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121.
122.
Rika Kawanishi Hiroshi Ueoka Masahiro Tabata Takuo Shibayama Tomofumi Yano Akio Matsushita Kenichi Chikamori Hiroyuki Kohara Mine Harada Taisuke Ohnoshi 《International journal of clinical oncology / Japan Society of Clinical Oncology》1997,2(2):118-120
We describe the spontaneous regression of a malignant pleural mesothelioma with left pleural effusion, chest pain, and a high
fever (38° to 39°C) in a 37-year-old man. The patient was referred to us because multiple nodules were seen on his chest radiograph
after he was successfully treated with thoracocentesis and conventional antibiotic therapy for pleural effusion. Our diagnosis
was malignant pleural mesothelioma, based on histologic findings in a biopsy specimen obtained during thoracoscopy. Interestingly,
the tumors markedly regressed without treatment, and the patient was doing well more than 5 months after the cancer was diagnosed.
The spontaneous regression of malignant pleural mesothelioma is rare, and this may represent the first case report. 相似文献
123.
Survey on visual and musculoskeletal symptoms in VDT workers] 总被引:2,自引:0,他引:2
Kazuyuki Iwakiri Ippei Mori Midori Sotoyama Kaori Horiguchi Takanori Ochiai Hiroshi Jonai Susumu Saito 《SANGYO EISEIGAKU ZASSHI》2004,46(6):201-212
With the spread of visual display terminals (VDT) in offices, the numbers of workers using VDT and the working hours at such equipment have increased rapidly in recent years. Also, preventive measures for fatigue have been proposed and the office-working environment has been improved. To examine the effects of the rapid changes in working conditions and environment on the health of VDT workers, we conducted a questionnaire survey in 2002. A self-reported questionnaire was distributed to 3,927 office workers; 2,374 (60.5%) responded. Subjects whose questionnaires had missing data were excluded from analysis. As a result, 1,406 (male: 1,069, female: 337) workers aged 20 to 59 were subjected to analysis. By a logistic regression model, we examined the association between VDT use and visual and musculoskeletal symptoms. Prevalence of eye strain and/or pain (72.1%) was the highest, followed by neck stiffness and/or pain (59.3%), low back stiffness and/or pain (30.0%) and hand or arm strain and/or pain (13.9%). Women consistently reported more discomfort than men. As a result of the logistic regression model, eye strain and/or pain was associated with dissatisfaction with airflow, but not with factors affecting visual symptoms as reported in previous studies, for example, reflection of light and blurred characters on the screen. It was thought that airflow appeared as a risk factor because the lighting environment had been improved in offices to prevent reflection of light on the screen. Neck stiffness and/or pain was associated with raising the shoulders during VDT work, the unsuitable shape of the computer mouse for a hand, and the inconvenient arrangement of the mouse in relation to the body. Hand or arm strain and/or pain were associated with the arrangement of the mouse and inappropriate height of the desk. Low back stiffness and/or pain were associated with dissatisfaction with the chair and using the keyboard without a wrist rest. Although measures to prevent fatigue had been implemented for VDT workers, risk factors for musculoskeletal symptoms would be the same as in previous studies. 相似文献
124.
Chemotherapyremainsoneofthemosteffectivetreatmentsfordisseminatedneoplasia[1 ] .However,theef ficacyofmanychemotherapeuticagentsislimitedbytheirtoxicitytonormaltissues,resultinginanarrowtherapeuticindex.Myelosuppressionisthemostfrequentacutedose limitingsideeffectresponsiblefordelaysindrugadminis trationordoseattenuationwithdecreasedantitumorre sponse[2 4] .Particularly,thrombocytopeniaremainsasig nificantcauseofmorbidityincancerpatientsundergoingallogenicorautologousbonemarrow/bloodstemcellt… 相似文献
125.
Yukiko Horinouchi Jotaro Akiyoshi Aki Nagata Hirotaka Matsushita Takashi Tsutsumi Koichi Isogawa Tetsuo Noda Haruo Nagayama 《European neuropsychopharmacology》2004,14(2):157-161
Cholecystokinin 2 (CCK2) receptors have been implicated as mediators of anxiety in standard mouse models such as exploratory behavior both in black and white test boxes and in elevated plus-mazes. We investigated the role of the CCK2 receptor in anxiety by evaluating the behavior of mice lacking the gene for this receptor in these standard anxiety models (i.e., exploratory behavior in a black and white test box and exploratory behavior in an elevated plus-maze). In the black and white test box, mice lacking the CCK2 receptor gene showed significantly increased numbers of transitions between the boxes compared to control mice. In the elevated plus-maze, mice lacking the CCK2 receptor gene displayed significantly more head dips than control mice. These results suggest that mice lacking the CCK2 receptor gene are less anxious than normal mice. 相似文献
126.
127.
Kazuyuki Enomoto Shuichi Takahashi Yasunari Maekawa 《Macromolecular chemistry and physics.》2012,213(1):72-78
Most polymer grafts in grafted polymer films obtained by radiation‐induced solid graft polymerization are not analyzed in detail due to difficulties in isolation of the grafts without structural decomposition. Herein, a novel structural and molecular weight characterization method is reported for polymer grafts that are chemically attached to thermally and chemically stable polymer substrates, based on a swelling‐induced graft detachment in hot water. Polymer grafts prepared by the radiation‐induced polymerization of alkyl acrylate into poly(ethylene‐co‐tetrafluoroethylene) (ETFE) followed by a sulfonation reaction are found to have a ternary copolymer structure whose monomer units contain –COOH or –SO3H groups, or both. 相似文献
128.
Hiroko Sato Tetsuya Sakairi Shiro Takagi Kazuyuki Kitamura 《Experimental and toxicologic pathology》2013,65(1-2):35-37
Altered hepatocellular focus was histopathologically observed in the liver of a 6-week-old Sprague-Dawley rat. The hepatocytes within this lesion had diffusely eosinophilic cytoplasm with scattered basophilia and slightly enlarged nuclei with prominent nucleoli. Based on these cytological characteristics, the lesion of these hepatocytes was classified as an amphophilic focus. This is the first report to describe spontaneous amphophilic focus in a young rat. 相似文献
129.
Tsuyoshi Ito Kazuyuki Uchida Hiroyuki Nakayama 《Experimental and toxicologic pathology》2013,65(1-2):121-125
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induces severe degeneration of dopaminergic (DA-ergic) neurons when administrated to C57BL/6 mice, but such lesions are not observed in BALB/c mice. To clarify the factors which influence such marked strain differences in the susceptibility to MPTP, the involvement of neuronal NOS (nNOS) and inducible NOS (iNOS) was investigated. MPTP was intraperitoneally (ip) administrated to adult C57BL/6 (highly sensitive) and BALB/c (resistant) mice. Immunohistochemical analysis using an antibody to tyrosine hydroxylase (TH) showed a significant decrease in TH-immunopositive areas in the striatum and TH-positive cells in the substantia nigra pars compacta (SNpc) of MPTP-treated C57BL/6 mice at 1 and 7 days (d) after administration, compared to control C57BL/6 mice. On the other hand, MPTP-treated BALB/c mice showed no significant changes. By Western blot analysis, TH, MAO-B, DAT, nNOS and iNOS protein expression levels were examined in intact and MPTP-treated mice. Intact BALB/c mice showed higher DAT protein expression in the striatum and TH protein expression in the midbrain than intact C57BL/6 mice. In addition, MPTP-treated BALB/c mice showed a more significant increase of MAO-B expression than MPTP-treated C57BL/6 mice at 12 h. The increase of nNOS and iNOS protein expressions in MPTP-treated BALB/c mice was more pronounced in the striatum and midbrain than in MPTP-treated C57BL/6 mice at 12 h and 2 d. These results indicate that MAO-B, DAT, nNOS or iNOS expression levels do not influence the different strain susceptibility to MPTP. 相似文献
130.
Impact of the Charlson comorbidity index and prognostic nutritional index on prognosis in patients with early gastric cancer after endoscopic submucosal dissection
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Naoto Iwai Osamu Dohi Yuji Naito Yutaka Inada Akifumi Fukui Shun Takayama Kazuyuki Ogita Kei Terasaki Takahiro Nakano Tomohiro Ueda Tetsuya Okayama Naohisa Yoshida Kazuhiro Katada Kazuhiro Kamada Kazuhiko Uchiyama Takeshi Ishikawa Osamu Handa Tomohisa Takagi Hideyuki Konishi Nobuaki Yagi Yoshito Itoh 《Digestive endoscopy》2018,30(5):616-623