全文获取类型
收费全文 | 1285篇 |
免费 | 68篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 41篇 |
妇产科学 | 11篇 |
基础医学 | 115篇 |
口腔科学 | 10篇 |
临床医学 | 68篇 |
内科学 | 363篇 |
皮肤病学 | 14篇 |
神经病学 | 81篇 |
特种医学 | 56篇 |
外科学 | 228篇 |
综合类 | 6篇 |
预防医学 | 42篇 |
眼科学 | 43篇 |
药学 | 60篇 |
中国医学 | 2篇 |
肿瘤学 | 215篇 |
出版年
2023年 | 7篇 |
2022年 | 28篇 |
2021年 | 40篇 |
2020年 | 18篇 |
2019年 | 26篇 |
2018年 | 33篇 |
2017年 | 16篇 |
2016年 | 25篇 |
2015年 | 25篇 |
2014年 | 41篇 |
2013年 | 51篇 |
2012年 | 57篇 |
2011年 | 58篇 |
2010年 | 33篇 |
2009年 | 27篇 |
2008年 | 46篇 |
2007年 | 47篇 |
2006年 | 54篇 |
2005年 | 68篇 |
2004年 | 59篇 |
2003年 | 65篇 |
2002年 | 82篇 |
2001年 | 60篇 |
2000年 | 41篇 |
1999年 | 45篇 |
1998年 | 18篇 |
1997年 | 12篇 |
1996年 | 10篇 |
1995年 | 13篇 |
1994年 | 17篇 |
1993年 | 7篇 |
1992年 | 16篇 |
1991年 | 17篇 |
1990年 | 25篇 |
1989年 | 20篇 |
1988年 | 22篇 |
1987年 | 17篇 |
1986年 | 25篇 |
1985年 | 24篇 |
1984年 | 17篇 |
1983年 | 9篇 |
1982年 | 3篇 |
1981年 | 6篇 |
1980年 | 3篇 |
1979年 | 4篇 |
1975年 | 4篇 |
1974年 | 3篇 |
1968年 | 2篇 |
1966年 | 2篇 |
1965年 | 3篇 |
排序方式: 共有1358条查询结果,搜索用时 15 毫秒
21.
Tsujikawa Kenji Okada Yuki Segawa Hiroki Yamamuro Tadashi Kuwayama Kenji Kanamori Tatsuyuki Iwata Yuko T. 《Forensic Toxicology》2022,40(1):125-131
Forensic Toxicology - Various forms of cannabidiol (CBD)-containing products are sold in Japan. CBD is easily converted to mixtures of ?9-tetrahydrocannabinol (?9-THC) and its isomer,... 相似文献
22.
23.
Tanaka Y Matsumoto I Iwanami K Inoue A Minami R Umeda N Kanamori A Ochiai N Miyazawa K Sugihara M Hayashi T Goto D Ito S Sumida T 《Modern rheumatology / the Japan Rheumatism Association》2012,22(1):128-136
Human six-transmembrane epithelial antigen of prostate4 (STEAP4), an ortholog of mouse tumor necrosis factor-α-induced adipose-related protein (TIARP), plays a role in tumor necrosis factor (TNF)-dependent arthritis models. However, its role in rheumatoid arthritis (RA) is still obscure. This study explored such a role for STEAP4. The expressions of STEAP4, TNFα, and IL-6 were compared in synovia of RA and osteoarthritis patients. STEAP4 induction was examined in TNFα-stimulated fibroblast-like synoviocytes (FLS) in vitro. FLS (with/without TNFα stimulation) were also analyzed for IL-6 expression after STEAP4 knockdown, using siRNA or transfection with STEAP4-plasmid DNA. IL-8, cell proliferation, and apoptosis were also evaluated in STEAP4-overexpressing FLS. The expression of STEAP4 in joints correlated with TNFα expression, specifically in RA synovium. In the cultured FLS, STEAP4 protein expression was augmented by TNFα activation, and localized in endosomal/lysosomal compartments. STEAP4 downregulation by siRNA enhanced the expression of IL-6 mRNA, while STEAP4 overexpression suppressed IL-6 and IL-8 expression, inhibited cell proliferation, and induced apoptosis via caspase-3. The results indicated that human STEAP4 is regulated by TNFα in synovium, where it controls IL-6 secretion and proliferation of FLS, suggesting that STEAP4 might potentially suppress the pathogenesis of TNFα-induced arthritis such as RA. 相似文献
24.
Koji Yamada Yutaka Kanamori Hideaki Tanaka Akihiro Fujino Toshihiko Watanabe Noriko Takeda Masataka Takahashi Waka Yamada Hideo Ishihama 《Surgery today》2013,43(11):1330-1332
Congenital prepubic sinus is a rare congenital anomaly situated in the midline of the lower abdomen. We report a case of congenital prepubic sinus, closely associated with a urachal remnant. Preoperative magnetic resonance imaging showed clearly that the sinus tracked the urachus caudally. This finding supports the theory that the anomaly is caused by abnormal remnant tissue originating from the cloacal membrane, which tracks the allantois duct caudally along with fetal longitudinal growth. 相似文献
25.
Murakoshi Miki Kamei Koichi Ogura Masao Sato Mai Nada Taishi Suzuki Ryutaro Kamae Chikako Nishi Kentaro Kanamori Toru Nagano China Nozu Kandai Nakanishi Koichi Iijima Kazumoto 《Clinical and experimental nephrology》2022,26(2):162-169
Clinical and Experimental Nephrology - The management of congenital nephrotic syndrome of the Finnish type (CNF) is challenging. It is difficult to withdraw intravenous albumin infusions, resulting... 相似文献
26.
Toshihiko Watanabe MD Reiko Horikawa MD Hidekazu Masaki MD Takako Yoshioka MD Kimikazu Matsumoto MD Yutaka Kanamori MD 《Pediatric blood & cancer》2016,63(7):1293-1295
Squamous cell carcinoma of the anal canal in children is rare. To date, the etiology and outcome of this condition have been not fully understood. Here, we report an 11‐year‐old child with anal canal cancer who had concomitant disorders of sex development. Radiotherapy followed by salvage surgery achieved disease‐free survival of 3 years. Since overexpression of cell cycle regulatory protein p16 was immunohistochemically evident in tumor tissue, human papillomavirus infection was considered as a causative factor in the carcinogenesis. 相似文献
27.
28.
Deverick J Anderson Luke F Chen David J Weber Rebekah W Moehring Sarah S Lewis Patricia F Triplett Michael Blocker Paul Becherer J Conrad Schwab Lauren P Knelson Yuliya Lokhnygina William A Rutalo Hajimori Kanamori Marina F Gergen Daniel J Sexton for the CDC Prevention Epicenters Program 《中华医院感染学杂志》2018,(12)
中文:背景患者入院后可从不当消毒的环境表面获得多药耐药菌和艰难梭菌。本文确定了3种强化的终末消毒(入住同一病房的两名患者之间的消毒)策略,对感染耐甲氧西林金黄色葡萄球菌(MRSA)、耐万古霉素肠球菌(VRE)、艰难梭菌(CD)和多重耐药不动杆菌的影响。方法本文在美国东南部的9家医院开展了一项务实的、集群-随机、交叉研究。凡曾有感染或定植目标细菌感染患者居住过的病房,患者出院后随机采取4种消毒策略中的一种方法进行终末消毒:对照(季胺盐类消毒剂消毒,但凡遇到CD采用含氯消毒剂);UV(季胺盐类+UV-C消毒,但凡遇到CD采用含氯消毒剂+UV-C);含氯消毒剂;含氯消毒剂+UV-C。凡入住目标病房的患者被列为暴露人群。这4种终末消毒方法分别在每家医院连续实施7个月的周期。本文随机设计这几种消毒策略在每家医院内的实施顺序(1:1:1:1)。主要产出的结果是,观察暴露患者中目标细菌的感染的发生或定植情况,以及ITT人群中暴露患者CD感染发生率。本研究ClinicalTrials.gov注册编号:NCT01579370。结果共有31 226名患者暴露,其中21 395(69%)符合标准,包括4 916名对照组,5 178名UV组,5 438名含氯消毒剂组,以及5 863名含氯消毒剂+UV组。在对照组中,22 426个暴露日中有115名患者发生目标细菌的感染(51.3/10000暴露日)。在标准清洁策略的基础上增加UV消毒的暴露患者,其目标细菌感染的发生率明显较低(n=76;33.9/10 000暴露日;RR:0.70,95%CI:0.50~0.988;P=0.036)。含氯消毒剂组(n=101;41.6/10 000暴露日;RR:0.85,95%CI:0.69~1.04;P=0.116),或含氯消毒剂+UV组患者(n=131;45.6/10 000暴露日;RR:0.91,95%CI:0.76~1.09;P=0.303)的目标细菌的感染率,其差异无统计学意义。同样,在含氯消毒剂的基础上增加UV消毒,暴露患者中CD感染率也没有发生改变((n=38 vs 36;30.4 vs 31.6/10 000暴露日;RR:1.0,95%CI:0.57-1.75;P=0.997)。解释污染的医疗机构环境是获得病原微生物的重要来源;强化终末消毒可以降低这一风险。 相似文献
29.
Toyoda H Kumada T Kiriyama S Sone Y Tanikawa M Hisanaga Y Kanamori A 《Intervirology》2007,50(4):241-244
30.
Different localizations of drugs simultaneously administered in a strand of hair by micro‐segmental analysis 下载免费PDF全文
Kenji Kuwayama Hajime Miyaguchi Yuko T. Iwata Tatsuyuki Kanamori Kenji Tsujikawa Tadashi Yamamuro Hiroki Segawa Hiroyuki Inoue 《Drug testing and analysis》2018,10(4):750-760
Segmental hair analysis is used to estimate the time of drug intake at monthly precision in drug‐related crimes. Previously, we advanced this analytical method to specify the day of drug intake by cutting a strand of hair into 0.4‐mm segments, which correspond to daily hair growth. Herein, we investigated the distributions of 7 compounds in a strand of hair using micro‐segmental analysis. Several strands of hair were collected 33.1?229.4 days after subjects were administered 4 pharmaceutical products that contained 10 drugs in single doses within 32 hours. The administered drugs and resulting metabolites were extracted from 0.4‐mm hair segments and quantified using liquid chromatography–tandem mass spectrometry. Acidic and neutral compounds were detected at low amounts in any of the hair segments analyzed. Epinastine, fexofenadine, dihydrocodeine, chlorpheniramine, and the chlorpheniramine metabolite, desmethylchlorpheniramine each was localized to 2 regions within a strand of hair. By contrast, methylephedrine and its metabolite, ephedrine, each was localized to only a region. Among 20 individual strands of hair associated with different subjects and head regions, few differences in the shapes of drug concentration–hair segment curves for each compound were detected. Our data indicated that 2 mechanisms for drug uptake into hair can operate depending on drug properties and that co‐administered drugs can be localized to different regions in a strand of hair. Micro‐segmental analysis may aid in the identification of the day of drug intake and help to elucidate the mechanisms of drug uptake into hair. 相似文献