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101.
102.
This study describes the use of radiologic methods in the identification of 256 bodies after the crash of an airliner in Gander, Newfoundland. Two hundred thirty-one (90%) of the victims were identified positively with dental and/or fingerprint comparisons. Radiologic data confirmed identification in 29 of these victims. Seventeen bodies without dental or fingerprint identification were presumptively identified with a variety of data, which included radiologic characteristics in four cases. Eight bodies were identified with an exclusion matrix. Radiologic input was critical in two of these. The procedures described provide practical information for radiologists in a mass casualty disaster investigation. 相似文献
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R S Weinstein S M Jakate J M Dominguez M D Lebovitz G K Koukoulis J R Kuszak L F Klusens T M Grogan T J Saclarides I B Roninson 《Cancer research》1991,51(10):2720-2726
P-glycoprotein mediates classic multidrug resistance by functioning as an efflux pump that excretes lipophilic chemotherapeutic drugs from cancer cells. We now report an association of P-glycoprotein in colon carcinomas with another tumor property, i.e., enhancement of local tumor aggressiveness. P-glycoprotein was detected with monoclonal antibody immunohistochemistry in 65 of 95 primary colon adenocarcinomas, which were stage B1 or greater. In all but 1 of the 95 cases, solitary invading carcinoma cells were present at the leading edge of the tumor. This subpopulation of invasive carcinoma cells expressed P-glycoprotein (P-Gp+) in 47 of the 95 surgically resected colon specimens. Cases were grouped on the basis of the presence (Group 1, 47 cases) or absence (Group 2, 48 cases) of P-Gp+ invasive carcinoma cells. There was a significantly greater incidence of vessel invasion (P less than 0.001) and lymph node metastases (P less than 0.01) in Group 1 cases. Groups 1 and 2 did not differ with respect to tumor size, depth of invasion of the bowel wall, histological grade, maximum tumor size, mitotic index, mucin production, or presence of perineural invasion (P greater than 0.1). Our findings indicate that P-Gp+ invasive colon cancer cells may have an increased potential for dissemination, suggesting that P-glycoprotein may influence cell behavior. 相似文献
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107.
Gaurav Sharma Ravijot Singh Kiran Kumar GN Vaibhav Jain Ankit Gupta Shivanand Gamanagatti Kamran Farooque Vijay Sharma 《International orthopaedics》2016,40(5):1009-1017
Purpose
To determine whether radiographic measurements derived from standard computed tomography (CT) evaluation can be used to predict likelihood of a peri-operative lateral femoral wall fracture in AO/OTA 31-A2 pertrochanteric fractures treated with a dynamic hip screw (DHS).Methods
Fifty-one patients with AO/OTA 31-A2 classified pertrochanteric fractures were evaluated using a pre-operative CT scan of the pelvis with both hips. Dimensions of the lateral wall were calculated for each patient using four parameters: (1) height of the lateral wall above the vastus ridge; (2) circumference of the lateral wall 2 cm below the vastus ridge at an angle of 135°; this circumference was further divided into an anterior, lateral and posterior component; (3) cortical thickness at the centre of the lateral component of the lateral wall; and (4) cortical index. All patients were treated with a 135° DHS. Postoperative radiographs were assessed for lateral femoral wall fracture.Results
Patients with a lateral wall fracture (17/51) had a smaller circumference (4.47 cm vs 5.44 cm p value?<0.001) as well as a lower height of the lateral femoral wall (1.37 cm vs 2.21 p value?<?0.001). Analysis of the three components of the circumference revealed a significant difference for the anterior component only and not for the lateral and posterior components. There was no statistical difference in the cortical thickness or cortical index in the two groups. The cutoff values for height of the lateral wall and anterior component were calculated using ROC curves and found to be 1.68 cm (AUC 0.918) and 2.10 cm (AUC 0.851) respectively.Conclusion
AO/OTA 31-A2 pertrochanteric fractures with a lateral wall height of > 1.68 cm and an anterior component of > 2.10 cm in circumference are not likely to sustain a lateral wall fracture when treated with a DHS.108.
Rokkas T Pistiolas D Sechopoulos P Margantinis G Koukoulis G 《World journal of gastroenterology : WJG》2008,14(22):3484-3489
AIM: To examine the risk of colorectal neoplasm in acromegalic patients by meta-analyzing all relevant controlled studies.
METHODS: Extensive English language medical literature searches for human studies, up to December 2007, were performed using suitable keywords. Pooled estimates [odds ratio (OR) with 95% confidence intervals (CI)] were obtained using either the fixed or random-effects model as appropriate. Heterogeneity between studies was evaluated with the Cochran Q test whereas the likelihood of publication bias was assessed by constructing funnel plots. Their symmetry was estimated by the adjusted rank correlation test.
RESULTS: For hyperplastic polyps the pooled ORs with 95% CI were 3.557 (2.587-4.891) by fixed effects model and 3.703 (2.565-5.347) by random effects model. The Z test values for overall effect were 7.81 and 6.984, respectively (P 〈 0.0001). For colon adenomas the pooled ORs with 95% CI were 2.486 (1.908-3.238) (fixed effects model) and 2.537 (1.914-3.364) (random effects model). The Z test values were 6.747 and 6.472, respectively (P 〈 0.0001). For colon cancer the pooled OR with 95% CI was identical for both fixed and random effects model (OR, 4.351; 95% CI, 1.533-12.354; Z = 2.762, P = 0.006]. There was no significant heterogeneity and no publication bias in all the above meta-analyses.
CONCLUSION: Acromegaly is associated with an increased risk of colorectal neoplasm. 相似文献
METHODS: Extensive English language medical literature searches for human studies, up to December 2007, were performed using suitable keywords. Pooled estimates [odds ratio (OR) with 95% confidence intervals (CI)] were obtained using either the fixed or random-effects model as appropriate. Heterogeneity between studies was evaluated with the Cochran Q test whereas the likelihood of publication bias was assessed by constructing funnel plots. Their symmetry was estimated by the adjusted rank correlation test.
RESULTS: For hyperplastic polyps the pooled ORs with 95% CI were 3.557 (2.587-4.891) by fixed effects model and 3.703 (2.565-5.347) by random effects model. The Z test values for overall effect were 7.81 and 6.984, respectively (P 〈 0.0001). For colon adenomas the pooled ORs with 95% CI were 2.486 (1.908-3.238) (fixed effects model) and 2.537 (1.914-3.364) (random effects model). The Z test values were 6.747 and 6.472, respectively (P 〈 0.0001). For colon cancer the pooled OR with 95% CI was identical for both fixed and random effects model (OR, 4.351; 95% CI, 1.533-12.354; Z = 2.762, P = 0.006]. There was no significant heterogeneity and no publication bias in all the above meta-analyses.
CONCLUSION: Acromegaly is associated with an increased risk of colorectal neoplasm. 相似文献
109.
Acute lung injury (ALI) is a complex and devastating illness, often occurring within the setting of sepsis, and carries an
annual mortality rate of 30–50%. Although the genetic basis of ALI has not been fully established, an increasing body of evidence
suggests that genetic predisposition contributes to disease susceptibility and severity. Significant difficulty exists, however,
in defining the exact nature of these genetic factors, including large phenotypic variance, incomplete penetrance, complex
gene–environment interactions, and strong potential for locus heterogeneity. We utilized the candidate gene approach and an
ortholog gene database to provide relevant gene ontologies and insights into the genetic basis of ALI. We employed a Medline
search of selected basic and clinical studies in the English literature and studies sponsored by the HopGene National Institutes
of Health sponsored Program in Genomic Applications. Extensive gene expression profiling studies in animal models of ALI (rat,
murine, canine), as well as in humans, were performed to identify potential candidate genes . We identified a number of candidate genes for ALI, with blood coagulation and inflammation gene ontologies being the most
highly represented. The candidate gene approach coupled with extensive gene profiling and novel bioinformatics approaches
is a valuable way to identify genes that are involved in ALI. 相似文献
110.
Methylenetetrahydrofolate reductase gene polymorphism as a risk factor for diabetic nephropathy: a meta-analysis 总被引:1,自引:1,他引:0
Zintzaras E Uhlig K Koukoulis GN Papathanasiou AA Stefanidis I 《Journal of human genetics》2007,52(11):881-890
Investigations into the association between diabetic nephropathy (DN) and MTHFR C677T gene polymorphism in several case–control
studies has yielded contradictory results. To shed light on these inconclusive findings, a meta-analysis of all available
studies relating the C677T polymorphism to the risk of developing DN was conducted. The PubMed database was searched, and
case–control studies investigating the association between MTHFR C677T gene polymorphism and DN were included in the meta-analysis.
The meta-analysis included 15 studies, of which 8 involved Caucasians and 5 East Asians; 11 studies involved subjects with
type 2 diabetes and 4 with type 1 diabetes. The main analysis (all studies) revealed significant heterogeneity between the
studies (P
Q < 0.01) and a marginal association between the 677T allele and the risk of developing DN; the random effects (RE) pooled
odds ratio (OR) was 1.30 (1.03–1.64). However, the sensitivity analysis (exclusion of studies not in Hardy–Weinberg equilibrium)
produced non-significant results. The recessive model derived significant results in main analysis [fixed effects (FE) OR = 1.32
(1.10–1.58), P
Q = 0.27], and in type 2 diabetes [FE OR = 1.30 (1.06–1.60), P
Q = 0.38]. The additive model produced significant association in main analysis [RE OR = 1.65 (1.13–2.42), P
Q < 0.01] in Caucasians [FE OR = 1.48 (1.11–1.98), P
Q = 0.17] and in type 2 diabetes [RE OR = 1.65 (1.03–2.67), P
Q < 0.01]. However, sensitivity analysis diminished the significant results in type 2 diabetes. There is no differential magnitude
of effect in large versus small studies. In conclusion, although there is some evidence of association between MTHFR C677T
gene polymorphism and DN, the above findings reinforce the need for further and more rigorous association studies. 相似文献