全文获取类型
收费全文 | 1760篇 |
免费 | 121篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 43篇 |
妇产科学 | 27篇 |
基础医学 | 262篇 |
口腔科学 | 15篇 |
临床医学 | 88篇 |
内科学 | 389篇 |
皮肤病学 | 43篇 |
神经病学 | 189篇 |
特种医学 | 26篇 |
外科学 | 395篇 |
综合类 | 7篇 |
预防医学 | 19篇 |
眼科学 | 21篇 |
药学 | 140篇 |
中国医学 | 1篇 |
肿瘤学 | 221篇 |
出版年
2023年 | 15篇 |
2022年 | 24篇 |
2021年 | 35篇 |
2020年 | 31篇 |
2019年 | 36篇 |
2018年 | 56篇 |
2017年 | 46篇 |
2016年 | 45篇 |
2015年 | 66篇 |
2014年 | 77篇 |
2013年 | 70篇 |
2012年 | 103篇 |
2011年 | 126篇 |
2010年 | 62篇 |
2009年 | 53篇 |
2008年 | 109篇 |
2007年 | 109篇 |
2006年 | 94篇 |
2005年 | 95篇 |
2004年 | 104篇 |
2003年 | 87篇 |
2002年 | 73篇 |
2001年 | 26篇 |
2000年 | 16篇 |
1999年 | 37篇 |
1998年 | 26篇 |
1997年 | 19篇 |
1996年 | 21篇 |
1995年 | 12篇 |
1994年 | 10篇 |
1993年 | 12篇 |
1992年 | 20篇 |
1991年 | 21篇 |
1990年 | 17篇 |
1989年 | 12篇 |
1988年 | 11篇 |
1987年 | 13篇 |
1986年 | 9篇 |
1985年 | 11篇 |
1984年 | 6篇 |
1981年 | 14篇 |
1980年 | 4篇 |
1979年 | 6篇 |
1978年 | 7篇 |
1977年 | 5篇 |
1973年 | 4篇 |
1972年 | 4篇 |
1968年 | 4篇 |
1967年 | 5篇 |
1966年 | 4篇 |
排序方式: 共有1892条查询结果,搜索用时 31 毫秒
51.
Reversible cerebral vasoconstriction syndrome and posterior reversible encephalopathy syndrome in a boy with Loeys‐Dietz syndrome 下载免费PDF全文
52.
53.
54.
Ryosuke Sakemi Suketo So Yosuke Morimitsu Hajime Imada Hiroshi Ishihara Kenjiro Kuhara Yuichiro Oku Hiroya Terabe Masahiro Kishi Ei Sasaki Miyuki Sakemi Masayuki Shimokobe 《Clinical journal of gastroenterology》2014,7(4):310-315
Primary squamous cell carcinoma is rarely observed, with a reported incidence of 0.04–0.07 % of all gastric cancers. An 81-year-old male underwent chemoradiotherapy for type 1 gastric cancer of the posterior wall of the cardiac region in 2005. The tumor disappeared after 1 year of therapy, following which an area of white epithelium, approximately 30 mm in diameter and continuous with the esophageal mucosa, became visible. Biopsy of the white epithelium indicated normal squamous epithelium. An elevated lesion was subsequently detected in the area of white epithelium on upper gastrointestinal endoscopy during a follow-up examination 5 years after therapy. As a biopsy of the same site indicated squamous cell carcinoma, we performed endoscopic submucosal dissection. Histopathological examination indicated high-grade fibrosis due to radiotherapy and showed a moderately differentiated squamous cell carcinoma invading the scarred portion. We describe a case where the developmental process of a squamous cell carcinoma was observed using endoscopy, including narrow band imaging with magnification. This carcinoma likely originated from squamous metaplasia that developed after chemoradiotherapy was administered for a gastric cancer. 相似文献
55.
G protein-coupled receptors (GPCRs) constitute a large family of seven transmembrane proteins that regulate major cellular functions. The important role of GPCRs in the neuroendocrine system is outlined by the great interest of pharmaceutical companies in developing new drugs targeting these receptors. GPCRs exist as monomers, but can also be organized in oligomeric structures composed of either homo- or heteromers. GPCR heteromerization may play an important role in modulating and fine-tuning GPCR function and signaling. The literature reports many examples of GPCR heteromers in vitro raising the question of the physiological relevance of these complexes in tissues. Considerable efforts are currently being directed towards conclusive evidence for the existence of GPCRs heteromers in vivo, a crucial step for the validation of the concept of GPCR heteromerization and future drug development. The present review will give a brief history of GPCR oligomerization and emphasize the importance and physiological relevance of GPCR heteromerization by discussing key examples of GPCR couples. 相似文献
56.
Hiroyoshi Adachi MD PhD Shunichiro Shinagawa MD PhD Kenjiro Komori MA Yasutaka Toyota MD PhD Takaaki Mori MD PhD Teruhisa Matsumoto MD PhD Naomi Sonobe MD PhD Tetsuo Kashibayashi MD PhD Tomohisa Ishikawa MD PhD Ryuji Fukuhara MD PhD Manabu Ikeda MD PhD 《Psychiatry and clinical neurosciences》2013,67(3):148-153
57.
58.
Atsushi Okada Takahiro Yasui Kazumi Taguchi Kazuhiro Niimi Yasuhiko Hirose Shuzo Hamamoto Ryosuke Ando Yasue Kubota Yukihiro Umemoto Keiichi Tozawa Shoichi Sasaki Yutaro Hayashi Kenjiro Kohri 《Urological research》2013,41(6):487-492
To evaluate the efficacy of company-initiated training of urologists on shock wave lithotripsy (SWL) treatment results, we retrospectively assessed 602 patients who underwent SWL in Nagoya City University Hospital between January 2004 and June 2011 using Lithotripter S (Dornier MedTech, Japan). Training—provided by a training specialist of the company in June 2010—focused on the targeting of renal and proximal ureter stones with a combination of radiography and ultrasonography (US). The stretcher wedges were positioned in the semi-prone position or the semi-supine position for middle and distal ureter stones, respectively. Success rates between 519 pre-training treatments and 83 post-training treatments were compared. Patient age and stone location, burden, number, and composition did not significantly differ between pre- and post-training. Training improved the overall success rate from 66.3 to 87.2 % (P < 0.0001). The mean number of SWL treatments decreased from 1.8 ± 1.8 to 1.4 ± 1.3 (P = 0.01). The first SWL treatment success rate increased from 67.1 to 83.7 % (P = 0.002), and the need for multiple treatments decreased. The frequency of detection of renal and proximal ureter stones by both radiography and US increased from 10.5 % before training to 58.2 % after training (P < 0.0001). Significant factors for successful SWL were determined to be training and prone position for distal ureter stones by multivariate analysis and ultrasonic detection for renal and proximal ureter stones by univariate analysis. Skills in targeting stones using ultrasonography and selecting the proper therapeutic position are essential for improving the success rate of stone removal. 相似文献
59.
Takeshita Y Takamura T Inoue O Okumura M Kato K Sunagozaka H Arai K Misu H Nakamura M Nakanuma Y Kaneko S 《Internal medicine (Tokyo, Japan)》2012,51(1):79-82
A 73-year-old woman had previously been diagnosed with CREST syndrome, PBC and diabetes. Hepatic fibrosis was not evident, in spite of the transudative ascites and active esophageal varices. ACA were positive, whereas AMA and anti-gp210 antibodies were negative. She showed low urinary excretion of C-peptide and was weakly positive for anti-GAD antibody. She was diagnosed with a form of PBC that progresses via portal hypertension rather than liver failure and with SPIDDM. Her HLA type did not contain risk allele for IDDM or PBC. SPIDDM should be considered when patients with PBC with portal hypertension-type progression develop diabetes. 相似文献
60.
Yasunori Itoh Atsushi Okada Takahiro Yasui Ryousuke Ando Keiichi Tozawa Shoichi Sasaki Kenjiro Kohri 《International urology and nephrology》2013,45(3):675-678