全文获取类型
收费全文 | 359篇 |
免费 | 28篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 6篇 |
妇产科学 | 16篇 |
基础医学 | 40篇 |
口腔科学 | 9篇 |
临床医学 | 37篇 |
内科学 | 41篇 |
皮肤病学 | 20篇 |
神经病学 | 27篇 |
特种医学 | 3篇 |
外科学 | 65篇 |
综合类 | 2篇 |
预防医学 | 18篇 |
眼科学 | 31篇 |
药学 | 16篇 |
肿瘤学 | 55篇 |
出版年
2023年 | 4篇 |
2022年 | 7篇 |
2021年 | 13篇 |
2020年 | 10篇 |
2019年 | 24篇 |
2018年 | 14篇 |
2017年 | 11篇 |
2016年 | 11篇 |
2015年 | 24篇 |
2014年 | 21篇 |
2013年 | 23篇 |
2012年 | 38篇 |
2011年 | 28篇 |
2010年 | 20篇 |
2009年 | 16篇 |
2008年 | 23篇 |
2007年 | 22篇 |
2006年 | 21篇 |
2005年 | 15篇 |
2004年 | 10篇 |
2003年 | 8篇 |
2002年 | 10篇 |
2001年 | 3篇 |
2000年 | 2篇 |
1999年 | 3篇 |
1997年 | 1篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1993年 | 1篇 |
1979年 | 2篇 |
排序方式: 共有387条查询结果,搜索用时 15 毫秒
31.
Hadaschik BA Paterson RF Fazli L Clinkscales KW Shalaby SW Chew BH 《The Journal of urology》2008,180(3):1161-1166
32.
Mostaghel EA Page ST Lin DW Fazli L Coleman IM True LD Knudsen B Hess DL Nelson CC Matsumoto AM Bremner WJ Gleave ME Nelson PS 《Cancer research》2007,67(10):5033-5041
33.
34.
Shahin Emami Meibodi Amir Reza Fatahi Meybodi Sholeh Rahebi Ladan Eslamian 《Orthodontic Waves》2009,68(3):112-115
The purpose of this study was to find the correlation coefficients between the mesiodistal widths of the permanent mandibular incisors and the permanent canine and premolars for each quadrant and establish a regression equation for prediction of the sum of canine and premolars based on the dimension of the lower incisors. 90 patients 12–20 years old (45 females and 45 males) were selected. The mesiodistal crown diameters of the permanent teeth were measured. The correlation coefficients between the permanent mandibular incisors and the permanent canine and premolars sizes varied from 0.63 to 0.8. An Iranian mixed dentition analysis based on the Tanaka and Johnston method was constructed with linear regression equations; for maxillary arch y = 6.3 + 0.65x (SEE = 0.8 mm) and for mandibular arch y = 5.1 + 0.67x (SEE = 0.8 mm). No significant sexual dimorphism was found in tooth sizes. This study revealed that Iranian population has smaller teeth than white North American. We found that prediction equations of Tanaka and Johnston or Moyers charts cannot accurately predict the size of buccal segment in Iranian population. 相似文献
35.
36.
Increased expression and differential phosphorylation of stathmin may promote prostate cancer progression 总被引:1,自引:0,他引:1
BACKGROUND: Proteins which regulate normal development may promote tumorigenesis, tumor progression, or metastasis through dysregulation of these functions. We postulate that proteins, which regulate prostate growth also promote prostate cancer (PCa) progression. METHODS: Two Dimensional Gel Electrophoresis was utilized to compare patterns of protein expression in 12T-7f prostates (LPB-Tag mouse model for PCa) during tumor development and progression with those of normal developing and adult wild type CD-1 prostates. Stathmin expression and phosphorylation patterns were analyzed in mouse and human PCa cell lines as well as in human PCa tissue arrays. RESULTS: Stathmin was identified by two-dimensional gel electrophoresis and mass spectrometry. Stathmin levels increase early during normal mouse prostate development and again during prostate tumor development and progression. In human prostate adenocarcinoma, stathmin increases in Gleason pattern 5. Further, stathmin is differentially phosphorylated in androgen-dependent LNCaP cells compared to androgen-independent PC-3 and DU145 cells. This differential phosphorylation is modulated by androgen and anti-androgen treatment. CONCLUSION: Stathmin expression is highest when the prostate is undergoing morphogenesis or tumorigenesis and these processes may be regulated through differential phosphorylation. Furthermore, modulation of stathmin phosphorylation may correlate with the development of androgen-independent PCa. 相似文献
37.
Statistical learning has been studied as a mechanism by which people automatically and implicitly learn patterns in the environment. Here, we sought to examine general assumptions about statistical learning, including whether the learning is long-term, and whether it can occur implicitly. We exposed participants to a stream of stimuli, then tested them immediately after, or 24 h after, exposure, with separate tests meant to measure implicit and explicit knowledge. To measure implicit learning, we analyzed reaction times during a rapid serial visual presentation detection task; for explicit learning, we used a matching questionnaire. Subjects’ reaction time performance indicated that they did implicitly learn the exposed sequences, and furthermore, this learning was unrelated to explicit learning. These learning effects were observed both immediately after exposure and after a 24-h delay. These experiments offer concrete evidence that statistical learning is long-term and that the learning involves implicit learning mechanisms. 相似文献
38.
Targeting ASCT2‐mediated glutamine uptake blocks prostate cancer growth and tumour development 下载免费PDF全文
Qian Wang Rae‐Anne Hardie Andrew J Hoy Michelle van Geldermalsen Dadi Gao Ladan Fazli Martin C Sadowski Seher Balaban Mark Schreuder Rajini Nagarajah Justin J‐L Wong Cynthia Metierre Natalia Pinello Nicholas J Otte Melanie L Lehman Martin Gleave Colleen C Nelson Charles G Bailey William Ritchie John EJ Rasko Jeff Holst 《The Journal of pathology》2015,236(3):278-289
39.
Marco Trerotola Kirat K. Ganguly Ladan Fazli Carmine Fedele Huimin Lu Anindita Dutta Qin Liu Tiziana De Angelis Luke W. Riddell Natalia A. Riobo Martin E. Gleave Amina Zoubeidi Richard G. Pestell Dario C. Altieri Lucia R. Languino 《Oncotarget》2015,6(16):14318-14328
In this study, we show that the transmembrane glycoprotein Trop-2 is up-regulated in human prostate cancer (PCa) with extracapsular extension (stages pT3/pT4) as compared to organ-confined (stage pT2) PCa. Consistent with this evidence, Trop-2 expression is found to be increased in metastatic prostate tumors of Transgenic Adenocarcinoma of Mouse Prostate mice and to strongly correlate with α5β1 integrin levels. Using PCa cells, we show that Trop-2 specifically associates with the α5 integrin subunit, as binding to α3 is not observed, and that Trop-2 displaces focal adhesion kinase from focal contacts. In support of the role of Trop-2 as a promoter of PCa metastatic phenotype, we observe high expression of this molecule in exosomes purified from Trop-2-positive PCa cells. These vesicles are then found to promote migration of Trop-2-negative PCa cells on fibronectin, an α5β1 integrin/focal adhesion kinase substrate, thus suggesting that the biological function of Trop-2 may be propagated to recipient cells. In summary, our findings show that Trop-2 promotes an α5β1 integrin-dependent pro-metastatic signaling pathway in PCa cells and that the altered expression of Trop-2 may be utilized for early identification of capsule-invading PCa. 相似文献
40.
Anna Broder Wenzhu B. Mowrey Ladan Golestaneh Chaim Putterman Karen H. Costenbader Mimi Kim 《Seminars in arthritis and rheumatism》2019,48(4):678-685