全文获取类型
收费全文 | 962篇 |
免费 | 26篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 23篇 |
妇产科学 | 42篇 |
基础医学 | 135篇 |
口腔科学 | 14篇 |
临床医学 | 73篇 |
内科学 | 173篇 |
皮肤病学 | 15篇 |
神经病学 | 80篇 |
特种医学 | 12篇 |
外科学 | 112篇 |
预防医学 | 72篇 |
眼科学 | 12篇 |
药学 | 106篇 |
中国医学 | 3篇 |
肿瘤学 | 119篇 |
出版年
2023年 | 5篇 |
2022年 | 8篇 |
2021年 | 21篇 |
2020年 | 8篇 |
2019年 | 8篇 |
2018年 | 22篇 |
2017年 | 12篇 |
2016年 | 12篇 |
2015年 | 23篇 |
2014年 | 27篇 |
2013年 | 52篇 |
2012年 | 59篇 |
2011年 | 59篇 |
2010年 | 30篇 |
2009年 | 34篇 |
2008年 | 57篇 |
2007年 | 68篇 |
2006年 | 65篇 |
2005年 | 67篇 |
2004年 | 46篇 |
2003年 | 60篇 |
2002年 | 72篇 |
2001年 | 12篇 |
2000年 | 8篇 |
1999年 | 14篇 |
1998年 | 11篇 |
1997年 | 9篇 |
1996年 | 18篇 |
1995年 | 12篇 |
1994年 | 7篇 |
1993年 | 9篇 |
1992年 | 11篇 |
1991年 | 5篇 |
1990年 | 3篇 |
1989年 | 7篇 |
1988年 | 12篇 |
1987年 | 3篇 |
1986年 | 8篇 |
1985年 | 4篇 |
1984年 | 4篇 |
1983年 | 4篇 |
1981年 | 3篇 |
1980年 | 3篇 |
1979年 | 4篇 |
1978年 | 3篇 |
1970年 | 1篇 |
1969年 | 1篇 |
1963年 | 1篇 |
1961年 | 1篇 |
1956年 | 1篇 |
排序方式: 共有995条查询结果,搜索用时 15 毫秒
31.
32.
Kiyomi Tsuyuki Jessica D. Gipson Regina Maria Barbosa Lianne A. Urada Donald E. Morisky 《Culture, health & sexuality》2018,20(9):1006-1022
Syndemic Zika virus, HIV and unintended pregnancy call for an urgent understanding of dual method (condoms with another modern non-barrier contraceptive) and consistent condom use. Multinomial and logistic regression analysis using data from the Pesquisa Nacional de Demografia e Saúde da Criança e da Mulher (PNDS), a nationally representative household survey of reproductive-aged women in Brazil, identified the socio-demographic, fertility and relationship context correlates of exclusive non-barrier contraception, dual method use and condom use consistency. Among women in marital and civil unions, half reported dual protection (30% condoms, 20% dual methods). In adjusted models, condom use was associated with older age and living in the northern region of Brazil or in urban areas, whereas dual method use (versus condom use) was associated with younger age, living in the southern region of Brazil, living in non-urban areas and relationship age homogamy. Among condom users, consistent condom use was associated with reporting Afro-religion or other religion, not wanting (more) children and using condoms only (versus dual methods). Findings highlight that integrated STI prevention and family planning services should target young married/in union women, couples not wanting (more) children and heterogamous relationships to increase dual method use and consistent condom use. 相似文献
33.
Kiyomi Matsuo Ichiro Morioka Mai Oda Yoko Kobayashi Yuji Nakamachi Seiji Kawano Miwako Nagasaka Tsubasa Koda Tomoyuki Yokota Satoru Morikawa Akihiro Miwa Akio Shibata Toshio Minematsu Naoki Inoue Hideto Yamada Kazumoto Iijima 《Brain & development》2014
Background
Infants with congenital cytomegalovirus infection (CCMVI) may develop brain abnormalities such as ventricular dilatation, which may potentially associate with sensorineural hearing loss. There is currently no recognized method for quantitative evaluation of ventricle size in infants with CCMVI. Our objectives were to establish a method for quantitative evaluation of ventricle size using computed tomography (CT) in infants with CCMVI, and determine a cut-off value associated with abnormal auditory brainstem response (ABR) early in life.Design/Subjects
This study enrolled 19 infants with CCMVI and 21 non-infected newborn infants as a control group. Infants with CCMVI were divided into two subgroups according to ABR at the time of initial examination: normal ABR (11 infants) or abnormal ABR (8 infants). Ventricle size was assessed by calculating Evans’ index (EI) and lateral ventricle width/hemispheric width (LVW/HW) ratio on brain CT images, and was compared among groups. A cut-off ventricle size associated with abnormal ABR was determined.Results
EI and LVW/HW ratio were significantly higher in the CCMVI with abnormal ABR group than the control and CCMVI with normal ABR groups. Cut-off values of 0.26 for EI and 0.28 for LVW/HW ratio had a sensitivity of 100% and 100%, respectively, and a specificity of 73% and 91%, respectively, for association with abnormal ABR.Conclusions
We established a method for quantitative evaluation of ventricle size using EI and LVW/HW ratio on brain CT images in infants with CCMVI. LVW/HW ratio had a more association with abnormal ABR in the early postnatal period than EI. 相似文献34.
Atsuo Hamada Eiichi Okuzawa Yuka Ujita Kiyomi Hondo Norihiko Ohkubo Tetsuo Nishikawa Norihiko Basugi 《Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases》2003,77(3):138-145
In order to study the prevalence of intestinal parasites among Japanese expatriates of developing countries, we conducted fecal specimen examinations annually from 1995 to 2000. Fecal specimens were collected from Japanese expatriates of each area: Asia, the Middle East, East Europe, Africa and Latin America. The specimens were fixed with 10% formalin in the local area, and then examined in Japan. We used the formalin-ether sedimentation method to find protozoan cysts or helminth eggs. In 1995, the infection ratio was 3.0% (N = 981), decreasing to 2.4% (N = 1,275) in 1996, 2.3% (N = 1,620) in 1997 and 1.6% (N = 1,574) in 1998. However, the ratio began to increase in 1999 (2.0%, N = 1,713) and 2000 (2.5%, N = 1,806). The ratio in Africa was the highest in each year, followed by Asia and Latin America. Heterophyidae (51 cases), Giardia lamblia (42) and Trichuris trichiura (30) were detected most frequently. In Egypt, the ratio of Heterophyidae rose by 28.8% in 2000. This was the prime reason for the increase in the overall ratio of infections worldwide. Most of the Japanese infected with Heterophyidae in Egypt had ingested dried mullet roe. This may explain the reason for the increase in the infection ratio there. Although the prevalence of intestinal parasites among Japanese expatriates in developing countries is decreasing, those who eat fish in these areas are still at risk. In order to eradicate intestinal parasitosis from this group, we must continue preventive measures such as health education. 相似文献
35.
Masahide Arita M.D. Mitsuo Okada M.D. Akira Motomura M.D. Toshiyuki Matsui M.D. Kiyomi Hosiko M.D. Tsuneyoshi Yao M.D. 《The American journal of gastroenterology》1994,89(2):214-219
The effects of single morning and single bedtime doses of famotidine on intragastric acidity were studied by 24-b intragastric pH monitoring in 16 patients with gastric ulcer. The patients were randomly allocated to tbe following regimen: one group (n = 8) received 40 mg famotidine at 8:30 AM and anotber group (n = 8) received tbo same dose at 10 PM. Tbe morning group showed significant inbibition of gastric acidity during the 24-b and daytime measurements, compared to those of the bedtime group (p < 0.05 in 24 h, p < 0.01 in daytime). Conversely, tbe bedtime group sbowed a sig-nificant inbibition of gastric acidity during tbe nocturnal period compared to tbe morning group (p < 0.01). These results indicate that the relative importance of suppression of gastric acidity on tbe gastric ulcer heal-ing process sbould be evaluated in a clinical trial. 相似文献
36.
Mitsuo Okada M.D. Masahide Arita Mitsuo Iida Tsuneyoshi Yao Toshihiro Sakurai Kiyomi Hoshiko Kazuhiro Maeda Yasuhiro Okada Kiyoto Sakamoto 《Journal of gastroenterology》1992,27(2):179-186
A randomized controlled study comparing once-a-day morning and once-a-day bedtime administration of 40 mg famotidine in treating
duodenal ulcers was carried out in 99 Japanese patients. Endoscopic examinations were performed at the baseline and repeated
at 3-week intervals until healing was confirmed. Eighty-two patients fulfilled the evaluation criteria (38 in the morning
group and 44 in the bedtime group). In 13 of these patients the antisecretory effects of these regimens were also assessed
by 24 h intragastric pH monitoring. The healing rates were 66% after 3 weeks and 95% after 6 weeks in the morning group, and
57% after 3 weeks and 80% after 6 weeks in the bedtime group. The differences were insignificant between the two groups, but
there was a higher healing rate tendency after 6 weeks in the morning group (0.05<P<0.10). Regarding pain subsidence, there
were no significant differences between the two groups. Both treatments were significantly superior to the controlgroup in
increasing 24 h intragastric pH. The morning regimen was significantly superior to the bedtime regimen in suppression of daytime
acidity. On the contrary, the bedtime regimen was significantly superior to the morning regimen in suppression of nocturnal
acidity. These findings suggest that suppression of nocturnal acidity is important but not essential to promote duodenal ulcer
healing and suppression of daytime acidity is equally important. Thus, once-a-day morning administration of 40 mg famotidine
seems to be at least as effective as once-a-day bedtime administration of 40 mg famotidine in treating duodenal ulcers. 相似文献
37.
38.
Abe Koichiro Ishizaki Umiko Ono Toshihiro Horiuchi Kiyomi Kanaya Kazuko Sakai Shuji Okamoto Takahiro 《Annals of nuclear medicine》2020,34(2):144-151
Annals of Nuclear Medicine - The efficacy of low-dose radioiodine therapy (RIT) for intermediate-risk or high-risk differentiated thyroid cancer (DTC) patients is controversial. Because of the... 相似文献
39.
Kiyomi Koike Seiji Ueda Sho-ichi Yamagishi Hideo Yasukawa Yusuke Kaida Miyuki Yokoro Kei Fukami Akihiko Yoshimura Seiya Okuda 《Clinical immunology (Orlando, Fla.)》2014,150(1):78-87
Inflammation is involved in renal fibrosis, a final common pathway for kidney diseases. To clarify how JAK/STAT/SOCS system was involved in renal fibrosis, UUO was induced in BALB/c or SOCS3+/− mice in the presence or absence of JAK inhibitor-incorporated nanoparticle (pyridine6–PGLA). UUO increased pSTAT3 and subsequently elevated SOCS3 levels in the obstructed kidneys. pSTAT3 levels were further increased in SOCS3+/− mice. UUO-induced renal fibrosis was markedly suppressed in SOCS3+/− mice, while it was aggravated by pre-treatment with pyridine6–PGLA. Although there were no differences in renal mRNA levels of TGF-β and collagens between wild and SOCS3+/− mice, MMP-2 activity was enhanced in SOCS3+/− UUO mice. Activated MMP-2 was completely suppressed by pyridine6–PGLA-pre-treatment. TNF-α one of JAK/STAT activators, increased pSTAT3 levels and subsequently induced MMP-2 activation in proximal tubular cells. These results suggest that JAK/STAT3 signaling may play a role in repair process of renal fibrosis in UUO partly via MMP-2 activation. 相似文献
40.