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61.
Hiroshige Mikamo Kyoko Kawazoe Yasumasa Sato Koji Izumi Kunihiko Ito Teruhiko Tamaya 《Journal of infection and chemotherapy》1998,4(1):12-15
This study was designed to investigate bacterial flora of the endometrial cavity in healthy puerperae. Thirty puerperae who
underwent an uneventful course in pregnancy, delivery or postpartum were subjects for this study. Intrauterine contents were
collected on the first and fifth days of the puerperium and submitted for microbiologic examination. On the puerperal first
day, a total of 76 strains (53 strains of aerobic bacteria, 21 strains of anaerobic bacteria, and 2 strains of fungi) were
detected in the uteri of the 30 subjects. More than 2 strains were detected in 97% (29/30 subjects). The incidence of aerobic
gram-positive cocci, aerobic gram-negative bacilli, and anaerobic bacteria was 51%, 16%, and 28% of 76 strains, respectively.
On the puerperal fifth day, a total of 102 strains (68 strains of aerobic bacteria, 30 strains of anaerobic bacteria, and
4 strains of fungi) were detected in the uteri of the 30 subjects. More than 2 strains were detected in 97% (29/30 subjects).
The incidence of aerobic gram-positive cocci, aerobic gram-negative bacilli, and anaerobic bacteria was 46.1%, 18.6%, and
29.4% of the 102 strains, respectively. The population of the former seemed to decrease, and that of the latter 2 seemed to
increase during the postpartum course. However, the number of strains detected for these 3 classifications of bacteria increased
from the first to fifth postpartum day. There is no significance between bacterial strains and frequency detected, using the
2×39 chi-square test (P=0.571). There is no significance between classification of bacteria and frequency detected, using the 2×7 chi-square test. 相似文献
62.
A case of transfusion-transmitted hepatitis E caused by blood from a donor infected with hepatitis E virus via zoonotic food-borne route 总被引:2,自引:0,他引:2
Matsubayashi K Kang JH Sakata H Takahashi K Shindo M Kato M Sato S Kato T Nishimori H Tsuji K Maguchi H Yoshida J Maekubo H Mishiro S Ikeda H 《Transfusion》2008,48(7):1368-1375
63.
64.
Kanako Sugawara Youichi Tajima Ikuo Kawashima Takahiro Tsukimura Seiji Saito Kazuki Ohno Kunihiko Iwamoto Toshihide Kobayashi Kohji Itoh Hitoshi Sakuraba 《Molecular genetics and metabolism》2009,96(4):233-238
Enzyme enhancement therapy (EET) for Fabry disease involving imino sugars has been developed and attracted interest. It is thought that imino sugars act as pharmacological chaperones for wild-type and mutant α-galactosidases (GLAs) in cells, but the mechanisms underlying the molecular interactions between the imino sugars and the enzyme have not been clarified yet. We examined various kinds of imino sugars and found that galactostatin bisulfite (GBS) inhibited GLA in vitro and increased the enzyme activity in cultured Fabry fibroblasts as in the case of 1-deoxygalactonojirimycin (DGJ). Then, we analyzed the molecular interactions between the imino sugars and recombinant human GLA by means of isothermal titration calorimetry and surface plasmon resonance biosensor assays, and first determined the thermodynamic and binding-kinetics parameters of imino sugar and GLA complex formation. The results revealed that DGJ bound to the enzyme more strongly than GBS, the binding of DGJ to the enzyme protein being enthalpy-driven. In the case of GBS, the reaction was mainly enthalpy-driven, but there was a possibility that entropy-driven factors were involved in the binding. Structural analysis in silico revealed that both the chemicals fit into the active-site pocket and undergo hydrogen bonding with residues comprising the active-site pocket including the catalytic ones. The side chain of GBS was oriented towards the entrance of the active-site pocket, and thus it could be in contact with residues comprising the wall of the active-site pocket. Thermodynamic, kinetic and structural studies should provide us with a lot of information for improving EET for Fabry disease. 相似文献
65.
Takamura M Ichida T Yokoyama J Matsuda Y Nomoto M Aoyagi Y 《Journal of gastroenterology》2004,39(7):681-684
We report a 54-year-old Japanese woman who developed liver tumors 102 months after hepatic resection for hepatocellular carcinoma (HCC) and percutaneous transluminal angioplasty (PTA) for membranous obstruction of the inferior vena cava (MOVC), which is one form of Budd-Chiari syndrome. In the present admission workup showed no evidence of co-infection with hepatitis B and C viruses. Dynamic computed tomography (CT) and magnetic resonance imaging showed an enhanced lesion, 1.5cm in diameter, in segment 3 of the liver, and no obstruction of the inferior vena cava after PTA. CT during both arterial portography and hepatic arteriography revealed another lesion, showing different hemodynamics, in segment 2. The patient therefore underwent hepatic resection, and the tumors were diagnosed histologically as HCC. The two tumors differed in their morphological features, one containing abundant fibrous stroma, whereas the other did not. The nontumorous liver tissue showed central zonal fibrosis, i.e., reversed lobulation, and partial expansion of nodule-like formations, indicating lack of progression since the situation seen at the initial hepatectomy. The presence of nontumorous liver tissue showing the above features suggests that, even after successful treatment for relief of congestion, patients who have had MOVC should be followed closely for as long as possible because of the risk of HCC recurrence. This is the first reported case of HCC recurrence after successful treatment of MOVC. 相似文献
66.
We report a 64-year-old woman with follicular thyroid cancer found by subacute bulbar palsy. Progressive bulbar palsy (PBP) was considered the most likely diagnosis, because no abnormal finding was detected on brain CT and blood test except for the decrease of free T4. An echogram of the thyroid revealed a small nodule which was shown to be class IIb by fine needle biopsy. However, 201Tl scintillation examination showed skull base metastasis. Follicular thyroid cancer sometimes seems to manifest as a distant metastasis with no clinically evident thyroid lesion. This case suggested the importance of a detailed survey for malignancy, when subacute bulbar palsy is seen. 相似文献
67.
Yoshiyuki Nishida M.D. Kunihiko Murase M.D. Ph.D. Ryuichi Ashida M.D. Osamu Sasaki M.D. Yoshiyuki Ozono M.D. Ph.D. Yohei Mizuta M.D. Ph.D. Fumitoshi Takeshima M.D. Ph.D. Kazuya Makiyama M.D. Ph.D. Shigeru Kohno M.D. Ph.D. 《The American journal of gastroenterology》1998,93(12):2599-2601
We describe a young Japanese woman who was diagnosed with Crohn's disease affecting the ileum, transverse colon, and rectum, as confirmed by barium studies, colonoscopy, and histopathological examination. Her father and sister also had Crohn's disease. After a 4-yr course of sulfasalazine and elemental diet therapy, she was readmitted for perianal abscess associated with the presence of pancytopenia, microhematuria with granular cast, hypocomplementemia, and high titers of autoimmune antibodies (anti-ANA and anti-dsDNA antibodies). Based on these features, a diagnosis of systemic lupus erythematosus (SLE) was made. Despite the rarity of such combination (Crohn's disease with SLE), patients with Crohn's disease who develop such clinical findings might need evaluation for SLE. 相似文献
68.
Zen Isobe Tatsuo Suga Toshimitsu Katou Kenichirou Hara Fumiaki Aoki Kana Aoyagi Manabu Ueno Toshitaka Maeno Masahiko Kurabayashi 《Nihon Kokyūki Gakkai zasshi》2008,46(3):226-231
A 54-year old man was admitted with general fatigue, muscle weakness and dyspnea on effort. Medical examinations led to a diagnosis of small cell lung carcinoma (SCLC) with Lambert-Eaton myasthenic syndrome (LEMS). Marked improvement of SCLC and symptoms of LEMS were recognized twice during chemoradiotherapy. On his third admission, he showed muscle weakness, dysaethesia, and neurodysfunction of the bladder and rectum. We initially considered these symptoms to be due to spinal metastasis because MRI findings showed multiple spinal metastases. However, electoromyogram and nerve conduction study demonstrated that his muscle weakness resulted from LEMS though dysethesia and neurodysfunction of bladder and rectum were caused by spinal metastasis. We believe that it is important to perform electomyogram and nerve conduction studies, not only radiographic findings, to detect the "hidden" symptoms of LEMS. 相似文献
69.