全文获取类型
收费全文 | 145647篇 |
免费 | 13547篇 |
国内免费 | 8377篇 |
专业分类
耳鼻咽喉 | 1467篇 |
儿科学 | 2698篇 |
妇产科学 | 1201篇 |
基础医学 | 11442篇 |
口腔科学 | 2527篇 |
临床医学 | 18564篇 |
内科学 | 16475篇 |
皮肤病学 | 2321篇 |
神经病学 | 4311篇 |
特种医学 | 5933篇 |
外国民族医学 | 22篇 |
外科学 | 12863篇 |
综合类 | 34097篇 |
现状与发展 | 48篇 |
一般理论 | 4篇 |
预防医学 | 14995篇 |
眼科学 | 2543篇 |
药学 | 16923篇 |
183篇 | |
中国医学 | 11274篇 |
肿瘤学 | 7680篇 |
出版年
2024年 | 543篇 |
2023年 | 1791篇 |
2022年 | 4491篇 |
2021年 | 6013篇 |
2020年 | 4974篇 |
2019年 | 3283篇 |
2018年 | 3512篇 |
2017年 | 4086篇 |
2016年 | 3512篇 |
2015年 | 5946篇 |
2014年 | 7772篇 |
2013年 | 9079篇 |
2012年 | 13357篇 |
2011年 | 13769篇 |
2010年 | 11465篇 |
2009年 | 10170篇 |
2008年 | 10954篇 |
2007年 | 10514篇 |
2006年 | 9657篇 |
2005年 | 7979篇 |
2004年 | 5699篇 |
2003年 | 4892篇 |
2002年 | 3946篇 |
2001年 | 3228篇 |
2000年 | 2431篇 |
1999年 | 1256篇 |
1998年 | 484篇 |
1997年 | 534篇 |
1996年 | 398篇 |
1995年 | 327篇 |
1994年 | 307篇 |
1993年 | 186篇 |
1992年 | 192篇 |
1991年 | 167篇 |
1990年 | 123篇 |
1989年 | 83篇 |
1988年 | 68篇 |
1987年 | 60篇 |
1986年 | 52篇 |
1985年 | 34篇 |
1984年 | 33篇 |
1983年 | 23篇 |
1982年 | 19篇 |
1981年 | 12篇 |
1980年 | 9篇 |
1979年 | 11篇 |
1964年 | 8篇 |
1959年 | 10篇 |
1958年 | 12篇 |
1957年 | 12篇 |
排序方式: 共有10000条查询结果,搜索用时 1 毫秒
101.
采用ELISA法检测104例各类型乙型肝炎(乙肝)患者的血清前-S2抗原(Pre-S2Ag)及其抗体(Pre-S2Ab),结果表明,Pre-S2Ag的出现与HBsAg、HBeAg、HBcAb呈显著相关性(P值均<0.005),主要见于乙肝急性期及慢性乙肝患者,说明病毒复制活跃、传染性强。而Pre-S2Ab阳性仅见于急性乙肝恢复期。 相似文献
102.
The relationship between induction of hepatic metallothionein (MT) synthesis and lipid peroxidation by free radical production following an injection of menadione or carbon tetrachloride (CCl4) in mice was studied. The hepatic concentration of MT was increased by menadione significantly at 25 mg/kg or higher. A significant increase in thiobarbituric acid (TBA) value, indicative of lipid peroxidation, was observed in the liver at menadione doses of 62.5 mg/kg or higher. Both the MT and the TBA value in the liver were significantly increased at the low dose of CCl4. The concentration of MT was increased significantly 4-8 hr after administrations of these compounds. The increase of TBA value over time was similar to that of MT concentration after administration of CCl4, but not after administration of menadione. The MT concentration in the menadione group was higher than that in the CCl4 group, and the TBA level in the menadione group was lower than that in the CCl4 group. Pretreatment with vitamin E caused a significant reduction in the TBA value, but did not affect the MT level in the liver. The concentration of MT did not significantly correlate with the TBA value in either the menadione or the CCl4 group. Pretreatment with phenobarbital, which promotes free radical production, did not influence induction of MT synthesis following an injection of menadione or CCl4. Neither L-buthionine sulfoximine nor 2-cyclo-hexen-1-one, which decreases hepatic glutathione, influenced the induction of MT by menadione. These data suggest that induction of MT synthesis by menadione or CCl4 is independent of free radical production in the liver. 相似文献
103.
乌苯美司体外对人单核细胞功能的活化作用 总被引:1,自引:0,他引:1
观察了国产乌苯美司(乌比美克)体外对人单核细胞功能的影响:①0.01 ̄100μg/ml乌苯美司能直接诱导人单核细胞生成IL-1;②经0.1μg/ml乌苯美司作用4h后,人单核细胞即开始分泌IL-1,24h达到高峰,以后逐渐下降;③经10 ̄100μg/ml乌苯美司预处理,单核细胞可促进NK细胞活性,而经0.01 ̄0.1μg/ml乌苯美司处理,单核细胞则抑制NK细胞活性。 相似文献
104.
医用低值材料采供管理的探讨 总被引:4,自引:2,他引:2
医疗消耗材料是医疗工作开展的基础,本文从医用低值消耗材料的计划制定、材料采购、库房库存结构、材料供应、成本核算等多方面探讨了如何对医疗消耗材料进行科学管理,这对医院的医疗发展和管理建设有着重要意义。 相似文献
105.
106.
A dual sensor Wiener filter (DSWF) technique was used to improve the image quality of a scanning type digital radiographic system. In a digital radiographic system, image quality is evaluated by resolution and SNR (signal-to-noise ratio), which are two important parameters representing the objective performance of the system. In this method, when two images are acquired in the same region using two sensors with different characteristics of resolution and SNR, they are processed simultaneously using DSWF, which is the extended concept of a Wiener filter to two dimensions. DSWF uses the cross power spectrum between dual sensor outputs of the same chest radiographic image in the design of filter parameters. It has been implemented with fast algorithm using FFT (fast Fourier transform). The performance of the proposed method is compared with that of conventional methods (Wiener filter and parametric projection filter). In simulation studies, it is shown in 12 cases that this new method has SNR improvement of 1-2 dB better than conventional methods. 相似文献
107.
Yoon-Ho Hong Jung-Joon Sung Kyung Seok Park Ohyun Kwon Ju-Hong Min Kwang-Woo Lee 《Clinical neurophysiology》2007,118(12):2605-2611
OBJECTIVE: To address the issue as to how best to perform statistical MUNE, we applied two different approaches and compared results in healthy subjects and ALS patients. METHODS: Twelve normal subjects (women 8, mean age 52years) and 11 ALS patients (women 4, mean age 54years) underwent two consecutive MUNE studies, which differed in terms of setting and modifying the recording window. These are referred to as the 'expansion' and 'narrowing' methods, respectively. Size-weighted average (Av) SMUP and MUNE values were obtained using the two methods, and compared in control and patient groups. RESULTS: Expansion method-derived Av SMUP sizes and MUNE values differed only slightly from those obtained using the narrowing method in healthy subjects, whereas the narrowing method resulted in significantly larger Av SMUP sizes and smaller MUNE values than the expansion method in ALS patients (Wilcoxon signed ranks test, p=0.003). The sizes of tested areas (mean+/-SD) were significantly larger for the narrowing method than the expansion method in both subject groups with much greater difference in ALS patients; 9.6+/-3.1% vs. 7.9+/-1.7% in healthy subjects and 16.1+/-5.1% vs. 11.2+/-3.0% in ALS patients (Student t-test, p<0.01). CONCLUSIONS: The present study shows, unlike that found in normal subjects, that the results of statistical MUNE in ALS patients are heavily dependent on the approach used to set and modify recording windows. SIGNIFICANCE: The expansion method using a 10%-sized window is likely to suffer from systemic errors due to the ceiling effect and the sampling of artifactually small motor units in ALS patients. The authors recommend that the narrowing method be considered as an alternative that avoids these problems. 相似文献
108.
扩大经蝶入路进入海绵窦内侧腔的应用显微解剖 总被引:1,自引:0,他引:1
目的为临床开展扩大经蝶入路进入海绵窦内侧腔手术提供解剖学依据。方法用50例成人头颅标本.在显微镜下对蝶窦外侧壁、蝶鞍、海绵窦及周围结构进行解剖学观察并测量。模拟扩大经蝶入路磨除海绵窦腹侧骨质,切开海绵窦内侧壁,显露海绵窦内侧腔。结果颈内动脉(ICA)明显隆起于蝶窦侧壁的占58%,蝶窦内隆起呈管型占3%。鞍底硬膜分为2层,海绵窦内侧壁的上部南垂体硬膜构成,无骨性结构支撑;下部由骨周硬膜构成,有蝶窦侧壁骨质支撑。两侧海绵窦内侧壁的距离为(14.8±2.7)mm。海绵窦内侧腔位于C4段ICA与垂体之间,腔内为丰富的静脉丛,最宽可达7mm,但常因ICA扭曲而闭塞。无颅神经穿越海绵窦内侧腔,ICA是扩大经蝶入路探查海绵窦遇到的第一个主要结构。结论扩大经蝶入路进入海绵窦内侧腔是安全可行的。 相似文献
109.
Adipose tissues differentiated by adipose-derived stem cells harvested from transgenic mice 总被引:2,自引:1,他引:1
Objective: To induce adipocyte differentiation in vitro by adipose-derived stromal cells (ASCs) harvested from transgenic mice with green fluorescent protein (GFP) and assess the possibility of constructing adipose tissues via attachment of ASCs to typeⅡcollagen scaffolds. Methods: Inguinal fat pads from GFP transgenic mice were digested by enzymes for isolation of ASCs (primary culture). After expansion to three passages of ASCs, the cells were incubated in an adipogenic medium for two weeks, and the adipocyte differentiation by ASCs in vitro was assessed by morphological observation and Oil Red O staining. Then they were attached to collagen scaffolds and co-cultured for 12 hours, followed by hypodermic implantation to the dorsal skin of nude mice for 2 months. The newly-formed tissues were detected by HE staining. Results: The cultured primary stem cells were fibroblast-like and showed active proliferation. After being incubated in an adipocyte differentiation medium, the lipid droplets in the cytoplasm accumulated gradually and finally developed into mature adipocytes, which showed positive in Oil Red O staining. A 0. 5-cm3 new tissue clot was found under the dorsal skin of the nude mice and it was confirmed as mature adipose tissues by fluorescent observation and HE staining. Conclusions: ASCs can successfully differentiate adipose tissues into mature adipocytes, which exhibit an adipocyte-like morphology and express as intracytoplasmic lipid droplets. It is an efficient model of adipose tissues engineered with ASCs and type I collagen scaffolds. 相似文献
110.
免水分离超声乳化白内障摘除术临床观察 总被引:2,自引:0,他引:2
目的 :探讨免水分离术在超声乳化白内障摘除术中临床应用的有效性。方法 :随机选择白内障患者 2 0 0只眼 ,分两组。一组 (对照组 ) 95例 10 0只眼进行常规水分离术 ,二组 (观察组 ) 94例 10 0只眼 ,行免水分离术 ,所有患者均由同一医师进行超声乳化白内障摘除术联合人工晶体植入。临床观察超声乳化能量和时间 ,术后第一天、第三天、一周时视力 ,术中、术后并发症。结果 :( 1)平均超声能量Ⅰ、Ⅱ、Ⅲ、Ⅳ级核 ,一组分别是 :( 10 5 6± 4 16) %、 ( 17 88± 2 2 6) %、 ( 2 9 2 2± 3 5 4) %、 ( 3 7 88± 2 67) % ;二组分别是 ( 11 3 0± 1 89) %、 ( 18 76± 1 61) %、 ( 2 7 99± 3 5 8) %、 ( 3 9 2 2± 3 3 3 ) % ;两组平均超声能量差异无显著意义 (t =-0 5 12、 -1 496、 1 70 6、 -1 3 60 ,P =0 615、 0 14 2、 0 0 91、 0 182 ) ;平均超声时间一组分别为 ( 7 5 6±3 2 1)s、 ( 2 6 68± 5 15 )s、 ( 71 72± 17 2 2 )s、 ( 13 7 71± 3 8 60 )s ,二组分别为 ( 9 10± 1 2 0 )s、 ( 2 4 71± 4 0 9)s、 ( 76 17± 18 74)s、 ( 12 2 0 9± 3 5 14 )s ,两组平均超声时间差异无显著意义 (t =-1 42、 -1 415、 -1 3 69、 1 3 3 3 ,P =0 173、0 164、 0 174、 0 190 )。 ( 2 )术后一 相似文献