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1.
Fotini Viras Yun-Zhu Luo Kyriakos Viras Richard H. Mobbs Terence A. King Colin Booth 《Macromolecular chemistry and physics.》1988,189(2):459-469
Block-copoly(oxypropylene/oxyethylene/oxypropylene)s, with central-block lengths of 39 and 75 oxyethylene units and end-block lengths in the range 1 to 13 oxypropylene units, were investigated in their solid states by small-angle X-ray diffraction and low-frequency Raman spectroscopy, supplemented by differential scanning calorimetry. Low-frequency Raman transitions were assigned to longitudinal modes (LAM) of either unfolded or once-folded chains. The solid state comprised stacked monolayer lamellae in which the chains were usually tilted with respect to the lamellar end plane. 相似文献
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Kyriakos Chatzopoulos Sotiris Sotiriou Andrea R. Collins Panagiotis Kartsidis Alessandra C. Schmitt Xianfeng Chen Khashayarsha Khazaie Michael L. Hinni Colleen A. Ramsower Matthew A. Zarka Samir H. Patel Joaquin J. Garcia 《Head and neck pathology》2021,15(2):509
The tumor immune microenvironment of oral tongue squamous cell carcinoma may be accountable for differences in clinical behavior, particularly between different age groups. We performed RNA expression profiling and evaluated tumor infiltrating lymphocytes (TILs) and their T-cell subsets in order to assess the functional status of oral tongue squamous cell carcinoma tumor microenvironment and detect potentially clinically useful associations. Archival surgical pathology material from sixteen oral tongue squamous cell carcinoma patients was microscopically evaluated for TIL densities. RNA was extracted from macrodissected whole tumor sections and normal controls and RNA expression profiling was performed by the NanoString PanCancer IO 360 Gene Expression Panel. Immunostains for CD4, CD8 and FOXP3 were evaluated manually and by digital image analysis. Oral tongue squamous cell carcinomas had increased TIL densities, numerically dominated by CD4 + T cells, followed by CD8 + and FOXP3 + T cells. RNA expression profiling of tumors versus normal controls showed tumor signature upregulation in inhibitory immune signaling (CTLA4, TIGIT and PD-L2), followed by inhibitory tumor mechanisms (IDO1, TGF-β, B7-H3 and PD-L1). Patients older than 44 years showed a tumor microenvironment with increased Tregs and CTLA4 expression. Immunohistochemically assessed CD8% correlated well with molecular signatures related to CD8 + cytotoxic T-cell functions. FOXP3% correlated significantly with CTLA4 upregulation. CTLA4 molecular signature could be predicted by FOXP3% assessed by immunohistochemistry (R2 = 0.619, p = 0.026). Oral tongue squamous cell carcinoma hosts a complex inhibitory immune microenvironment, partially reflected in immunohistochemically quantified CD8 + and FOXP3 + T-cell subsets. Immunohistochemistry can be a useful screening tool for detecting tumors with upregulated expression of the targetable molecule CTLA4.Electronic supplementary materialThe online version of this article (10.1007/s12105-020-01229-w) contains supplementary material, which is available to authorized users. 相似文献
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Ueda M Psarras K Jinno H Ikeda T Enomoto K Kitajima M Futami J Yamada H Seno M 《Breast cancer (Tokyo, Japan)》1997,4(4):253-255
Recombinant human ribonuclease 1 (RNasel) was chemically linked to recombinant human epidermal growth factor (EGF). The cytotoxicity
of this conjugate was assayed using MTT assay. The EGF-RNase conjugate showed dose-dependent cytotoxicity against breast and
squamous cell carcinomas overexpressing the EGF receptor (EGFR). The cytotoxicity of the conjugate correlated positively with
the level of EGFR expression by each cell line. These results suggest that the EGF-RNase conjugate is a more effective anticancer
agent with less immunogenicity and toxicity than conventional chimeric breast cancer toxins. 相似文献
5.
Malignant transformation of aneurysmal bone cyst, with an analysis of the literature 总被引:1,自引:0,他引:1
An 11-year-old girl had a lytic, benign-appearing, expansive lesion of the distal tibia radiologically interpreted as an aneurysmal bone cyst (ABC). Tissue from two extensive curettage procedures was also histologically diagnosed as ABC. Approximately 50 months after the onset of symptoms, and 28 months after her last curettage, a highly pleomorphic osteosarcoma developed. The patient had not received prior radiation therapy. The cases in the literature of possible malignant transformation of ABC are reviewed. The authors separate their case from telangiectatic osteosarcoma, and from "aneurysmal bone cyst-like osteosarcoma." 相似文献
6.
Objective. To report the clinicopathologic features of solitary skeletal hemangioma of the extremities and to review previous cases
in the English language medical literature. Patients. In addition to five of our own cases, 34 literature cases with substantial and 75 with partial clinicopathologic information
were found. Results. Our patients, three men and two women, ranged in age from 37 to 83 years (mean 65.6 years). The lesion was an incidental
radiologic finding in two patients, while three were symptomatic. In no case was a correct preoperative radiologic diagnosis
made, a malignant process being considered as a possibility in all. The hemangiomas were medullary; two involved a metacarpal,
two the fibula, and one the humerus. In contrast, previously reported patients were younger (mean age 32 years), predominantly
female (60%), and symptomatic in over 90% of cases. The lesion is rare in those younger than age 10 years or older than age
60 years. As in our patients, the long bones are most frequently involved (75%), with the diaphysis or metadiaphysis, as in
four of our patients, the most common locations. Although 20% of cases occur in the hands or feet, metacarpal involvement
is rare. Medullary origin, as in all of our cases, is most frequent, but 45% of cases are either periosteal (33%) or intracortical
(12%). In the literature, cavernous hemangioma is the most frequent type. Three of our hemangiomas were cavernous, one capillary,
and one venous, the latter being rarely reported in extremity bones. Conclusions. Due to the diversity of radiologic patterns produced by skeletal hemangioma, a correct preoperative diagnosis is rarely
made. Almost all patients do well, even those with less than complete removal of the lesion; local recurrence is rare. All
of our patients were well following either therapeutic or simple diagnostic procedures. Due to the destructive nature of some
biopsy procedures, the histologic diagnosis of hemangioma may at times also be problematic.
Received: 7 February 2000 Revision requested: 31 March 2000 Revision received: 25 May 2000 Accepted: 26 May 2000 相似文献
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Kyriakos Aloumanis Marianna Benroubi Sotiria Sourmeli Vangelis Drossinos 《Primary Care Diabetes》2013,7(3):235-242
AimsTo evaluate the quality of metabolic control, clinical outcomes, resource costs, and quality of life among patients with type 2 diabetes mellitus (T2DM), who initiated insulin for the first time as part of routine clinical practice.MethodsThe INSTIGATE study is a prospective, multicentric, observational study of patients initiating insulin treatment. This sub-cohort analysis focuses on Hellenic outcomes.ResultsAt baseline, 263 Greek patients were enrolled just before initiating insulin for the first time. At the 6-month visit, 237 patients (90.1%) remained and consented to an additional 18-month observation period. In these 237 extension patients, over the 24-month post-initiation period, HbA1c (mean(SD)) decreased from 9.7%(1.6%) to 7.1%(0.9%) and body weight and BMI increased (+3(6) kg and +1.1(2.2) kg/m2, respectively). At each post-baseline visit approximately one in five patients reported ≥1 episodes of hypoglycaemia in the preceding 3–6 months. Median total costs fluctuated from 438€ at baseline to 538€ up to 6 months and 451€ at 24 months; mean costs were 496(383)€, 573(276)€ and 485(247)€, respectively.ConclusionsIn this cohort, insulin treatment seems to be effective with little long-term impact on cost. Findings should be interpreted in the context of an observational study. 相似文献