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21.
Daskalakis G Papapanagiotou A Mesogitis S Papantoniou N Mavromatis K Antsaklis A 《Fetal diagnosis and therapy》2006,21(2):172-176
OBJECTIVE: To evaluate the relationship between bacterial vaginosis (BV) and group B streptococcal (GBS) colonization in the 2nd trimester of pregnancy and preterm delivery. METHODS: 1,197 pregnant women between 22 and 25 weeks' gestation had a high vaginal swab for assessment of BV and GBS. Exclusion criteria were: previous preterm delivery, or mid-trimester abortion or termination of pregnancy, multiple gestation, oligo- or polyhydramnios, placenta previa, fetal abnormalities, uterine malformations, cervical incompetence, cervical cerclage, or receipt of an antibiotic effective against BV or GBS following the screening. All women had no risk factors for preterm delivery. The primary outcome measure in this analysis was spontaneous preterm delivery before 37 weeks' gestation. RESULTS: The preterm delivery rate was 8.7%, while the maternal BV and GBS colonization rates were 7.9 and 12.5%, respectively. Following adjustment for potential confounders BV was associated with an increased risk of preterm delivery (RR 2.19; CI: 1.21-3.98) (p = 0.01). On the contrary, GBS colonization was found to have a negative correlation with preterm birth (RR 0.43; 95% CI: 0.19-1.00). CONCLUSIONS: Although BV is a risk factor for preterm delivery, GBS colonization in the 2nd trimester of pregnancy has an inverse correlation with preterm delivery. 相似文献
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Konstantinos Mavromatis Natalia Ivanova Iain Anderson Athanasios Lykidis Sean D. Hooper Hui Sun Victor Kunin Alla Lapidus Philip Hugenholtz Bharat Patel Nikos C. Kyrpides 《PLoS Clinical Trials》2009,4(1)
Halothermothirx orenii is a strictly anaerobic thermohalophilic bacterium isolated from sediment of a Tunisian salt lake. It belongs to the order Halanaerobiales in the phylum Firmicutes. The complete sequence revealed that the genome consists of one circular chromosome of 2578146 bps encoding 2451 predicted genes. This is the first genome sequence of an organism belonging to the Haloanaerobiales. Features of both Gram positive and Gram negative bacteria were identified with the presence of both a sporulating mechanism typical of Firmicutes and a characteristic Gram negative lipopolysaccharide being the most prominent. Protein sequence analyses and metabolic reconstruction reveal a unique combination of strategies for thermophilic and halophilic adaptation. H. orenii can serve as a model organism for the study of the evolution of the Gram negative phenotype as well as the adaptation under thermohalophilic conditions and the development of biotechnological applications under conditions that require high temperatures and high salt concentrations. 相似文献
23.
End‐stage renal disease and severe aortic stenosis. Does valve replacement improve one‐year outcomes?
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Jose F. Condado MD MS Aneel Maini Bradley Leshnower MD Vinod Thourani MD Jessica Forcillo MD Chandan Devireddy MD Kreton Mavromatis MD Eric L. Sarin MD James Stewart MD Robert Guyton MD Amy Simone PA Patricia Keegan NP Stamatios Lerakis MD Peter C. Block MD Vasilis Babaliaros MD 《Catheterization and cardiovascular interventions》2017,89(6):1109-1115
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Grigoriadis N Tselios T Deraos S Orologas A Deraos G Matsoukas J Mavromatis I Milonas I 《Current medicinal chemistry》2005,12(13):1513-1519
Experimental allergic encephalomyelitis (EAE) is a T helper 1 (Th1) mediated autoimmune disease and the principal animal model for multiple sclerosis (MS). Like MS, EAE is characterized by a coordinated inflammatory attack on the myelin sheath in the central nervous system (CNS), with damage to axons. No matter whether the ideal animal model is not yet available, much knowledge concerning the pathogenesis of MS has been achieved through studies on EAE. Dissecting the underlying immune mechanisms provided recognition of several myelin antigens that are vulnerable in autoimmune attack. The beneficial effect and the mechanism of action of a number of the currently used immunomodulating agents in MS therapy were first indicated in EAE. Altered peptide ligands (APL) can modulate T-cell responses to native peptide antigens implicated in the pathogenesis of autoimmune diseases such as MS and EAE. However, peptide therapy is hindered due to the sensitivity of peptides to proteolytic enzymes as well as due to some immune-mediated side effects. A number of cyclic myelin peptide analogs seem to be potential candidates in maintaining the biological function of the original peptide and effective in controlling inflammation in EAE. Additional data regarding the immunomodulating and neuroprotective effect of these much promising agents is required. Based on the data from studies on EAE models, clinical trials should also be designed in order to elucidate the impact of such APL-induced immune responses in MS disease activity. These clinical trials should carefully incorporate monitoring of both clinical, neuroimaging and immunological parameters. 相似文献
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M. Büchler P. Malfertheiner H. Schädlich T. Nevalainen T. Mavromatis H. G. Beger 《Journal of molecular medicine (Berlin, Germany)》1989,67(3):186-189
Summary Serum from 48 patients with acute pancreatitis (21 with interstitial-edematous and 27 with necrotizing pancreatitis) was monitored for immunoreactive (IR) phospholipase A2 (PLA2) protein concentration and PLA catalytic activity. In both groups within 48 h after start of acute pancreatitis an up to tenfold increase of IR-PLA2 was demonstrable. Determination of IR-PLA2 revealed no differences between the groups. In contrast, determination of PLA catalytic activity allowed us to differentiate between patients with interstitial-edematous and necrotizing pancreatitis. 相似文献
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B De Bruyne NH Pijls B Kalesan E Barbato PA Tonino Z Piroth N Jagic S Mobius-Winckler G Rioufol N Witt P Kala P MacCarthy T Engström KG Oldroyd K Mavromatis G Manoharan P Verlee O Frobert N Curzen JB Johnson P Jüni WF Fearon;FAME Trial Investigators 《The New England journal of medicine》2012,367(11):991-1001