全文获取类型
收费全文 | 595篇 |
免费 | 41篇 |
国内免费 | 12篇 |
专业分类
儿科学 | 84篇 |
妇产科学 | 3篇 |
基础医学 | 29篇 |
口腔科学 | 10篇 |
临床医学 | 41篇 |
内科学 | 182篇 |
皮肤病学 | 10篇 |
神经病学 | 83篇 |
特种医学 | 78篇 |
外科学 | 32篇 |
综合类 | 22篇 |
预防医学 | 17篇 |
药学 | 37篇 |
肿瘤学 | 20篇 |
出版年
2022年 | 1篇 |
2021年 | 1篇 |
2020年 | 4篇 |
2019年 | 8篇 |
2018年 | 11篇 |
2017年 | 10篇 |
2016年 | 6篇 |
2015年 | 9篇 |
2014年 | 14篇 |
2013年 | 20篇 |
2012年 | 19篇 |
2011年 | 15篇 |
2010年 | 25篇 |
2009年 | 19篇 |
2008年 | 7篇 |
2007年 | 18篇 |
2006年 | 29篇 |
2005年 | 25篇 |
2004年 | 15篇 |
2003年 | 22篇 |
2002年 | 19篇 |
2001年 | 16篇 |
2000年 | 19篇 |
1999年 | 21篇 |
1998年 | 31篇 |
1997年 | 26篇 |
1996年 | 23篇 |
1995年 | 21篇 |
1994年 | 24篇 |
1993年 | 17篇 |
1992年 | 15篇 |
1991年 | 17篇 |
1990年 | 17篇 |
1989年 | 15篇 |
1988年 | 12篇 |
1987年 | 11篇 |
1986年 | 15篇 |
1985年 | 10篇 |
1984年 | 8篇 |
1983年 | 6篇 |
1982年 | 4篇 |
1981年 | 4篇 |
1980年 | 3篇 |
1979年 | 4篇 |
1977年 | 3篇 |
1976年 | 2篇 |
1975年 | 3篇 |
1974年 | 1篇 |
1964年 | 1篇 |
1950年 | 1篇 |
排序方式: 共有648条查询结果,搜索用时 15 毫秒
21.
The CT appearance of asymptomatic splenic necrosis in a 11-year-old girl with Wegener's granulomatosis is presented. Sonography showed splenic inhomogeneity with patency of the splenic artery and vein. Follow-up CT showed lobulation and shrinkage of the spleen with return to a normal attenuation. 相似文献
22.
The authors reviewed the medical histories and radiological examinations of five pediatric patients with a histologic diagnosis of Wegener's granulomatosis (WG) seen over a six year period in whom a total of 22 thoracic CT scans were performed. Involvement of both the upper and lower respiratory tracts was seen in all patients at presentation. One patient had subglottic stenosis necessitating tracheotomy. Pulmonary hemorrhage occurred in three patients at initial diagnosis. Classic cavitary lung nodules were seen in two patients — one at initial presentation, the other at relapse. The plain radiographic lower respiratory tract manifestations of pediatric WG were protean both at initial presentation and during follow up. Similarly, disease expression was highly variable on thoracic CT examinations but, overall, multifocal parenchymal infiltrates with or without small peripheral nodules were the commonest thoracic CT manifestations. As a consequence of cytotoxic and corticosteroid therapy the long-term prognosis of WG has improved considerably in recent years. Knowledge of the varied patterns of the primary disease and potential for iatrogenic complications are necessary for successful radiologic assessment of pediatric patients with WG. 相似文献
23.
S Padeh R M Laxer G J Gleich P F Armstrong E D Silverman 《The Journal of pediatrics》1992,121(3):417-419
Eosinophilic synovitis occurred in a 7-year-old boy. Synovial fluid leukocytes were mostly eosinophils; the peripheral blood showed only mild eosinophilia. The level of eosinophil-derived neurotoxin in the synovial fluid was higher than that in the serum, suggesting intraarticular eosinophil degranulation. The IgE level was also elevated in the synovial fluid (3854 ng/ml) but normal in the serum (408 ng/ml), suggesting a localized immediate hypersensitivity immune response. 相似文献
24.
Serum-soluble interleukin-2 receptor levels in Kawasaki disease 总被引:1,自引:0,他引:1
B A Lang E D Silverman R M Laxer V Rose D L Nelson L A Rubin 《The Journal of pediatrics》1990,116(4):592-596
25.
R M Laxer E A Roberts K R Gross J R Britton E Cutz J Dimmick R E Petty E D Silverman 《The Journal of pediatrics》1990,116(2):238-242
We report the cases of neonatal lupus erythematosus associated with significant hepatic involvement in three living infants and in one infant who died 3 hours after delivery. The three living infants had neonatal cholestasis as a major component of their clinical findings. Pathologic changes included giant cell transformation, ductal obstruction, and extramedullary hematopoiesis. Liver involvement has been noted incidentally in children with neonatal lupus erythematosus, but it has generally been attributed to hemodynamic compromise as a result of congenital heart block or systemic toxic reactions. We speculate that neonatal hepatitis proceeding to hepatic fibrosis may occur in neonatal lupus erythematosus, analogous to the occurrence of "idiopathic" congenital heart block. The neonatal hepatitis associated with neonatal lupus erythematosus is a form distinguishable from the "idiopathic" group. Liver involvement may be more common than was previously recognized, and prospective studies to look for maternal autoantibodies in idiopathic neonatal liver disease should be undertaken. 相似文献
26.
PC Ng J Hiu TF Fok EAS Nelson KL Cheung W Wong 《Acta paediatrica (Oslo, Norway : 1992)》1995,84(8):955-956
We report an unusual case of localized congenital tuberculosis otitis in a preterm infant. Unlike disseminated congenital cases, the manifestations of localized otitis are associated with a triad of signs: (i) regional lymphadenopathy in the absence of typical systemic features of tuberculosis; (ii) delayed onset of presentation; and (iii) refractory otitis unresponsive to conventional antimicrobial agents. The need for greater diligence in looking for neonatal tuberculosis is emphasized, especially in an ethnic or socioeconomic environment where the disease is prevalent. Congenital tuberculosis, otitis, preterm
PC Ng, Department of Paediatrics, Level 6, Clinical Sciences Building, Prince of Wales Hospital, Shatin, NT, Hong Kong 相似文献
PC Ng, Department of Paediatrics, Level 6, Clinical Sciences Building, Prince of Wales Hospital, Shatin, NT, Hong Kong 相似文献
27.
We report seven patients with chronic recurrent multifocal osteomyelitis, an uncommon childhood disease of unknown etiology. These patients presented with insidious onset of bone pain at one or more sites associated with erythema, swelling and tenderness. Scintigraphy and radiography were consistent with osteomyelitis at multiple sites. Bone biopsies confirmed osteomyelitis but no organisms were consistently isolated. During a 1- to 3-year follow-up, most patients developed new symptomatic lesions. The disease was unaffected by antimicrobial therapy. Two of our patients had psoriasis and all were rheumatoid factor-, antinuclear factor- and HLA-B27-negative. We speculate that chronic recurrent osteomyelitis is a noninfectious inflammatory condition, a seronegative spondyloarthropathy. Chronic recurrent osteomyelitis is a clinical entity that should be recognized so that invasive diagnostic procedures and antimicrobial therapy are appropriately used. The patient may be reassured that this is not a malignant condition although there may be exacerbations over many years. 相似文献
28.
Following social disruption (SDR) stress in male mice, corticosterone resistance of splenocytes was accompanied by enhanced LPS-stimulated interleukin (IL)-6 secretion. The present study examined the role of IL-6 in the development of corticosterone resistance. Addition of IL-6 to control splenocyte cultures did not induce corticosterone resistance. SDR also elevated IL-6 in plasma and liver, but not in spleen. IL-6 deficient mice that were exposed to SDR developed glucocorticoid resistance despite the absence of systemic IL-6. These findings suggest that although SDR enhanced IL-6 responses, IL-6 was not essential for the development of stress-induced splenocyte corticosterone resistance. 相似文献
29.
Capizzano AA Vermathen P Laxer KD Matson GB Maudsley AA Soher BJ Schuff NW Weiner MW 《AJNR. American journal of neuroradiology》2002,23(8):1359-1368
BACKGROUND AND PURPOSE: Extensive metabolic impairments have been reported in association with mesial temporal lobe epilepsy (mTLE). We investigated whether proton MR spectroscopy ((1)H-MRS) depicts metabolic changes beyond the hippocampus in cases of mTLE and whether these changes help lateralize the seizure focus. METHODS: MR imaging and (1)H-MRS were performed in 15 patients with mTLE with a postoperative diagnosis of mesial temporal sclerosis and in 12 control volunteers. Point-resolved spectroscopy and multisection (1)H-MRS measured N-acetylaspartate (NAA), creatine (Cr), and choline (Cho) in the hippocampus, temporal opercular and lateral cortices, insula and cerebellum, and frontal, parietal, and occipital lobes. Metabolites were assessed as ratios to Cr and in absolute units. RESULTS: Twelve patients had ipsilateral hippocampal atrophy; three had negative imaging results. In the ipsilateral hippocampus, absolute NAA (/NAA/) was 27.3% lower in patients compared with that in control volunteers (P <.001) and 18.5% lower compared with that in the contralateral side (P <.01). /NAA/ averaged over selected regions in the ipsilateral temporal lobes of patients with mTLE was 19.3% lower compared with the mean in the control group (P <.0001) and by 17.7% lower compared with the contralateral values (P <.00001). Using only hippocampal data, 60% of the cases of mTLE were correctly lateralized. Lateralization, determined using whole temporal lobe data, had 87% sensitivity and 92% specificity. /NAA/ was bilaterally reduced in the frontal, parietal, and occipital lobes of patients with mTLE compared with that in control volunteers (P <.01). CONCLUSION: Multisection (1)H-MRS depicts interictal reductions of NAA in the ipsilateral temporal lobe beyond the hippocampus and accurately lateralizes seizure foci. 相似文献
30.
Honorati Masanja Joanna Armstrong Schellenberg Hassan M Mshinda Meera Shekar Joseph KL Mugyabuso Godwin D Ndossi Don de Savigny 《BMC health services research》2006,6(1):142