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991.
Ron R Allison MD Gordon H Downie MD PhD Rosa Cuenca MD Xin-Hua Hu PhD Carter JH Childs MD Claudio H Sibata PhD 《Photodiagnosis and Photodynamic Therapy》2004,1(1):27-42
Photosensitizers in photodynamic therapy allow for the transfer and translation of light energy into a type II chemical reaction. In clinical practice, photosensitizers arise from three families—porphyrins, chlorophylls, and dyes. All clinically successful photosensitizers have the ability to a greater or lesser degree, to target specific tissues or their vasculature to achieve ablation. Each photosensitizer needs to reliably activate at a high enough light wavelength useful for therapy. Their ability to fluoresce and visualize the lesion is a bonus. Photosensitizers developed from each family have unique properties that have so far been minimally clinically exploited. This review looks at the potential benefits and consequences of each major photosensitizer that has been tried in a clinical setting. 相似文献
992.
993.
KL Chal BSc JH Stacey MSc GE Sacks MB ChB MRCGP 《International journal of clinical practice》1995,49(2):73-77
SUMMARY A 4-week study involving 354 patients with the symptoms of gastro-oesophageal reflux disease was conducted to assess the effect of ranitidine (as effervescent tablets) on their relief and quality of life. All patients received 150 mg bd for 2 weeks, with those responding to treatment continuing on the same dosage for a further 2-week period and 'non-responders' having the dosage increased to 150 mg qds for a further 2 weeks. Quality of life and symptom assessments were carried out at 0, 2 and 4 weeks. Two weeks' treatment with ranitidine 150 mg bd was effective at controlling the GORD symptoms in 78% of patients. A 4-week treatment with either 150 mg bd or qds controlled the symptoms in 85% of patients. All patients had significant improvements in all dimensions of their quality of life over the study period. 相似文献
994.
Supraglottic subtotal laryngectomy (SSL) is a radical, yet voice-conserving, surgical procedure commonly performed for carcinoma of the supraglottic larynx. The pharyngograms and computed tomographic (CT) scans of 35 patients obtained after SSL were evaluated retrospectively. These examinations reliably demonstrated the changes in anatomy caused by removal of the epiglottis, aryepiglottic folds, and false vocal cords. Fourteen patients had documented recurrence of cancer; five mucosal, nine extramucosal. Three of five macroscopic mucosal recurrences in the larynx/pharynx were detected on the barium pharyngograms; the two mucosal lesions not seen were in the base of the tongue and tonsillar fossa. CT enabled detection of five of five recurrences and was superior to pharyngography in demonstrating the soft-tissue extent of disease. CT findings mimicking recurrence were seen in two patients: one with diffuse histiocytic lymphoma; the second, with benign hyperkeratosis. Barium and CT examinations are useful adjuncts to the clinical examination in detecting recurrent squamous cell carcinoma in patients following SSL. 相似文献
995.
The purpose of this paper is to study the alterations produced by pregnancy in women who submitted to breast reduction. We studied a group of 50 women younger than 32 years of age who submitted to this operation and had an incidence of pregnancy of 22%. The alterations of ponderable weight and increased breast volume had no relation to pregnancy. Breast ptosis was twice as frequent in the group of women who became pregnant than in the group of women who did not become pregnant. Breast-feeding was normal. We found a large percentage of women were gratified by the results of the operation (92%), and those not fully satisfied did not report any disturbances in their sexual life. 相似文献
996.
Anthony JH Hall FRACO Mark J. Renehan MB BS C Alex Harper FRACO 《Clinical & experimental ophthalmology》1993,21(1):29-30
The biological mothers of 23 patients presenting with acute chorioretinal toxoplasmosis had sera screened for the presence of antibodies to Toxoplasma gondii. Twenty-two of the mothers (96%) had positive serology and one (4%) had negative serology. This is consistent with the hypothesis that most cases of ocular toxoplasmosis are congenital in origin, but indicates that some cases are due to acquired toxoplasmosis. 相似文献
997.
998.
Duplex Doppler US of the kidney: differentiation of obstructive from nonobstructive dilatation 总被引:4,自引:0,他引:4
Distinction of the obstructed from the nonobstructed dilated renal collecting system is a difficult problem often requiring interventional procedures and pressure measurements. The authors prospectively performed duplex Doppler ultrasound (US) evaluations in 21 kidneys (obstructed, n = 14; nonobstructed, n = 7) immediately before percutaneous nephrostomy. In addition, ten of the obstructed kidneys were evaluated with follow-up Doppler US after percutaneous nephrostomy. Renal obstruction caused a change in the Doppler waveform detected by means of the resistive index (RI). Thirteen of the 14 obstructed kidneys had a RI value greater than .70, while none of the nonobstructed kidneys had a RI value exceeding .70. Relief of the obstruction resulted in a reduced RI; in nine of ten kidneys, the RI was less than or equal to .70 (similar to that of the nonobstructed kidneys). When a dilated collecting system is being imaged, additional evaluation with duplex Doppler US may help distinguish obstructed from nonobstructed dilatation, which may be of particular benefit in patients with conditions that usually predispose them to collecting system dilatation. 相似文献
999.
1000.