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101.
A N Kingsley 《The Nebraska medical journal》1990,75(12):321-323
A study of twenty-nine patients suffering from post-traumatic anal incontinence is presented. Twenty-eight patients had reconstructive surgery with a 96% overall success rate. Careful patient selection, preoperative evaluation and preparation, meticulous surgical technique and careful postoperative management insure a successful therapeutic result. 相似文献
102.
Molecular cloning and characterization of an invertebrate homologue of a neuropeptide Y receptor 总被引:1,自引:0,他引:1
Cornelis P.Tensen Kingsley J. A.Cox Julian F.Burke RobLeurs Roel C. van der Schors Wijnand P. M.Geraerts ErnoVreugdenhil Harm van Heerikhuizen 《The European journal of neuroscience》1998,10(11):3409-3416
Neuropeptide Y is an abundant and physiologically important peptide in vertebrates having effects on food intake, sexual behaviour, blood pressure and circadian rhythms. Neuropeptide Y homologues have been found in invertebrates, where they are very likely to play similar, important roles. Although five neuropeptide Y-receptor subtypes have been identified in mammals, none has been reported from invertebrates. Here we describe the cloning of a neuropeptide Y-receptor from the brain of the snail Lymnaea stagnalis. The identity of the receptor was deduced by expressing the neuropeptide Y-receptor-encoding cDNA in Chinese Hamster Ovary cells, which were subsequently challenged with size-fractionated Lymnaea brain extracts. An active peptide, selected on the basis of its ability to induce changes in cAMP levels, was purified to homogeneity, analysed by mass spectrometry and amino acid sequence determination, and turned out to be a Lymnaea homologue of neuropeptide Y. 相似文献
103.
The National Neighborhood Indicators Partnership (NNIP), a collaborative effort, uses local information in community building and policy making. A local intermediary in 19 NNIP partnership cities builds local data systems. Partners have learned five important lessons: (1) neighborhood-level data are essential for developing public policy, (2) technological advances have made it possible to maintain detailed local databases at relatively low cost, (3) various types of local organizations can serve as local partners, (4) good leadership is critical to building bridges across agencies, and (5) providing data is only the first step. Data must be used in ways that are visible, useful, and responsive to the community if the project is to succeed. 相似文献
104.
This study evaluated the self-reported patterns of handedness among a large subsample (n = 1612) of the gay/bisexual men comprising the Multicenter AIDS Cohort Study (MACS). There was a small but significant elevation in left-handedness among gay/bisexual men compared to available normative data. However, there were no differences within the cohort in measures of immune function, self-reported autoimmune disorders, asthma, or hay fever, although there was an association between handedness and allergy. Performance on neuropsychological tests also did not differ as a function of handedness. 相似文献
105.
106.
D P Kingsley W A Hendrickse B E Kendall M Swash V Singh 《Journal of neurology, neurosurgery, and psychiatry》1987,50(1):30-36
Serial computed tomographic scans were performed during the course of tuberculous meningitis in 25 patients aged 1-70 years. Hydrocephalus rarely occurred without other abnormalities. Marked ventricular enlargement was associated with extensive basal enhancement. Basal meningeal enhancement was not a good indicator of the clinical state although marked enhancement was a risk factor for the development of basal ganglia infarction. Infarcts were much more common in children than in adults and were sometimes asymptomatic. Radiological abnormalities sometimes developed during treatment and often did not resolve completely. Many patients had severe residual neurological problems. 相似文献
107.
J Ferbas M A Rahman L A Kingsley J A Armstrong M Ho S Y Zhou C R Rinaldo 《AIDS (London, England)》1992,6(11):1273-1278
OBJECTIVE: To determine the frequency of Epstein-Barr virus (EBV) oropharyngeal shedding during HIV infection in homosexual men in the Multicenter AIDS Cohort Study. DESIGN: The cohort consisted of 210 men who were HIV-seronegative at their baseline study visit, 39 of whom seroconverted to HIV at a later date, and 73 asymptomatic and mildly symptomatic men with HIV infection of indeterminate duration. METHODS: EBV in throat washings was detected by transformation of newborn cord blood lymphocytes. RESULTS: EBV was isolated from 49% (35 out of 71) of the HIV-seropositive and 16% (33 out of 204) of the HIV-seronegative homosexual men tested at their baseline visit. Elevated EBV shedding frequency was noted 6 months before, as well as during the first HIV-seropositive clinic visit, in the men who seroconverted to HIV. Seronegative men who shed EBV at their baseline visit seroconverted to HIV within a shorter period than did non-shedders during 5 years of follow-up. Shedding of EBV was not significantly associated with either abnormal T-cell numbers, clinical symptoms or risk for development of AIDS. CONCLUSIONS: There is an increased rate of EBV shedding in HIV-seropositive homosexual men that occurs very early in the course of HIV infection. 相似文献
108.
人胎肝cDNA文库构建及鉴定 总被引:2,自引:0,他引:2
从人胎肝组织提取总RNA并纯化出mRNA,经反转录合成第一、二链cDNA,去除小于200bp的cDNA片段后,连接EcoRI人工接头,与去磷酸化的λgt11噬菌体长、短臂连接,体外包装后感染E.coliY1090,成功构建含4.2×108重组子的人胎肝cDNA表达文库,重组子平均外源插入片段约1.5kb,适合用于筛选低丰度mRNA的cDNA克隆。 相似文献
109.
The Centers for Disease Control and Prevention (CDC) continues to be aware of the need for response to public concern as well as to state and local agency concern about cancer clusters. In 1990 the CDC published the "Guidelines for Investigating Clusters of Health Events," in which a four-stage process was presented. This document has provided a framework that most state health departments have adopted, with modifications pertaining to their specific situations, available resources, and philosophy concerning disease clusters. The purpose of this present article is not to revise the CDC guidelines; they retain their original usefulness and validity. However, in the past 15 years, multiple cluster studies as well as scientific and technologic developments have affected duster science and response (improvements in cancer registries, a federal initiative in environmental public health tracking, refinement of biomarker technology, cluster identification using geographic information systems software, and the emergence of the Internet). Thus, we offer an addendum for use with the original document. Currently, to address both the needs of state health departments as well as public concern, the CDC now a) provides a centralized, coordinated response system for cancer cluster inquiries, b) supports an electronic cancer cluster listserver, c) maintains an informative web page, and d) provides support to states, ranging from laboratory analysis to epidemiologic assistance and expertise. Response to cancer clusters is appropriate public health action, and the CDC will continue to provide assistance, facilitate communication among states, and foster the development of new approaches in duster science. 相似文献
110.