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131.
Lia?L?Lewis-XimenezEmail author Kycia?MR?do ó Cleber?F?Ginuino Jucimara?C?Silva Hermann?G?Schatzmayr Sherri?Stuver Clara?FT?Yoshida 《BMC public health》2002,2(1):26
Background
Despite international efforts to prevent hepatitis B virus (HBV) infection through global vaccination programs, new cases are still being reported throughout the world. 相似文献132.
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Schell U; Wienberg J; Kohler A; Bray-Ward P; Ward DE; Wilson WG; Allen WP; Lebel RR; Sawyer JR; Campbell PL; Aughton DJ; Punnett HH; Lammer EJ; Kao FT; Ward DC; Muenke M 《Human molecular genetics》1996,5(2):223-229
Holoprosencephaly (HPE) is a common developmental defect involving the
brain and face in humans. Cytogenetic deletions in patients with HPE have
localized one of the HPE genes (HPE2) to the chromosomal region 2p21. Here
we report the molecular genetic characterization of nine HPE patients with
cytogenetic deletions or translocations involving 2p21. We have determined
the parental origin of the deleted chromosomes and defined the HPE2
critical region between D2S119 and D2S88/D2S391. As a first step towards
cloning the HPE2 gene which is crucial for normal brain development we have
constructed a YAC contig which spans the smallest region of deletion
overlap. Several of these YACs could be identified which span three
different 2p21 breakpoints in HPE patients. These YACs narrow the HPE2
critical region to less than 1 Mb and are now being further analyzed to
identify the gene causing holoprosencephaly on chromosome 2.
相似文献
136.
We present cell cycling and functional evidence that the CD34+CD38- immunophenotype can be used to define a rare and primitive subpopulation of progenitor cells in umbilical cord blood. CD34+CD38- cells comprise 0.05% +/- 0.08% of the mononuclear cells present in cord blood. Cell cycle analysis with the fluorescent DNA stain 7- aminoactinomycin D showed that the percentage of CD34+ cells in cycle directly correlated with increasing CD38 expression. CD34+CD38- cord blood cells were enriched for long-term culture-initiating cells (LTCIC; cells able to generate colony-forming unit-cells [CFU-C] after 35 to 60 days of coculture with bone marrow stroma) relative to CD34+CD38- cells. In an extended LTCIC assay, CD34+CD38- cells were able to generate CFU-C between days 60 and 100, clearly distinguishing them from CD34+CD38+ cells that did not generate CFU-C beyond day 40. When plated as single cells, onset of clonal proliferation was markedly delayed in a subpopulation of CD34+CD38- cells; clones (defined as > 100 cells) appeared after 60 days of culture in 2.9% of CD34+CD38- cells. In contrast, 100% of CD34+CD38+ cells formed clones by day 21. Although the CD34+CD38- immunophenotype defines highly primitive populations in both bone marrow and cord blood, important functional differences exist between the two sources. CD34+CD38- cord blood cells have a higher cloning efficiency, proliferate more rapidly in response to cytokine stimulation, and generate approximately sevenfold more progeny than do their counterparts in bone marrow. 相似文献