全文获取类型
收费全文 | 388篇 |
免费 | 24篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 4篇 |
妇产科学 | 7篇 |
基础医学 | 37篇 |
口腔科学 | 8篇 |
临床医学 | 23篇 |
内科学 | 135篇 |
皮肤病学 | 4篇 |
神经病学 | 12篇 |
特种医学 | 19篇 |
外科学 | 51篇 |
综合类 | 2篇 |
预防医学 | 12篇 |
药学 | 24篇 |
肿瘤学 | 80篇 |
出版年
2023年 | 19篇 |
2022年 | 19篇 |
2021年 | 48篇 |
2020年 | 23篇 |
2019年 | 27篇 |
2018年 | 31篇 |
2017年 | 18篇 |
2016年 | 10篇 |
2015年 | 10篇 |
2014年 | 17篇 |
2013年 | 13篇 |
2012年 | 24篇 |
2011年 | 16篇 |
2010年 | 6篇 |
2009年 | 3篇 |
2008年 | 9篇 |
2007年 | 5篇 |
2006年 | 9篇 |
2005年 | 7篇 |
2004年 | 5篇 |
2003年 | 3篇 |
2002年 | 12篇 |
2001年 | 3篇 |
2000年 | 12篇 |
1999年 | 6篇 |
1998年 | 1篇 |
1997年 | 1篇 |
1996年 | 1篇 |
1995年 | 3篇 |
1994年 | 1篇 |
1992年 | 1篇 |
1991年 | 8篇 |
1990年 | 2篇 |
1989年 | 5篇 |
1988年 | 4篇 |
1987年 | 4篇 |
1986年 | 8篇 |
1985年 | 2篇 |
1984年 | 9篇 |
1983年 | 8篇 |
1981年 | 1篇 |
1980年 | 1篇 |
1979年 | 3篇 |
1977年 | 1篇 |
1973年 | 1篇 |
1972年 | 1篇 |
1971年 | 1篇 |
排序方式: 共有422条查询结果,搜索用时 31 毫秒
91.
Obesity, which is one of the causes of the lifestyle-related disease, is a hepatopathic exacerbation factor that causes a chronic hepatic disorder. In this study, we examined the pathological changes in the liver in mice with obesity induced by monosodium glutamate administration. Pathological analysis revealed the deposition of many lipid droplets in hepatocytes and sinusoidal dilatation in obese mice. Scanning electron microscopic analysis revealed the presence of sinusoidal dilatation, and the fenestrations of the sinusoid were significantly swollen in obese mice. These results suggest that a dysfunction of the sinusoidal endothelium occurs in chronic obesity. 相似文献
92.
93.
94.
Hiroaki Soyama Morikazu Miyamoto Hiroki Ishibashi Masaya Nakatsuka Haruka Kawauchi Takahiro Sakamoto Hiroko Matuura Mika Kuwahara Kazuki Takasaki Hideki Iwahashi Kento Kato Masashi Yoshida Masashi Takano Hidenori Sasa Kenichi Furuya 《Taiwanese journal of obstetrics & gynecology》2019,58(1):159-163
Objective
Recently, Bakri balloon (BBT) was effective for women with placenta previa to reduce hemorrhage. However, about 10% of women needed to receive an invasive strategy. Thus, the identification of risk factors and the development of additional measurements for BBT failure was needed. The aim of our study is to investigate the cause and measurements of failing prophylactic BBT in women with placenta previa.Materials and methods
Women with placenta previa who underwent cesarean section and had a prophylactic BBT inserted during the operation at our institution between January 2015 and December 2017 were enrolled. Patients requiring additional procedures after cesarean section for massive hemorrhage were defined as BBT failures. Additionally, the patterns and risk factors of BBT failure were retrospectively evaluated.Results
Seventy women met the inclusion criteria. Of them, 9 (13%) were in the balloon failure group and 61 (87%), in the balloon success group. Between two groups, the median of postoperative blood loss was 1153 g vs. 70 g (p < 0.01) and the total blood loss 2409 g vs. 971 g (p < 0.01). There were two types of failures in the balloon failure group: balloon prolapse in eight patients (89%) and accidental placental retention in one patient (11%). The hemorrhage was controlled in all patients with balloon prolapse by reinsertion and inflation of the balloon. The patient with placental retention required a uterine artery embolization (UAE). Although three patients required a blood transfusion, none required a hysterectomy. The logistic regression for the risk of balloon failure revealed classification of major previa to be the highest risk factor (Hazard Ratio; 19.1, 95% Confidence Interval; 3.17–367.9, p < 0.01).Conclusion
The major cause of BBT failure was balloon prolapse. It could be treated with non-invasive methods; however, patients with placental retention could not avoid invasive treatment to stop the hemorrhage. 相似文献95.
96.
We investigated the effect of low molecular weight barley β-glucan (LMW-BG) on cecal fermentation, glucose, and lipid metabolism through comparisons to high molecular weight β-glucan (HMW-BG). C57BL/6J male mice were fed a moderate-fat diet for 61 days. LMW-BG or HMW-BG was added to the diet corresponding to 4% β-glucan. We measured the apparent absorption of fat, serum biomarkers, the expression levels of genes involved in glucose and lipid metabolism in the liver and ileum, and bacterial counts of the major microbiota groups using real time PCR. The concentration of short-chain fatty acids (SCFAs) in the cecum was analyzed by GC/MS. Significant reductions in serum leptin, total- and LDL-cholesterol concentrations, and mRNA expression levels of sterol regulatory element-binding protein-1c (SREBP-1c) were observed in both BG groups. HMW-BG specific effects were observed in inhibiting fat absorption and reducing abdominal deposit fat, whereas LMW-BG specific effects were observed in increasing bacterial counts of Bifidobacterium and Bacteroides and cecal total SCFAs, acetate, and propionate. mRNA expression of neurogenin 3 was increased in the LMW-BG group. We report that LMW-BG affects glucose and lipid metabolism via a prebiotic effect, whereas the high viscosity of HMW-BG in the digestive tract is responsible for its specific effects. 相似文献
97.
Kazuhisa Kodama Takumi Kawaguchi Hideyuki Hyogo Tomoaki Nakajima Masafumi Ono Masataka Seike Hirokazu Takahashi Yuichi Nozaki Miwa Kawanaka Saiyu Tanaka Kento Imajo Yoshio Sumida Yoshihiro Kamada Hideki Fujii Yuya Seko Tetsuo Takehara Yoshito Itoh Atsushi Nakajima Naohiko Masaki Takuji Torimura Toshiji Saibara Yoshiyasu Karino Kazuaki Chayama Katsutoshi Tokushige 《Journal of gastroenterology and hepatology》2019,34(9):1626-1632
98.
Non‐alcoholic fatty liver disease comorbid with major depressive disorder: The pathological features and poor therapeutic efficacy
下载免费PDF全文
![点击此处可从《Journal of gastroenterology and hepatology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
99.
Masayoshi Oikawa Atsushi Kobayashi Kento Wada Takamasa Sato Satoshi Suzuki Akiomi Yoshihisa Kazuhiko Nakazato Hitoshi Suzuki Shu-ichi Saitoh Takafumi Ishida Yasuchika Takeishi 《Journal of cardiac failure》2018,24(1):29-32
Background
Several echocardiographic parameters are currently used to evaluate left ventricular (LV) filling pressure. However, these parameters are not always consistent in the clinical setting. We aimed to determine a novel parameter by multiplying log B-type natriuretic peptide (lnBNP) and the ratio of mitral inflow early and late diastolic filling velocities (E/A) for the prediction of pulmonary capillary wedge pressure (PCWP).Methods and Results
One hundred ninety-eight patients suspected of chronic heart failure were analyzed. The product of lnBNP and E/A (BNP?×?E/A) showed the highest correlation coefficient with mean PCWP (R?=?0.7326) compared with E/A (R?=?0.7010) and E/e′ (R?=?0.3922). Multivariate logistic regression analysis revealed that BNP?×?E/A was associated with elevated PCWP (odds ratio 1.640, 95% confidence interval 1.312–2.197; P?<.01). In the receiver operating characteristic curve analysis for detecting elevated PCWP, BNP?×?E/A showed the largest area under the curve (AUC) compared with E/A and E/e′ (0.880 vs 0.827 and 0.788, respectively; P?<.05). BNP?×?E/A still showed large AUC (0.842) for detection of elevated PCWP in patients with normal LV ejection fraction.Conclusion
BNP?×?E/A is a useful parameter for detecting elevated PCWP regardless of the LV ejection fraction. 相似文献100.
Kento Imajo Louise Tetlow Andrea Dennis Elizabeth Shumbayawonda Sofia Mouchti Timothy J Kendall Eve Fryer Shogi Yamanaka Yasushi Honda Takaomi Kessoku Yuji Ogawa Masato Yoneda Satoru Saito Catherine Kelly Matt D Kelly Rajarshi Banerjee Atsushi Nakajima 《World journal of gastroenterology : WJG》2021,27(7):609-623
BACKGROUND Non-invasive assessment of non-alcoholic steatohepatitis(NASH)is increasing in desirability due to the invasive nature and costs associated with the current form of assessment;liver biopsy.Quantitative multiparametric magnetic resonance imaging(mpMRI)to measure liver fat(proton density fat fraction)and fibroinflammatory disease[iron-corrected T1(cT1)],as well as elastography techniques[vibration-controlled transient elastography(VCTE)liver stiffness measure],magnetic resonance elastography(MRE)and 2D Shear-Wave elastography(SWE)to measure stiffness and fat(controlled attenuated parameter,CAP)are emerging alternatives which could be utilised as safe surrogates to liver biopsy.AIM To evaluate the agreement of non-invasive imaging modalities with liver biopsy,and their subsequent diagnostic accuracy for identifying NASH patients.METHODS From January 2019 to February 2020,Japanese patients suspected of NASH were recruited onto a prospective,observational study and were screened using noninvasive imaging techniques;mpMRI with LiverMultiScan?,VCTE,MRE and 2DSWE.Patients were subsequently biopsied,and samples were scored by three independent pathologists.The diagnostic performances of the non-invasive imaging modalities were assessed using area under receiver operating characteristic curve(AUC)with the median of the histology scores as the gold standard diagnoses.Concordance between all three independent pathologists was further explored using Krippendorff’s alpha(a)from weighted kappa statistics.RESULTS N=145 patients with mean age of 60(SD:13 years.),39%females,and 40%with body mass index≥30 kg/m2 were included in the analysis.For identifying patients with NASH,MR liver fat and cT1 were the strongest performing individual measures(AUC:0.80 and 0.75 respectively),and the mpMRI metrics combined(cT1 and MR liver fat)were the overall best non-invasive test(AUC:0.83).For identifying fibrosis≥1,MRE performed best(AUC:0.97),compared to VCTE-liver stiffness measure(AUC:0.94)and 2D-SWE(AUC:0.94).For assessment of steatosis≥1,MR liver fat was the best performing non-invasive test(AUC:0.92),compared to controlled attenuated parameter(AUC:0.75).Assessment of the agreement between pathologists showed that concordance was best for steatosis(a=0.58),moderate for ballooning(a=0.40)and fibrosis(a=0.40),and worst for lobular inflammation(a=0.11).CONCLUSION Quantitative mpMRI is an effective alternative to liver biopsy for diagnosing NASH and non-alcoholic fatty liver,and thus may offer clinical utility in patient management. 相似文献