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71.
Kerry T. Holmes Alan W. Hampson Robert L. Raison Robert G. Webster William J. O'Sullivan Carolyn E. Mountford 《European journal of immunology》1982,12(6):523-526
The specificities of two anti-neuraminidase monoclonal antibodies have been compared by their ability to fix complement. They were found to differ to some extent in their reactivity with a range of N2 influenza viruses. Thus, as in the case of anti-hemagglutinin antibodies, anti-neuraminidase monoclonal antibodies are able to detect subtle structural changes in the viral antigen. Although both monoclonal antibodies fixed complement with intact virus, neither one fixed complement when complexed with isolated neuraminidase “heads”. 相似文献
72.
Julie Hoover‐Fong Adekemi Yewande Alade Michael Ain Ivor Berkowitz Michael Bober Erin Carter Jacqueline Hecht Dan Hoerschemeyer Debra Krakow Gretchen MacCarrick William G. Mackenzie Roberto Mendoza‐Londono Ericka Okenfuss Deirdre Popplewell Cathleen Raggio Kerry Schulze John McGready 《American journal of medical genetics. Part A》2020,182(1):150-161
Hypertension, compounded by obesity, contributes to cardiovascular disease and mortality. Data describing hypertension prevalence in adults with short stature skeletal dysplasias are lacking, perhaps due to poor fit of typical adult blood pressure cuffs on rhizomelic or contracted upper extremities. Through health screening research, blood pressure was measured in short stature adults attending support group meetings and skeletal dysplasia clinics. Blood pressure was measured with a commercially available, narrower adult cuff on the upper and/or lower segment of the arm. Height, weight, age, gender, diagnosis, exercise, and medications were collected. Subjects were classified as normotensive, prehypertensive, or hypertensive for group analysis; no individual clinical diagnoses were made. In 403 short stature adults, 42% were hypertensive (systolic >140, diastolic >90 OR taking antihypertensive medications). For every BMI unit and 1 kg weight increase in males, there was a 9% and an 8% increase, respectively, in the odds of hypertension versus normotension. In females, the increase was 10% and 6%, respectively. In those with achondroplasia, the most common short stature dysplasia, males (n = 106) had 10% greater odds of hypertension versus normotension for every BMI unit and kilogram increase. In females with achondroplasia (n = 128), the odds of hypertension versus normotension was 8% greater for each BMI unit and 7% for each additional kilogram. These data suggest a high population prevalence of hypertension among short stature adults. Blood pressure must be monitored as part of routine medical care, and measuring at the forearm may be the only viable clinical option in rhizomelic short stature adults with elbow contractures. 相似文献
73.
Kerry B. Jedele Virginia V. Michels 《American journal of medical genetics. Part A》1991,39(2):201-203
Urticaria in response to various physical stimuli has been reported in sporadic and familial patterns. The most common of these physical urticarias, dermographism, is a localized urticarial response to stroking or scratching of the skin and has not been reported previously to be familial. A four-generation family with dermographism, probably inherited as an autosomal dominant trait, is presented along with a discussion of sporadic dermographism and other types of familial physical urticarias. 相似文献
74.
Exercise motivation and adherence in cancer survivors after participation in a randomized controlled trial: An attribution theory perspective 总被引:1,自引:0,他引:1
Courneya KS Friedenreich CM Sela RA Quinney HA Rhodes RE Jones LW 《International journal of behavioral medicine》2004,11(1):8-17
The purpose of this study was to examine postprogram exercise motivation and adherence in cancer survivors who participated
in the Group Psychotherapy and Home-Based Physical Exercise (GROUP-HOPE; Courneya, Friedenreich, Sela, Quinney, & Rhodes,
2002) trial. At the completion of the GROUP-HOPE trial, 46 of 51 (90%) participants in the exercise group completed measures
of attribution theory constructs. A5-week follow-up self-report of exercise wasthen completed by 30 (65%) participants. Correlational
analyses indicated that program exercise, perceived success, expected success, and affective reactions were strong predictors
of postprogram exercise. In multivariate stepwise regression analyses, program exercise and perceived successwere the strongest
predictors of postprogram exercise. Additionally, perceived success was more important than objective success in understanding
the attribution process, and it interacted with personal control to influence expected success and negative affect. Finally,
postprogram quality of life and changes in physical fitness were correlates of perceived success. We concluded that attribution
theory may have utility for understanding postprogram exercise motivation and adherence in cancer survivors. 相似文献
75.
Differences in host susceptibility to disease progression in the human challenge model of Haemophilus ducreyi infection
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Spinola SM Bong CT Faber AL Fortney KR Bennett SL Townsend CA Zwickl BE Billings SD Humphreys TL Bauer ME Katz BP 《Infection and immunity》2003,71(11):6658-6663
With human volunteers inoculated at two sites with Haemophilus ducreyi, outcomes for a subject were not independent. In a reinfection trial, 2 of 11 previous pustule formers and 6 of 10 previous resolvers resolved all sites of infection. There was no correlation between serum bactericidal or phagocytic activity and outcome in the trial. These data indicate that different hosts are differentially susceptible to disease progression versus resolution in the model. 相似文献
76.
Roberts AD Clark SA Townsend NE Anderson ME Gore CJ Hahn AG 《European journal of applied physiology》2003,88(4-5):390-395
Nineteen well-trained cyclists (14 males and 5 females, mean initial V˙O2max 62.3 ml kg–1 min–1) completed a multistage cycle ergometer test to determine maximal mean power output in 4 min (MMPO4min), maximal oxygen uptake (V˙O2max) and maximal accumulated oxygen deficit (MAOD). The athletes were divided into three groups, each of which completed 5, 10
or 15 days of both a control condition (C) and live high:train low altitude exposure (LHTL). The C groups lived and trained
at the ambient altitude of 610 m. The LHTL groups spent 8–10 h night–1 in normobaric hypoxia at a simulated altitude of 2,650 m, and trained at the ambient altitude of 610 m. The changes to MMPO4min, V˙O2max and MAOD in response to LHTL altitude exposure were not significantly different for the 5-, 10- and 15-day treatment periods.
For the pooled data from all three treatment periods, there were significant increases in MMPO4min [mean (SD) 5.15 (0.83) W kg–1 vs 5.34 (0.78) W kg–1] and MAOD [50.1 (14.2) ml kg–1 vs 54.9 (13.1) ml kg–1] in the LHTL athletes between pre- and post-altitude exposure. There were no significant changes in MMPO4min [5.09 (0.76) W kg–1 vs 5.16 (0.86) W kg–1] or MAOD [50.5 (14.1) ml kg–1 vs 49.1 (13.0) ml kg–1] in the C athletes over the corresponding period. There were significant increases in V˙O2max in the athletes during both the LHTL [63.2 (9.0) ml kg–1 min–1 vs 64.1 (9.0) ml kg–1 min–1] and C [62.0 (8.6) ml kg–1 min–1 vs 63.4 (9.2) ml kg–1 min–1] conditions. In these athletes, there was no difference in the impact of 5, 10 or 15 days of LHTL on the increases observed
in MMPO4min, V˙O2max or MAOD; and LHTL increased MMPO4min and MAOD more than training at low altitude alone.
Electronic Publication 相似文献
77.
Variable expression of vision in sibs with albinism 总被引:4,自引:0,他引:4
Oculocutaneous albinism is defined by the presence of cutaneous and ocular hypopigmentation, the latter associated with nystagmus, iris transillumination, reduced retinal pigment, foveal hypoplasia, and misrouting of the optic fibers at the chiasm. The visual acuity is variable but almost always reduced. We report on two brothers with oculocutaneous albinism and markedly different visual acuity. One brother has a visual acuity of 20/100, while the second has similar cutaneous pigmentation and visual acuity of 20/20 and had not previously been recognized as having oculocutaneous albinism. Both brothers have foveal hypoplasia and misrouting of the optic fibers at the chiasm. Biochemical analysis suggests that this is a tyrosinase-related type of oculocutaneous albinism. This study demonstrates that careful observation of foveal development in relatives with normal vision is necessary to detect all individuals with albinism in a family. A suspected diagnosis of albinism may be confirmed when the visual-evoked potentials show excessive decussation of the optic fibers at the chiasm. 相似文献
78.
Emma Bell Grant Townsend David Wilson Jules Kieser Toby Hughes 《American journal of human biology》2001,13(5):690-698
Abnormal growth in Down syndrome (DS) is reflected by variable reduction in size and simplification in form of many physical traits. This study aimed to compare the thickness of enamel and dentine in deciduous and permanent mandibular incisor teeth between DS and non‐DS individuals and to clarify how these tissues contribute to altered tooth size in DS. Sample groups comprised 61 mandibular incisors (29 permanent and 32 deciduous) from DS individuals and 55 mandibular incisors (29 permanent and 26 deciduous) from non‐DS individuals. Maximum mesiodistal and labiolingual crown dimensions were measured initially, then the crowns were sectioned midsagittally and photographed using a stereomicroscope. Linear measurements of enamel and dentine thickness were obtained on the labial and lingual surfaces of the crowns, together with enamel and dentine–pulp areas and lengths of the dentino‐enamel junction. Reduced permanent crown size in DS was associated with a reduction in both enamel and dentine thickness. After adjustments were made for tooth size, DS permanent incisors had significantly thinner enamel than non‐DS permanent teeth. The DS permanent teeth also exhibited significant differences in shape and greater variability in dimensions than the non‐DS permanent teeth. Crown dimensions of deciduous incisors were similar in size or larger in DS compared with non‐DS deciduous teeth. Enamel and dentine thicknesses of the deciduous teeth were similar in DS and non‐DS individuals. The findings indicate that growth retardation in DS reduces both enamel and dentine deposition in the permanent incisors but not in the earlier‐forming deciduous predecessors. The results are also consistent with the concept of amplified developmental instability for dental traits in DS. Am. J. Hum. Biol. 13:690–698, 2001. © 2001 Wiley‐Liss, Inc. 相似文献
79.
80.
Walker TS Tomlin KL Worthen GS Poch KR Lieber JG Saavedra MT Fessler MB Malcolm KC Vasil ML Nick JA 《Infection and immunity》2005,73(6):3693-3701
Cystic fibrosis (CF) lung disease features persistent neutrophil accumulation to the airways from the time of infancy. CF children are frequently exposed to Pseudomonas aeruginosa, and by adulthood, 80% of CF patients are chronically infected. The formation of biofilms is a particularly important phenotypic characteristic of P. aeruginosa that allows for bacterial survival despite aggressive antibiotic therapy and an exuberant immune response. Here, we show that the presence of neutrophils enhances initial P. aeruginosa biofilm development over a period of 72 h through the formation of polymers comprised of actin and DNA. F-actin was found to be a site of attachment for P. aeruginosa. These actin and DNA polymers are present in CF sputum, and disruption of the polymers dispersed the associated P. aeruginosa cells and reduced biofilm development. These findings demonstrate a potential maladaptation of the primary innate response. When the host fails to eradicate the infection, cellular components from necrotic neutrophils can serve as a biological matrix to facilitate P. aeruginosa biofilm formation. 相似文献