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排序方式: 共有6613条查询结果,搜索用时 15 毫秒
41.
H Fukui H Ide F Hanyu H Ikemoto N Okushima Y Murata Y Sato A Yamada 《Gan to kagaku ryoho. Cancer & chemotherapy》1987,14(4):1106-1110
Subrenal Capsule Assay (SRCA) as a chemosensitivity test was performed on 14 esophageal squamous cell carcinomas in order to select a more effective form of chemotherapy. Of the 14 assays, 12 were evaluable. Mice were treated with anticancer agents (e.g. Cisplatin, Bleomycin, Methotrexate, Vindesine) on days 1 and 3 after transplantation, and on day 6, the sensitivities were determined. Fresh esophageal cancers yielded an evaluable assay rate of 74%. The implant grew progressively for six days in the remaining group of control mice. Histologically, host cell infiltration at the border of the implant was observed from day 3 after transplantation, and cells had degenerated or had been partially replaced by scar tissue by day 6. The results of chemosensitivity tests differed according to the anticancer agent used or from case to case. Clinically, correspondence between the assay results and clinical results was obtained in 5 out of 7 cases. SRCA is a new promising chemosensitivity test which is clinically useful, and the present results indicated the feasibility of its use in developing an effective chemotherapy for esophageal cancer. 相似文献
42.
Mariko Kobayashi Yukihiro Takahashi Makoto Ando Naoki Wada Masamitsu Murata Toshio Kikuchi 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2005,53(12):635-637
A 6 month-old male infant (weight: 4.5 kg) with congenital aortic stenosis underwent aortic valve replacement with a pulmonary
autograft (Ross procedure). The right ventricular outflow tract (RVOT) was reconstructed with a polytetrafluoroethylene (PTFE)-valved
equine pericardial conduit. At the age of 5, re-RVOT reconstruction with an equine pericardial patch bearing a PTFE monocusp
was required because of severe pulmonary stenosis resistant to 2 attempts of percutaneous transluminal pulmonary valvotomy.
Currently, at the age of 8, the degree of aortic regurgitation is trivial and the pulmonary autograft is free of functional
deterioration despite somatic growth. 相似文献
43.
44.
Therapeutic effect of SF-2103A, a novel carbapenem antibiotic, in combination with cefotaxime, cefoperazone and other cephalosporins 总被引:1,自引:0,他引:1
Combinations of SF-2103A with cefotaxime, cefoperazone or cefazolin showed synergistic efficacy at a wide range of combination ratios against experimental infection in mice due to Proteus vulgaris GN76/C-1, producing type Ic cephalosporinase, Escherichia coli No. 29/36 RGN823, producing type IIIa (TEM-2) penicillinase and E. coli GN206, producing type Ib cephalosporinase. These effects by SF-2103A were greater than those seen with sulbactam. The in vitro and in vivo synergistic activities were roughly correlated. Potent in vivo activity of SF-2103A was related to good pharmacokinetic properties, with blood half-life of 30 minutes and urinary recovery of 55.2% after parenteral administration to rats. Furthermore, SF-2103A was stable to rat kidney homogenate. The high stability of SF-2103A in aqueous and biological media was correlated with the sulfonate group at C-3. 相似文献
45.
Determination of the phylogenetic relationships among Pacific salmonids by using short interspersed elements (SINEs) as temporal landmarks of evolution. 总被引:14,自引:2,他引:12 下载免费PDF全文
S Murata N Takasaki M Saitoh N Okada 《Proceedings of the National Academy of Sciences of the United States of America》1993,90(15):6995-6999
Several subfamilies of the salmonid Hpa I short interspersed element (SINE) family were isolated from salmonid genomes and were sequenced. For each genomic locus that represented the subfamily, amplification by PCR of the orthologous loci in the 12 fish allowed us to determine the order of branching of the Pacific salmonid species. The deduced phylogeny suggests three evolutionary lines, namely, a line of chum salmon, pink salmon, and kokanee; a line of coho salmon and chinook salmon; and a line of steelhead trout. Our data also support a change in the phylogenetic assignment of steelhead trout from Salmo to Oncorhynchus. We present here an extensive phylogenetic tree constructed from an analysis of differential insertion of SINEs, and we propose that SINE insertion analysis is one of the best available methods for clarifying the order of divergence of closely related species. 相似文献
46.
47.
M Murata M Otsuka Y Hayakawa E Takahashi H Tsuji T Hori 《The Japanese journal of human genetics》1990,35(4):291-302
A population survey of a common folate-sensitive fragile site, fra(3)(p14), was carried out on PHA-stimulated peripheral lymphocytes of 1,078 healthy subjects. Fra(3)(p14) was expressed more frequently in the younger than in the older, and in males than in females. It also showed some seasonal variation. The age difference of the expression frequency was also observed by aphidicolin treatment. A positive correlation of the expression frequency was found, though not so strongly, between both culture conditions of folate deprivation and aphidicolin treatment, These findings suggest that the inter-individual variation in the expressivity of common fragile sites is not only ascribable to chance, but to some physiological conditions of blood donors such as response rate of lymphocyte to PHA stimulation and blood concentration of folic acid. 相似文献
48.
Human anticentriole autoantibody in patients with scleroderma and Raynaud's phenomenon 总被引:5,自引:0,他引:5
Y Moroi I Murata A Takeuchi N Kamatani K Tanimoto R Yokohari 《Clinical immunology and immunopathology》1983,29(3):381-390
Unique autoantibody was found in sera from two different patients that reacted with centrioles of both cultured mammalian cells and human peripheral leukocytes as detected by the indirect immunofluorescent method. Sera from the same individuals, one with scleroderma and the other suffering from Raynaud's phenomenon, also stained the basal bodies of rat tracheal ciliated cells by the identical technique. Data from subsequent investigations have suggested that the antigen(s) involved in the reaction are water-insoluble protein(s) or polypeptide(s) associated with centrioles and are distinct from microtubular proteins or purine nucleoside phosphorylase. 相似文献
49.
Possible contribution of follicular interleukin-1beta to nitric oxide generation in human pre-ovulatory follicles 总被引:2,自引:0,他引:2
Tao M; Kodama H; Kagabu S; Fukuda J; Murata M; Shimizu Y; Hirano H; Tanaka T 《Human reproduction (Oxford, England)》1997,12(10):2220-2225
The aim of this study was to investigate the relationships between
follicular nitric oxide (NO) metabolite concentrations and several related
variables, with special reference to follicular interleukin- 1beta
(IL-1beta). The follicular fluid from the leading and secondary follicles
was collected individually from 20 women undergoing in-vitro fertilization
(IVF) treatment, and the concentrations of nitrite (NO2-) and nitrate
(NO3-) were determined fluorometrically using 2,3- diaminonaphthalene. Both
follicular nitrite (r = 0.42, P < 0.01) and nitrate (r = 0.49, P <
0.001) were found to be significantly correlated with follicular IL-1beta
concentrations. There were also significant positive correlations between
follicular nitrate and the number of oocytes retrieved (P < 0.01) and
serum oestradiol concentration on the day of human chorionic gonadotrophin
(HCG) administration (P < 0.05). When follicular cells were incubated in
vitro with 10 ng/ml of IL-1beta for 24 h, nitrate generation was
significantly (P < 0.01) elevated compared with the control. In
conclusion, our study demonstrates that follicular IL-1beta and the number
of developing follicles are significant variables that affect follicular NO
concentrations, and points to the possible contribution of IL-1beta to NO
generation in human preovulatory follicles.
相似文献
50.
Yoshio Hiasa Noriyuki Ito Masato Ohshima Tomoyoshi Ohmori Asao Seki Toshikazu Tatsumi Hiromu Yokoi Chikayoshi Iwata Yoshio Murata Nobuyuki Ito † 《Pathology international》1978,28(4):637-644
Light and electron microscopic studies have been made on an anaplastic giant-cell tumor that developed in a woman 8 years after an operation on the thyroid for papillary carcinoma. Many giant cells were observed in the anaplastic tumor tissue, but no follicles. Numerous tightly-packed mitochondria and abundant ribosomes were present, but there were no desmosomes. The basement membrane was not distinct. 相似文献