全文获取类型
收费全文 | 10552篇 |
免费 | 550篇 |
国内免费 | 78篇 |
专业分类
耳鼻咽喉 | 208篇 |
儿科学 | 162篇 |
妇产科学 | 140篇 |
基础医学 | 1394篇 |
口腔科学 | 370篇 |
临床医学 | 691篇 |
内科学 | 2681篇 |
皮肤病学 | 209篇 |
神经病学 | 727篇 |
特种医学 | 305篇 |
外科学 | 1701篇 |
综合类 | 38篇 |
预防医学 | 321篇 |
眼科学 | 231篇 |
药学 | 690篇 |
中国医学 | 30篇 |
肿瘤学 | 1282篇 |
出版年
2023年 | 62篇 |
2022年 | 127篇 |
2021年 | 216篇 |
2020年 | 102篇 |
2019年 | 136篇 |
2018年 | 165篇 |
2017年 | 151篇 |
2016年 | 182篇 |
2015年 | 183篇 |
2014年 | 233篇 |
2013年 | 310篇 |
2012年 | 561篇 |
2011年 | 524篇 |
2010年 | 284篇 |
2009年 | 276篇 |
2008年 | 454篇 |
2007年 | 503篇 |
2006年 | 498篇 |
2005年 | 534篇 |
2004年 | 473篇 |
2003年 | 461篇 |
2002年 | 457篇 |
2001年 | 367篇 |
2000年 | 400篇 |
1999年 | 368篇 |
1998年 | 147篇 |
1997年 | 106篇 |
1996年 | 112篇 |
1995年 | 71篇 |
1994年 | 73篇 |
1993年 | 61篇 |
1992年 | 276篇 |
1991年 | 209篇 |
1990年 | 202篇 |
1989年 | 192篇 |
1988年 | 193篇 |
1987年 | 184篇 |
1986年 | 190篇 |
1985年 | 156篇 |
1984年 | 111篇 |
1983年 | 95篇 |
1979年 | 82篇 |
1978年 | 57篇 |
1977年 | 43篇 |
1974年 | 62篇 |
1973年 | 43篇 |
1972年 | 49篇 |
1971年 | 39篇 |
1970年 | 45篇 |
1969年 | 58篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
71.
Hirotaka Horiguchi Shingo Hatakeyama Tohru Yoneyama Mihoko Sutoh Yoneyama Toshikazu Tanaka Naoki Fujita Teppei Okamoto Hayato Yamamoto Takahiro Yoneyama Tadashi Yoshizawa Yasuhiro Hashimoto Toshiaki Kawaguchi Chikara Ohyama 《Urologic oncology》2021,39(4):238.e9-238.e17
ObjectivesTo investigate the association between Ki67 index and programmed death-ligand 1 (PD-L1) expression in muscle-invasive bladder cancer (MIBC) patients after RC.Materials and MethodsWe retrospectively evaluated 262 MIBC patients treated with RC between April 2004 and April 2020. The impact of Ki67 index and PD-L1 expression on prognosis was evaluated by univariate Cox regression analysis. In addition, a pathomolecular risk score, including Ki67 and PD-L1, was developed to predict prognosis and pathological factors. We also evaluated the link between the Ki67 index and PD-L1 under the IL-6 stimulation in the bladder cancer cell lines of T24 and 5637 cells.ResultsThe median age and follow-up period was 69 years and 52 months, respectively. Ki67 index and PD-L1 expression were significantly associated with tumor recurrence. Univariate Cox regression analysis showed that pT3–4, mixed histology, lymphovascular invasion positive (LVI+), pN+, Ki67-high (>17%), and PD-L1+ were significantly associated with recurrence-free survival (RFS). The pathomolecular risk score was developed using resection margin+ (1 point), mixed histology (1 point), LVI+ (1 point), pN+ (1 point), and Ki67-high (1 point). RFS and overall survival were significantly shorter in patients with higher pathomolecular risk scores (>1) than in those with lower risk scores (≤1). Cell proliferation was significantly increased in the T24 and 5637 cells under the IL-6 stimulation, while PD-L1 expression was not.ConclusionsA significant effect of Ki67-high and PD-L1 expression on poor prognosis was observed in patients with MIBC. Further studies are necessary to elucidate the precise mechanisms of cell proliferation and PD-L1 expression in patients with MIBC. 相似文献
72.
73.
74.
Twenty-five patients who required mechanical ventilatory support (MVS) after major surgery or severe burns were studied to determine whether airway occlusion pressure (P0.1) is a clinically useful indicator to predict the success or failure of the weaning trial. A total of 33 weaning trials were attempted on these patients. Of the 33 trials, 24 were followed by successful weaning and 9 by failure. Although the success group, when compared with the failure group, had a lower respiratory rate (P 0.001), a lower minute ventilation (P 0.001), a higher maximal voluntary ventilation to minute ventilation ratio (P 0.01) and a higher forced vital capacity (P 0.05), no threshold values separated the success from the failure group. The alveolar-arterial PO
2 gradient, with an Fi
O
2 of 1.0, in weaning success and failure showed no statistical difference. In contrast, all patients in the success group had a P0.1 of less than 3.5cmH2O and those in the failure group had a P0.1 of greater than 3.5cmH2O (P 0.001). We conclude that P0.1 is a clinically superior indicator for discontinuing MVS in patients with acute respiratory failure.(Okamoto K, Sato T, Morioka T: Airway occlusion pressure (P0.1)—A useful predictor for the weaning outcome in patients with acute respiratory failure—. J Anesth 4: 95–101, 1990) 相似文献
75.
We evaluated the reliability of conventional weaning criteria from a ventilator during 33 weaning trials on 25 patients with acute respiratory failure (ARF). Of 13 criteria, a ratio of maximal voluntary ventilation to minute ventilation (MV) 2, a vital capacity 12ml·kg–1, a spontaneous respiratory rate 25 breaths·min–1, and a MV 10l·min–1 appeared to be useful for predicting successful weaning outcome. However, even using those criteria, there were many falsely-negative cases. The alveolar-arterial PO
2 gradient 350mmHg at an Fi
O
2 1.0 was not useful as a predictor of weaning outcome. The present study demonstrates that conventional criteria are frequently inaccurate for predicting weaning outcomes and suggests that the use of some of these criteria may unnecessarily prolong the length of ventilator support. Since ventilation of most patients with poor oxygenation can be successfully discontinued by placing them on a continuous positive airway pressure system, these results suggest that the improvement of oxygenation is not an indispensable prerequisite for weaning from mechanical ventilators.(Okamoto K, Iwamasa H, Dogomori H, et al.: Evaluation of conventional weaning criteria in patients with acute respiratory failure. J Anesth 4: 213–218, 1990) 相似文献
76.
77.
78.
Summary Complaints resulting from reduced neck movements were investigated in 50 patients who had operations for cervical spondylotic myelopathy. Seventy per cent had difficulty in performing 11 basic movements of daily living. Lateral bending or rotation were more difficult than flexion and extension. To look backwards was the most difficult movement. Complaints were highest among those in whom more than three levels of fusion had been carried out.
Résumé La gêne dûe à la réduction d'amplitude des mouvements du cou chez 50 patients opérés pour spondylo-myélopathie cervicale est étudiée. Soixante-douze pour cent des malades ont des difficultés pour faire 11 mouvements fondamentaux de la vie quotidienne. Les mouvements qui nécessitent une inflexion latérale ou une rotation sont plus difficiles à pratiquer que les mouvements nécessitant de la flexion extension. Regarder en arrière est le mouvement le plus difficile à exécuter et seulement 32% des malades ne sont pas gênés du tout. C'est parmi les malades dont la fusion antérieure intéresse 3 niveaux ou plus que se rencontre le plus grand nombre de plaintes fonctionnelles.相似文献
79.
Portal blood flow and liver regeneration in auxiliary partial orthotopic liver transplantation in a canine model 总被引:4,自引:0,他引:4
Yabe S Nishizawa H Egawa H Nakayama H Okamoto S Kiuchi T Uemoto S Asonuma K Shapiro AM Inomata Y Yamaoka Y Tanaka K 《European surgical research. Europ?ische chirurgische Forschung. Recherches chirurgicales européennes》1999,31(1):83-92
Functional competition has been shown to lead to a detrimental outcome in auxiliary liver transplantation. We evaluated the interaction in auxiliary partial orthotopic liver transplantation between the native liver and the graft in terms of portal flow and regeneration. The need for diversion of the portal flow to the graft was also assessed. Reduced-size liver grafts were transplanted orthotopically after partial hepatectomy in beagles. There were two groups: the preserved group, where portal inflow to the native liver was preserved, and the ligated group, where it was interrupted. Portal flow was measured serially and liver regeneration was evaluated on postoperative day 5. Functional competition was not observed in the preserved group. On the other hand, ligation of the native liver portal vein had no obviously detrimental effects on the remnant native liver. This leads to the conclusion that the portal vein to the native liver can be safely ligated to prevent functional competition. 相似文献
80.
Murakami M Kuroda Y Takeda H Okamoto Y Kono K Mizowaki T Kusumi F Hajiro K Nishimura S Nakajima T Matsusue S 《Radiation Medicine》1999,17(6):459-462
A 51-year-old man with increasing dysphasia was admitted to our hospital on March 18, 1985. Several examinations revealed thoracic esophageal squamous cell carcinoma 11 cm in length staged T3N0M0 (stage IIA) by UICC 1987. As he rejected our proposal of surgery, definitive radiotherapy (60 Gy) was delivered, and complete response was obtained. The patient had been doing well for 5 years after radiotherapy until superficial local recurrence was discovered at a periodic endoscopic examination. High-dose-rate intraluminal brachytherapy (10 Gy/2 Fr) was administered. After a 3-year disease-free interval, superficial recurrence developed in the same location, and early gastric cancer was detected as a secondary cancer. Radical salvage surgery was performed. The patient was alive and disease free 5 years and 5 months after surgery. We present this rare case of a patient who survived 14 years after the initial radiotherapy. The present case demonstrated the importance of long-term follow-up after radiotherapy, long-term local controllability of relatively low doses of intraluminal brachytherapy after superficial recurrence, and the feasibility of salvage surgery as long as local recurrence is limited to within the mucosal layer. 相似文献