全文获取类型
收费全文 | 1882篇 |
免费 | 115篇 |
国内免费 | 31篇 |
专业分类
耳鼻咽喉 | 17篇 |
儿科学 | 45篇 |
妇产科学 | 32篇 |
基础医学 | 192篇 |
口腔科学 | 24篇 |
临床医学 | 93篇 |
内科学 | 614篇 |
皮肤病学 | 30篇 |
神经病学 | 121篇 |
特种医学 | 69篇 |
外科学 | 422篇 |
综合类 | 4篇 |
预防医学 | 30篇 |
眼科学 | 38篇 |
药学 | 77篇 |
中国医学 | 2篇 |
肿瘤学 | 218篇 |
出版年
2024年 | 3篇 |
2023年 | 26篇 |
2022年 | 36篇 |
2021年 | 77篇 |
2020年 | 58篇 |
2019年 | 78篇 |
2018年 | 70篇 |
2017年 | 47篇 |
2016年 | 71篇 |
2015年 | 62篇 |
2014年 | 90篇 |
2013年 | 87篇 |
2012年 | 114篇 |
2011年 | 134篇 |
2010年 | 73篇 |
2009年 | 68篇 |
2008年 | 113篇 |
2007年 | 92篇 |
2006年 | 104篇 |
2005年 | 116篇 |
2004年 | 102篇 |
2003年 | 83篇 |
2002年 | 85篇 |
2001年 | 21篇 |
2000年 | 19篇 |
1999年 | 19篇 |
1998年 | 19篇 |
1997年 | 14篇 |
1996年 | 15篇 |
1995年 | 18篇 |
1994年 | 12篇 |
1993年 | 7篇 |
1992年 | 3篇 |
1991年 | 9篇 |
1990年 | 6篇 |
1989年 | 5篇 |
1988年 | 5篇 |
1987年 | 5篇 |
1986年 | 6篇 |
1985年 | 3篇 |
1984年 | 7篇 |
1983年 | 6篇 |
1982年 | 9篇 |
1981年 | 10篇 |
1980年 | 3篇 |
1978年 | 2篇 |
1976年 | 2篇 |
1975年 | 5篇 |
1972年 | 2篇 |
1971年 | 3篇 |
排序方式: 共有2028条查询结果,搜索用时 31 毫秒
31.
Fumitake ONO Shinichiro YASUMOTO Minao FURUMURA Takahiro HAMADA Norito ISHII Takashi GYOTOKU Mitsunari HIGUCHI Kenichiro INOKUCHI Kazuo JYO Hideaki KOGA Ayako KOMAI Koji MARUTA Tami MASHIKO Tsukasa MIHARA Hiroko MIYAHARA Minoru MIYASATO Koichiro MUTO Koichi NAGASE Masakazu NAGATA Hideki SAKIHAMA Tomoko TANAHASHI Atsuto UEDA Kyoko YAMAKAWA Chika OHATA Teruki DAINICHI Daisuke TSURUTA Takashi HASHIMOTO 《The Journal of dermatology》2012,39(11):902-908
Famciclovir is a guanine analog antiviral drug used commonly for herpes zoster. Efficacy of famciclovir treatment has been reported to be comparable to valacyclovir treatment. Both of these medications reduce the time to complete cessation of zoster‐associated pain including post‐herpetic neuralgia, as compared to acyclovir. We conducted a multicenter, randomized, open clinical trial in order to evaluate the extent of pain relief afforded by these two antiviral drugs during the acute disease phase of herpes zoster. The study group comprised 86 immunocompetent adult patients suffering from herpes zoster, who were treated with either famciclovir or valacyclovir for 7 days. Of these, 55 patients enrolled in this study within 72 h of the onset of the rash and 31 patients after 72 h of the onset. There was a significant reduction in acute herpes zoster pain with famciclovir on day 7 and at 2–3 weeks in both of these patient groups, while with valacyclovir, there was not significant reduction in pain on day 7. Of patients aged 50 years or older, there was a significantly earlier reduction in pain with famciclovir than with valacyclovir. In addition, a significant reduction in the number of patients with pain was observed as early as days 3–4 with famciclovir treatment as compared with valacyclovir treatment. We conclude that famciclovir was superior to valacyclovir in the relief of acute pain of herpes zoster. Accordingly, famciclovir is recommended for herpes zoster patients with moderate symptoms and a visual analog scale score of under 50 mm. 相似文献
32.
Mayu Isotani Osamu Yamada Joshua L. Lachowicz Kyoichi Tamura Hiroko Yagihara Yasuhito Fujino Kenichiro Ono Tsukimi Washizu Makoto Bonkobara 《British journal of haematology》2010,148(1):144-153
The purpose of the current study was to investigate the mutation status of KIT in feline mast cell tumours (MCTs) and to examine the effects of tyrosine kinase inhibition on the phosphorylation of mutant kit in vitro and in clinical cases of cats. Sequence analysis of KIT identified mutations in 42/62 MCTs (67·7%). The vast majority of the mutations were distributed in exons 8 and 9, both of which encode the fifth immunoglobulin-like domain (IgD) of kit. All five types of kit with a mutation in the fifth IgD were then expressed in 293 cells and examined for phosphorylation status. The mutant kit proteins showed ligand-independent phosphorylation. The tyrosine kinase inhibitor imatinib mesylate suppressed the phosphorylation of these mutant kit proteins in transfectant cells. In a clinical study of 10 cats with MCTs, beneficial response to imatinib mesylate was observed in 7/8 cats that had a mutation in the fifth IgD of kit in tumour cells. Mutations in the fifth IgD of kit thus appear to be common and potentially sensitive to imatinib mesylate in feline MCTs. These data provide an in vivo model for paediatric mastocytosis where mutations in the fifth IgD of kit also occur. 相似文献
33.
Fukuhara K Osugi H Takada N Takemura M Lee S Morimura K Taguchi S Kaneko M Tanaka Y Fujiwara Y Nishizawa S Fukushima S Kinoshita H 《Hepato-gastroenterology》2004,51(59):1515-1518
BACKGROUND/AIMS: Helicobacter pylori infection is known to induce gastritis, oxidative stress, and cyclooxygenase (COX)-2 expression in the gastric mucosa. However, the effect of H. pylori infection on remnant gastritis has not been studied. We investigated whether the severity of remnant gastritis and COX-2 expression were affected by H. pylori infection after distal gastrectomy. METHODOLOGY: The study included 97 patients with gastric cancer who underwent curative distal gastrectomy with lymphadenectomy in our department between May 1999 and April 2001. All patients underwent endoscopic examination 2 weeks before and 12 weeks after surgery. The presence of H. pylori infection was determined by urease activity, hematoxylin-eosin staining, and immunochemical staining. Histologic remnant gastritis was graded based on the degree of neutrophil infiltration using the updated Sydney System. COX-2 expression was estimated immunohistochemically. RESULTS: Both the degree of neutrophil infiltration and the level of COX-2 expression were significantly higher in patients with than without H. pylori (p<0.05). There was a significant correlation between the degree of neutrophil infiltration and the degree of COX-2 expression (p<0.001). CONCLUSIONS: H. pylori eradication may become a treatment for preventing both remnant gastritis as well as remnant gastric carcinoma after distal gastrectomy. 相似文献
34.
Kenichiro Noda 《Disability and rehabilitation. Assistive technology》2018,13(7):674-675
Environmental Control Units (ECU) are devices or a system that allows a person to control appliances in their home or work environment. Such system can be utilized by clients with physical and/or functional disability to enhance their ability to control their environment, to promote independence and improve their quality of life. Over the last several years, there have been an emergence of several inexpensive, commercially-available, voice activated smart speakers into the market such as Google Home and Amazon Echo. These smart speakers are equipped with far field microphone that supports voice recognition, and allows for complete hand-free operation for various purposes, including for playing music, for information retrieval, and most importantly, for environmental control. Clients with disability could utilize these features to turn the unit into a simple ECU that is completely voice activated and wirelessly connected to appliances. Smart speakers, with their ease of setup, low cost and versatility, may be a more affordable and accessible alternative to the traditional ECU.
- Implications for Rehabilitation
Environmental Control Units (ECU) enable independence for physically and functionally disabled clients, and reduce burden and frequency of demands on carers.
Traditional ECU can be costly and may require clients to learn specialized skills to use.
Smart speakers have the potential to be used as a new-age ECU by overcoming these barriers, and can be used by a wider range of clients.
35.
Tatsuro Tamatsukuri Masayuki Ohbayashi Noriko Kohyama Yasuna Kobayashi Toshinori Yamamoto Kenichiro Fukuda Shunsuke Nakamura Yasufumi Miyake Kenji Dohi Mari Kogo 《Journal of infection and chemotherapy》2018,24(10):834-840
In recent years, augmented renal clearance (ARC), in which renal function is excessively enhanced, has been reported, and its influence on β-lactam antibiotics has been investigated. In this study, we aimed to determine the optimum population pharmacokinetic model of meropenem in patients with sepsis with ARC, and evaluated dosing regimens based on renal function. Seventeen subjects (6 with ARC and 11 without) were enrolled in this study. Predicted meropenem concentrations were evaluated for bias and precision using the Bland–Altman method. To examine the dosing regimen, Monte Carlo simulation was performed to calculate the cumulative fraction of response (CFR). In patients with ARC, the bias (average of the predicted value and measured value residuals) of models constructed by Crandon et al. (2011), Roberts et al. (2009), and Jaruratanasirikul et al. (2015) were 5.96 μg/mL, 10.91 μg/mL, and 4.41 μg/mL, respectively. Following 2 g meropenem every 8 h (180 min infusion), CFR ≥ 90%, a criterion of success for empirical therapy, was achieved, even with creatinine clearance of 130–250 mL/min. For patients with sepsis and ARC, the model of Jaruratanasirikul et al. showed the highest degree of accuracy and precision and confirmed the efficacy of the meropenem dosing regimen in this patient population. 相似文献
36.
Kai Lin Kenichiro Suwa Heng Ma Jeremy D. Collins Michael Markl James C. Carr 《The international journal of cardiovascular imaging》2018,34(10):1637-1645
The aim of the present study was to establish T1 variation (T1v) thresholds for duplicated measurements of regional T1 values in left ventricle (LV) using magnetic resonance imaging (MRI). Eighteen healthy volunteers were recruited to undergo two consecutive cardiac MRI scans using modified Look-Locker Inversion recovery (MOLLI) with two spatial resolutions on different days to repeat T1 measurements on LV. The absolute differences (d) and standard deviations (SDs) of regional T1 values were acquired with the two scans and two readers. T1v threshold (mean difference?+?2SD), intra-class correlation coefficient (ICC) and coefficient of variation (CoV) were calculated. T1 mapping using the MOLLI sequence (with multiple spatial resolutions) was successfully performed in all 18 volunteers twice. On a per-slice basis, ICCs for intra-observer, inter-observer, inter-resolution and inter-study T1v were 0.988, 0.899, 0.763 and 0.6. CoVs were 0.72, 2.39, 3.90 and 4.28%. T1v thresholds were 22, 66, 118 and 120 ms. On a per-segment basis, ICCs for intra-observer, inter-observer, inter-resolution and inter-study T1v were 0.974, 0.859, 0.711 and 0.594. CoVs were 1.09, 3.36, 4.69 and 5.01%. T1v thresholds were 33, 94, 140 and 144 ms. Those thresholds may be useful for discriminating disease-initiated T1v from random errors of T1 measurements. 相似文献
37.
Junya Sato Hiroyuki Matsubayashi Hirotoshi Ishiwatari Tatsunori Satoh Junichi Kaneko Kazuma Ishikawa Masao Yoshida Kohei Takizawa Yohei Yabuuchi Yoshihiro Kishida Kenichiro Imai Kinichi Hotta Katsuhiko Uesaka Keiko Sasaki Hiroyuki Ono 《Internal medicine (Tokyo, Japan)》2021,60(5):739
We herein report a unique form of autoimmune pancreatitis (AIP) spreading along the main pancreatic duct (MPD). A 70-year-old man was referred for a small lesion at the pancreatic neck, accompanying an adjacent cyst and dilated upstream MPD. Four years earlier, health checkup images had shown a pancreatic cyst but no mass lesion. Endoscopic ultrasonography showed a contrast-enhanced, tumorous lesion, mainly occupying the MPD. With a preoperative diagnosis of ductal neoplasms mainly spreading in the MPD, Whipple''s resection was performed. The resected specimens showed MPD periductitis with IgG4-related pathology, indicating type 1 AIP. Clinicians should practice caution concerning the various AIP forms. 相似文献
38.
Masahiro Saito Tomoyuki Koike Yasuaki Abe Kenichiro Nakagawa Takeshi Kanno Xiaoyi Jin Waku Hatta Kaname Uno Naoki Asano Akira Imatani Fumiyoshi Fujishima Atsushi Masamune 《Internal medicine (Tokyo, Japan)》2021,60(3):391
We herein report the first case of foveolar-type gastric adenocarcinoma that developed after the initiation of vonoprazan (VPZ). A 51-year-old man had heartburn at the first visit and reflux esophagitis endoscopically, so he started taking VPZ. An approximately 5-mm-sized reddish polyp with a raspberry-like morphology was detected at the anterior wall of the upper body of the stomach 156 weeks after starting maintenance therapy with VPZ 10 mg/day. It was diagnosed as foveolar-type gastric adenocarcinoma based on a biopsy. Another approximately 4-mm-sized foveolar-type gastric adenocarcinoma was also detected at the posterior wall of the middle body of the stomach. 相似文献
39.
Nakatsuka Takuma Nakagawa Hayato Hayata Yuki Wake Taijiro Yamada Tomoharu Nishibatake Kinoshita Mizuki Nakagomi Ryo Sato Masaya Minami Tatsuya Uchino Koji Enooku Kenichiro Kudo Yotaro Tanaka Yasuo Kishikawa Takahiro Otsuka Motoyuki Tateishi Ryosuke Koike Kazuhiko 《Journal of gastroenterology》2021,56(5):456-469
Journal of Gastroenterology - Liquid biopsies, particularly those involving circulating tumor DNA (ctDNA), are rapidly emerging as a non-invasive alternative to tumor biopsies. However, clinical... 相似文献
40.
Iwakawa Hidehiro Takigawa Masateru Goya Masahiko Iwata Toyoto Martin Claire A. Anzai Tatsuhiko Takahashi Kunihiko Amemiya Miki Yamamoto Tasuku Sekigawa Masahiro Shirai Yasuhiro Tao Susumu Hayashi Tatsuya Takahashi Yoshihide Watanabe Hiroyuki Sasano Tetsuo 《Journal of interventional cardiac electrophysiology》2022,63(1):185-195
Journal of Interventional Cardiac Electrophysiology - Clinical implication of local impedance (LI) for radiofrequency (RF) ablation has not been fully established. This study aimed to investigate... 相似文献