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991.
992.
Agent Orange exposure and its long-term health consequences on Vietnam veterans have been widely discussed in the past few years. Myriad physical and mental disabilities have been studied with regard to exposure to various herbicides. The number of persons potentially exposed is large, since 2.4-2.8 million U.S. military personnel served in Vietnam. A case-control study was undertaken to determine if persons who served in the U.S. military in Vietnam have either cardiovascular or pulmonary effects that can be demonstrated on long-term follow-up chest radiographs. Information regarding military service in Vietnam was obtained from interviews and, in some cases, review of military records. Vietnam veterans did not have an increased prevalence of abnormalities on follow-up chest radiographs. A subset of Vietnam veterans who had greater estimated opportunities for Agent Orange exposure also did not appear to be at greater risk than the control population. 相似文献
993.
994.
An association between auto-immune disorders and interferon (IFN) has been reported. High levels of natural IFNα are present
in the blood of patients with auto-immune disease and correlate with disease activity. In addition, IFNα treatment of humans
has resulted in multiple reports of associatied auto-immune phenomena. We describe a patient who underwent resection of regionally
metastatic melanoma, was given adjuvant high-dose IFNα2b, and subsequently developed dermatomyositis. To the author's knowledge
this is the first report of dermatomyositis in association with IFNα treatment. We review the literature reporting associations
between IFNα and auto-immune disease and discuss possible mechanisms by which IFNα may contribute to the development of auto-immune
disease. High dose IFNα2b is more commonly prescribed since it was approved as an adjuvant treatment for patients with surgically
resected high-risk melanoma. The potential for cases of IFN-associated autoimmune disease is therefore a clinical concern.
Standard side effects of high-dose IFN therapy resemble symptoms of auto-immune diseases, which may make prompt diagnosis
difficult. Therefore, it is important that auto-immune diseases such as dermatomyositis are recognized as potential side effects
of treatment with high-dose IFNα. 相似文献
995.
目的:分析椎弓崩裂症的MRI表现,并探讨MR诊断椎弓崩裂症的价值。方法:笔者收集40例本室自1995年8月至2000年6月MR检查诊为椎弓崩裂的病例,使用SIEMENS IMPAC1.0TMR机,采用脊柱线圈,自旋回波和快速自旋回波序列扫描,结果:显示椎弓崩裂发生于腰4、5椎体,大部分双侧受累(35例),双侧受累者较单侧受累者滑脱的发生率高,椎弓崩裂均位于椎弓峡部,表现为椎弓峡部骨皮质及髓质信号均不连贯,显示如下MR征象:断裂处呈线状;断裂处上下两端分离;断裂处下端后移,部分病例成角移位。结论:MRI检查能显示椎弓崩裂的位置及上述相关的MRI征象,在日常腰椎MRI检查中,如加留意,可及早发现。 相似文献
996.
SS LEUNG KS STEINBECK SL MORRIS MR KOHN SJ TOWNS DL BENNETT 《Journal of paediatrics and child health》1997,33(2):107-112
To describe the inter-relationship of chronic illness severity as perceived by adolescents with both psychosocial well-being and objective measures of illness severity. Additionally to compare the adolescents' perception of illness severity with how their physicians believe that the adolescents perceive their illness severity.
The psychological well-being of 48 adolescents with either cystic fibrosis (CF) or insulin-dependent diabetes mellitus (IDDM) was measured by four standardized questionnaires. The adolescents' perception of severity of illness was measured using an original instrument (PSCI), and this measure was compared to their physicians' estimates of how the adolescents perceived the severity of their illness and clinical illness.
There were 24 patients in both the CF and IDDM groups. Both groups were found to function well psychosocially; although, there were more patients with low self image compared to normative values. Depression and low self image were associated with a greater adolescent perception of illness severity. For both chronic illness groups, physicians' assessment of assumed adolescent perception of disease severity correlated with clinical indices of disease severity and was higher than the perception of illness severity reported by the adolescents. For adolescents with CF, but not with IDDM, perception of severity of chronic illness correlated with clinical indices.
For adolescents with chronic illness, their perception of illness severity is an important indicator of psychosocial well-being. Physicians do not accurately infer their patients' perception of illness severity. 相似文献
Methods:
The psychological well-being of 48 adolescents with either cystic fibrosis (CF) or insulin-dependent diabetes mellitus (IDDM) was measured by four standardized questionnaires. The adolescents' perception of severity of illness was measured using an original instrument (PSCI), and this measure was compared to their physicians' estimates of how the adolescents perceived the severity of their illness and clinical illness.
Results:
There were 24 patients in both the CF and IDDM groups. Both groups were found to function well psychosocially; although, there were more patients with low self image compared to normative values. Depression and low self image were associated with a greater adolescent perception of illness severity. For both chronic illness groups, physicians' assessment of assumed adolescent perception of disease severity correlated with clinical indices of disease severity and was higher than the perception of illness severity reported by the adolescents. For adolescents with CF, but not with IDDM, perception of severity of chronic illness correlated with clinical indices.
Conclusions:
For adolescents with chronic illness, their perception of illness severity is an important indicator of psychosocial well-being. Physicians do not accurately infer their patients' perception of illness severity. 相似文献
997.
To estimate the prevalence of toxoplasma antibodies in schoolchildren and their association with clinical and environmental data, antibody titres were measured in 1276 children aged 4 to 18 years attending primary and secondary schools. Environmental and clinical data were obtained by questionnaire. Altogether 12.8% (163/1276) of children had antibodies to Toxoplasma gondii with no difference between the sexes. Seroprevalence was higher in country children (16.6% (50/302)) than town children (10.2% (75/737)). The proportion testing positive increased with age in both town and country children. No association with cat ownership was found. Toxoplasma seropositivity was associated with a positive toxocara titre, having had a bitch whelp in the past two years, and having an unwormed dog at home. Lack of energy or tiredness in the last 12 months were the only clinical features associated with a positive titre. 相似文献
998.
D GANGULY JM BORCAR RS RAJAN V RAVISHANKAR MR WACHRAY KS RAO 《Medical Journal Armed Forces India》1996,52(3):141-144
Twelve cases of intracardiac tumours operated during the period 1975 to 1994 are presented. There were 8 males and 4 females in the age range of 18 years to 64 years. Tumours were located in the left atrium in 10 patients and in the right atrium in 2 patients. Standard cardiopulmonary techniques were followed. The right atrial tumours were approached through a right atrial incision while the left atrial tumours were approached through a bi-atrial trans-septal approach. One patient underwent a perineal urethrolithotomy for an impacted urethral calculus at the same sitting. Eleven of the tumour masses excised were myxomas confirmed on histopathology. The last patient, operated for synovial sarcoma of the left knee 2 years before, presented with a metastatic tumour mass in the left atrium. No deaths occurred in the series.KEY WORDS: Heart neoplasms, Heart surgery, Myxomas 相似文献
999.
1000.
Cartegni L; di Barletta MR; Barresi R; Squarzoni S; Sabatelli P; Maraldi N; Mora M; Di Blasi C; Cornelio F; Merlini L; Villa A; Cobianchi F; Toniolo D 《Human molecular genetics》1997,6(13):2257-2264
Emery-Dreifuss muscular dystrophy (EDMD) is an X-linked inherited disease
characterized by early contracture of the elbows, Achilles tendons and
post-cervical muscles, slow progressive muscle wasting and weakness and
cardiomyopathy presenting with arrhythmia and atrial paralysis: heart block
can eventually lead to sudden death. The EDMD geneencodes a novel
ubiquitous protein, emerin, which decorates the nuclear rim of many cell
types. Amino acid sequence homology and cellular localization suggested
that emerin is a member of the nuclear lamina-associated protein family.
These findings did not explain the role of emerin nor account for the
skeletal muscle- and heart-specific clinical manifestations associated with
the disorder. Now we report that emerin localizes to the inner nuclear
membrane, via its hydrophobic C-terminal domain, but that in heart and
cultured cardiomyocytes it is also associated with the intercalated discs.
We propose a general role for emerin in membrane anchorage to the
cytoskeleton. In the nuclear envelope emerin plays a ubiquitous and
dispensable role in association of the nuclear membrane with the lamina. In
heart its specific localization to desmosomes and fasciae adherentes could
account for the characteristic conduction defects described in patients.
相似文献