Significant Increases in Serum CA125 and CA19-9 Following Torsion from an Adenofibroma of the Ovary: A Case Report

Significant increases in the serum levels of cancer antigen125 (CA 125) and carbohydrate antigen 19-9 (CA19-9) were observedover one month prior to the removal of an ovarian adenofibroma.The serum levels of CA125 and CA19-9 decreased rapidly aftersurgery. The surface of the tumor at surgery showed marked inflammation,probably induced by the necrosis produced by torsion. Pathologically,most of the tumor was necrotic, and histo immunochemical stainingof the viable cells was weak for CA125 but intense for CA19-9.Clinicopathological observations of the case suggested thatCA125 and CA19-9 might be stimulated in the cells by inflammationor that originally existing CAT25 and CA19-9 were released fromthe tumor cells following the cell necrosis.     

A case of triple cancer--gastric, esophageal and hepatocellular carcinoma

A case of triple cancer involving a tubular adenocarcinoma of the stomach, a squamous cell carcinoma of the esophagus, and hepatocellular carcinoma of the live is reported. These three cancers had been diagnosed while the patient was alive and later were confirmed by autopsy. The esophageal cancer and hepatocellular carcinoma were found almost simultaneously, 6 years after surgery for the gastric cancer. Although many cases of triple cancer have been reported, a triple cancer of this combination is very rare (0.3% of all cases of triple cancer), our case being the fifth such case in Japan.     

Active specific immunotherapy using the immune reaction of a low-dose irradiated tumor tissue

Active specific immunotherapy using the immune reaction of a low-dose irradiated tumor tissue was studied on the transplanted MM46 tumor of female C3H/He mice after radiotherapy. MM46 tumor cells were inoculated into the right hind paws of mice. On the 5th day, irradiation with the dose of 3000 rad was performed. On the 11 th day, tumor cells and mononuclear cells, which were separated from the low-dose irradiated tumor tissue (2000 rad on the fifth day), were injected into the left hind paws of the tumor-bearing mice. Effectiveness of this active specific immunotherapy against tumor was evaluated by the regression of tumor and survival rate of mice. Tumor was markedly regressed and survival rate was significantly increased by the active specific immunotherapy.