全文获取类型
收费全文 | 44253篇 |
免费 | 2569篇 |
国内免费 | 397篇 |
专业分类
耳鼻咽喉 | 544篇 |
儿科学 | 2612篇 |
妇产科学 | 717篇 |
基础医学 | 4993篇 |
口腔科学 | 1160篇 |
临床医学 | 3426篇 |
内科学 | 7556篇 |
皮肤病学 | 1207篇 |
神经病学 | 2556篇 |
特种医学 | 1372篇 |
外科学 | 6322篇 |
综合类 | 2627篇 |
现状与发展 | 4篇 |
一般理论 | 17篇 |
预防医学 | 2568篇 |
眼科学 | 1455篇 |
药学 | 4577篇 |
8篇 | |
中国医学 | 720篇 |
肿瘤学 | 2778篇 |
出版年
2023年 | 385篇 |
2022年 | 1111篇 |
2021年 | 1779篇 |
2020年 | 1025篇 |
2019年 | 1057篇 |
2018年 | 1446篇 |
2017年 | 1149篇 |
2016年 | 1419篇 |
2015年 | 1498篇 |
2014年 | 2167篇 |
2013年 | 2546篇 |
2012年 | 3559篇 |
2011年 | 3467篇 |
2010年 | 2194篇 |
2009年 | 1802篇 |
2008年 | 2421篇 |
2007年 | 2455篇 |
2006年 | 2202篇 |
2005年 | 1921篇 |
2004年 | 1717篇 |
2003年 | 1436篇 |
2002年 | 1246篇 |
2001年 | 890篇 |
2000年 | 763篇 |
1999年 | 604篇 |
1998年 | 265篇 |
1997年 | 216篇 |
1996年 | 222篇 |
1995年 | 192篇 |
1994年 | 156篇 |
1993年 | 134篇 |
1992年 | 352篇 |
1991年 | 338篇 |
1990年 | 359篇 |
1989年 | 329篇 |
1988年 | 285篇 |
1987年 | 246篇 |
1986年 | 234篇 |
1985年 | 231篇 |
1984年 | 174篇 |
1983年 | 124篇 |
1982年 | 68篇 |
1981年 | 75篇 |
1980年 | 69篇 |
1979年 | 109篇 |
1978年 | 71篇 |
1977年 | 87篇 |
1976年 | 66篇 |
1973年 | 62篇 |
1971年 | 60篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
Role of adenosine receptors in resveratrol‐induced intraocular pressure lowering in rats with steroid‐induced ocular hypertension
下载免费PDF全文
![点击此处可从《Clinical & experimental ophthalmology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
992.
Rakhi Bandyopadhyay Arkendu Chatterjee Sambit Banerjee Samir Kumar Bandyopadhyay Anup Mondol 《Saudi Journal of Ophthalmology》2015,29(3):238-241
Frontal osteomyelitis is a rare clinical entity that can occur as sequelae to frontal sinusitis, head trauma, as a postoperative complication following sinus surgery or due to haematogenous spread. It usually presents with a soft, fluctuant forehead swelling with pain and fever. Cicatricial ectropion is an extremely rare feature of frontal osteomyelitis. We present a young male patient presenting with cicatricial ectropion that occurred as the sole manifestation of an underlying frontal osteomyelitis. Extensive Medline search did not find any such reported case. We feel that frontal osteomyelitis should be kept in mind as a possible etiology when considering the differential diagnosis of cicatricial ectropion. 相似文献
993.
Brijesh Takkar Vinod Kumar Renu Agrawal Raghav Ravani Shorya Azad 《Saudi Journal of Ophthalmology》2015,29(4):315-316
Small intraocular foreign body in the outer coats of the eye may be wrongly interpreted as optic nerve head on ultrasound imaging. Such errors can be avoided by performing multiple sonography scans in different axes. 相似文献
994.
995.
Background: A sugar rich diet induces inflammation and insulin resistance (IR) mainly through gut microbiota alteration. Gut dysbiosis increases lipopolysaccharide (LPS) and reduces propionate and butyrate levels to impair the insulin signalling cascades by different molecular pathways, which progresses into IR. The present study was designed to investigate the effect of spectrum specific antibiotics on the modulation of gut microbiota and its signalling pathways to prevent diet-induced diabetes. Methods: Healthy male Wistar rats were divided into a non-diabetic group with a control diet (CD), a diabetic group with a high sucrose diet (HSD) and two antibiotic fed groups (linezolid and cefdinir; administered by oral gavage) along HSD. Physiological, biochemical, inflammatory and microbiome parameters were examined. Results: Cefdinir administration in HSD rats reduced fasting glucose, serum triglyceride, and cholesterol levels compared to HSD alone. In addition, cefdinir reduced serum LPS by decreasing the population of Gram-negative phyla, that is, Bacteroidetes and Proteobacteria in the fecal content. Furthermore, cefdinir treatment decreased hepatic/ileal/colonic Tlr4, Nlr1, and Nf-κB at the mRNA level. Moreover, cefdinir-treated rats had shown increased fecal butyrate and propionate and reduced acetate levels compared to HSD alone. Cefdinir treatment also induced ileal/colonic Gpr43 and Glut4 at the mRNA level after 12 weeks of administration. Conclusions: Taken together, these data suggest that administration of a Gram-negative spectrum antibiotic, that is, cefdinir, has modulated the gut microbiota, and reduced serum LPS and triglycerides, which prevented the progression of IR and inflammation in HSD rats.A sugar rich diet induces inflammation and insulin resistance (IR) mainly through gut microbiota alteration. 相似文献
996.
997.
998.
999.
Rathinam Arunadevi Shanmugam Murugammal Dinesh Kumar Surendra Kumar Tandan 《Indian journal of pharmacology》2015,47(6):638-643
Objective:
The study is aimed to evaluate anti-inflammatory activity of Caesalpinia bonducella Fleming (Caesalpiniaceae) flower extract (CBFE) and to study its effect on radiographic outcome in adjuvant induced arthritis and authentication by high performance thin layer chromatography (HPTLC) chemical fingerprinting.Materials and Methods:
CBFE was administered orally (30, 100, and 300 mg/kg b.wt.) and tested for its anti-inflammatory activity in carrageenan-induced inflammation, cotton pellet induced chronic granulomatous inflammation and autacoids-induced inflammation. Effect on radiographic outcome was tested in adjuvant-induced arthritis. CBFE was HPTLC fingerprinted in suitable solvent system.Result:
In carrageenan-induced inflammation, CBFE produced significant inhibition in edema volume at all the doses (30, 100 and 300 mg/kg b.wt.) and percentage of inhibition was 28.68, 31.00, and 22.48, respectively as compared to control at 5 h of its administration. In cotton pellet granuloma assay, CBFE significantly decreased the granuloma weight at 300 mg/kg dose level by 22.53%. CBFE (300 mg/kg) caused significant inhibition by 37.5, 44.44, and 35.29% edema volume, at ½, 1 and 3 h after 5-hydroxytryptamine injection, respectively. Radiographic score of animals treated with 300 mg/kg CBFE was significantly decreased when compared to arthritic control animals.Conclusion:
The extract was found to possess significant anti-inflammatory activity. CBFE treatment improved the bony architecture in adjuvant-induced arthritis in rats. The developed HPTLC fingerprint would be helpful in the authentication of C. bonducella flower extract.KEY WORDS: 5-hydroxy tryptamine, Caesalpinia bonducella, carrageenan-induced inflammation, cotton pellet granuloma, high performance thin layer chromatography, radiography 相似文献1000.
Devbrat Yadav Arvind Kumar Pramod Kumar Diwaker Mishra 《Indian journal of pharmacology》2015,47(6):663-667