全文获取类型
收费全文 | 3363篇 |
免费 | 165篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 61篇 |
儿科学 | 241篇 |
妇产科学 | 142篇 |
基础医学 | 408篇 |
口腔科学 | 75篇 |
临床医学 | 288篇 |
内科学 | 607篇 |
皮肤病学 | 96篇 |
神经病学 | 226篇 |
特种医学 | 92篇 |
外科学 | 600篇 |
综合类 | 49篇 |
一般理论 | 2篇 |
预防医学 | 132篇 |
眼科学 | 67篇 |
药学 | 252篇 |
中国医学 | 14篇 |
肿瘤学 | 192篇 |
出版年
2024年 | 6篇 |
2023年 | 32篇 |
2022年 | 81篇 |
2021年 | 147篇 |
2020年 | 76篇 |
2019年 | 124篇 |
2018年 | 124篇 |
2017年 | 94篇 |
2016年 | 111篇 |
2015年 | 124篇 |
2014年 | 170篇 |
2013年 | 179篇 |
2012年 | 303篇 |
2011年 | 326篇 |
2010年 | 165篇 |
2009年 | 120篇 |
2008年 | 196篇 |
2007年 | 154篇 |
2006年 | 173篇 |
2005年 | 164篇 |
2004年 | 138篇 |
2003年 | 108篇 |
2002年 | 89篇 |
2001年 | 27篇 |
2000年 | 29篇 |
1999年 | 25篇 |
1998年 | 20篇 |
1997年 | 9篇 |
1996年 | 9篇 |
1995年 | 11篇 |
1994年 | 19篇 |
1993年 | 6篇 |
1992年 | 14篇 |
1991年 | 21篇 |
1990年 | 7篇 |
1989年 | 10篇 |
1988年 | 8篇 |
1987年 | 9篇 |
1986年 | 8篇 |
1985年 | 11篇 |
1984年 | 9篇 |
1983年 | 7篇 |
1982年 | 7篇 |
1981年 | 6篇 |
1979年 | 12篇 |
1978年 | 8篇 |
1975年 | 10篇 |
1974年 | 6篇 |
1973年 | 5篇 |
1970年 | 6篇 |
排序方式: 共有3544条查询结果,搜索用时 15 毫秒
81.
82.
Anand Swaroop Manashi Bagchi Pawan Kumar Harry G. Preuss Kiran Tiwari Palma Ann Marone 《Toxicology mechanisms and methods》2014,24(7):495-503
Safety and anti-diabetic efficacy of a novel, proprietary Trigonella foenum-graecum seed extract [novel fenugreek extract (FE), Fenfuro?, CR0010810) enriched in furostanolic saponins (>60% w/w, HPLC) were assessed. Concerning safety, we undertook studies dealing with acute oral toxicity, 28-d sub-chronic toxicity and Ames’ bacterial reverse mutation assay that revealed no toxicity. Concerning efficacy, we examined beneficial effects of the extract on rats with type 2 diabetes (T2D). Male Sprague–Dawley rats received a high-fat diet for 2 weeks followed by streptozotocin (STZ, 35?mg/kg i.p.) to produce T2D. Seven days post-STZ, rats showing ≥300?mg/dl fasting plasma glucose level (PGL) were included in the study. FE (150- or 450- mg/kg p.o.) and glipizide (5?mg/kg p.o.) were administered once daily for 20?d and then twice daily for another 10?d (total 30?d). Blood samples were collected at 0, 10, 20 and 30?d of treatment and estimated for fasting plasma triglyceride (PTG), total cholesterol and insulin levels. After 30?d, FE and glipizide-treated diabetic animals were treated in combination with or without metformin (100?mg/kg) twice daily for another 10?d. FE did not influence body weight, feed and water intake. FE (150?mg/kg p.o.) reduced PTG levels in T2D rats by 22%, 24.6% and 29% at 10, 20 and 30?d of treatment, respectively, while glipizide (5?mg/kg p.o.) reduced the PTG levels by 57.4%, 46.2% and 39.4% at these time points. FE (450?mg/kg) treatment in STZ-induced diabetic rats produced significant hypoglycemic activity (approximately 31.5%) as compared to insulin (48.2% with 1 U/kg i.p.). FE (150?mg/kg p.o.) and metformin (100?mg/kg p.o.) combined produced significant reduction (20.7%) of PGL in T2D rats. No adverse effects were observed. We conclude after extensive in vitro and in vivo safety and efficacy studies that FE is safe and effective in treating T2D. 相似文献
83.
Carine Beysen DPhil Patricia Schroeder PhD Eric Wu PhD Julie Brevard MPH Maria Ribadeneira PhD Wei Lu PhD Kiran Dole PharmD Terry O'Reilly MD Linda Morrow MD Marcus Hompesch MD Marc K. Hellerstein MD Kelvin Li PhD Lars Johansson PhD Patrick F. Kelly MD 《Diabetes, obesity & metabolism》2021,23(3):700-710
84.
Giovanni Maconi Cristina Bosetti Alberta De Monti Ray Kiran Boyapati Edward Shelton Nicole Piazza Anna Maria Carvalhas Gabrielli Marco Vincenzo Lenti Cristina Bezzio Chiara Ricci Salvatore Greco Samanta Romeo Francesco Giangregorio Daniele Gridavilla Fabio Tagliani Alessandro Massari Luca Pastorelli Antonio Di Sabatino Sandro Ardizzone 《Digestive and liver disease》2021,53(3):263-270
BackgroundIt is unclear whether patients with inflammatory bowel disease (IBD) are at increased risk of COVID-19.ObjectivesThis observational study compared the prevalence of COVID-19 symptoms, diagnosis and hospitalization in IBD patients with a control population with non-inflammatory bowel disorders.MethodsThis multicentre study, included 2733 outpatients (1397 IBD patients and 1336 controls), from eight major gastrointestinal centres in Lombardy, Italy. Patients were invited to complete a web-based questionnaire regarding demographic, historical and clinical features over the previous 6 weeks. The prevalence of COVID-19 symptoms, diagnosis and hospitalization for COVID-19 was assessed.Results1810 patients (64%) responded to the questionnaire (941 IBD patients and 869 controls). IBD patients were significantly younger and of male sex than controls. NSAID use and smoking were more frequent in controls. IBD patients were more likely treated with vitamin-D and vaccinated for influenza. Highly probable COVID-19 on the basis of symptoms and signs was less frequent in the IBD group (3.8% vs 6.3%; OR:0.45, 95%CI:0.28–0.75). IBD patients had a lower rate of nasopharyngeal swab-PCR confirmed diagnosis (0.2% vs 1.2%; OR:0.14, 95%CI:0.03–0.67). There was no difference in hospitalization between the groups (0.1% vs 0.6%; OR:0.14, 95%CI:0.02–1.17).ConclusionIBD patients do not have an increased risk of COVID-19 specific symptoms or more severe disease compared with a control group of gastroenterology patients. 相似文献
85.
Mane Atish Mahendra Dube Kiran Varghese Tincy Chavan Balasaheb Ramdas Kamble Manoj Tukaram 《Proceedings of the National Academy of Sciences, India. Section B.》2019,89(1):275-281
Proceedings of the National Academy of Sciences, India Section B: Biological Sciences - A nursery rearing experiment of fry to fingerling was conducted in cages in Dimbhe reservoir of Pune District... 相似文献
86.
87.
Fahid Tariq Rasul Zane Jaunmuktane Akbar Ali Khan Rahul Phadke Michael Powell 《Acta neurochirurgica》2014,156(1):141-146
Plurihormonal pituitary adenomas are tumours that show immunoreactivity for more than one hormone that cannot be explained by normal adenohypophysial cytodifferentiation. The most common combinations in these adenomas include growth hormone (GH), prolactin (PRL) and one or more glycoprotein hormone sub-units (β-TSH, β-FSH, β-LH and αSU). The authors report two cases of a plurihormonal pituitary adenoma expressing the rare combination of ACTH and GH. They both underwent successful transphenoidal hypophysectomy (TSH). Long-term post-operative follow-up revealed no evidence of tumour recurrence. Due to the multiple secretions and plurihormonal characteristics clinical diagnosis of composite pituitary adenomas can be difficult. The authors discuss the diagnosis and management of composite pituitary adenomas and review the literature regarding this rare phenomenon. 相似文献
88.
89.
90.
Tushar Narayan Rathod Ajay Chandanwale Kiran M Ladkat Shital Chavan Arvind Chavan Pradeep B Bhosale 《Indian Journal of Orthopaedics》2014,48(4):354-359