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101.
Junko?KishikawaEmail author Shinsuke?Kazama Koji?Oba Kiyoshi?Hasegawa Hiroyuki?Anzai Yuzo?Harada Hiroyuki?Abe Keisuke?Matsusaka Kumiko?Hongo Masaru?Oba Koji?Yasuda Kensuke?Otani Takeshi?Nishikawa Toshiaki?Tanaka Junichiro?Tanaka Tomomichi?Kiyomatsu Keisuke?Hata Kazushige?Kawai Hiroaki?Nozawa Hironori?Yamaguchi Soichiro?Ishihara Eiji?Sunami Tetsuo?Ushiku Joji?Kitayama Masashi?Fukayama Norihiro?Kokudo Toshiaki?Watanabe 《Annals of surgical oncology》2016,23(6):1916-1923
Background
CD133 is a transmembrane protein that is proposed to be a stem cell marker of colorectal cancer (CRC); however, the correlation between CD133 expression and survival of CRC patients with liver metastasis has not been fully examined.Methods
CD133 expression was evaluated immunohistochemically, both in primary tumors and synchronous liver metastases of 88 consecutive CRC patients, as well as recurrent lesions in the remnant liver of 27 of these 88 patients. The relationship between CD133 expression and clinicopathological characteristics, recurrence-free survival, and overall survival (OS) was analyzed.Results
CD133 expression in liver metastases (mCD133) was detected in 50 of 88 patients (56.8 %), and had significant correlation with CD133 expression in primary lesions (pCD133) (p < 0.001). CD133 expression in liver recurrent lesions (recCD133) also had a significant correlation with mCD133 (p < 0.001). mCD133+ patients had significantly longer disease-free survival (p = 0.043) and OS (p = 0.014) than mCD133? patients. In addition, mCD133+ patients had a significantly lower rate of extrahepatic recurrence (p < 0.001).Conclusions
Patients without CD133 expression in liver metastasis had significantly shorter survival, perhaps because mCD133? patients had a significantly higher rate of extrahepatic recurrence.102.
Maeshiro K Sugawara M Sakai A Sugawara K 《Shinrigaku kenkyu : The Japanese journal of psychology》2007,78(2):182-188
This study developed revised Japanese versions of the self-perception profile for Children, for Adolescents and for College Students. The original versions have an idiosyncratic and time-consuming item format, which was revised by using only one statement for each item. Subjects were fifth to sixth grade students (Boys=129, Girls= 152), tenth to twelfth grade students (Boys=112, Girls=100), and college students (Boys=96, Girls=153) in Japan. The reliability and validity measures showed that the revised versions were similar to the original versions. The present study provides some evidence for the use of these scales with Japanese students. 相似文献
103.
Cloning of B cell-specific membrane tetraspanning molecule BTS possessing B cell proliferation-inhibitory function 总被引:1,自引:0,他引:1
Suenaga T Arase H Yamasaki S Kohno M Yokosuka T Takeuchi A Hattori T Saito T 《European journal of immunology》2007,37(11):3197-3207
Lymphocyte proliferation is regulated by signals through antigen receptors, co-stimulatory receptors, and other positive and negative modulators. Several membrane tetraspanning molecules are also involved in the regulation of lymphocyte growth and death. We cloned a new B cell-specific tetraspanning (BTS) membrane molecule, which is similar to CD20 in terms of expression, structure and function. BTS is specifically expressed in the B cell line and its expression is increased after the pre-B cell stage. BTS is expressed in intracellular granules and on the cell surface. Overexpression of BTS in immature B cell lines induces growth retardation through inhibition of cell cycle progression and cell size increase without inducing apoptosis. This inhibitory function is mediated predominantly by the N terminus of BTS. The development of mature B cells is inhibited in transgenic mice expressing BTS, suggesting that BTS is involved in the in vivo regulation of B cells. These results indicate that BTS plays a role in the regulation of cell division and B cell growth. 相似文献
104.
Takahashi N Kiyokawa K Rikimaru H Watanabe K Inoue Y 《The Journal of craniofacial surgery》2007,18(1):208-211
Congenital pharyngeal atresia is a very rare gastrointestinal anomaly, with only seven cases of complete pharyngeal atresia having been reported. Five of these cases were autopsy reports and success in surgery to enable oral ingestion was not reported even for the two surviving cases. This is a report of a 1.5-year-old boy with complete congenital pharyngeal atresia who was saved by an emergency tracheostomy directly after birth, and on whom we performed surgery to reconstruct the pharyngeal cavity and prevent re-occlusion and restonosis. Approximately four years after the surgery, no restenosis of the pharyngeal cavity has been observed, and the patient is capable of orally ingesting ordinary meals and breathing and vocalizing by closing the tracheal lumen for nearly satisfactory results. 相似文献
105.
Hanada Mitsuru Hotta Kensuke Furuhashi Hiroki Matsuyama Yukihiro 《European journal of orthopaedic surgery & traumatology : orthopedie traumatologie》2020,30(5):917-921
European Journal of Orthopaedic Surgery & Traumatology - Surgical site infection (SSI) and periprosthetic joint infection are the most important problems after total hip arthroplasty (THA) and... 相似文献
106.
107.
Maruyama Suguru Kawaguchi Yoshihiko Akaike Hidenori Shiraishi Kensuke Saito Ryo Shimizu Hiroki Furuya Shinji Hosomura Naohiro Amemiya Hidetake Kawaida Hiromichi Sudo Makoto Inoue Shingo Kono Hiroshi Ichikawa Daisuke 《World journal of surgery》2020,44(3):863-868
World Journal of Surgery - Gastric cancers located within the upper-third of the stomach (UGC), especially the esophagogastric junction GC (EGJGC), have distinct clinicopathological features due to... 相似文献
108.
Mitsuro Kanda Tsutomu Fujii Hideki Takami Masaya Suenaga Yoshikuni Inokawa Suguru Yamada Goro Nakayama Hiroyuki Sugimoto Masahiko Koike Shuji Nomoto Yasuhiro Kodera 《Surgery today》2014,44(9):1692-1701
Purpose
The aim of this study was to detect high-performance prognostic biomarkers of pancreatic cancer which would enable the identification of high-risk patients.Methods
The subjects were 324 patients who underwent radical surgery for pancreatic ductal adenocarcinoma without neoadjuvant therapy. We evaluated the prognostic impact of four perioperative serum tumor markers, including carbohydrate antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA). We also evaluated the indices by multiplying the values of two tumor markers (e.g., CA19-9 × CEA).Results
The preoperative CA19-9 × CEA index had a strong correlation with the prognosis of patients with pancreatic cancer, even when the cut-off was set at the median value. CA19-9 × CEA ≥500 was an independent predictor of mortality (hazard ratio: 1.642, p = 0.021). In the ROC curve analysis of early mortality after surgery, the CA19-9 × CEA index had the highest goodness of fit. The presence of CA19-9 × CEA ≥500 had the largest attributable risk proportion because of its combined high predictive performance and prevalence. The postoperative CA19-9 × CEA index was also a significant predictive marker of mortality.Conclusion
The CA19-9 × CEA index is a strong prognostic biomarker that could help identify pancreatic cancer patients expected to have a poor prognosis so that they can be administered appropriate multidisciplinary treatment. 相似文献109.
Mikiya Inoue Kiminobu Sugito Taro Ikeda Hiroyuki Kawashima Manabu Hanada Takeshi Furuya Kensuke Ohashi Tsugumichi Koshinaga 《Journal of gastrointestinal surgery》2014,18(3):580-583
Background
The present study aimed to assess the long-term results of seton placement for fistula-in-ano (FIA) in infants.Methods
Data of patients aged <1 year who presented to our department with perianal abscess (PA) between January 2006 and February 2010 were retrospectively reviewed. Our standard initial treatment for PA was incision and drainage. Patients with systemic diseases and inflammatory bowel diseases were excluded.Results
Ninety-five patients were treated for PA and/or FIA during the 5-year period, and follow-up data were available for 90 patients. The mean follow-up duration in these patients was 49.8?±?11.4 months, and mean age at presentation was 3.1?±?2.7 months. Of the 90 patients, 36 (40 %) developed FIA (39 lesions) and underwent seton placement. The condition healed in a mean period of 6.3?±?4.0 weeks after the placement of a cutting seton. Healing of the fistula was achieved in 35 (97.2 %) of 36 patients after the initial seton procedure, and one patient who showed recurrence underwent a second seton placement, resulting in successful healing of the FIA after 5 weeks.Conclusions
The long-term success of seton placement indicates that this procedure should be a treatment option for FIA in infants. 相似文献110.
Masahiko Noguchi MD Minoru Tabata MD Kotaro Obunai MD Kentaro Shibayama MD Joji Ito MD Hiroyuki Watanabe MD Fumiaki Yashima MD Yusuke Watanabe MD Toru Naganuma MD Motoharu Araki MD Futoshi Yamanaka MD Shinichi Shirai MD Hiroshi Ueno MD Kazuki Mizutani MD Akihiro Higashimori MD Kensuke Takagi MD Norio Tada MD Masanori Yamamoto MD Kentaro Hayashida MD 《Catheterization and cardiovascular interventions》2021,97(1):E113-E120