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101.
Anna M. R. Hayes Linda Tsan Alicia E. Kao Grace M. Schwartz La Dcarie-Spain Logan Tierno Lauer Molly E. Klug Lindsey A. Schier Scott E. Kanoski 《Nutrients》2022,14(22)
Children frequently consume beverages that are either sweetened with sugars (sugar-sweetened beverages; SSB) or low-calorie sweeteners (LCS). Here, we evaluated the effects of habitual early life consumption of either SSB or LCS on energy balance later during adulthood. Male and female rats were provided with chow, water, and a solution containing either SSB (sucrose), LCS (acesulfame potassium (ACE-K) or stevia), or control (no solution) during the juvenile and adolescent periods (postnatal days 26–70). SSB or LCS consumption was voluntary and restricted within the recommended federal daily limits. When subsequently maintained on a cafeteria-style junk food diet (CAF; various high-fat, high-sugar foods) during adulthood, ACE-K-exposed rats demonstrated reduced caloric consumption vs. the controls, which contributed to lower body weights in female, but not male, ACE-K rats. These discrepant intakes and body weight effects in male ACE-K rats are likely to be based on reduced gene expression of thermogenic indicators (UCP1, BMP8B) in brown adipose tissue. Female stevia-exposed rats did not differ from the controls in terms of caloric intake or body weight, yet they consumed more SSB during CAF exposure in adulthood. None of the SSB-exposed rats, neither male nor female, differed from the controls in terms of total adult caloric consumption or body weight measures. The collective results reveal that early life LCS consumption alters sugar preference, body weight, and gene expression for markers of thermogenesis during adulthood, with both sex- and sweetener-dependent effects. 相似文献
102.
Prof. Dr. Ferd Klug 《Pflügers Archiv : European journal of physiology》1902,92(6-7):281-292
Ohne Zusammenfassung 相似文献
103.
W. J. Klug 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》1928,208(1):33-40
Ohne Zusammenfassung
Mit 2 Abbildungen.
Eingegangen: 19. 11. 27. 相似文献
104.
105.
Ferd Klug 《Pflügers Archiv : European journal of physiology》1895,60(1-2):43-70
Ohne Zusammenfassung 相似文献
106.
107.
108.
109.
Matthias Schmidt Klemens Scheidhauer Cordelia Luyken Eberhard Voth Gerhard Hildebrandt Norfrid Klug Harald Schicha 《European journal of nuclear medicine and molecular imaging》1998,25(7):675-686
The somatostatin analogue [111In-DTPA-d-Phe1]-octreotide (111In-octreotide) allows scintigraphic visualization of somatostatin receptor-expressing tissue. While it is well known that
a large variety of tissues express somatostatin receptors and 111In-octreotide scintigraphy has a clearly defined role in various neuroendocrine diseases, the clinical value of 111In-octreotide scintigraphy in brain tumours is still under clinical investigation. In 124 patients with 141 brain lesions
(63 meningiomas, 24 pituitary adenomas, 10 gliomas WHO class I and II, 12 gliomas WHO class III and IV, 11 neurinomas and
2 neurofibromas, 7 metastases and 12 other varieties: three non-Hodgkin B-cell lymphomas, two epidermoids, one abscess, one
angioleiomyoma, one chordoma, one haemangiopericytoma, one osteosarcoma, one plasmacytoma and one pseudocyst), 111In-octreotide scintigraphy was performed 4–6 and 24 h after i.v. injection of 110–220 MBq 111In-octreotide. Planar images of the head in four views with a 128×128 matrix and single-photon emission tomographic images
(64×64 matrix) were acquired, and lesions were graded according to qualitative tracer uptake. Fifty-nine of the 63 meningiomas
showed moderate to intense tracer uptake. Nine of 24 pituitary adenomas were visible; the remaining 15 did not show any tracer
uptake. None of the class I and II gliomas with an intact blood-brain barrier were detected whereas 11/12 class III and IV
gliomas showed 111In-octreotide uptake. None of the neurinomas or neurofibromas were positive. Five of seven metastases were classified as positive,
as were the osteosarcoma, two of three non-Hodgkin B-cell lymphomas, one abscess, one angioleiomyoma, one chordoma and one
haemangiopericytoma. The other varieties (one non-Hodgkin B-cell lymphoma, two epidermoids, one plasmacytoma and one pseudocyst)
did not show 111In-octreotide uptake. The results demonstrate that a large variety of intracranial lesions express somatostatin receptors
and therefore can be visualized by [111In-DTPA-d-Phe1]-octreotide scintigraphy. This technique can be valuable in the differentiation between meningiomas and pituitary adenomas,
based on qualitative tracer uptake. [111In-DTPA-d-Phe1]-octreotide scintigraphy allows differentiation between meningiomas and neurinomas or neurofibromas and therefore provides
complementary information to computed tomography or magnetic resonance imaging. Furthermore, this technique allows differentiation
between scar tissue and recurrent meningiomas postoperatively and can help in non-invasive tumour differentiation of multiple
intracranial lesions, which can be of value in defining the most adequate therapeutic strategy.
Received 1 December 1997 and in revised form 17 March 1998 相似文献
110.
C Einspieler W N L?scher R Kurz K Rosanelli H Rosegger I Bachler E M Klug F Reiterer R Schenkeli R Kerbl 《Klinische P?diatrie》1992,204(2):88-91
In a prospective study (1988-1990) the SIDS risk questionnaire SRFB was applied to 6000 infants born in the Department of Obstetrics, University Hospital Graz. In all infants at an increased statistical risk for SIDS a standardized intervention including pediatric and polysomnographic investigations was performed. As a result the SIDS incidence decreased from an average of 1.92 per thousand lifeborns (1984-1988) to 0.83 per thousand lifeborns (1989-1990) in our test group, which means a striking reduction of the SIDS incidence by 57%. In addition to this effect, the intensified information of parents and physicians about possible signs of an increased risk for SIDS lead to a general reduction of SIDS in Styria. 相似文献