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排序方式: 共有354条查询结果,搜索用时 31 毫秒
101.
FR Kaufman G Costin DW Thomas FR Sinatra TF Roe HB Neustein 《Archives of disease in childhood》1984,59(8):787-789
The diagnosis of optic nerve hypoplasia and hypopituitarism must be entertained in infants who present for evaluation of cholestatic jaundice, particularly if there is associated hypoglycaemia and wandering nystagmus. Although the hepatic dysfunction seems to resolve, the long term prognosis of liver disease in optic nerve hypoplasia remains unknown. 相似文献
102.
103.
The incidence of neutralizing isoantibody formation to infused factor VIII in a cohort of 67 hemophilia A patients, born between January 1, 1971 and April 30, 1990, who had been treated exclusively with lyophilized cryoprecipitate, was 6% (5.3 per 1,000 patient years of observation). The age-dependent cumulative risk was 4.6% at 4 years of age and 6.7% at 8 years of age. Recent reports in patients treated with a variety of more pure concentrates show a much higher incidence of inhibitor formation and tend to be used as a reference when new concentrates are introduced. We believe that a patient group, such as the one studied here, is a more suitable reference population because these patients have been exclusively treated with a single factor VIII preparation. 相似文献
104.
Nemunaitis J; Appelbaum FR; Singer JW; Lilleby K; Wolff S; Greer JP; Bierman P; Resta D; Campion M; Levitt D 《Blood》1993,82(11):3273-3278
Recombinant human interleukin-3 (rhIL-3) was administered to 30 patients undergoing autologous bone marrow transplant (ABMT) for treatment of lymphoma. In this phase I dose escalation study, rhIL-3 was administered from day 0 to 20 after ABMT by 2-hour intravenous infusion at dose levels of 1, 2, 5, and 10 micrograms/kg/d. Seventeen patients did not complete therapy with rhIL-3. Eleven requested early discontinuation for malaise, confusion, transplant complications, or rapid engraftment and were removed from the study, whereas six patients developed grade III toxicity, including fever (three patients), or headache (three patients) possibly attributable to rhIL3. Other common toxicities included diarrhea, rigors, mucositis, and rash. The maximum tolerated dose of rhIL-3 was 2 micrograms/kg/d. No evidence of earlier hematopoietic cell recovery was observed compared with similar historical patients treated with recombinant human granulocyte- macrophage colony-stimulating factor. Future trials will be needed to determine alternate schedules of administration of rhIL-3 or the use of rhIL-3 in combination or in sequence with other growth factors. 相似文献
105.
Posterior atlantooccipital subluxation in Down syndrome 总被引:3,自引:0,他引:3
Three Down syndrome patients with posterior atlantooccipital (AO) subluxation are described. All are asymptomatic. The subluxation becomes manifest during active extension of the neck and reduces in flexion. Methods of assessing posterior AO subluxation are discussed. The abnormality is attributed to ligamentous laxity in patients with Down syndrome. 相似文献
106.
107.
Bernardes-Silva CF Damião AO Sipahi AM Laurindo FR Iriya K Lopasso FP Buchpiguel CA Lordello ML Agostinho CL Laudanna AA 《Digestive diseases and sciences》2004,49(10):1569-1574
The aim of this study was to evaluate the effect of ursodeoxycholic acid (UDCA) on intestinal permeability (IP) and reactive oxygen species (ROS) generation in indomethacin-induced enteropathy, a well-known experimental model of Crohn's disease. Seventy-eight male Wistar rats were randomly assigned to receive indomethacin, indomethacin + UDCA, or vehicles. Indomethacin induced a significant increase in the fraction of urinary excretion of 51Cr-EDTA following oral administration (7.9 +/- 1.3 vs 2.3 +/- 0.2%; P < 0.05) and lucigenin-amplified chemiluminescence in intestinal fragments ex vivo (10.1 +/- 1.9 vs 2.6 +/- 0.4 cpm x 10(3)/mg; P < 0.05) compared to controls. UDCA significantly reversed these effects (P < 0.05), without being incorporated in biliary bile acid composition (HPLC analysis). These findings support a local protective effect of UDCA in experimental ileitis by the modulation of intestinal barrier dysfunction and oxidative stress. In short, they provide insights into mechanisms of action of UDCA in intestinal inflammation and a new perspective on the treatment of Crohn's disease. 相似文献
108.
FR Balkwill DB Griffin HA Band PCL Beverley 《The Journal of experimental medicine》1983,157(3):1059-1063
We have described in this paper a novel human interferon (IFN) with antigenic and cross-species reactivity of α-IFN and physicochemical properties of γ-IFN. This IFN is produced by normal peripheral blood mononuclear cells during an immune response but has also been associated with autoimmune disease (10). The system described here will be useful in elucidating the biological significance and cell of origin of this IFN. 相似文献
109.
110.
GEORGE D. VEENHUYZEN M.D. SÉBASTIEN KNECHT M.D. MARK D. O’NEILL M.B.B.Ch. D. Phil. MATTHEW WRIGHT M.B.B.S. Ph.D. ISABELLE NAULT M.D. WEERASOORIYA RUKSHEN M.B.B.S. SHINSUKE MIYAZAKI M.D. FRÉDÉRIC SACHER M.D. MÉLÈZE HOCINI M.D. PIERRE JAÏS M.D. MICHEL HAÏSSAGUERRE M.D. 《Pacing and clinical electrophysiology : PACE》2009,32(3):393-398