Ipsilateral projection from the subiculum to the retrosplenial cortex in the guinea pig

A projection from the subiculum to the retrosplenial cortex (area 29a and b) was studied by autoradiographic tracing of anterogradely transported proteins following injections of radioactive amino acids into ventral and dorsal parts of the subiculum. Only the dorsal parts of the subiculum projected to the retrosplenial cortex. The projection was exclusively ipsilateral, and topographically arranged along both the longitudinal septotemporal axis and the transverse plane of the subiculum. The termination in the retrosplenial cortex was confined to the relatively cell free superficial layer (lamina 1) and the underlying cell-rich layers (laminae 3–4). Between these two terminations a narrow zone (lamina 2) was only weakly labeled. The projection constitutes an output route for hippocampal activity in addition to the fimbria-fornix system and the subicular projections to the parahippocampal areas.     

Partial laryngectomy following irradiation

Partial laryngectomy after full course of irradiation was performed in 65 patients as a salvage for residual tumors and local recurrences. The results are reviewed and compared to results obtained by primary operation.     

Gelchromatographie,Versuche zur Strömungsdispersion mit radioaktivem Polystyrol

Experiments with mixtures of ¹⁴C-labelled monodisperse polystyrene and inactive polystyrene show, that in gel chromatography a molecularly nonuniform polymer acts like the sum from molecularly uniform samples.     

Hyperoxia-induced decrease in aortic accumulation of cholesterol in rabbits previously fed a cholesterol-enriched diet

Increasing the oxygen concentration in breathing air of rabbits from 21 to 34% for 16 weeks, starting immediately after discontinuing 8 weeks of cholesterol feeding, significantly reduced the accumulation of cholesterol in inner aorta in comparison to controls breathing normal atmospheric air.     

RENIN AND PRORENIN IN REPRODUCTIVE TISSUES DURING GESTATION IN PIGS AND CATTLE

1. High concentrations of prorenin and active renin were previously found in ovarian follicular fluid from cattle but not from pigs. In the present study female reproductive tissues and fluids from cattle and pigs during gestation were investigated to clarify a possible species difference in active renin and prorenin concentrations. 2. Very high concentrations of active renin but no prorenin were found in corpus luteum from both species. 3. Relatively low concentrations of active renin, in the same order as in maternal blood plasma, were found in myometrium, endometrium, placenta and fetal membranes from both species. Prorenin was undetectable in these tissues except for bovine myometrium and porcine endometrium in some animals. 4. The concentrations of active renin and prorenin in amnionic fluid from both species were below the maternal plasma values. In allantoic fluid the concentrations were higher than in amnionic fluid. 5. The plasma concentrations of active renin and prorenin did not change during gestation in pigs. This finding is in contrast to the observations in humans and does not support a systemic effect of prorenin during gestation. 6. The presence of renin in the reproductive tissues, especially the very high concentrations in the corpus luteum, indicates a local function of the renin-angiotensin system during gestation.     

Patellectomy—a 20-year follow-up

Twenty-seven patients with 28 patellectomies were re-examined after an average of 20 years. Twelve knees rated as excellent, ten as good and six as fair.

Even though 12 patients had strenuous work, only three patients had changed occupation. Quadriceps power was on average two-thirds that of the opposite limb. Radiographs showed incipient femoro-tibial arthrosis in four patients only.     

Mucosal growth and enzyme activity during the early phase of adaptation after jejunal bypass in the rat

Morphological variables and mucosal enzyme activities were measured in the bypassed and remaining parts of the small intestine 3, 7, and 14 days after a jejunal bypass operation. In the bypassed segment tissue mass, enzyme activity per unit intestinal length, and enzyme activity per unit DNA were gradually reduced. In sham-operated animals tissue mass increased, whereas enzyme activity per unit DNA was reduced. In the segment remaining in function, tissue mass increased, whereas enzyme activities decreased temporarily. In this part of the intestine, the changes were more or less parallel in bypassed and sham-operated animals. It may be concluded that the enzymatic changes are not correlated to the morphologic changes in the early phase of adaptation to intestinal bypass.     

Anaphylactic reaction to orthoiodohippurate

A case of an anaphylactic reaction following administration of ¹²⁵I- and ¹³¹I-o-iodohippurate in a 32-year-old woman is reported. The patient had a renography performed because of hematuria. She was known to react to an intravenous pyelography previously performed with an anaphylactic shock. The importance of reporting all adverse reactions to radiopharmaceuticals for central registration is stressed.     

The Action of Thioridazine and Promazine on Biological Membranes: Relationship between ATPase Inhibition and Membrane Stabilization

The effects of promazine and thioridazine on hypotonic haemolysis of human erythrocytes are compared with their effect on Na⁺-K⁺-ATPase of washed human erythrocyte ghosts. Promazine (5 × 10^-5 - 5 × 10^-4 M) and thioridazine (10^-5 - 10^-4 M) stabilize erythrocytes against hypotonic haemolysis, but have lytic effects at higher concentrations. Both drugs inhibit Na⁺-K⁺-ATPase of erythrocyte membranes. This inhibition is slight at drug concentrations which have a membrane-stabilizing action, but is complete and irreversible at lytic concentrations of the drugs. Promazine and thioridazine also inhibit Na⁺-K⁺-ATPase in a membrane fraction prepared from rat hearts. The relative order of potency of the two drugs in this respect does not reflect their relative potency as general cardiac depressants. It is concluded that Na⁺-K⁺-ATPase is not a primary target for the action of promazine and thioridazine in the rat heart. It is suggested that inhibition of Na⁺-K⁺-ATPase by these agents is secondary to more general alterations of the physical properties of the cell membrane.