Infarction recommends the detection of troponin levels above the 99th percentile.Objectives To evaluate the occurrence of early death and acute myocardial infarction (AMI) in patients without elevation of troponin (<0.034 ng/mL), patients with mild elevation (above the 99th percentile [>0.034 ng/mL and <0.12 ng/mL)], and patients with significant elevation of troponin (above the diagnostic cutoff for AMI defined by the troponin kit (≥0.12 ng/mL)]; and to analyze the impact of troponin on the indication for invasive strategy and myocardial revascularization.Methods Cross-sectional cohort study of patients with ACS with assessment of peak troponin I, risk score, prospective analysis of 30-day clinical outcomes and two-sided statistical tests, with statistical significance set at p<0.05.Results A total of 494 patients with ACS were evaluated. Troponin > 99th percentile and below the cutoff point, as well as values above the cutoff, were associated with higher incidence of composite endpoint (p<0.01) and higher rates of percutaneous or surgical revascularization procedures (p<0.01), without significative difference in 30-day mortality.Conclusions Troponin levels above the 99th percentile defined by the universal definition of AMI play a prognostic role and add useful information to the clinical diagnosis and risk scores by identifying those patients who would most benefit from invasive risk stratification and coronary revascularization procedures. 相似文献
24.
Isabel G. Quirino Jose Silverio S. Diniz Maria Candida F. Bouzada Alamanda K. Pereira Thais J. Lopes Gabriela M. Paix?o Natalia N. Barros Luisa C. Figueiredo Antonio Carlos V. Cabral Ana Cristina Sim?es e Silva Eduardo A. Oliveira 《Clinical journal of the American Society of Nephrology》2012,7(3):444-451
25.
26.
27.
Saidy Vásconez Noguera Evelyn Patrícia Sánchez Espinoza Marina Farrel Côrtes Izabel Cristina Vilela Oshiro Fernanda de Sousa Spadão Laura Maria Brasileiro Brandão Ana Natiele da Silva Barros Sibeli Costa Bianca Leal de Almeida Paula Gemignani Soriano Alessandra Grassi Salles Mirian Elizabete Marques Escorcio Cristina Madeira Barretti Fernanda Spadotto Baptista Glaura Souza Alvarenga Igor Marinho Leila Suemi Harima Letaif Ho Ye Li Silvia Figueiredo Costa 《American journal of infection control》2021,49(4):512-515
28.
Fábio Teixeira Kuhn Fabíola Trevizol Verônica Tironi Dias Raquel Cristine Silva Barcelos Camila Simonetti Pase Karine Roversi Caren Tatiane de David Antoniazzi Katiane Roversi Nardeli Boufleur Dalila Moter Benvegnú Tatiana Emanuelli Marilise Escobar Bürger 《Toxicology letters》2015
Chronic consumption of processed food causes structural changes in membrane phospholipids, affecting brain neurotransmission. Here we evaluated noxious influences of dietary fats over two generations of rats on amphetamine (AMPH)-conditioned place preference (CPP). Female rats received soybean oil (SO, rich in n-6 fatty acids (FA)), fish oil (FO, rich in n-3 FA) and hydrogenated vegetable fat (HVF, rich in trans fatty acids (TFA)) for two successive generations. Male pups from the 2nd generation were maintained on the same supplementation until 41 days of age, when they were conditioned with AMPH in CPP. While the FO group showed higher incorporation of n-3 polyunsaturated-FA (PUFA) in cortex/hippocampus, the HVF group showed TFA incorporation in these same brain areas. The SO and HVF groups showed AMPH-preference and anxiety-like symptoms during abstinence. Higher levels of protein carbonyl (PC) and lower levels of non-protein thiols (NPSH) were observed in cortex/hippocampus of the HVF group, indicating antioxidant defense system impairment. In contrast, the FO group showed no drug-preference and lower PC levels in cortex. Cortical PC was positively correlated with n-6/n-3 PUFA ratio, locomotion and anxiety-like behavior, and hippocampal PC was positively correlated with AMPH-preference, reinforcing connections between oxidative damage and AMPH-induced preference/abstinence behaviors. As brain incorporation of trans and n-6 PUFA modifies its physiological functions, it may facilitate drug addiction. 相似文献
29.
Eskandarifard Ebrahim Silva Rui Nobari Hadi Clemente Filipe Manuel Pérez-Gómez Jorge Figueiredo António José 《Sport Sciences for Health》2022,18(2):297-305
Sport Sciences for Health - The purposes of this study were to describe the fitness and hormonal levels according to playing time (PT) (i.e., PT during season less (PT1) or more (PT2) than 50% of... 相似文献
30.
Radaelli Régis Brusco Clarissa M. Machado Carlos Leonardo Figueiredo Martins Dominique Sakugawa Raphael Luiz Diefenthaeler Fernando Pinto Ronei S. 《Sport Sciences for Health》2022,18(2):455-462
Sport Sciences for Health - The generalized joint hypermobility (GJH) syndrome is a condition characterized by a connective tissue disorder that may negatively affect the muscle function and muscle... 相似文献