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排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
992.
James Reigle Dina Secic Jacek Biesiada Collin Wetzel Behrouz Shamsaei Johnson Chu Yuanwei Zang Xiang Zhang Nicholas J. Talbot Megan E. Bischoff Yongzhen Zhang Charuhas V. Thakar Krishnanath Gaitonde Abhinav Sidana Hai Bui John T. Cunningham Qing Zhang Laura S. Schmidt W. Marston Linehan Mario Medvedovic David R. Plas Julio A. Landero Figueroa Jarek Meller Maria F. Czyzyk-Krzeska 《The Journal of clinical investigation》2021,131(1)
993.
Daria Capece Daniel DAndrea Federica Begalli Laura Goracci Laura Tornatore James L. Alexander Alessandra Di Veroli Shi-Chi Leow Thamil S. Vaiyapuri James K. Ellis Daniela Verzella Jason Bennett Luca Savino Yue Ma James S. McKenzie Maria Luisa Doria Sam E. Mason Kern Rei Chng Hector C. Keun Gary Frost Vinay Tergaonkar Katarzyna Broniowska Walter Stunkel Zoltan Takats James M. Kinross Gabriele Cruciani Guido Franzoso 《The Journal of clinical investigation》2021,131(11)
994.
Navarro-Haro María V. Botella Verónica Guillén Badenes-Ribera Laura Borao Luis García-Palacios Azucena 《Cognitive therapy and research》2021,45(3):480-493
Cognitive Therapy and Research - Dialectical Behavior Therapy (DBT) has shown evidence of its effectiveness in the treatment of borderline personality disorder (BPD) and eating disorders (EDs)... 相似文献
995.
Lyons Naomi Strasser Alexa Beitz Bernard Teismann Tobias Ostermann Thomas Anderle Laura Michalak Johannes 《Cognitive therapy and research》2021,45(3):508-516
Cognitive Therapy and Research - Emotions play a central role in mental disorder and especially in depression. They are sensed in the body, and it has recently been shown in healthy participants... 相似文献
996.
Cognitive Therapy and Research - The current study experimentally tested the hypothesis that elevated facial appearance concern is characterised by an elevated tendency to experience... 相似文献
997.
Pietro Crivello Nina Lauterbach Laura Zito Federico Sizzano Cristina Toffalori Jessica Marcon Laura Curci Arend Mulder Lotte Wieten Elisabetta Zino Christien E.M. Voorter Marcel G.J. Tilanus Katharina Fleischhauer 《Human immunology》2013
The functional relevance of polymorphisms outside the peptide binding groove of HLA molecules is poorly understood. Here we have addressed this issue by studying HLA-DP3, a common antigen relevant for functional matching algorithms of unrelated hematopoietic stem cell transplantation (HSCT) encoded by two transmembrane (TM) region variants, DPB1*03:01 and DPB1*104:01. The two HLA-DP3 variants were found at a overall allelic frequency of 10.4% in 201 volunteer stem cell donors, at a ratio of 4.2:1. No significant differences were observed in cell surface expression levels of the two variants on B lymphoblastoid cell lines (BLCL), primary B cells or monocytes. Three different alloreactive T cell lines or clones showed similar levels of activation marker CD107a and/or CD137 upregulation in response to HLA-DP3 encoded by DPB1*03:01 and DPB1*104:01, either endogenously on BLCL or after lentiveral-vector mediated transfer into the same cellular background. These data provide, for the first time, direct evidence for a limited functional role of a TM region polymorphism on expression and allorecognition of HLA-DP3 and are compatible with the notion that the two variants can be considered as a single functional entity for unrelated stem cell donor selection. 相似文献
998.
André F. Pastor Laís Rodrigues Moura José W.D. Neto Eduardo J.M. Nascimento Carlos E. Calzavara-Silva Ana Lisa V. Gomes Ana Maria da Silva Marli T. Cordeiro Ulisses Braga-Neto Sergio Crovella Laura H.V.G. Gil Ernesto T.A. Marques Jr. Bartolomeu Acioli-Santos 《Human immunology》2013
Four genetic polymorphisms located at the promoter (C-257T) and coding regions of CFH gene (exon 2 G257A, exon 14 A2089G and exon 19 G2881T) were investigated in 121 dengue patients (DENV-3) in order to assess the relationship between allele/haplotypes variants and clinical outcomes. A statistical value was found between the CFH-257T allele (TT/TC genotypes) and reduced susceptibility to severe dengue (SD). Statistical associations indicate that individuals bearing a T allele presented significantly higher protein levels in plasma. The −257T variant is located within a NF-κB binding site, suggesting that this variant might have effect on the ability of the CFH gene to respond to signals via the NF-κB pathway. The G257A allelic variant showed significant protection against severe dengue. When CFH haplotypes effect was considered, the ancestral CG/CG promoter-exon 2 SNP genotype showed significant risk to SD either in a general comparison (ancestral × all variant genotypes), as well as in individual genotypes comparison (ancestral × each variant genotype), where the most prevalent effect was observed in the CG/CG × CA/TG comparison. These findings support the involvement of −257T, 257A allele variants and haplotypes on severe dengue phenotype protection, related with high basal CFH expression. 相似文献
999.
Rosanna Tortelli Francesca Luisa Conforti Rosa Cortese Eustachio D'Errico Eugenio Distaso Rosalucia Mazzei Carmine Ungaro Angela Magariello Antonio Gambardella Giancarlo Logroscino Isabella Laura Simone 《Neurobiology of aging》2013
Copper-zinc superoxide dismutase-1 (SOD1) is the second most common mutated gene in amyotrophic lateral sclerosis (ALS). To date more than 150 missense mutations of SOD1 have been reported. The objective of this study was to describe a novel SOD1 mutation and its phenotypic expression. We describe a 74-year-old Caucasian man who began to complain of progressive weakness and atrophy of the right hand and over 10 months developed a severe tetraparesis, with atrophies of upper and lower limbs and neck muscles, dysphagia, and dyspnea that led to percutaneous endoscopic gastrostomy and tracheotomy. A diagnosis of ALS was made. Genetic analysis identified a heterozygous mutation in exon 4 of SOD1 that results in the amino acid substitution from arginine to cysteine at position 115 (p.R115C). We identified a novel pathogenic SOD1 mutation in a patient with a very rapid disease progression and aggressive phenotype providing additional information on the wide range of SOD1 mutations in apparently sporadic ALS and confirming the possibility of a strong genotype-phenotype correlation for distinct SOD1 mutations. 相似文献
1000.
Colin J. Mahoney Ian B. Malone Gerard R. Ridgway Aisling H. Buckley Laura E. Downey Hannah L. Golden Natalie S. Ryan Sebastien Ourselin Jonathan M. Schott Martin N. Rossor Nick C. Fox Jason D. Warren 《Neurobiology of aging》2013
The primary progressive aphasias (PPA) are a heterogeneous group of language-led neurodegenerative diseases resulting from large-scale brain network degeneration. White matter (WM) pathways bind networks together, and might therefore hold information about PPA pathogenesis. Here we used diffusion tensor imaging and tract-based spatial statistics to compare WM tract changes between PPA syndromes and with respect to Alzheimer's disease and healthy controls in 33 patients with PPA (13 nonfluent/agrammatic PPA); 10 logopenic variant PPA; and 10 semantic variant PPA. Nonfluent/agrammatic PPA was associated with predominantly left-sided and anterior tract alterations including uncinate fasciculus (UF) and subcortical projections; semantic variant PPA with bilateral alterations in inferior longitudinal fasciculus and UF; and logopenic variant PPA with bilateral but predominantly left-sided alterations in inferior longitudinal fasciculus, UF, superior longitudinal fasciculus, and subcortical projections. Tract alterations were more extensive than gray matter alterations, and the extent of alteration across tracts and PPA syndromes varied between diffusivity metrics. These WM signatures of PPA syndromes illustrate the selective vulnerability of brain language networks in these diseases and might have some pathologic specificity. 相似文献