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141.
Evaluating the safety and efficacy of the 1,440‐nm laser in the treatment of photodamage in Asian skin 下载免费PDF全文
Shoshana Marmon MD PhD Samantha Y. N. Shek MBBS C.K. Yeung MD MBBS Nicola P.Y. Chan MRCP Johnny CY Chan MBBS Henry H.L. Chan MD PhD FRCP 《Lasers in surgery and medicine》2014,46(5):375-379
Background and Objective
As the demand for diminished procedure‐associated downtime continues to increase, nonablative fractional laser resurfacing is becoming a more popular intervention in the progression of photoaging. Patients with pigmented skin and a mild degree of photodamage may be particularly suited for a less intensive laser treatment. In this study, we have evaluated the safety and efficacy of a low energy, low density 1,440‐nm fractional laser in the treatment of multiple signs of photoaging including dyspigmentation, wrinkling, tissue laxity, enlarged pores, and skin roughness in Asians.Study Design/Materials and Methods
Ten Chinese subjects with Fitzpatrick skin types III–V and visible signs of photodamage participated in this study. Patients received four treatments at 2‐week intervals with a 1,440‐nm diode‐based fractional laser. Photographs were taken at baseline, 2 weeks after each of the first three treatments and 4 weeks after the final treatment. Images were evaluated independently by two physicians. Clinical improvement and adverse events were analyzed. Discomfort, heat sensation and overall patient satisfaction associated with the procedure were also quantified.Results
In this prospective single‐arm study, signs of photoaging were examined after treatment with the 1,440‐nm laser. Here we show that a series of four treatments with this device produced a mild improvement in skin texture, pigmentation, and wrinkling. Changes in pore size and skin laxity failed to reach statistical significance. Immediate after‐effects of the procedure included erythema and edema which were transient and left no permanent sequela. A significant proportion of patients reported some degree of discomfort during the procedure despite use of a topical anesthetic. One patient developed a discrete, localized area of post‐inflammatory hyperpigmentation which completely resolved by the final follow up visit.Conclusion
The low energy, low density nonablative 1,440‐nm fractional laser produces a mild improvement in select signs of photodamage after four treatments without any long‐term adverse effects. Lasers Surg. Med. 46:375–379, 2014. © 2014 Wiley Periodicals, Inc. 相似文献142.
Sarah Marrinan MBBS MRCP Anton V. Emmanuel MD FRCP David J. Burn MD FRCP 《Movement disorders》2014,29(1):23-32
Gastrointestinal symptoms are evident in all stages of Parkinson's disease (PD). Most of the gastrointestinal abnormalities associated with PD are attributable to impaired motility. At the level of the stomach, this results in delayed gastric emptying. The etiology of delayed gastric emptying in PD is probably multifactorial but is at least partly related to Lewy pathology in the enteric nervous system and discrete brainstem nuclei. Delayed gastric emptying occurs in both early and advanced PD but is underdetected in routine clinical practice. Recognition of delayed gastric emptying is important because it can cause an array of upper gastrointestinal symptoms, but additionally it has important implications for the absorption and action of levodopa. Delayed gastric emptying contributes significantly to response fluctuations seen in people on long‐term l ‐dopa therapy. Neurohormonal aspects of the brain‐gut axis are pertinent to discussions regarding the pathophysiology of delayed gastric emptying in PD and are also hypothesized to contribute to the pathogenesis of PD itself. Ghrelin is a gastric‐derived hormone with potential as a therapeutic agent for delayed gastric emptying and also as a novel neuroprotective agent in PD. Recent findings relating to ghrelin in the context of PD and gastric emptying are considered. This article highlights the pathological abnormalities that may account for delayed gastric emptying in PD. It also considers the wider relevance of abnormal gastric pathology to our current understanding of the etiology of PD. © 2013 International Parkinson and Movement Disorder Society 相似文献
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Ava Kwong BSc MBBS PhD FRCS Wai Wang Chau BSc MSc Oscar W. K. Mang MSc CStat Connie H. N. Wong MSc BSc Dacita T. K. Suen MBBS R. Leung MBCHB MRCP Kerry Wong BSc MBiostats Andrea Lee Catherine Shea MBBS Elliot Morse Stephen C. K. Law MBBS FRCR 《Annals of surgical oncology》2014,21(4):1246-1253
Background
Male breast cancer (MBC) is uncommon. As a result, there is limited availability of studies and reviews and even fewer reports from Asia. This is the largest population-based study to compare Chinese MBC patients with female patients during a 10-year period in Hong Kong, Southern China.Methods
A retrospective review of medical records of 132 male and 8,118 female breast cancer patients between year 1997 and 2006 in Hong Kong was performed. Each MBC patient was matched with three female breast cancer patients for further analysis. Different characteristics, overall, breast-cancer specific, and disease-free survivals (DFS) were compared.Results
Mean age at diagnosis of male and female patients was 64.5 and 52.7 years respectively. Male patients showed lower histological grade, overall stage, smaller tumor size, and more positive sensitivity in hormone receptors. They were more likely to die of causes other than breast cancer. Matched analysis found that the 5-year overall survival (OS), breast-cancer–specific mortality, and DFS for male and female patients were 78.7, 90.5, 90.5, and 77.9, 86.4, and 81.4 % respectively. Male patients had poorer OS at early overall stage but better breast-cancer—specific mortality rates at any age (p < 0.01). Male patients had a significant risk of dying due to any cause in the presence of distant relapse and had less risk of dying when tumor was ER-positive and HER2-positive.Conclusions
Chinese male breast cancer patients tend to have poorer OS but better breast-cancer—specific survival compared with their female counterparts. 相似文献146.
Naomi Holman PhD Peter Knighton MPhys Jackie OʼKeefe MSc Sarah H. Wild PhD Sarah Brewster MRCP Hermione Price FRCP Kiran Patel PhD Wasim Hanif MD Vinod Patel MD Edward W. Gregg PhD Richard I. G. Holt PhD Roger Gadsby MB Kamlesh Khunti MD Jonathan Valabhji MD Bob Young MD Naveed Sattar MD 《Diabetes, obesity & metabolism》2021,23(12):2728-2740
147.
Sandeep Basavarajaiah MD MRCP FESC Sampath Athukorala MD MRCP Konstantinos Kalogeras MD MRCP Vasileios Panoulas MD MRCP Bhagya H. Loku Waduge MBBS Gurbir Bhatia MD MRCP Richard Watkin MD MRCP FESC George Pulikal MD MRCP Kaeng Lee MD MRCP Jerome Ment MD MRCP Bethan Freestone MD MRCP Michael Pitt MD MRCP 《Catheterization and cardiovascular interventions》2021,98(1):57-65
148.
Amir Aziz MRCP PhD Gurbir Bhatia MD MRCP Michael Pitt MD MRCP Anirban Choudhury MD MRCP Ahmed Hailan MD FRCP Subramanya Upadhyaya MD MRCP Leong Lee MD MRCP Luca Testa MD Matteo Casenghi MD Alfonso Ielasi MD Bernardo Cortese MD Hannah Rides MSc Sandeep Basavarajaiah MD MRCP FESC 《Catheterization and cardiovascular interventions》2021,98(2):225-235
149.
Aung Myat MD Florence Mouy BMBS Luke Buckner BMBS James Cockburn MD Andreas Baumbach MD Philip MacCarthy PhD Adrian P. Banning MD Nick Curzen PhD Roland Hilling-Smith MD Daniel J. Blackman MD Michael Mullen MD Mark de Belder MD Ian Cox MD Jan Kovac MD Ganesh Manoharan MD Azfar Zaman MD Douglas Muir MBChB David Smith MD Stephen Brecker MD Mark Turner PhD Saib Khogali MD Iqbal S. Malik PhD Osama Alsanjari MRCP Francesca D'Auria PhD Simon Redwood MD Bernard Prendergast DM Uday Trivedi MD Derek Robinson DPhil Peter Ludman MD Adam de Belder MD David Hildick-Smith MD 《Catheterization and cardiovascular interventions》2021,98(3):E444-E452
150.
Ross Kruger MB BS BSc Simon Freeman MB BS MRCP FRCR 《Journal of clinical ultrasound : JCU》2019,47(3):172-174
Splenosis is an unusual condition representing auto-transplantation of splenic tissue following splenic trauma or surgery. When detected on imaging studies, the splenosis deposits are usually misinterpreted as pathological masses. We present a case where a pelvic mass incidentally visualized on an MRI examination, was proven to represent a deposit of splenosis by contrast enhanced ultrasound (CEUS). CEUS demonstrated persistent late-phase enhancement characteristic of splenic tissue. Ultrasound practitioners should be aware of this condition when an unusual abdominal or pelvic mass is encountered in a patient with a history of splenic trauma or surgery. CEUS is ideally suited to confirming the diagnosis. 相似文献