全文获取类型
收费全文 | 2344篇 |
免费 | 124篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 20篇 |
儿科学 | 21篇 |
妇产科学 | 37篇 |
基础医学 | 267篇 |
口腔科学 | 86篇 |
临床医学 | 123篇 |
内科学 | 716篇 |
皮肤病学 | 11篇 |
神经病学 | 131篇 |
特种医学 | 116篇 |
外科学 | 339篇 |
综合类 | 30篇 |
预防医学 | 72篇 |
眼科学 | 143篇 |
药学 | 101篇 |
肿瘤学 | 262篇 |
出版年
2023年 | 16篇 |
2022年 | 28篇 |
2021年 | 54篇 |
2020年 | 25篇 |
2019年 | 39篇 |
2018年 | 45篇 |
2017年 | 32篇 |
2016年 | 48篇 |
2015年 | 49篇 |
2014年 | 70篇 |
2013年 | 63篇 |
2012年 | 108篇 |
2011年 | 110篇 |
2010年 | 60篇 |
2009年 | 51篇 |
2008年 | 120篇 |
2007年 | 144篇 |
2006年 | 136篇 |
2005年 | 116篇 |
2004年 | 116篇 |
2003年 | 101篇 |
2002年 | 89篇 |
2001年 | 73篇 |
2000年 | 63篇 |
1999年 | 60篇 |
1998年 | 21篇 |
1997年 | 26篇 |
1996年 | 37篇 |
1995年 | 23篇 |
1994年 | 15篇 |
1993年 | 23篇 |
1992年 | 53篇 |
1991年 | 55篇 |
1990年 | 39篇 |
1989年 | 41篇 |
1988年 | 38篇 |
1987年 | 52篇 |
1986年 | 40篇 |
1985年 | 41篇 |
1984年 | 23篇 |
1983年 | 17篇 |
1982年 | 11篇 |
1981年 | 23篇 |
1980年 | 7篇 |
1979年 | 15篇 |
1978年 | 10篇 |
1977年 | 14篇 |
1976年 | 7篇 |
1975年 | 6篇 |
1968年 | 5篇 |
排序方式: 共有2475条查询结果,搜索用时 15 毫秒
11.
12.
Using a questionnaire survey, we analyzed the relationship between the frequency of breast self-examination (BSE) and the
clinical stage and course of breast cancer in Japanese patients. BSE had been performed monthly by only 5.4% of the patients
(M group), occasionally by 35.4% (O group), and not at all by 59.2% (N group). There was a positive relationship between more
frequent BSE and an earlier clinical stage, the percentages of Tis/stage 0 and I for the M, O, and N groups being 83%, 44%,
and 36%, respectively (P<0.05). The mean maximum tumor diameters for the three groups were 1.7cm, 2.5cm, and 3.0cm, respectively. The tumor size in
the M and O groups was significantly smaller than that in the N group atP<0.01 andP<0.05, respectively. The percentages of patients in the M, O, and N groups who underwent breast-conserving therapy were 42%,
11%, and 19%, respectively, with patients who had performed monthly, BSE more frequently undergoing breast-conserving therapy
(P<0.05). At a median follow-up time of 34 months, 0%, 3.8%, and 7.6% of the patients from the M, O, and N groups, respectively,
had died of breast cancer, the overall survival curve of the M group being significantly better than that of the N group (P<0.01). This retrospective study suggests the positive correlation of BSE frequency with earlier detection, and a more favorable
clinical course in Japanese breast cancer patients. 相似文献
13.
14.
Kiyotaka KUROSE Toshikazu MASUMOTO S. M. Fazle AKBAR Kojiro MICHITAKA Norio HORIIKE Morikazu ONJI 《Digestive endoscopy》1997,9(1):34-37
Abstract: Fifty -two patients with primary biliary cirrhosis (PBC), 10 of whom were 65 years or older at the time of diagnosis, were investigated by laparo-scopy. Laparoscopic findings in these 10 patients were evaluated and compared with those in younger patients. The 10 cases were composed of nine females and one male, and two had been diagnosed as having symptomatic PBC with skin itching, while the remaining eight had asymptomatic PBC. Two, seven and one case were in Scheuer's stage I, II and III, respectively, and eight had chronic non-suppurative destructive cholangitis (CNSDC) on liver biopsy specimens. The majority of senescent PBC patients had typical findings of the early stage of PBC on the liver surface; mild undulations in nine and reddish patches in eight. The laparoscopic findings in senescent PBC were relatively mild. 相似文献
15.
Sadataka Inuzuka Takato Ueno Hideo Tateishi Takuji Torimura Michio Sata Kyuichi Tanikawa Masamichi Kojiro 《Pathology international》1994,44(5):391-397
Elevation of the serum angiotensin-converting enzyme (sACE) level and hepatic granulomas were found during a clinical relapse in a 22 year old patient with acute viral hepatitis type A (AVH-A). The serum transaminase level and sACE level remained high for more than 6 months. In the biopsied specimen of the liver, fibrous rings of granulomas composed of collagen types I, III, and V were observed. Furthermore, the localization of ACE was visible in the rough endoplasmic reticulum of epithelioid cells of granulomas in the liver under electron microscopy using the indirect immunoperoxidase method. These results suggest that granuloma cells in the liver caused by hepatitis A may be involved in ACE production. In addition, other diseases associated with the presence of granulomas in the liver, such as lymphoma, cytomegalovirus infection, visceral leishmaniasis, and lupoid hepatitis, were ruled out. However, the hepatic granulomas disappeared with the healing of AVH-A. In this regard, the present case is considered to be one of the very few cases of hepatic sarcoidosis. 相似文献
16.
Yosuke Morimitsu Hiroshi Tanaka Shigeaki Iwanaga Masamichi Kojiro 《Pathology international》1993,43(4):204-208
A rare case of an alveolar soft part sarcoma of the uterine cervix in an 8 year old girl is presented. The patient was admitted because of genital bleeding lasting for 7 months. A polypoid tumor, 2times1.5 cm in diameter, was found in her external uterine os and was surgically resected. Microscopically, the tumor consisted of a uniform sheet of tumor cells in the cytoplasm which contained granules and which were stained with periodic acid-Schiff, both before and after the diastase digestion. Alveolar arrangement of the tumor cells was manifested with reticulin silver impregnation. Dense, membrane bound granules were evident at an ultrastructural level in the cytoplasm of the tumor cells. An immunohistochemical examination demonstrated a positive reaction for anti-desmin, anti-myoglobin, anti-HHF35 and anti-neuron specific enolase in the cytoplasm. 相似文献
17.
A new recognisable syndrome in three sibs with congenital heart disease, round face with depressed nasal bridge, short stature, and developmental retardation. 下载免费PDF全文
We report three sibs with congenital heart disease, round face with depressed nasal bridge, small mouth, short stature, developmental retardation, relatively dark skin, and high axial triradius. The chromosomes of the three patients were normal and the parents were unrelated, healthy, and of normal intelligence. The mother denied infections, drinking, drug intake, or exposure to known teratogenic agents during each pregnancy. 相似文献
18.
T. Ohno M. Mizokami M. G. Saleh E. Orito K. -I. Ohba R. -R. Wu T. Koide C. J. Tibbs K. T. Nouri-Aria S. Tokudome R. Williams 《Archives of virology》1996,141(6):1101-1113
Summary We report here the nucleotide sequences of the core region of HCV isolates from Egyptian and Yemeni patients and the method for classifying these HCV isolates by phylogenetic analysis. Sequence comparison suggested that the genotypes of these isolates were the same. Preliminary phylogenetic analysis of the HCV core region indicated that the genotypes of both isolates were 1c. However, an additional phylogenetic tree of the HCV core region constructed using a greater number of HCV isolates than that used in the preliminary analysis and on the basis of alignment of nucleotide sequences in an appropriate length indicated that the genotypes of these isolates were 4 and not 1c. For a more detailed analysis, the nucleotide sequences of the HCV E1 region as well as the core region for the same Yemeni patient were determined. A phylogenetic tree of the E1 region confirmed that the genotype of the HCV isolate from the Yemeni patient was 4. These data indicate that even when classifying HCV isolates using phylogenetic analysis, the misclassification would occur if care is not taken regarding the number and sequence lengths of the isolates included in the analysis. 相似文献
19.
Hirokazu Taniguchi Kenjiro Hamamoto Takahiro Nagano Yuji Kishimoto Takashi Kimura Hideki Fujitake Kojiro Yasunaga 《Medical Electron Microscopy》1993,26(1):13-18
Ultrastructural myeloperoxidase (MPO) activity and myeloid-associated antigen (MyAg) expression were investigated in 12 adult
patients with acute lymphoblastic leukemia (ALL). Ultrastructural MPO was detected by 3 different methods. Immunophenotyping
was performed by flow cytometry, using a series of monoclonal antibodies. Ultrastructural MPO-positive blast cells were detected
in 6 patients (50%). In 5 of these 6 patients, the methods detecting both MPO and platelet peroxidase (PPO) activities found
MPO-positive blast cells more frequently than those detecting MPO activity alone. In 2 patients (17%), at least one kind of
MyAg was positive. Ultrastructural MPO activity was detected more frequently than MyAg expression in ALL patients. This method
of detecting PPO and MPO is recommended for detection of ultrastructural MPO-positive ALL. 相似文献
20.
Satoshi Muraki Masahiro Yamasaki Kojiro Ishii Kunio Kikuchi Kunihiro Seki 《European journal of applied physiology》1996,72(4):330-334
The purposes of the present study were to examine the response of the skin blood flux (SBF) in the paralyzed lower limbs of persons with spinal cord injury (PSCI) and to clarify the relationship between the SBF and core temperature during prolonged arm exercise. Eight male PSCI with lesions from T6 to L5 and six male control subjects (CS) participated in this study. The subjects rested for 60 min and then performed arm-cranking exercise at 20 W for 30 min at 25 °C. The tympanic membrane temperature (T
ty) and SBF in the anterior thigh (SBFT) and in the posterior calf (SBFC) were continuously measured throughout the experiment. The SBFC did not change in either PSCI or CS during the experiment. The SBFT in four PSCI with high lesions (T6 to T12), remained unchanged during exercise. The SBFT in the other four PSCI with low lesions (T12 to L5, SBFT+) began to elevate markedly when the T t, exceeded a threshold temperature of 36.69 °C. The pattern of increase of SBFT in SBFT+ was similar to that in CS, although onset of the increase in SBFT was delayed and the peak of SBFT during exercise was significantly lower in comparison with the CS. We consider that these differences between the SBFT+ and CS were largely attributable to the lowerT
ty in the former group, which took a prolonged time to reach the threshold of 36.69 °C. 相似文献