全文获取类型
收费全文 | 302篇 |
免费 | 26篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 8篇 |
妇产科学 | 4篇 |
基础医学 | 84篇 |
临床医学 | 34篇 |
内科学 | 45篇 |
皮肤病学 | 3篇 |
神经病学 | 46篇 |
特种医学 | 7篇 |
外科学 | 16篇 |
预防医学 | 26篇 |
眼科学 | 1篇 |
药学 | 15篇 |
肿瘤学 | 38篇 |
出版年
2024年 | 1篇 |
2023年 | 7篇 |
2022年 | 5篇 |
2021年 | 21篇 |
2020年 | 8篇 |
2019年 | 16篇 |
2018年 | 15篇 |
2017年 | 11篇 |
2016年 | 10篇 |
2015年 | 12篇 |
2014年 | 14篇 |
2013年 | 19篇 |
2012年 | 26篇 |
2011年 | 24篇 |
2010年 | 13篇 |
2009年 | 12篇 |
2008年 | 14篇 |
2007年 | 17篇 |
2006年 | 16篇 |
2005年 | 15篇 |
2004年 | 18篇 |
2003年 | 8篇 |
2002年 | 14篇 |
2001年 | 1篇 |
2000年 | 1篇 |
1999年 | 1篇 |
1998年 | 2篇 |
1997年 | 4篇 |
1996年 | 1篇 |
1994年 | 1篇 |
1990年 | 1篇 |
排序方式: 共有328条查询结果,搜索用时 0 毫秒
71.
Kyra Hamilton Mikaela Bonham Jason Bishara Jeroen Kroon Ralf Schwarzer 《International journal of behavioral medicine》2017,24(3):420-427
Purpose
Although poor oral hygiene practices can have serious health consequences, a large number of adults brush or floss their teeth less than the recommended time or not at all. This study examined the mediating effect of two key self-regulatory processes, self-efficacy and planning, as the mechanisms that translate dental flossing intentions into behavior.Method
Participants (N = 629) comprised young adults attending a major university in Queensland, Australia. A longitudinal design guided by sound theory was adopted to investigate the sequential mediation chain for the effect of dental flossing intentions (time 1) on behavior (time 3) via self-efficacy and planning (time 2).Results
A latent variable structural equation model with standardized parameter estimates revealed the model was a good fit to the data. Controlling for baseline flossing, the effect of intentions on behavior was mediated via self-efficacy and planning, with 64 % of the flossing variance accounted for by this set of predictors. Controlling for age and sex did not change the results.Conclusion
The results extend previous research to further elucidate the mechanisms that help to translate oral hygiene intentions into behavior and make a significant contribution to the cumulative empirical evidence about self-regulatory components in health behavior change.72.
Broadfield ZJ Hain RD Harrison CJ Reza Jalali G McKinley M Michalová K Robinson HM Zemanová Z Martineau M 《British journal of haematology》2004,126(3):307-312
Prenatal acquisition of leukaemia-associated gene rearrangements is a well-established phenomenon. This is the first report of a complex cytogenetic clone, in association with an ETV6/AML1 fusion, developing in utero. Identical twin girls, aged 4 years, developed ETV6/AML1-positive acute lymphoblastic leukaemia (ALL) within 3 months of one another. Both demonstrated an identical four way, variant t(12;21). There was gain of an AML1 signal in twin 1 and loss of an ETV6 one in twin 2 at interphase. This unique case study demonstrates that ETV6/AML1 fusion and the associated complex chromosomal rearrangements occurred in utero. Clonal expansion of the abnormal cell in one twin was followed by metastasis to the other. There was a prolonged preleukaemic phase, which lasted well into childhood. The short time between the two diagnoses of ALL suggests a common precipitating event. The significance of the different secondary markers remains unclear. 相似文献
73.
Induction of regulatory T cells by macrophages is dependent on production of reactive oxygen species
Marina D. Kraaij Nigel D. L. Savage Sandra W. van der Kooij Karin Koekkoek Jun Wang J. Merlijn van den Berg Tom H. M. Ottenhoff Taco W. Kuijpers Rikard Holmdahl Cees van Kooten Kyra A. Gelderman 《Proceedings of the National Academy of Sciences of the United States of America》2010,107(41):17686-17691
The phagocyte NAPDH–oxidase complex consists of several phagocyte oxidase (phox) proteins, generating reactive oxygen species (ROS) upon activation. ROS are involved in the defense against microorganisms and also in immune regulation. Defective ROS formation leads to chronic granulomatous disease (CGD) with increased incidence of autoimmunity and disturbed resolution of inflammation. Because regulatory T cells (Tregs) suppress autoimmune T-cell responses and are crucial in down-regulating immune responses, we hypothesized that ROS deficiency may lead to decreased Treg induction. Previously, we showed that in p47phox-mutated mice, reconstitution of macrophages (Mph) with ROS-producing capacity was sufficient to protect the mice from arthritis. Now, we present evidence that Mph-derived ROS induce Tregs. In vitro, we showed that Mph ROS-dependently induce Treg, using an NADPH-oxidase inhibitor. This finding was confirmed genetically: rat or human CGD Mph with mutated p47phox or gp91phox displayed hampered Treg induction and T-cell suppression. However, basal Treg numbers in these subjects were comparable to those in controls, indicating a role for ROS in induction of peripheral Tregs. Induction of allogeneic delayed-type hypersensitivity with p47phox-mutated Mph confirmed the importance of Mph-derived ROS in Treg induction in vivo. We conclude that NAPDH oxidase activity in Mph is important for the induction of Tregs to regulate T cell-mediated inflammation. 相似文献
74.
75.
76.
Barsevick AM Whitmer K Nail LM Beck SL Dudley WN 《Journal of pain and symptom management》2006,31(1):85-95
Cancer patients may experience multiple concurrent symptoms caused by the cancer, cancer treatment, or their combination. The complex relationships between and among symptoms, as well as the clinical antecedents and consequences, have not been well described. This paper examines the literature on cancer symptom clusters focusing on the conceptualization, design, measurement, and analytic issues. The investigation of symptom clustering is in an early stage of testing empirically whether the characteristics defined in the conceptual definition can be observed in cancer patients. Decisions related to study design include sample selection, the timing of symptom measures, and the characteristics of symptom interventions. For self-report symptom measures, decisions include symptom dimensions to evaluate, methods of scaling symptoms, and the time frame of responses. Analytic decisions may focus on the application of factor analysis, cluster analysis, and path models. Studying the complex symptoms of oncology patients will yield increased understanding of the patterns of association, interaction, and synergy of symptoms that produce specific clinical outcomes. It will also provide a scientific basis and new directions for clinical assessment and intervention. 相似文献
77.
78.
Kyra Hamilton Courtney E. Thomson Katherine M. White 《Maternal and child health journal》2013,17(5):968-976
Given increasing trends of obesity being noted from early in life and that active lifestyles track across time, it is important that children at a very young age be active to combat a foundation of unhealthy behaviours forming. This study investigated, within a theory of planned behaviour (TPB) framework, factors which influence mothers’ decisions about their child’s (1) adequate physical activity (PA) and (2) limited screen time behaviours. Mothers (N = 162) completed a main questionnaire, via on-line or paper-based administration, which comprised standard TPB items in addition to measures of planning and background demographic variables. One week later, consenting mothers completed a follow-up telephone questionnaire which assessed the decisions they had made regarding their child’s PA and screen time behaviours during the previous week. Hierarchical multiple regression analyses revealed support for the predictive model, explaining an overall 73 and 78 % of the variance in mothers’ intention and 38 and 53 % of the variance in mothers’ decisions to ensure their child engages in adequate PA and limited screen time, respectively. Attitude and subjective norms predicted intention in both target behaviours, as did intentions with behaviour. Contrary to predictions, perceived behavioural control (PBC) in PA behaviour and planning in screen time behaviour were not significant predictors of intention, neither was PBC a predictor of either behaviour. The findings illustrate the various roles that psycho-social factors play in mothers’ decisions to ensure their child engages in active lifestyle behaviours which can help to inform future intervention programs aimed at combating very young children’s inactivity. 相似文献
79.
80.
Zemanova Z Michalova K Sindelarova L Smisek P Brezinova J Ransdorfova S Vavra V Dohnalova A Stary J 《Leukemia research》2005,29(3):273-281
In this study, 107 children with acute lymphoblastic leukemia (ALL) were analysed for the presence of hyperdiploidy by cytogenetics and interphase fluorescence in situ hybridisation (I-FISH). Structural aberrations in hyperdiploid cells were investigated by multiple colour FISH (mFISH). Clones with high hyperdiploidy (>50 chromosomes) (HeH) were found in 46 patients (43%). In nine of these (20%), the abnormal clone was present in <20% of the total cell population. There was no significant difference in EFS between those patients with HeH in 2.5-20% or >20% of cells. Structural rearrangements in the HeH clone were found in 10 patients (22%). In this study, HeH karyotypes containing structural aberrations were an indication of a poor prognosis in childhood ALL. 相似文献