全文获取类型
收费全文 | 2531篇 |
免费 | 150篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 23篇 |
儿科学 | 82篇 |
妇产科学 | 66篇 |
基础医学 | 311篇 |
口腔科学 | 29篇 |
临床医学 | 286篇 |
内科学 | 512篇 |
皮肤病学 | 86篇 |
神经病学 | 152篇 |
特种医学 | 60篇 |
外国民族医学 | 3篇 |
外科学 | 291篇 |
综合类 | 36篇 |
预防医学 | 66篇 |
眼科学 | 25篇 |
药学 | 127篇 |
中国医学 | 12篇 |
肿瘤学 | 525篇 |
出版年
2023年 | 9篇 |
2022年 | 12篇 |
2021年 | 46篇 |
2020年 | 29篇 |
2019年 | 49篇 |
2018年 | 58篇 |
2017年 | 38篇 |
2016年 | 27篇 |
2015年 | 47篇 |
2014年 | 80篇 |
2013年 | 103篇 |
2012年 | 197篇 |
2011年 | 163篇 |
2010年 | 115篇 |
2009年 | 92篇 |
2008年 | 164篇 |
2007年 | 164篇 |
2006年 | 151篇 |
2005年 | 147篇 |
2004年 | 165篇 |
2003年 | 128篇 |
2002年 | 124篇 |
2001年 | 89篇 |
2000年 | 76篇 |
1999年 | 75篇 |
1998年 | 13篇 |
1997年 | 27篇 |
1996年 | 11篇 |
1995年 | 12篇 |
1994年 | 15篇 |
1993年 | 13篇 |
1992年 | 33篇 |
1991年 | 36篇 |
1990年 | 26篇 |
1989年 | 15篇 |
1988年 | 24篇 |
1987年 | 12篇 |
1986年 | 23篇 |
1985年 | 11篇 |
1984年 | 12篇 |
1983年 | 16篇 |
1982年 | 5篇 |
1979年 | 7篇 |
1977年 | 3篇 |
1973年 | 3篇 |
1972年 | 3篇 |
1971年 | 4篇 |
1970年 | 3篇 |
1969年 | 3篇 |
1967年 | 4篇 |
排序方式: 共有2692条查询结果,搜索用时 15 毫秒
51.
52.
53.
54.
Chin-An Yang Steven Shinn-Forng Peng Wu-Shiun Hsieh Po-Nien Tsao Chien-Yi Chen Hung-Chieh Chou 《Child's nervous system》2013,29(7):1069-1072
Background
Midline cranial defects can be divided into lesions with intracranial tissue herniation (cranium bifidum cysticum) and lesions mainly with ossification failure (cranium bifidum occultum). Herniated cephaloceles mostly require surgical resection, while persisted parietal foramina might become smaller with age.Clinical case
Here, we report a neonate with large symmetric midline skull defect at high parietal area. A mild bulging mass was noticed. Interestingly, unlike sac herniation, it was surrounded by bony ridges extended from the rim of the calvarial defect, which suggests aberrant ossification. Persistent falcine sinus was also detected. At the corrected age of 11 months, the size of the skull defect had decreased spontaneously, favoring the diagnosis of parietal bone ossification defect. Potential mechanisms resulting in the special appearance of skull bone were discussed.Conclusion
Incomplete closing of the parietal foramina might be expected due to the aberrant ridge formation. We suggest protective measures for the calvarial defect. 相似文献55.
We examined sex differences in self-initiated school nurse visits and pain-associated symptoms in 57 pre-adolescents (36 girls), aged 9-11, with a brief, pain-focused version of the Children's Somatization Inventory (CSI). Using sequential multiple regression, pain symptom scores, sex, and their interaction were analyzed in relation to nurse visits prospectively collected for 1 year. Neither sex, nor pain scores alone, predicted total nurse visits. For girls only, higher pain symptom scores predicted increased total visits and increased visits for complaints with documented physical findings. For both sexes, higher pain symptom scores predicted more visits for complaints without documented physical findings. A complex relationship between sex, pain-related symptoms, and self-initiated nurse visits was found in this pre-adolescent sample. Our findings suggest pain-focused symptom measures may be useful in studies of early predictors of adult pain-related healthcare utilization. 相似文献
56.
Michael S. Fine Peter S. Lum Elizabeth B. Brokaw Matthew S. Caywood Anthony J. Metzger Alexander V. Libin Jill Terner Jack W. Tsao Jacob N. Norris David Milzman Diane Williams Jeff Colombe Alexander W. Dromerick 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2016,234(11):3173-3184
57.
Mönkkönen KS Aflatoonian R Lee KF Yeung WS Tsao SW Laitinen JT Tuckerman EM Li TC Fazeli A 《Human reproduction (Oxford, England)》2007,22(5):1224-1230
BACKGROUND: Heterotrimeric G proteins take part in membrane-mediated cell signalling and have a role in hormonal regulation. This study clarifies the expression and localization of the G protein subunit G alpha(i2) in the human endometrium and Fallopian tube and changes in G alpha(i2) expression in human endometrium during the menstrual cycle. METHODS: The expression of G alpha(i2) was identified by Polymerase chain reaction (PCR), and localization confirmed by immunostaining. Cyclic changes in G alpha(i2) expression during the menstrual cycle were evaluated by quantitative real-time PCR. RESULTS: We found G alpha(i2) to be expressed in human endometrium, Fallopian tube tissue and in primary cultures of Fallopian tube epithelial cells. Our studies revealed enriched localization of G alpha(i2) in Fallopian tube cilia and in endometrial glands. We showed that G alpha(i2) expression in human endometrium changes significantly during the menstrual cycle, with a higher level in the secretory versus proliferative and menstrual phases (P < 0.05). CONCLUSIONS: G alpha(i2) is specifically localized in human Fallopian tube epithelial cells, particularly in the cilia, and is likely to have a cilia-specific role in reproduction. Significantly variable expression of G alpha(i2) during the menstrual cycle suggests G alpha(i2) might be under hormonal regulation in the female reproductive tract in vivo. 相似文献
58.
59.
Tsao PN Chan FT Wei SC Hsieh WS Chou HC Su YN Chen CY Hsu WM Hsieh FJ Hsu SM 《Critical care medicine》2007,35(8):1955-1960
OBJECTIVE: To determine the putative role in the modulation of inflammation of a soluble form of Flt-1 (sFlt), a potent vascular endothelial growth factor antagonist, in experimental endotoxemia and sepsis. DESIGN: Randomized prospective experimental study. SETTING: University medical laboratory. SUBJECTS: Male C56BL/6 strain mice. INTERVENTIONS: We investigated the expression patterns and the effects of vascular endothelial growth factor and soluble Flt-1 in experimental endotoxic shock and sepsis. The possible anti-inflammatory mechanism of soluble Flt-1 was also evaluated. MEASUREMENTS AND MAIN RESULTS: Both vascular endothelial growth factor and sFlt-1 were rapidly released from macrophages activated in vitro by lipopolysaccharide and in the plasma of endotoxemic mice. Administration of vascular endothelial growth factor enhanced proinflammatory cytokine production and mediated a dramatic increase in mortality in endotoxemic mice. Treatment with sFlt-1 attenuated inflammatory responses, inhibited recruitment of inflammatory cells into the peritoneal cavity, and improved survival in a lethal endotoxemia and cecal ligation and puncture-induced sepsis model, even when administered as late as 24 hrs after the onset of sepsis. CONCLUSIONS: These findings support a critical protective role of sFlt-1 in endotoxic shock and sepsis. sFlt-1 may therefore have utility as an adjunctive agent for the treatment of sepsis syndrome. 相似文献
60.