Formulation and Evaluation of Dextromethorphan Hydrobromide Sustained Release Tablets

Sustained release (SR) matrix tablets of dextromethorphan hydrobromide were prepared by wet granulation using hydroxypropyl methyl cellulose (HPMC-K-100 CR) as the hydrophilic rate controlling polymer. The effect of the concentration of the polymer and different fillers on the in vitro drug release rate was studied. The studies indicated that the drug release can be modulated by varying the concentration of the polymer and the fillers. A complete cross-over bioavailability study of the optimized formulation of the developed sustained tablets and marketed immediate release tablets was performed on six healthy male volunteers. The extent of absorption of drug from the SR tablets was significantly higher than that for the marketed dextromethorphan hydrobromide tablet because of lower elimination rate and longer half-life.     

Impact of generational differences on the future of radiology: proceedings of the 11th annual ACR Forum

The 2011 ACR Forum focused on the impact of generational differences on the future of radiology, seeking to inform ACR leadership and members on how best to address the influence of the new integrated workforce on the specialty of radiology and on individual practices.     

Insulin Signalling: Essential Role of a 222 Da Molecular Mediator,Co-Insulin (Co-Ins)

Proceedings of the National Academy of Sciences, India Section B: Biological Sciences - An attempt has been made to probe into the molecular basis of insulin resistance. The target was to look into...     

Clinical considerations in the management of non-alcoholic steatohepatitis cirrhosis pre-and post-transplant: A multi-system challenge

Non-alcoholic steatohepatitis(NASH) is the most common chronic liver disease worldwide, and the fastest growing indication for liver transplantation in the United States. NASH is now the leading etiology for liver transplantation in women, the second leading indication for men, and the most common cause amongst recipients aged 65 years and older. Patients with end-stage liver disease related to NASH represent a unique and challenging patient population due the high incidence of associated comorbid diseases, including obesity, type 2 diabetes(T2 D), and hypertension. These challenges manifest in the pre-liver transplantation period with increased waitlist times and waitlist mortality. Furthermore, these patients carry considerable risk of morbidity and mortality both before after liver transplantation, with high rates of T2 D, cardiovascular disease, chronic kidney disease, poor nutrition, and disease recurrence. Successful transplantation for these patients requires identification and management of their comorbidities in the face of liver failure. Multidisciplinary evaluations include a thorough pre-transplant workup with a complete cardiac evaluation, control of diabetes, nutritional support, and even, potentially, consultation with a bariatric surgeon. This article provides a comprehensive review of the conditions and challenges facing patients with NASH cirrhosis undergoing liver transplantation and provides recommendations for evaluation and management to optimize them before liver transplantation to produce successful outcomes.     

Cystic changes in dental follicle associated with radiographically normal impacted mandibular third molar

The aim of the study was to find out the incidence of histological abnormalities in soft tissues that are associated with impacted lower third molars with no pericoronal lytic lesion. We studied 100 patients who had a radiographically normal asymptomatic impacted lower third molar (<2.4mm radiolucency). The incidence of cystic changes in the dental follicle was 46%. There was a high incidence in the right side and in men. We recommend histopathological evaluation and radiographic diagnosis in the management of impacted third molars.     

Myxoid liposarcoma of the breast--report of a rare case

Breast sarcomas are very rare. A 40 year old lady presented with a well-defined hard lump, 6 cm in size, in the left breast. Patient underwent simple mastectomy with axillary clearance following a diagnosis of phylloides tumour on fine needle aspiration cytology. Grossly, it was a circumscribed myxoid tumour. Histopathologically, it fulfilled all the criteria for a diagnosis of myxoid liposarcoma. The absence of epithelial component excluded phylloides tumour.