全文获取类型
收费全文 | 3252篇 |
免费 | 107篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 14篇 |
儿科学 | 65篇 |
妇产科学 | 8篇 |
基础医学 | 578篇 |
口腔科学 | 85篇 |
临床医学 | 186篇 |
内科学 | 819篇 |
皮肤病学 | 20篇 |
神经病学 | 278篇 |
特种医学 | 168篇 |
外科学 | 407篇 |
综合类 | 67篇 |
一般理论 | 1篇 |
预防医学 | 98篇 |
眼科学 | 31篇 |
药学 | 265篇 |
中国医学 | 22篇 |
肿瘤学 | 259篇 |
出版年
2023年 | 12篇 |
2022年 | 18篇 |
2021年 | 43篇 |
2020年 | 27篇 |
2019年 | 18篇 |
2018年 | 38篇 |
2017年 | 37篇 |
2016年 | 30篇 |
2015年 | 46篇 |
2014年 | 44篇 |
2013年 | 57篇 |
2012年 | 118篇 |
2011年 | 170篇 |
2010年 | 116篇 |
2009年 | 97篇 |
2008年 | 158篇 |
2007年 | 188篇 |
2006年 | 217篇 |
2005年 | 218篇 |
2004年 | 263篇 |
2003年 | 278篇 |
2002年 | 306篇 |
2001年 | 45篇 |
2000年 | 42篇 |
1999年 | 72篇 |
1998年 | 66篇 |
1997年 | 70篇 |
1996年 | 55篇 |
1995年 | 40篇 |
1994年 | 36篇 |
1993年 | 39篇 |
1992年 | 30篇 |
1991年 | 29篇 |
1990年 | 30篇 |
1989年 | 33篇 |
1988年 | 20篇 |
1987年 | 22篇 |
1986年 | 16篇 |
1985年 | 17篇 |
1984年 | 34篇 |
1983年 | 13篇 |
1982年 | 17篇 |
1981年 | 21篇 |
1980年 | 25篇 |
1979年 | 11篇 |
1978年 | 7篇 |
1977年 | 12篇 |
1976年 | 7篇 |
1975年 | 8篇 |
1974年 | 11篇 |
排序方式: 共有3371条查询结果,搜索用时 15 毫秒
11.
12.
Atsuhiro Yoshida Asami Takeda Katsushi Koyama Yasuhiro Ohtsuka Kunio Morozumi Tadashi Oikawa 《Clinical and experimental nephrology》1997,1(4):292-296
Kimura's disease is a rare disorder that involves regional lymph nodes and the major salivary glands, which become infiltrated
by eosinophils and lymphocytes. Renal lesions associated with Kimura's disease are rare. We describe the case of a 60-year-old
Japanese woman who first noted a nodular mass in a salivary gland. As the nodule grew, nephrotic syndrome and heart failure
developed. A biopsy of the nodule revealed Kimura's disease, and surgical excision was performed. After the operation, the
heart failure and nephrotic syndrome, which were diagnosed as minimal change disease on renal biopsy, improved rapidly without
steroid therapy. Four months later, the nephrotic syndrome recurred without recurrence of Kimura's disease. The patient showed
marked improvement during prednisolone therapy (40 mg/d) and was in complete remission 4 weeks after the initiation of steroid
therapy. This case shows that surgical excision and prednisolone therapy are useful for nephrotic syndrome associated with
Kimura's disease. 相似文献
13.
14.
Kei-ichi Katayama Masaki Ueno Hirofumi Yamauchi Hiroyuki Nakayama Kunio Doi 《Experimental and toxicologic pathology》2002,54(3):193-196
Ethylnitrosourea (ENU) is a simple alkylating agent. It induces gene mutations in fetal primordial germ cells (PGCs), and a high incidence of congenital malformations is also found in the offspring of male mice treated with ENU at the embryonic stage. It is also reported that decreases in the fertility rate and weights of the testis and ovary were found in the offspring from dams treated with ENU. In this study, we analyzed the occurrence of apoptotic cell death and the expression of p53 protein which is thought to play an important role in the DNA damage-induced apoptosis after administration of ENU to pregnant rats on day 13 of gestation to obtain a clue for clarifying the toxic effect of ENU on PGCs. Apoptotic cells increased in PGCs in fetal gonads from 3 h after treatment. The number of apoptotic PGCs peaked at 6 h and gradually decreased towards 24 h after treatment. On the other hand, p53-positive PGCs increased from I h after treatment, prior to the induction of apoptosis. The number of p53-positive PGCs peaked at 3 h and returned to the control level at 24 h after treatment. These results suggest that ENU induces apoptosis in rat fetal PGCs immediately after its administration to dams and excess cell death by apoptosis may have a close relation to the later occurrence of decreases in the fertility rate and gonadal weight. Moreover, a possible involvement of p53 is suggested in the ENU-induced apoptosis in PGCs. 相似文献
15.
Tohru SONODA Shozo OHDO Ken-ichi OHBA Takahiro OKISHIMA Kunio HAYAKAWA 《Congenital anomalies》1991,31(2):89-94
Sodium valproate was administered to Jcl:ICR mice in order to evaluate teratogenicity in the cardiovascular system. A single dose of 600mg/kg of sodium valproate was injected intraperitoneally on gestational day 6, 7, 8 or 9. On day 18 of gestation, dams were laparotomized to observe incidence and type of cardiovascular abnormality in live fetuses. Cardiovascular abnormalities were found most frequently in the group treated on day 7, being recognized in 86% of litters (19/22) and in 29% of live fetuses (70/238). Among these, there were 28 cases of transposition of the great arteries, 13 of double outlet right ventricle, 11 of endocardial cushion defect, 9 of ventricular septal defect, 5 of tricuspid atresia, and 4 of hypoplastic left heart syndrome. 相似文献
16.
Yoshio Hayashi Kazuyoshi Ikuta Nobutaka Fujii Kunio Ezawa Shiro Kato 《Archives of virology》1989,105(1-2):129-135
Summary Only one peptide of CD4 (amino acid residues 70–132) among 16 synthetic peptide fragments selectively inhibited HIV-1 replication and HIV-1-induced syncytium formation. Several smaller peptides within this region did not show any activity, except for the peptide (86–132) which showed somewhat lower activity. 相似文献
17.
Aya Umeda-Ikawa Yoshiyuki Ishii Kazuhiko Suzuki Koji Uetsuka Hjroyuki Nakayama Kunio Doi 《Experimental and toxicologic pathology》2002,54(3):239-244
Mini rats (Jcl: WistarTGN(ARGHGEN) 1Nts) (MRs) are Wistar rat (WR)-derived transgenic rats in which the expression of growth hormone (GH) gene is suppressed under the presence of antisense RNA transgene. In order to evaluate the effects of GH-deficiency on the acute injury by external stimuli, the dorsal skin responses to a single topical application with 20% hydrogen peroxide (HPO), one of the environmental oxidative stressors, were histologically compared between male MRs and WRs of 8 weeks old, whose hair cycle was under the telogen phase. As a result, formation of granulation tissues, reepithelialization and regrowth of hair follicles were delayed in MRs compared with WRs. While hair follicles of MRs of this age are under a long-lasting telogen phase after their 2nd cycle, a new hair cycle started not only in the HPO-applied area but also in the solvent-applied area with a little time lag. These findings suggest that GH-deficiency may influence the skin responses to the external chemical stimuli. 相似文献
18.
作者通过内窥镜对新疆奎屯地区氟中毒患者35名,氟砷中毒患者32名,对照组25名的胃粘膜进行观察,旨在了解氟元素和砷元素对胃粘膜的影响,在3个组中慢性胃炎的炎症程度与炎症活动性有显著性差异。2个中毒组间无显著性差异。结果表明在高氟区和高氟砷区患者的胃粘膜层病理改变主要是任性氟中毒引起,单纯性砷中毒并无协同作用。 相似文献
19.
目的探讨123I-MIBG心肌显像在治疗前预测依那普利对扩张型心肌病(DCM)患者治疗效果的临床价值。方法对24例DCM患者于依那普利治疗前行早期(20min)及延迟(3h)123I-MIBG心肌显像,采用心/上纵隔(H/M)比和心脏放射性洗脱率(WR)作为相对半定量计数分析,与超声心功能参数进行对比。根据123I-MI-BG心肌显像延迟相的H/M分为3组延迟H/M≥1.7为组Ⅰ,1.5<延迟H/M<1.7为组Ⅱ,延迟H/M≤1.5为组Ⅲ。组Ⅰ和组Ⅱ在平均治疗4.5个月后重复以上检查。结果治疗前3组间超声心功能参数比较均无统计学差异。治疗后组Ⅰ的左室射血分数(LVEF)和左室收缩末径(LVDs)明显改善,早期H/M和延迟H/M均明显改善(P<0.05),而WR无明显变化。治疗后组Ⅱ的延迟H/M明显改善(P<0.05),而早期H/M和WR均无明显变化,心功能参数也无改善。组Ⅰ和组Ⅱ患者均能耐受依那普利治疗,而组Ⅲ患者均不能耐受依那普利治疗。结论123I-MIBG心肌显像在治疗前预测依那普利对DCM患者的治疗效果方面有一定价值。 相似文献
20.
Yasuo Ito Yoshihiko Nakazato Ryo Tomioka Naotoshi Tamura Kunio Shimazu 《Clinical neurology》2007,47(8):512-515
We present a suspicious case of central neurosarcoidosis that presented with progressive gait disturbance probably caused by central vestibular dysfunction. And this case showed elevated level of angiotensin converting enzyme (ACE) in the cerebrospinal fluid, compared with the average level of two cases with acute inflammatory demyelinating neuropathy syndrome and four cases of multiple sclerosis. A 33-year-old man was admitted to our hospital with chief complaint of a gait disturbance that had appeared 3 years prior to the admission. And the symptom had exacerbated in these 3 months. Except for the gait disturbance and positive Romberg's sign, no neurological abnormality was detected. The findings of the cerebrospinal fluid test supported the diagnosis of meningitis. An increased level of angiotensine converting enzyme was detected when compared with our previous samplings from two cases of Guillain Barré syndrome and four cases of multiple sclerosis. With T1 weighted imaging of brain MRI, a high intensity lesion with gadolinium enhancement was identified in the central gray matter of the midbrain. Scan of the chest confirmed bilateral hilar lymphadenopathy. Based on these findings and the patient's clinical course, central neurosarcoidosis was suspected. The patient's symptoms improved dramatically after the administration of corticosteroid. The enhancement of the central gray matter ameliorated, and the ACE level of the CSF was decreased to the level of the demyelinating disorders. 相似文献