全文获取类型
收费全文 | 550篇 |
免费 | 29篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 3篇 |
妇产科学 | 9篇 |
基础医学 | 53篇 |
口腔科学 | 18篇 |
临床医学 | 30篇 |
内科学 | 192篇 |
皮肤病学 | 2篇 |
神经病学 | 105篇 |
特种医学 | 11篇 |
外科学 | 28篇 |
预防医学 | 28篇 |
药学 | 16篇 |
肿瘤学 | 82篇 |
出版年
2023年 | 1篇 |
2022年 | 6篇 |
2021年 | 6篇 |
2020年 | 11篇 |
2019年 | 6篇 |
2018年 | 6篇 |
2017年 | 4篇 |
2016年 | 11篇 |
2015年 | 13篇 |
2014年 | 9篇 |
2013年 | 11篇 |
2012年 | 25篇 |
2011年 | 26篇 |
2010年 | 30篇 |
2009年 | 28篇 |
2008年 | 38篇 |
2007年 | 35篇 |
2006年 | 31篇 |
2005年 | 27篇 |
2004年 | 28篇 |
2003年 | 17篇 |
2002年 | 16篇 |
2001年 | 16篇 |
2000年 | 21篇 |
1999年 | 17篇 |
1998年 | 7篇 |
1997年 | 5篇 |
1996年 | 4篇 |
1995年 | 4篇 |
1994年 | 6篇 |
1993年 | 4篇 |
1992年 | 5篇 |
1991年 | 4篇 |
1990年 | 11篇 |
1989年 | 8篇 |
1988年 | 2篇 |
1987年 | 9篇 |
1986年 | 6篇 |
1985年 | 11篇 |
1984年 | 10篇 |
1983年 | 7篇 |
1982年 | 7篇 |
1981年 | 5篇 |
1980年 | 4篇 |
1979年 | 3篇 |
1977年 | 1篇 |
1973年 | 3篇 |
1972年 | 10篇 |
1971年 | 1篇 |
1969年 | 3篇 |
排序方式: 共有579条查询结果,搜索用时 15 毫秒
101.
102.
103.
Luiz Fernando Scalli Mathias Duarte MDSc Heitor Batista dos Reis MDSc Renata Tucci DDS PhD Luciano Lauria Dib DDS PhD 《Special care in dentistry》2014,34(2):77-83
Bisphosphonate‐related osteonecrosis of the jaws (BRONJ) is an adverse effect of drugs used to treat bone metabolism diseases, such as osteoporosis and bone metastases. The present study retrospectively evaluated the clinical characteristics and evolution of BRONJ cases that were diagnosed and treated at a dental school from 2004 to 2011. During that period, 13 patients met the criteria of the study among a population of 2,342 patients with oral lesions. Of the 13 patients, 12 were females. Ten were intravenous bisphosphonate users, and nine had breast cancer as the primary disease. Eight mandibular cases were observed. Eight patients interrupted the use of the bisphosphonates temporarily during the treatment. Surgical treatment was conducted in 10 patients, which was associated with platelet‐rich plasma in six cases, which led to a regression to Stage I in 50% of these and cure in 33.3%. Of the total sample, four (30.8%) cases were cured, six (46.1%) regressed to Stage I, and three (23.1%) remained in Stage II after treatment. Dental rehabilitation occurred in seven patients. Dissemination of knowledge among professionals is essential for prevention and early diagnosis of BRONJ. Dental schools must act as reference centers and participate in the multidisciplinary care of bisphosphonate users. 相似文献
104.
Different mechanisms lead to a karyotypically identical t(20;21) in myelodysplastic syndrome and in acute myelocytic leukemia 总被引:3,自引:0,他引:3
Matteucci C La Starza R Crescenzi B Romoli S Santoro A Magrin S Lauria F Coco FL Martelli MF Mecucci C 《Cancer Genetics and Cytogenetics》2003,140(1):13-17
A new t(20;21)(q11;q11), associated with a deletion on the long arm of chromosome 20, was found in one patient with an acute myelocytic leukemia (AML) and in one with myelodysplastic syndrome (MDS). In both cases deletion was interstitial, extending from band q11 to band q13, as shown by comparative genomic hybridization (CGH) and fluorescence in situ hybridization (FISH). FISH analysis with whole arm paints, subtelomeric probes, and locus-specific probes for the long arms of chromosomes 20 and 21 revealed in patient 1 a reciprocal translocation between the deleted 20q and the long arm of chromosome 21, that is, del(20)(q11q13)t(20;21)(q11;q11), and in patient 2, material from 21q was inserted into the deleted 20q, that is, del(20)(q11q13)ins(20;21)(q11;q11q22). This is the first identification of a complex 20;21 rearrangement in MDS/AML. Deletion at 20q and juxtaposition between 20q11 and 21q11 appear to be the critical genomic events. 相似文献
105.
M.S. Bianchim E.F. Sperandio G.S. Martinh?o A.C. Matheus V.T. Lauria R.P. da Silva R.C. Spadari A.R.T. Gagliardi R.L. Arantes M. Romiti V.Z. Dourado 《Brazilian journal of medical and biological research》2016,49(3)
The autonomic nervous system maintains homeostasis, which is the state of balance in
the body. That balance can be determined simply and noninvasively by evaluating heart
rate variability (HRV). However, independently of autonomic control of the heart, HRV
can be influenced by other factors, such as respiratory parameters. Little is known
about the relationship between HRV and spirometric indices. In this study, our
objective was to determine whether HRV correlates with spirometric indices in adults
without cardiopulmonary disease, considering the main confounders (e.g., smoking and
physical inactivity). In a sample of 119 asymptomatic adults (age 20-80 years), we
evaluated forced vital capacity (FVC) and forced expiratory volume in 1 s
(FEV1). We evaluated resting HRV indices within a 5-min window in the
middle of a 10-min recording period, thereafter analyzing time and frequency domains.
To evaluate daily physical activity, we instructed participants to use a triaxial
accelerometer for 7 days. Physical inactivity was defined as <150 min/week of
moderate to intense physical activity. We found that FVC and FEV1,
respectively, correlated significantly with the following aspects of the RR interval:
standard deviation of the RR intervals (r =0.31 and 0.35),
low-frequency component (r =0.38 and 0.40), and Poincaré plot SD2
(r =0.34 and 0.36). Multivariate regression analysis, adjusted
for age, sex, smoking, physical inactivity, and cardiovascular risk, identified the
SD2 and dyslipidemia as independent predictors of FVC and FEV1
(R
2=0.125 and 0.180, respectively, for both). We conclude that pulmonary
function is influenced by autonomic control of cardiovascular function, independently
of the main confounders. 相似文献
106.
Epidermal innervation: changes with aging, topographic location, and in sensory neuropathy. 总被引:16,自引:0,他引:16
G Lauria N Holland P Hauer D R Cornblath J W Griffin J C McArthur 《Journal of the neurological sciences》1999,164(2):172-178
In previous work we demonstrated little effect of aging on the density and spatial pattern of epidermal innervation, however, this was restricted to two sites proximal and distal in the leg. To expand on these observations, we used punch skin biopsy in ten healthy controls to examine the variation in intra-epidermal nerve fiber (IENF) density at multiple specific sites in the leg. There was a consistent gradient in IENF from proximal to distal sites in all subjects, but minimal effect of age was noted. In the older age group (> or =70 years), the IENF densities ranged from 28.6+/-1.9 IENF/mm at the trunk to 15.5+/-1.5 at the distal leg. In a group of six patients with painful sensory neuropathy, we confirmed a length-dependent reduction in IENF. We observed what may be a predegenerative change, namely increased branching of epidermal nerve fibers at clinically unaffected sites. These data suggest little age-related change in IENF, at least up to age 75 years, in healthy normals. The increased branching complexity noted in unaffected sites in patients with sensory neuropathies implies that this may be a predegenerative change, preceding the actual loss of nerve fibers. Skin biopsy may be a useful tool for assessing the topographic extent and degree of nerve fiber damage in sensory neuropathies and its quantitative interpretation should be little affected by aging changes. 相似文献
107.
Daniel Hinojosa-Nogueira Sergio Prez-Burillo Beatriz Navajas-Porras Bartolom Ortiz-Viso Silvia Pastoriza de la Cueva Fabio Lauria Alexandra Fatouros Kostas N. Priftis Vernica Gonzlez-Vigil Jos ngel Rufin-Henares 《Nutrients》2021,13(12)
The European Commission funded project Stance4Health (S4H) aims to develop a complete personalised nutrition service. In order to succeed, sources of information on nutritional composition and other characteristics of foods need to be as comprehensive as possible. Food composition tables or databases (FCT/FCDB) are the most commonly used tools for this purpose. The aim of this study is to describe the harmonisation efforts carried out to obtain the Stance4Health FCDB. A total of 10 FCT/FCDB were selected from different countries and organizations. Data were classified using FoodEx2 and INFOODS tagnames to harmonise the information. Hazard analysis and critical control points analysis was applied as the quality control method. Data were processed by spreadsheets and MySQL. S4H’s FCDB is composed of 880 elements, including nutrients and bioactive compounds. A total of 2648 unified foods were used to complete the missing values of the national FCDB used. Recipes and dishes were estimated following EuroFIR standards via linked tables. S4H’s FCDB will be part of the smartphone app developed in the framework of the Stance4Health European project, which will be used in different personalized nutrition intervention studies. S4H FCDB has great perspectives, being one of the most complete in terms of number of harmonized foods, nutrients and bioactive compounds included. 相似文献
108.
Palermo A Napoli N Manfrini S Lauria A Strollo R Pozzilli P 《Diabetes, obesity & metabolism》2011,13(1):42-46
Aim: Postprandial hyperglycaemia is a consequence of reduced first phase insulin response and is associated with increased cardiovascular risk and mortality. The aim of this proof‐of‐concept study was to investigate the safety and efficacy of treatment with buccal spray insulin (Oral‐lyn?, Generex Biotechnology Corporation, Toronto, Ontario, Canada) on postprandial plasma glucose and insulin levels in subjects with impaired glucose tolerance (IGT). Methods: A total of 19 female and 12 male Caucasian subjects, 52.2 ± 13.5 (SD) years old, having a body mass index of 33.1 ± 6 (SD) kg/m2 with confirmed IGT were included in the study. Subjects were randomized to take 4, 6 or 12 Oral‐lyn puffs (1 puff = 1 s.c. rapid insulin UI) split into two equal doses each, one before and the second 30 min after a standard 75 g oral glucose tolerance test (OGTT). Glucose and insulin levels were measured at baseline and 30, 60, 90, 120 and 180 min afterwards. Results: Glucose fluctuations during OGTT were not modified by 4 or 6 Oral‐lyn puffs. Treatment with 12 puffs was followed by 29.6% decrease in plasma glucose at 2 h and 26.8% decrease at 3 h, altogether p = 0.01. Considering all time points of the OGTT, there was a mean reduction of 15.8% in glucose levels. With 6 of the total 12 puffs used in group C there was a significant increase in the insulin levels during OGTT at 30 min (p < 0.04) but not at 2 or 3 h. No hypoglycaemic episodes were observed at any time points of the OGTT. Conclusions: This proof‐of‐concept study demonstrates that treatment with buccal spray insulin is a simple and valuable therapy for reducing postprandial hyperglycaemia in obese subjects with IGT. Importantly, this treatment is safe and none of the study subjects experienced hypoglycaemia. 相似文献
109.
R. A. Malik A. Veves S. Tesfaye G. Smith N. Cameron D. Zochodne G. Lauria 《Diabetes/metabolism research and reviews》2011,27(7):678-684
Small fibres constitute 70–90% of peripheral nerve fibres and regulate several key functions such as tissue blood flow, temperature and pain perception as well as sweating, all of which are highly relevant to the clinical presentation and adverse outcomes associated with foot ulcerations in patients with diabetes. Recent studies demonstrated significant abnormalities in the small fibres in subjects with impaired glucose tolerance and diabetes, despite normal electrophysiology, suggesting that the earliest nerve fibre damage is to the small fibres. Unfortunately, guidelines and consensus statements focus on large fibres and continue to advocate electrophysiology as a diagnostic modality and as a primary end point for the assessment of therapeutic benefit. (In part, this reflects the difficulties in quantifying small fibre dysfunction and damage.) We have therefore critically assessed currently available techniques that measure small fibre dysfunction in diabetic neuropathy, using quantitative sensory and sudomotor testing. We have assessed the role of identifying structural damage by quantifying intraepidermal nerve fibre density in skin biopsies and corneal nerve morphology using corneal confocal microscopy. Finally, we propose a definition for diabetic neuropathy that incorporates small fibre damage. Copyright © 2011 John Wiley & Sons, Ltd. 相似文献