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831.
To examine whether CBF can be imaged by color Doppler technique, we visualized CBF using a transesophageal color Doppler imaging system. In 36 of 39 patients with normal coronary arteriograms after heart surgery, the LMT and the proximal LAD were clearly imaged by 2-dimensional echocardiography. Among them, CBF was coded mainly in blue in 32 patients, showing that the flow runs from proximal to distal. In some cases, yellowish and/or reddish components were seen, suggesting the occurrence of aliasing associated with augmentation of flow velocity or flow turbulence. The fast Fourier transformation spectrogram of the pulsed Doppler sampled in the colored flow showed a typical flow velocity pattern of the LAD, which mainly consisted of a predominantly diastolic component. These results indicate that the transesophageal color Doppler technique is advantageous in noninvasively imaging CBF. It should be further sought whether flow abnormality due to coronary stenosis could be determined by this technique. 相似文献
832.
Urinary bile acids in normal subjects and patients with obstructive jaundice and liver cirrhosis were quantitated by mass fragmentography after separation into nonglucuronidated-nonsulfated, glucuronidated and sulfated fractions. Mean values of total bile acids in urine were as follows: Control subjects (n = 7), 1.90 +/- 0.67; obstructive jaundice (n = 9), 77.90 +/- 40.39; liver cirrhosis, compensated (n = 6), 15.14 +/- 8.97, and decompensated (n = 6), 11.84 +/- 9.32 (mean +/- SD, mg/day). The percentages of each conjugate was 19-29% in the non-glucuronidated-nonsulfated fraction, 6-14% in the glucuronidated fraction and 60-74% in the sulfated fraction. Bile acids in urine and serum correlated well in each fraction (r = 0.82-0.84, p less than 0.001). The clearance of the three conjugates was the highest in the sulfates, and the clearance of glucuronides was higher than that of non-esterified bile acids. The glucuronidation and sulfation of bile acids play an important role in the detoxication of bile acids by excreting them into urine, especially in patients with elevated serum bile acids. 相似文献
833.
To elucidate the mechanism of regional hemostasis in the left ventricular (LV) cavity during myocardial infarction, the blood pathway in LV cavity was examined with contrast echocardiography injected from the left atrium before and after coronary ligation in nine canines. Before coronary ligation, contrast echoes spread over LV cavity with one rush. After ligation, smokelike echoes indicating hemostasis were observed at the apical middle of the LV cavity in five dogs with apical akinesis and at the apical area in four dogs with apical dyskinesis. The contrast echoes did not reach the apex within one diastolic period but turned upward to the outflow tract in the middle of the cavity in all dogs. In the cardiac beats that followed, some contrast echoes spread slowly toward the apex, forming a thin layer along the posterior wall in cases with akinesis but not in cases with dyskinesis. The area separated from the blood pathway developed where the smokelike echoes had been developed. Tachycardia exaggerated the abnormality of blood pathway and widened the contrast echo-free area. The abnormal pathway of the blood in apical myocardial infarction develops hemostasis in the apex. This should be one of the mechanisms of thrombus formation in myocardial infarction. 相似文献
834.
S Beppu 《Journal of cardiology》1990,20(4):1009-1019
A deformation of the left ventricular cavity is commonly observed in myocardial infarction, which directly influences the ventricular function. Even in cases without ischemia, a deformation of the left ventricle during systole or diastole is presumed to affect its function. Inward bending of the left ventricular posterobasal wall in giant left atrium is an example of the unfavourable effects of such a deformation. Systolic flattening of the left ventricle is atrial septal defect complicated by pulmonary hypertension is an example of the favourable influences by such a deformation. A regional wall motion abnormality observed in these cases is explained by the deformation attributed to the relationship between the left ventricle and left atrium or between the left and right ventricles. The relationship between the deformation and the function of the left ventricle in ventricular aneurysm can be explained well by the mode of blood turnover within the left ventricle. Contrast studies via the left atrium revealed that blood flow into the left ventricle did not reach the cardiac apex with an aneurysm, but immediately turned upwards towards the outflow tract. These results indicate that, although the left ventricle is anatomically a single cavity, it consists of functioning and non-functioning portions for blood turnover. A morphological abnormality of the left ventricle influences its function even without myocardial ischemia. It is necessary to relate all morphological changes of the left ventricle to cardiac function, regardless of the causes of a deformation. 相似文献
835.
T Masuzawa Y Beppu H Kawabata Y Yanagihara Y Iwamoto T Shimizu R C Johnson 《Journal of clinical microbiology》1992,30(11):3016-3018
Infectivity of Borrelia burgdorferi strain 297 in normal outbred ddY mice was examined. Strain 297 was inoculated intraperitoneally in 3-week-old outbred ddY mice. B. burgdorferi was routinely cultured from the heart and urinary bladder 5 to 84 days postinoculation. The combined isolation rate from both heart and urinary bladder was significantly higher than the rate from spleen, kidney, liver, urine, and blood samples. Three- and 10-week-old mice were infected with inocula of 10(4) and 10(5) or more, respectively. Passive transfer of undiluted and 10-fold-diluted anti-297 rabbit serum and active immunization of 50 to 100 micrograms of lyophilized whole cells completely protected mice from infection with B. burgdorferi. These results suggest that the outbred mouse is a convenient model for experimental infection with B. burgdorferi. 相似文献
836.
S Beppu T Nakatani N Tanaka H Noda K Kumon Y Taenaka S Nakatani H Takano K Miyatake Y Nimura 《Journal of cardiology》1991,21(3):707-716
To investigate the time course of recovery of a failing heart using the left ventricular assist system (LVAS) and to predict the outcome of weaning from the LVAS, 14 patients with a failing heart were studied. Among them, 5 had recovered and survived for more than 2 weeks after weaning from the LVAS (recovered group), while 9 could not be weaned or died within 2 weeks after weaning (unrecovered group). All patients were gradually weaned from the LVAS with adequate support for systemic circulation for 3 days. In the recovered group, indices of systolic time intervals (STIs) showed improvement within a week. However, improvement of STIs was slow reaching a plateau around the 10th day in the unrecovered group. On weaning from the LVAS, aortic systolic pressure and ejection time were regulated by the patients' own hearts and were nearly the same between the 2 groups. However, left atrial pressure was significantly higher in the unrecovered group than in the recovered group. These hemodynamic features were first present on the 7th day. Therefore, hemodynamic data on the 7th assistant day can be a reliable factor in predicting the possibility of successful weaning from the LVAS and recovery in patients with a failing heart. 相似文献
837.
S Kitano K Nagamine T Iwanaga K Beppu N Koyanagi Y Iso K Sugimachi 《Gastroenterologia Japonica》1986,21(1):1-5
Esophageal varices in 50 cirrhotic patients were treated with repeated injection sclerotherapy. Eradication of varices was achieved in 27 patients (54.0%) with a mean of 4.5 injections (range 2-12) after a mean period of 3.1 months (range 1-11). There was no variceal bleeding in these 27 patients once eradication had been achieved, with a mean follow up period of 5.6 months, although bleeding occurred in 5 of the same group before eradication of the varices had been achieved, during an average of 3.1 months, and in 6 of the remaining 23 patients (10 episodes) with residual varices after a mean of 4.7 injections (range 2-12) in a mean period of 12.2 months (range 1-33). Esophageal varices can thus be eradicated with repeated injections and bleeding from recurrent esophageal varices can be prevented in many patients after eradication has been achieved. 相似文献
838.
Shoji Terui M.D. Takashi Terauchi Hiroyuki Abe Yukio Muramatsu Hisatoshi Fukuma Yasuo Beppu Ryohei Yokoyama 《Skeletal radiology》1995,24(5):331-336
The purpose of this study was to investigate technetium-99m pertechnetate (Tc-99m) as a tumor-scanning agent in patients with extra-abdominal fibromatosis, and to establish the sensitivity of this type of scintigraphy. Eleven patients with extra-abdominal fibromatosis were studied: all but one having postsurgical recurrences. Of the 11 patients, diagnosed histologically, 5 underwent repeated Tc-99m scintigraphic follow-up examinations. The injected 370 MBq Tc-99m gave us an early scintigram within 10 min and a delayed one 2 h later. For adequate comparison, the region of interest (ROI) of the scintigram was placed over the tumor. The tumor-to-background (T/BG) count ratio was computed. Extra-abdominal fibromatoses, even recurrences, were demonstrated scintigraphically in both the early and the delayed phase, in all 11 patients. The average T/BG ratio was 2.11 in the early scintigram and 2.15 in the delayed one. The sensitivity and the specificity were both 100%. Tc-99m scintigraphy has proved useful in detecting extra-abdominal fibromatoses and in the follow-up of patients. 相似文献
839.
840.
Hareyama Masato; Nagakura Hisayasu; Tamakawa Mitsuharu; Hyodo Kazusa; Asakura Kohji; Horikoshi Takashi; Tanaka Shigemichi; Imai Kohzoh; Hattori Atsuo; Oouchi Atsushi; Shido Mitsuo; Koshiba Hirofumi; Sakata Koh-ichi; Morita Kazuo 《Japanese journal of clinical oncology》1996,26(3):189-193
Collagen disease are frequently associated with malignant tumors.Recently, radiotherapy combined with chemotherapy has been recommendedfor improving the efficacy of treatment for nasopharyngeal carcinoma.Two patients with nasopharyngeal carcinoma complicated by collagendiseases (dermatomyositis in one, and Sjögren's syndromewith mixed connective tissue disease in the other) were givenradiotherapy combined with chemotherapy consisting of cis-platinumand 5-fluorouracil. Following this combination therapy, bothpatients developed retropharyngeal abscess and ulceration ofthe mucosal membrane on the posterior wall of the oropharynx;there was no tumor cell involvement. Because these injurieswere more severe than would have been expected from radiotherapyalone, it is recommended that special attention be paid to combinationtherapy in patients with nasopharyngeal carcinoma complicatedby collagen disease. 相似文献