全文获取类型
收费全文 | 6010篇 |
免费 | 260篇 |
国内免费 | 102篇 |
专业分类
耳鼻咽喉 | 63篇 |
儿科学 | 71篇 |
妇产科学 | 172篇 |
基础医学 | 442篇 |
口腔科学 | 198篇 |
临床医学 | 440篇 |
内科学 | 1999篇 |
皮肤病学 | 84篇 |
神经病学 | 401篇 |
特种医学 | 219篇 |
外科学 | 1302篇 |
综合类 | 27篇 |
现状与发展 | 1篇 |
一般理论 | 2篇 |
预防医学 | 220篇 |
眼科学 | 131篇 |
药学 | 238篇 |
中国医学 | 3篇 |
肿瘤学 | 359篇 |
出版年
2024年 | 6篇 |
2023年 | 70篇 |
2022年 | 150篇 |
2021年 | 276篇 |
2020年 | 163篇 |
2019年 | 218篇 |
2018年 | 263篇 |
2017年 | 155篇 |
2016年 | 191篇 |
2015年 | 178篇 |
2014年 | 292篇 |
2013年 | 337篇 |
2012年 | 509篇 |
2011年 | 547篇 |
2010年 | 350篇 |
2009年 | 311篇 |
2008年 | 442篇 |
2007年 | 465篇 |
2006年 | 428篇 |
2005年 | 310篇 |
2004年 | 258篇 |
2003年 | 179篇 |
2002年 | 143篇 |
2001年 | 31篇 |
2000年 | 7篇 |
1999年 | 12篇 |
1998年 | 25篇 |
1997年 | 13篇 |
1996年 | 8篇 |
1995年 | 7篇 |
1994年 | 14篇 |
1993年 | 2篇 |
1992年 | 3篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1984年 | 2篇 |
1979年 | 1篇 |
1975年 | 2篇 |
1969年 | 1篇 |
排序方式: 共有6372条查询结果,搜索用时 15 毫秒
41.
Mia Faerch Marie K. Schroeder Birgitte T. Mahler Jane H. Christensen Konstantinos Kamperis Soren Rittig 《Scandinavian journal of clinical and laboratory investigation》2018,78(1-2):114-119
The synthetic AVP analogue 1-desamino-8-d-arginine-vasopressin (dDAVP) is used for treatment of polyuric disorders. Lack of commercially available assays limits the usefulness of dDAVP as a diagnostic tool in the assessment of renal concentrating capacity. We aimed to develop a specific radioimmunoassay (RIA) for determination of plasma dDAVP (pdDAVP) in order to investigate the relationship between pdDAVP levels and urine osmolality (Uosm). Further, we aimed to determine the onset, duration, and maximum concentrating capacity following intravenous (i.v.) bolus dDAVP injection. The dDAVP assay was based on a well-established RIA for measurements of AVP. Fourteen healthy subjects (aged 15–18 years) participated. Blood and urine samples were collected prior to and after i.v. bolus of 0.03?µg/kg dDAVP. Diuresis and Uosm was measured for nine hours following dDAVP administration. PdDAVP and Uosm were analyzed.We established a specific RIA for the measurement of pdDAVP. All subjects reached maximal pdDAVP concentration (Cmax) 30 minutes following infusion, and a rise in Uosm after 60 minutes. Maximal Uosm varied between subjects, with no direct correlation to the achieved pdDAVP levels. We found no significant intra-individual variation between two dDAVP infusions and the effect was reproducible in terms of Cmax and maximal Uosm. We characterized the relationship between pdDAVP and Uosm after dDAVP bolus injection in healthy adolescents using our dDAVP assay. Maximal Uosm achieved correlated with the baseline Uosm levels and seemed unrelated to achieved pdDAVP levels. The urine concentrating response was maintained at least eight hours. 相似文献
42.
Adamos-Konstantinos Konstantinou Konstantinos Bonotis Maria Sokratous Vasileios Siokas Efthimios Dardiotis 《Archives of Psychiatric Nursing》2018,32(3):449-456
Background
Job burnout is one of the most serious occupational health hazards, especially, among mental health nurses. It has been attributed among others to staff shortages, health service changes, poor morale and insufficient employee participation in decision-making.Aim
The aim of this study was to measure burnout among mental health nurses, investigate relations between burnout and organizational factors and examine potential predictors of nurses' burnout. Specifically, this study aimed to investigate whether role conflict, role ambiguity, organizational commitment and subsequent job satisfaction could predict each of the three dimensions of burnout.Design/methodology/approach
During current cross sectional, the survey was administered to 232 mental health nurses, employed in four private psychiatric clinics in the region of Larissa, Thessaly, Greece in May 2015. Our findings were based on the responses to 78 usable questionnaires. Different statistical analyses, such as correlation analyses, regression analyses and analyses of variance were performed in order to explore possible relations.Findings
High emotional exhaustion (EE) accounted for 53.8% of the sample, while high depersonalization (DP) and high personal accomplishment (PA) accounted for 24.4% and 25.6%, respectively. The best predictors of burnout were found to be role conflict, satisfaction with workload, satisfaction with training, role ambiguity, satisfaction with pay and presence of serious family issues.Practical implications
These findings have implications for organizational and individual interventions, indicating that mental health nurses' burnout could be reduced, or even prevented by team building strategies, training, application of operation management, clear instructions and psychological support. 相似文献43.
Gkiouras Konstantinos Grammatikopoulou Maria G. Simopoulou Theodora Daniil Zoe Bogdanos Dimitrios P. 《Clinical rheumatology》2021,40(8):3379-3380
Clinical Rheumatology - 相似文献
44.
Aimo Alberto Pateras Konstantinos Stamatelopoulos Kimon Bayes-Genis Antoni Lombardi Carlo Mario Passino Claudio Emdin Michele Georgiopoulos Georgios 《Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy》2021,35(5):1067-1076
Cardiovascular Drugs and Therapy - Sacubitril/valsartan, vericiguat, and the sodium-glucose co-transporter-2 inhibitors (SGLT2i) dapagliflozin and empagliflozin proved effective in phase 3 trials... 相似文献
45.
Clinical Rheumatology - Systemic sclerosis is a debilitating autoimmune disease with unknown pathogenesis. The clinical phenotype of fibrosis is preceded by vascular and immunologic aberrations.... 相似文献
46.
Bazoukis George Tyrovolas Konstantinos Letsas Konstantinos P. Vlachos Konstantinos Radford Danny Chung Cheuk To Liu Tong Efremidis Michael Tse Gary Baranchuk Adrian 《Heart failure reviews》2022,27(6):2067-2076
Heart Failure Reviews - Left ventricular non-compaction cardiomyopathy (LVNC) is a congenital heart disease with autosomal dominant inheritance. This review aims to summarize the existing data... 相似文献
47.
Ultralow temperature cryoablation: Safety and efficacy of preclinical atrial and ventricular lesions
Felix Bourier MD Masateru Takigawa MD PhD Anna Lam MD Konstantinos Vlachos MD F. Daniel Ramirez MD MSc Claire A. Martin MD Antonio Frontera MD PhD Takeshi Kitamura MD Josselin Duchateau MD Thomas Pambrun MD Nicolas Derval MD Arnaud Denis MD Jerry Cox MD David Cabrita MD Alexander Babkin PhD Marion Constantin MA Pierre Jais MD Frédéric Sacher MD PhD Rémi Dubois MD PhD Oliver Bernus PhD Michel Haissaguerre MD Mélèze Hocini MD 《Journal of cardiovascular electrophysiology》2021,32(3):570-577
48.
Theodorou Daphne J. Theodorou Stavroula J. Georgiadis Georgios Papakostidis Konstantinos 《Emergency radiology》2022,29(1):219-223
Emergency Radiology - Carpal scaphoid fracture is rare in children and is important to recognize early because of an increased risk for serious complications including non-union, avascular... 相似文献
49.
50.
Elefsiniotis IS Pantazis KD Ilias A Pallis L Mariolis A Glynou I Kada H Moulakakis A 《European journal of gastroenterology & hepatology》2004,16(6):593-598
OBJECTIVE: Tamoxifen induced hepatotoxicity has not been investigated in breast cancer patients with pre-existing liver steatosis. The aim of our study was to investigate the most common predisposing factors for non-alcoholic fatty liver disease in breast cancer patients with liver steatosis, treated with adjuvant tamoxifen therapy, in order to evaluate their role in the appearance of tamoxifen induced hepatotoxicity. METHODS: Clinical and laboratory evaluation, including an oral glucose tolerance test, was done in 60 women with breast cancer and liver steatosis before the beginning of adjuvant tamoxifen treatment and every 6 months during treatment. Tamoxifen induced hepatotoxicity was defined as abnormal liver function tests during tamoxifen treatment whereas these test results were below the normal range at baseline control. Statistical evaluation of data was performed using parametric methodology (the chi-squared test, and Student's t-test, P < 0.05). RESULTS: Twenty-six patients (43.3%) exhibited tamoxifen induced hepatotoxicity (group A) whereas 34 (56.7%) did not (group B). The mean overall follow-up period for the whole group was 37.5 months (SD 27.8, range 6-120 months) and did not differ between the two groups (P = 0.055). There was significant statistical difference in body mass index (BMI) and baseline fasting glucose, cholesterol and triglyceride levels between the two groups. Eighteen of 26 patients (69.2%) from group A had impaired glucose tolerance compared with only 8/34 patients (23.5%) from group B (P < 0.001), a finding observed even in BMI matched patients from the two groups (62.5% vs 12.5%, P = 0.002). CONCLUSIONS: Tamoxifen induced hepatotoxicity is observed in a great proportion of breast cancer patients with pre-existing liver steatosis, especially those with higher BMI and higher glucose and lipid levels at baseline control. Glucose intolerance before the beginning of tamoxifen treatment seems to be a predictor of the hepatotoxicity, unrelated to baseline BMI. 相似文献