Gleichstrommessungen an der menschlichen Haut bei Quellung und Entquellung des Gewebes

Zusammenfassung 1. Die biophysikalischen Ursachen meßbarer Veränderungen im Verhalten des menschlichen Hautwiderstandes werden mit der Methode des Elektropermeagramms durch Aufzeichnung eines gewebsaufladenden Gleichstroms untersucht.2. Durch verschiedenartige und variierte experimentelle Versuchsanordnungen sowie klinische Beobachtungen wird nachgewiesen, daß den Schweißdrüsen weder in morphologischer noch funktioneller Beziehung ein erkennbarer Einfluß auf das Verhalten des polarisatorischen Hautwiderstandes, des Anfangs- und Endwiderstandes im Elektropermeagramm zuzuschreiben ist.3. Für Veränderungen der Hautwiderstände ist der Hydratationszustand der lebenden Epidermis im Sinne ihrer Quellung und Entquellung maßgebend.     

Trisomy 4 as the sole cytogenetic abnormality in a Waldenström macroglobulinemia

We report a case of Waldenstr?m macroglobulinemia with trisomy 4 as the sole cytogenetic abnormality. Trisomy 4 has been reported previously in Waldenstr?m macroglobulinemia, but only in conjunction with multiple chromosomal aberrations. Trisomy 4 has been reported in other hematologic malignancies including acute myeloid and lymphoid leukemias.     

Über den tatsächlichen Orthophosphat- und N-Phosphorylkreatingehalt des Säugetierherzens

Summary 1. Cardiac ventricular muscle of adult, anesthetized, open-chest dogs, guinea pigs, and rabbits given artificial respiration was compressed by means of a pair of –190°C cold aluminum tongs in situ in 0.02–0.4 seconds to frozen plates 0.4–1.5 mm in thickness.2. Determinations of phosphates extracted from the finely powdered plates with 0° or –35°C cold perchloric acid yielded, among other results, the following values per gram of dog, guinea pig, and rabbit myocardium, respectively: 1.9, 2.0, and 1.9 moles of orthophosphate; and 12.8, 10.9, and 8.2 moles of N-phosphorylcreatine (labile phosphate). Bound creatine, analyzed in extracts of guinea pig and rabbit hearts, corresponded quantitatively to the labile phosphate.3. Cardiac muscle samples which were excised and immediately immersed in liquid air contained 3–4 times as much orthophosphate and only a little more than half as much phosphorylcreatine as the metal-cooled tissue. There was also less total acid-soluble phosphate present. The sum of orthophosphate and phosphorylcreatine and the amounts of 10-minute-phosphate and of total creatine were not significantly altered by excision and freezing in liquid air.4. The rapidly beating hearts contained per gram (a) less orthophosphate than is found in the resting skeletal musculature; and (b) as much as or more phosphorylcreatine than there exists, according to data in the literature, in certain types of skeletal muscle in the resting state.5. The problem of obtaining a warm-blooded heart, or a part of it, for analysis without inducing changes in chemical composition is considered in relation to the anatomy of the organ. The advantage is noted which the cooling tongs technique affords in this regard over other methods of tissue freezing.

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Vorläufige Mitteilung: Wollenberger, Krause u. Wahler (1958).     

Über Funktionsänderungen markhaltiger Kaltblüternerven nach Adrenalektomie und Zufuhr rindenwirksamer Steroide in Abhängigkeit von der Ionenverteilung

Ohne ZusammenfassungBenutzte Symbole und Abkürzungen NNR Nebennierenrinde - DOCA Desoxycorticosteronacetat - K _i intracelluläres Kalium (sinngemäß für Natrium) - K _a extracelluläres Kalium (sinngemäß für Natrium) - Q Ladung - E _m Membranruhepotential - _m Zeitkonstante der Membran - R _m Membranwiderstand - C _m Membrankapazität     

Differential increases of neurokinin B- and enkephalin-like immunoreactivities and their mRNAs after chronic haloperidol treatment in the rat.

Changes in neurokinin B-like immunoreactivity (NKB-IR) and neurokinin B mRNA were investigated after daily injection of haloperidol for 10 days on adjacent sections by means of immunocytochemistry and in situ hybridization in the caudate putamen of the rat. In the dorsal striatum the number of NKB immunoreactive perikarya and the staining intensity of striatal efferents increased. The number of NKB mRNA-expressing cells (45%) and the grain density over single positive cells (37%) were significantly higher after the neuroleptic treatment. The levels for enkephalin mRNA were uniformly increased throughout the rostrocaudal extent of the caudate putamen (85%). A main difference to the enkephalin system was that the dorsal pallidum was nearly devoid of NKB-IR in untreated as well as in haloperidol-treated animals. The present data for the first time provide evidence for the regulation of the biosynthesis of NKB after pharmacological intervention.     

Immune function did not decline with aging in apparently healthy, well-nourished women

Nutrition plays a crucial role in immune function. Most studies on age-associated changes in immunocompetence in healthy adults did not examine the nutritional status of participants extensively. Inadequate nutritional status may confound the relationship of aging and immune response. The purpose of this study was to examine age-related changes in parameters of acquired and innate immunity in healthy and generally well-nourished older (62-88 years) versus younger (20-40 years) women. Subjects were screened for participation using the health criteria of the SENIEUR protocol as well as a number of nutrition criteria related to undernutrition, and protein, iron, vitamin B12, and folate status. Young and old women did not differ in total T (CD3+), T-helper (CD4+), or T-cytotoxic (CD8+) cell number. However, older women tended to have lower T-cell proliferation response to concanavalin A (P < 0.10) and significantly reduced response to phytohemagglutinin (P < 0.05). No age-related changes were noted in natural killer cell number or cytotoxicity. Phagocytosis and subsequent oxidative burst activity also did not differ between young and old women. Most immune parameters were not compromised with aging in this cohort of apparently healthy, well-nourished women. These findings highlight the importance of simultaneous examination of health and nutritional status in studies of immune function with aging.     

Selective inhibition of the transmembrane Ca conductivity of mammalian myocardial fibres by Ni,Co and Mn ions

Pflügers Archiv - European Journal of Physiology - According to earlier studies on mammalian papillary muscles, Ni and Co ions reduce the Ca dependent mechanical response whilst the action...