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排序方式: 共有1171条查询结果,搜索用时 15 毫秒
51.
Hiromichi Ishiyama Takefumi Satoh Masashi Kitano Ken-ichi Tabata Shouko Komori Masaomi Ikeda Itaru Soda Shinji Kurosaka Akane Sekiguchi Masaki Kimura Shogo Kawakami Masatsugu Iwamura Kazushige Hayakawa 《Journal of radiation research》2014,55(3):509-517
The purpose of this study was to report the outcomes of high-dose-rate (HDR) brachytherapy and hypofractionated external beam radiotherapy (EBRT) combined with long-term androgen deprivation therapy (ADT) for National Comprehensive Cancer Network (NCCN) criteria-defined high-risk (HR) and very high-risk (VHR) prostate cancer. Data from 178 HR (n = 96, 54%) and VHR (n = 82, 46%) prostate cancer patients who underwent 192Ir-HDR brachytherapy and hypofractionated EBRT with long-term ADT between 2003 and 2008 were retrospectively analyzed. The mean dose to 90% of the planning target volume was 6.3 Gy/fraction of HDR brachytherapy. After five fractions of HDR treatment, EBRT with 10 fractions of 3 Gy was administered. All patients initially underwent ≥6 months of neoadjuvant ADT, and adjuvant ADT was continued for 36 months after EBRT. The median follow-up was 61 months (range, 25–94 months) from the start of radiotherapy. The 5-year biochemical non-evidence of disease, freedom from clinical failure and overall survival rates were 90.6% (HR, 97.8%; VHR, 81.9%), 95.2% (HR, 97.7%; VHR, 92.1%), and 96.9% (HR, 100%; VHR, 93.3%), respectively. The highest Radiation Therapy Oncology Group-defined late genitourinary toxicities were Grade 2 in 7.3% of patients and Grade 3 in 9.6%. The highest late gastrointestinal toxicities were Grade 2 in 2.8% of patients and Grade 3 in 0%. Although the 5-year outcome of this tri-modality approach seems favorable, further follow-up is necessary to validate clinical and survival advantages of this intensive approach compared with the standard EBRT approach. 相似文献
52.
53.
Takenori Kanazawa MD Kazushige Kadota MD PhD Kazuaki Mitsudo MD 《Catheterization and cardiovascular interventions》2015,86(5):942-945
Rotational atherectomy is an indispensable modality for percutaneous coronary intervention of severely calcified lesions. An entrapped rotablator burr is a rare but life‐threatening complication because retrieval is difficult. Although emergent surgical removal is a reliable option for this complication, it is invasive. There are various methods to retrieve an entrapped burr by bailout endovascular approaches. We present two cases of successful rescue of stuck rotablator burr entrapment using a Kiwami straight catheter (4 Fr, Heartrail II, Terumo, Tokyo, Japan). © 2015 Wiley Periodicals, Inc. 相似文献
54.
Mariko O. Uchida Takeshi Arimitsu Kiyomi Yatabe Kazushige Ikeda Takao Takahashi Yasuyo Minagawa 《Developmental psychobiology》2018,60(2):140-149
While the influence of the mother's voice on neonatal heart‐rate response and its relevant activity on cerebral cortex and the autonomic nervous system (ANS) are well known, few studies have assessed its influence on respiratory activity. We investigated the relationship among the respiration rate, the delta wave amplitudes through electroencephalography, and the basal state of ANS through the respiratory variability index while 22 full‐term neonates hear their mother's voice and an unknown voice. It was found that when respiratory variability was large, a transient (<5 s) change in respiration rates was observed in response to an unknown voice, while a greater increase in the delta wave amplitude was observed in the frontal lobe than the parietal one in response to the mother's voice. Conversely, when respiratory variability was small, a sustained increase (>10 s) in respiration rates was observed in response to the mother's voice, while a greater increase in the delta wave amplitude was found in both the frontal and parietal lobes. These results suggest that the basal state of ANS influences the latency of increases in respiration rates. Furthermore, induced by the mother's voice, transient increases in respiration rates are reduced in association with frontal lobe activity, and sustained increases in respiration rates are promoted in association with frontal and parietal lobe activities. 相似文献
55.
Yamashita H Ohno K Amada Y Hattori H Ozawa-Funatsu Y Toya T Inami H Shishikura J Sakamoto S Okada M Yamaguchi T 《The Journal of pharmacology and experimental therapeutics》2004,308(1):127-133
The anticonvulsant activity of 2-[N-(4-chlorophenyl)-N-methylamino]-4H-pyrido[3.2-e]-1,3-thiazin-4-one (YM928), a novel alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist, was studied in animal models of generalized seizure. YM928 exerted significant anticonvulsant effects in the maximal electroshock (MES) seizure test (ED50 = 7.4 mg/kg p.o.), pentylenetetrazol (PTZ)-induced seizure test (ED50 = 9.6 mg/kg p.o.), AMPA-induced seizure test (ED50 = 5.5 mg/kg p.o.), and strychnine-induced seizure test (ED50 = 14.0 mg/kg p.o.) in mice. Effects in rats were detected in the MES seizure test (ED50 = 4.0 mg/kg p.o.) and PTZ-induced seizure test (ED50 = 6.2 mg/kg p.o.). The profile of YM928 was compared with that of established antiepileptics. Valproate showed beneficial effects in all tests used. In contrast, carbamazepine, phenytoin, lamotrigine, phenobarbital, diazepam, ethosuximide, and gabapentin were not active against seizures induced by at least one stimulant. In the rotarod test, YM928 impaired motor coordination (TD50 = 22.5 mg/kg p.o.). The protective index (TD50 value of the rotarod test/ED50 value of MES seizure) was 3.0, suggesting that YM928 can exert antiepileptic effects with only minor motor disturbances. YM928 at doses of 2, 4, and 8 mg/kg p.o. did not significantly affect the threshold of electroshock seizure in rats after 16 days of repeated administration. These data indicate that YM928 does not induce tolerance after subchronic administration. These results indicate that YM928 is a broad-spectrum anticonvulsant that would prove useful for the treatment of generalized seizure in human epileptic patients. 相似文献
56.
Aim of the study
Aged animals as well as elderly humans commonly exhibit calcium (Ca) shortage because of increased Ca excretion into urine and decreased intestinal Ca absorption, which induce elevation of serum PTH levels to maintain serum Ca levels between a normal physiological range. The most important organ that regulates this Ca homeostasis is the kidney. Hachimijiogan (HJG), a traditional herbal medicine in Japan and China, has been used for treating clinical diseases associated with kidney dysfunctions in elderly humans. However, the mechanisms of its pharmacological actions remain to be understood poorly. The present study was designed to examine whether HJG improves age-related unbalance of Ca metabolism at the systemic level using aged rats.Materials and methods
HJG was administered to 21-month-old aged rats for 3 months, and several parameters associated with Ca metabolism in serum and urine were measured.Results
Although HJG as well as aging itself did not affect serum Ca levels compared to young (11-week-old) rats, HJG improved increase in urinary Ca excretion and elevation of serum parathyroid hormone (PTH) levels in aged rats. However, HJG did not improve marked reduction of intestinal Ca absorption in aged rats.Conclusion
HJG showed regulating action for age-related unbalance of Ca metabolism at the systemic level. This finding would provide useful information for treating age-related several disorders associated with Ca unbalance. 相似文献57.
Purpose The aim of this study was to assess the variation of probe rotation angles for detecting a single needle using sagittal images
of transrectal ultrasonography (TRUS).
Materials and methods A phantom study was performed. One needle was inserted through each of 10 holes of the template, and variations in the probe
rotation angles for detecting the needle were measured.
Results The mean variation of probe rotation for detecting a single needle was 17.0° (range 4°–25°). Slightly broader variation was
seen for the needle in holes farther away from the probe.
Conclusion Probe rotation angles for detecting a single needle displayed considerable variation. Seed locations recognized on sagittal
imaging by TRUS are thus indeterminate, and real-time dose calculations using TRUS for 125I seed implantation should be used with care. 相似文献
58.
Shibata T Yasuoka T Inoue K Ikuta T Bito Y 《General thoracic and cardiovascular surgery》2007,55(10):440-441
We hereby present our technique for using the self-retaining flexible arm retractor and its attachments for mitral valve exposure.
The Aortic Valve Assistant, which was developed for aortic valve exposure, is also very useful for exposure of the inferior
wall of the left atrium. Our modified atrial hook provides excellent exposure of the anterior mitral annulus. Extensive dissection
and the combined use of the flexible arm and attachments allows us comfortable access for mitral valve operations. 相似文献
59.
Nobuhiro Koyanagi Kiyoshi Inokuchi Kazushige Beppu Kenji Nagamine Makoto Hashizume Keizo Sugimachi 《Surgery today》1985,15(2):134-139
The time of appearance of the left gastric vein on serial celiac arteriograms in patients with portal hypertension and esophageal
varices was compared with that of the portal vein to assess regional hemodynamics in the left venous portion of the stomach,
an area located in close proximity to the varices. In two thirds of all the patients with cirrhosis or non-cirrhotic idiopathic
portal hypertension (IPH), the left gastric vein was visualized earlier or simultaneously than or with the portal vein, while
in all but one patient with prehepatic portal obstruction, there was a delayed opacification of the left gastric vein. These
results suggest the presence of a hyperdynamic circulatory state which promotes venous hypertension in the left gastric venous
area of the stomach of a considerable number of patients with cirrhosis or IPH. In such a hemodynamic state, selective decompression
of varices can be achieved by a left gastric venous caval shunt. 相似文献
60.
K Koyama K Kameda N Nakamura K Kubota M Shigeta S Isojima 《Fertility and sterility》1991,56(5):954-959
STUDY OBJECTIVE: To study carbohydrate natures in the antigen epitopes corresponding to sperm-immobilizing antibodies in infertile women. DESIGN: Antibody absorption with human sperm and seminal plasma before and after treatments with trifluoromethanesulfonic acid or sodium metaperiodate. PATIENTS: Thirty-three patients who showed a positive sperm immobilization test provided their sera for the experiment. RESULTS: In 25 patients' sera whose sperm-immobilizing antibodies were absorbed with human seminal plasma, the antibody absorbing capabilities were completely abolished by deglycosylation treatment with trifluoromethanesulfonic acid. The sperm-immobilizing antibodies in 4 patients' sera were absorbed out with sperm membrane fraction before the treatment but not after the treatment with trifluoromethanesulfonic acid. In some patients' sera, the antibody-absorbing capabilities of ejaculated sperm were markedly reduced by sodium metaperiodate treatment. CONCLUSION: The majority of sperm-immobilizing antibodies in infertile patients might be generated to carbohydrate structures of the sperm-coating antigens or sperm membrane antigens. 相似文献