全文获取类型
收费全文 | 656篇 |
免费 | 30篇 |
专业分类
耳鼻咽喉 | 11篇 |
儿科学 | 40篇 |
妇产科学 | 9篇 |
基础医学 | 55篇 |
口腔科学 | 21篇 |
临床医学 | 37篇 |
内科学 | 88篇 |
皮肤病学 | 45篇 |
神经病学 | 47篇 |
特种医学 | 22篇 |
外科学 | 188篇 |
综合类 | 8篇 |
预防医学 | 20篇 |
眼科学 | 11篇 |
药学 | 39篇 |
中国医学 | 1篇 |
肿瘤学 | 44篇 |
出版年
2023年 | 5篇 |
2022年 | 13篇 |
2021年 | 19篇 |
2020年 | 19篇 |
2019年 | 20篇 |
2018年 | 21篇 |
2017年 | 22篇 |
2016年 | 9篇 |
2015年 | 14篇 |
2014年 | 30篇 |
2013年 | 42篇 |
2012年 | 61篇 |
2011年 | 60篇 |
2010年 | 42篇 |
2009年 | 23篇 |
2008年 | 24篇 |
2007年 | 26篇 |
2006年 | 39篇 |
2005年 | 37篇 |
2004年 | 36篇 |
2003年 | 39篇 |
2002年 | 38篇 |
2001年 | 10篇 |
2000年 | 2篇 |
1999年 | 5篇 |
1998年 | 1篇 |
1997年 | 2篇 |
1995年 | 1篇 |
1994年 | 3篇 |
1993年 | 2篇 |
1991年 | 1篇 |
1990年 | 2篇 |
1989年 | 1篇 |
1988年 | 4篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1985年 | 3篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1981年 | 1篇 |
1979年 | 2篇 |
1978年 | 2篇 |
1974年 | 1篇 |
排序方式: 共有686条查询结果,搜索用时 46 毫秒
101.
Atul K. Patel Ketan K. Patel Kamlesh Patel Swati Gohel Arunaloke Chakrabarti 《Mycoses》2017,60(6):407-411
The prevalence of mucormycosis is reportedly high in India, although the studies are mainly from north and south India only. We analysed the mucormycosis cases at tertiary care centres of West India. We retrieved the clinical details of all the patients with probable and proven mucormycosis diagnosed at Sterling Hospital and ID clinic at Ahmedabad, Gujarat over the period from 1 January 2013 through 30 April 2015. The data were analysed to determine demography, risk factors, underlying diseases, site of infection and outcome of these patients. A total of 27 patients with the median age of 50 (16‐65) years were diagnosed with mucormycosis during the period. Rhino‐orbital‐cerebral mucormycosis was the most common (51.9%) presentation. Majority (55.6%) of the patients had uncontrolled diabetes with or without ketoacidosis; 25.9% patients had no underlying disease and most of them (85.7%) had cutaneous mucormycosis. In this group, the mortality was 25.9% and an equal percentage of patients were lost to follow up; 14 (51.9%) patients could complete 6 weeks of amphotericin B therapy. All patients who completed antifungal therapy survived except one. Like other parts of India, uncontrolled diabetes was the predominant risk factor for mucormycosis in our group. Patients completing 6 weeks of amphotericin B treatment were likely to survive. 相似文献
102.
103.
Martin M. Mortazavi Ketan Verma Aman Deep Fatemeh B. Esfahani Patrick R. Pritchard R. Shane Tubbs Nicholas Theodore 《Child's nervous system》2011,27(8):1297-1306
Introduction
There are significant differences between the propensity of neural regeneration between the central and peripheral nervous systems. 相似文献104.
Martin M. Mortazavi Ketan Verma Aman Deep Fatemeh B. Esfahani Patrick R. Pritchard R. Shane Tubbs Nicholas Theodore 《Child's nervous system》2011,27(8):1307-1316
Introduction
Spinal cord injury is a complex cascade of reactions secondary to the initial mechanical trauma that puts into action the innate properties of the injured cells, the circulatory, inflammatory, and chemical status around them, into a non-permissive and destructive environment for neuronal function and regeneration. Priming means putting a cell, in a state of “arousal” towards better function. Priming can be mechanical as trauma is known to enhance activity in cells. 相似文献105.
Sam Safavi-Abbasi Nicholas C. Bambakidis Joseph M. Zabramski Ryan Workman Ketan Verma Mehmet Senoglu Randall W. Porter Robert F. Spetzler 《Acta neurochirurgica》2010,152(1):35-46
Purpose
Nonvestibular cranial nerve schwannomas (NVCNS) are relatively rare tumors. We evaluated our experience with radiosurgical and microsurgical treatment alone and in combination for the management of NVCNS. 相似文献106.
Amit Mahajan Tejas C. Manchandia Grahame Gould Ketan R. Bulsara 《Neurosurgical review》2010,33(1):115-119
Intracerebral arteriovenous malformations (AVMs) are traditionally recognized as congenital lesions. However, with the advent
of frequent, noninvasive imaging of the brain, that notion has been challenged. We describe another patient with a de novo
cerebral arteriovenous malformation and evaluate the reported literature for trends in the development of these lesions. Cases
were selected from the English literature using the PUBMED database using the search term “acquired or de novo cerebrovascular
arteriovenous malformations”. A total of seven patients (including the one reported in this study) with de novo arteriovenous
malformations are reported. Majority of patients were female, and mostly diagnosed as children. Their mean age at diagnosis
was 18 years (6–32), and the mean time from the initial intracranial study to the diagnosis of an AVM was 8 years (3–17).
De novo formation of AVMs is being increasingly reported, especially in young females. We present only the seventh such case
reported in the literature and challenge the traditional view that all arteriovenous malformations are congenital in nature. 相似文献
107.
Raymond Macharia PhD Anthony Otto PhD Petr Valasek PhD Ketan Patel PhD 《Muscle & nerve》2010,42(1):38-52
Gene compensation by members of the myogenic regulatory factor (MRF) family has been proposed to explain the apparent normal adult phenotype of MyoD?/? mice. Nerve and field stimulation were used to investigate contraction properties of muscle from MyoD?/? mice, and molecular approaches were used to investigate satellite‐cell behavior. We demonstrate that MyoD deletion results in major alterations in the organization of the neuromuscular junction, which have a dramatic influence on the physiological contractile properties of skeletal muscle. Second, we show that the lineage progression of satellite cells (especially initial proliferation) in the absence of MyoD is abnormal and linked to perturbations in the nuclear localization of β‐catenin, a key readout of canonical Wnt signaling. These results show that MyoD has unique functions in both developing and adult skeletal muscle that are not carried out by other members of the MRF family. Muscle Nerve, 2010 相似文献
108.
Alana M. Murphy Douglas S. Berkman Manisha Desai Mitchell C. Benson James M. McKiernan Ketan K. Badani 《BJU international》2010,105(2):176-179
Study Type – Therapy (case series)Level of Evidence 4
OBJECTIVES
To assess patients who had radical prostatectomy (RP) and pelvic lymph node dissection (PLND) for pT2–4 N0M0 prostate cancer, to determine if LN yield affects the risk of biochemical failure (BCF), as the extent of PLND at the time of RP has become increasingly uncertain with the decreasing trend in tumour stage.PATIENTS AND METHODS
We reviewed the Columbia University Urologic Oncology Database for patients with pT2–4 N0M0 prostate cancer treated with RP from 1990 to 2005. Exclusion criteria included <12 months of follow‐up, incomplete clinical and pathological data, and neoadjuvant androgen‐deprivation therapy (ADT) or immediate adjuvant ADT or external beam radiotherapy. Unadjusted and adjusted models were used to determine the ability of clinical and pathological variables to predict BCF.RESULTS
The final dataset included 964 patients, with a mean age of 60.5 years and median preoperative prostate‐specific antigen (PSA) level of 6.2 ng/mL. The median (range) LN yield was 7 (1–42) and the median follow‐up 59 (12–190) months. In the unadjusted and adjusted models, preoperative PSA, pathological Gleason score, pathological stage, surgical margin status and year of surgery were significant predictors of BCF. The LN group was not a significant predictor of BCF in both the unadjusted and adjusted model (P = 0.759 and 0.408, respectively). When patients were stratified into high‐ and low‐risk groups, LN yield remained an insignificant predictor of BCF.CONCLUSION
A higher LN yield at the time of RP does not increase the chance of cure for patients with pT2–4N0M0 prostate cancer. This lack of a survival advantage holds true for patients with high‐risk disease. 相似文献109.
Study Type – Therapy (case series)Level of Evidence 4
OBJECTIVE
To evaluate factors that affect compliance in men who enrol in a phosphodiesterase type 5 inhibitor (PDE5I) protocol after nerve‐sparing robot‐assisted prostatectomy (RAP), and report on short‐term outcomes, as PDE5Is may help restore erectile function after RAP and patient adherence to the regimen is a factor that potentially can affect outcome.PATIENT AND METHODS
We prospectively followed 77 men who had nerve‐sparing RAP and enrolled in a postoperative penile rehabilitation protocol. The men received either sildenafil citrate or tadalafil three times weekly. The minimum follow‐up was 8 weeks. Potency was defined as erection adequate for penetration and complete intercourse. Compliance was defined as men adhering to the regimen for ≥2 months.RESULTS
The mean age of the cohort was 57.8 years and the median follow‐up was 8 months. In all, 32% of the men discontinued the therapy <2 months after RAP and were deemed noncompliant with an additional 39% discontinuing therapy by 6 months, with the high cost of medication being the primary reason (65%). Long‐term compliance and preoperative erectile dysfunction were independent predictors of potency return after adjusting for age and nerve sparing.CONCLUSIONS
The high cost of medication remains a significant barrier to maintaining therapy. Noncompliance to PDE5I therapy in a tertiary care centre was much higher than reported in clinical trial settings. With longer‐term follow‐up, we need to further define the factors that improve overall recovery of sexual function after RAP. 相似文献110.