全文获取类型
收费全文 | 645篇 |
免费 | 38篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 33篇 |
妇产科学 | 7篇 |
基础医学 | 59篇 |
口腔科学 | 17篇 |
临床医学 | 88篇 |
内科学 | 177篇 |
皮肤病学 | 32篇 |
神经病学 | 15篇 |
特种医学 | 126篇 |
外科学 | 20篇 |
综合类 | 27篇 |
预防医学 | 34篇 |
眼科学 | 5篇 |
药学 | 17篇 |
1篇 | |
肿瘤学 | 27篇 |
出版年
2023年 | 2篇 |
2022年 | 5篇 |
2021年 | 5篇 |
2020年 | 7篇 |
2019年 | 6篇 |
2018年 | 14篇 |
2017年 | 6篇 |
2016年 | 10篇 |
2015年 | 12篇 |
2014年 | 13篇 |
2013年 | 18篇 |
2012年 | 7篇 |
2011年 | 15篇 |
2010年 | 27篇 |
2009年 | 30篇 |
2008年 | 16篇 |
2007年 | 28篇 |
2006年 | 21篇 |
2005年 | 20篇 |
2004年 | 12篇 |
2003年 | 11篇 |
2002年 | 12篇 |
2001年 | 10篇 |
2000年 | 8篇 |
1999年 | 11篇 |
1998年 | 41篇 |
1997年 | 47篇 |
1996年 | 39篇 |
1995年 | 20篇 |
1994年 | 29篇 |
1993年 | 22篇 |
1992年 | 9篇 |
1991年 | 9篇 |
1990年 | 11篇 |
1989年 | 23篇 |
1988年 | 20篇 |
1987年 | 9篇 |
1986年 | 8篇 |
1985年 | 5篇 |
1984年 | 15篇 |
1983年 | 14篇 |
1982年 | 12篇 |
1981年 | 11篇 |
1980年 | 7篇 |
1979年 | 1篇 |
1978年 | 3篇 |
1977年 | 2篇 |
1976年 | 4篇 |
1969年 | 1篇 |
排序方式: 共有688条查询结果,搜索用时 15 毫秒
91.
Efficacy of a Work Disability Prevention Program for People with Rheumatic and Musculoskeletal Conditions: A Single‐Blind Parallel‐Arm Randomized Controlled Trial 下载免费PDF全文
Julie J. Keysor Michael P. LaValley Carrie Brown David T. Felson Rawan A. AlHeresh Molly W. Vaughan Robert Yood John I. Reed Saralynn J. Allaire 《Arthritis care & research》2018,70(7):1022-1029
Objective
Work disability rates are high among people with rheumatic and musculoskeletal conditions. Effective disability preventive programs are needed. We examined the efficacy of a modified vocational rehabilitation approach delivered by trained occupational therapists and physical therapists on work limitation and work loss over 2 years among people with rheumatic and musculoskeletal conditions.Methods
Eligibility criteria for this single‐blind, parallel‐arm randomized trial included ages 21–65 years, 15 or more hours/week employment, a self‐reported doctor‐diagnosed rheumatic or musculoskeletal condition, and concern about staying employed. The intervention consisted of a 1.5‐hour meeting, an action plan, written materials on employment supports, and telephone calls at 3 weeks and 3 months. Control group participants received the written materials. The primary outcome was the Work Limitations Questionnaire (WLQ) output job demand subscale. The secondary outcome was work loss. Intent‐to‐treat analyses were performed.Results
Between October 2011 and January 2014, 652 individuals were assessed for eligibility. A total of 287 participants were randomized: 143 intervention and 144 control participants. In total, 264 participants (92%) completed 2‐year data collection. There was no difference in the mean ± SD WLQ change scores from baseline to 2‐year followup (?8.6 ± 1.9 intervention versus ?8.3 ± 2.2 control; P = 0.93). Of the 36 participants who experienced permanent work loss at 2 years, 11 (8%) were intervention participants and 25 (18%) control participants (P = 0.03).Conclusion
The intervention did not have an effect on work limitations but reduced work loss. The intervention can be delivered by trained rehabilitation therapists.92.
93.
94.
Waldmann TA; Goldman CK; Bongiovanni KF; Sharrow SO; Davey MP; Cease KB; Greenberg SJ; Longo DL 《Blood》1988,72(5):1805-1816
Human T-cell lymphotropic virus I (HTLV-I)-induced adult T-cell leukemia (ATL) cells constitutively express interleukin-2 (IL-2) receptors identified by the anti-Tac monoclonal antibody (MoAb), whereas normal resting cells do not. This observation provided the scientific basis for a trial of intravenous anti-Tac in the treatment of nine patients with ATL. The patients did not suffer untoward reactions and did not have a reduction in the normal formed elements of the blood, and only one of the nine produced antibodies to the anti-Tac MoAb. Three patients had transient mixed, partial, or complete remissions lasting from 1 to more than 8 months after anti-Tac therapy, as assessed by routine hematologic tests, immunofluorescence analysis of circulating cells, and molecular genetic analysis of HTLV-I provirus integration and of the T-cell receptor gene rearrangement. The precise mechanism of the antitumor effects is unclear; however, the use of a MoAb that prevents the interaction of IL-2 with its receptor on ATL cells provides a rational approach for the treatment of this malignancy. 相似文献
95.
96.
97.
98.
Murakami T; Baron RL; Peterson MS; Oliver JH rd; Davis PL; Confer SR; Federle MP 《Radiology》1996,200(1):69
99.
100.
J-B Liu† M Li‡§ H Chen† S-Q Zhong† S Yang¶ W-D Du¶ J-H Hao†† T-S Zhang‡‡ X-J Zhang¶ MP Zeegers§§¶¶ 《Journal of the European Academy of Dermatology and Venereology》2007,21(2):205-213
BACKGROUND: Linkage and association studies suggest that the human leucocyte antigen (HLA) region may be involved in the genetic susceptibility of vitiligo. HLA-A2 has been reported to be associated with vitiligo in some, but not all, studies. OBJECTIVE: To identify sources of the heterogeneity among studies and to quantify effect estimates, we examined the association of HLA-A2 with vitiligo in a meta-analysis of all observational studies comparing the frequencies of HLA-A2 between vitiligo individuals and controls during 1966-2005. METHODS: The summary odds ratio (OR) was calculated by using a fixed- or a random-effects model. Meta-regression analysis was undertaken to investigate the effects of study characteristics on the pooled OR. RESULTS: Eleven case-controlled studies fulfilled our inclusion criteria. The studies identified a total of 777 patients and 4820 controls. Meta-analysis showed a significantly increased frequency of HLA-A2 in vitiligo among cases [OR = 2.07, 95% confidence interval (CI) 1.67-2.58]. Heterogeneity was explained by the quality of the study and the ethnic background of the participants. Meta-regression analysis further showed that the percentage of familial vitiligo among the subjects had a significant effect on the pooled OR (P = 0.008). No study had a significant effect on the pooled OR and no publication bias presented in the studies analysed (P = 0.688). CONCLUSION: These findings strongly suggest an association between HLA-A2 and vitiligo. 相似文献