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991.
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Possible pro‐inflammatory role of heparin‐binding epidermal growth factor‐like growth factor in the active phase of systemic sclerosis
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![点击此处可从《The Journal of dermatology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Megumi Hirabayashi Yoshihide Asano Takashi Yamashita Shunsuke Miura Kouki Nakamura Takashi Taniguchi Ryosuke Saigusa Takehiro Takahashi Yohei Ichimura Takuya Miyagawa Ayumi Yoshizaki Tomomitsu Miyagaki Makoto Sugaya Shinichi Sato 《The Journal of dermatology》2018,45(2):182-188
Heparin‐binding epidermal growth factor (EGF)‐like growth factor (HB‐EGF) is a member of the EGF family growth factors, which affects multiple aspects of the wound healing process such as epithelialization, wound contraction and angiogenesis. In our study, we measured the serum HB‐EGF levels of 51 systemic sclerosis (SSc) patients, which showed a significant increase compared with those of 20 normal subjects. Further analysis revealed a positive correlation between the HB‐EGF level and pulmonary ground‐glass score but no correlation between the former and pulmonary fibrosis score. Other findings include: a significant increase of serum sialylated carbohydrate antigen KL‐6 levels and significant shortness of disease duration in the diffuse cutaneous SSc patients with elevated HB‐EGF levels; and significantly higher HB‐EGF levels in the presence of Raynaud's phenomenon, in that of telangiectasia, and in the absence of contracture of phalanges in all SSc patients. We then evaluated HB‐EGF mRNA levels of fibroblasts harvested from skin samples of the SSc patients and those of foreskin‐derived fibroblasts treated with transforming growth factor‐β, both of which were significantly higher than each control. In conclusion, we speculate that HB‐EGF plays a pro‐inflammatory role in the active skin and lung lesions of SSc. 相似文献
994.
996.
Epigenetic down‐regulation of SOX2 is an independent poor prognostic factor for hypopharyngeal cancers
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![点击此处可从《Histopathology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
997.
Hironori Takahashi Michi Hisano Haruhiko Sago Atsuko Murashima 《Hypertension in pregnancy》2014,33(1):55-60
Objective: To find a risk factor for “uncomplicated” preeclampsia (PE) comparing blood biochemical parameters between women with uncomplicated PE and healthy pregnant women in each trimester of pregnancy. Methods: A retrospective study was performed on 83 cases of uncomplicated PE, selected from 434 patients with PE, disregarding subjects with other complications relevant to hypertension during pregnancy. The study was limited to women with PE occurring in the third trimester, and records of blood biochemical parameters were evaluated. Controls were recruited from 108 healthy volunteers with normal singleton pregnancies. Results: A significant decrease in total protein was observed in the uncomplicated PE group in the second trimester prior to the onset of clinical symptoms. Conclusion: Hypoproteinemia during pregnancy may be a risk factor for this pathophysiology, and the maintenance of sufficient protein in early pregnancy could contribute to prophylaxis for women with uncomplicated PE. 相似文献
998.
Effectiveness of electric toothbrushing in patients with neuromuscular disability: A randomized observer‐blind crossover trial
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![点击此处可从《Special care in dentistry》网站下载免费的PDF全文](/ch/ext_images/free.gif)
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1000.